ES2054623T3 - Un procedimiento para producir una preparacion farmaceutica estable que contiene nicorandil. - Google Patents

Un procedimiento para producir una preparacion farmaceutica estable que contiene nicorandil.

Info

Publication number
ES2054623T3
ES2054623T3 ES87100549T ES87100549T ES2054623T3 ES 2054623 T3 ES2054623 T3 ES 2054623T3 ES 87100549 T ES87100549 T ES 87100549T ES 87100549 T ES87100549 T ES 87100549T ES 2054623 T3 ES2054623 T3 ES 2054623T3
Authority
ES
Spain
Prior art keywords
preparation containing
procedure
producing
pharmaceutical preparation
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87100549T
Other languages
English (en)
Inventor
Yoshimitsu Iida
Shuji Sumida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26342067&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2054623(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2054623T3 publication Critical patent/ES2054623T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE UN METODO PARA LA PRODUCCION DE UNA PREPARACION QUE CONTIENE NICORANDIL, UN ACIDO ALIFATICO SUPERIOR SATURADO O UN ALCOHOL SUPERIOR SATURADO QUE ES SOLIDO A TEMPERATURA AMBIENTE Y, OPCIONALMENTE, UN ACIDO ORGANICO, TAL COMO ACIDO FUMARICO, ACIDO OXALICO, ACIDO SALICILICO, ACIDO TARTARICO O ACIDO GLUTARICO. EL NICORANDIL ES UTIL COMO CURATIVO PARA VARIOS TIPOS DE ANGINA DE PECHO. SIN EMBARGO ES INESTABLE EN CONDICIONES HUMEDAS Y BAJO PRESION COMPRESIVA EJERCIDA POR OPERACIONES DE TABLETEO EN LA FABRICACION DE PASTILLAS Y, POR TANTO, SE HA DESEADO EL DESARROLLO DE LA PREPARACION DE NICORANDIL ESTABLE.
ES87100549T 1986-01-17 1987-01-16 Un procedimiento para producir una preparacion farmaceutica estable que contiene nicorandil. Expired - Lifetime ES2054623T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP772286 1986-01-17
JP6185686 1986-03-19

Publications (1)

Publication Number Publication Date
ES2054623T3 true ES2054623T3 (es) 1994-08-16

Family

ID=26342067

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87100549T Expired - Lifetime ES2054623T3 (es) 1986-01-17 1987-01-16 Un procedimiento para producir una preparacion farmaceutica estable que contiene nicorandil.

Country Status (21)

Country Link
US (1) US4822808A (es)
EP (1) EP0230932B1 (es)
KR (1) KR940000232B1 (es)
CN (1) CN1009525B (es)
AR (1) AR241514A1 (es)
AU (1) AU591958B2 (es)
CA (1) CA1285486C (es)
CS (1) CS276587B6 (es)
DE (1) DE3769662D1 (es)
DK (1) DK174918B1 (es)
EG (1) EG18088A (es)
ES (1) ES2054623T3 (es)
FI (1) FI87043C (es)
GR (1) GR3002288T3 (es)
HK (1) HK66193A (es)
HU (1) HU196705B (es)
MX (1) MX167912B (es)
NO (1) NO173590C (es)
NZ (1) NZ218917A (es)
PT (1) PT84124B (es)
SG (1) SG64893G (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2148220A1 (en) * 1992-11-06 1994-05-26 Kiyoshi Tamura Method for producing composition for solid medicine
AU8561298A (en) * 1997-08-08 1999-03-01 Chugai Seiyaku Kabushiki Kaisha Remedies for complications of diabetes
IT1293835B1 (it) * 1997-08-08 1999-03-10 Foscama Biomed Chim Farma Composizioni farmaceutiche orali in forma solida a cessione modulata contenenti nicorandil e procedimento per la loro preparazione
WO1999059552A1 (en) * 1998-05-15 1999-11-25 Chugai Seiyaku Kabushiki Kaisha Regulated release preparations
US6417207B1 (en) 1999-05-12 2002-07-09 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
TWI324074B (en) * 2001-10-09 2010-05-01 Bristol Myers Squibb Co Flashmelt oral dosage formulation
FR2872705B1 (fr) * 2004-07-08 2008-07-18 Aventis Pharma Sa Compositions contenant du nicorandil, procede de preparation et utilisation
WO2008112227A1 (en) * 2007-03-12 2008-09-18 Reliant Pharmaceuticals, Inc. Treatment with nicorandil and omega-3 fatty acids, and a combination product thereof
SI2098249T1 (sl) * 2008-03-05 2013-02-28 Rivopharm Sa Nosilci nikorandila s povečano stabilnostjo
KR20100007082A (ko) * 2008-07-11 2010-01-22 주식회사 엘지생명과학 니코란딜을 포함하는 서방성 제제
KR20110044780A (ko) * 2008-08-14 2011-04-29 교린 세이야꾸 가부시키 가이샤 안정화된 의약 조성물
CA2910112C (en) 2013-04-25 2021-02-16 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
CN110123749B (zh) * 2019-06-03 2022-01-25 太阳升(亳州)生物医药科技有限公司 尼可地尔脂微球制剂及其制备方法
CN111574441B (zh) * 2020-05-26 2021-12-31 中国科学院上海药物研究所 一种尼可地尔与水杨酸的共晶及其制备方法和应用
CN115429763B (zh) * 2021-06-02 2024-01-02 北京四环科宝制药股份有限公司 尼可地尔片剂及其制备方法
CN114732792A (zh) * 2022-03-25 2022-07-12 北京诺康达医药科技股份有限公司 一种尼可地尔口腔崩解片及其制备方法
CN115317456A (zh) * 2022-08-17 2022-11-11 北京科源创欣科技有限公司 一种尼可地尔片组合物及其制备方法
CN115282123B (zh) * 2022-09-13 2023-11-03 南京比逊医药科技有限公司 一种稳定的尼可地尔制剂的制备方法
CN117547534B (zh) * 2023-11-10 2024-07-12 江南大学 尼可地尔缓释制剂及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3168438A (en) * 1962-08-09 1965-02-02 Synergistics Inc Vasodilation by nitric acid ester derivatives of nicotinic acid
US3332848A (en) * 1963-07-10 1967-07-25 Hoffmann La Roche Microcrystalline cellulose with starch in niacinamide ascorbic acid tablet granulations
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
JPS599539B2 (ja) * 1979-11-13 1984-03-03 日本化薬株式会社 ニトログリセリン水溶液及びその製造法
US4490377A (en) * 1980-07-29 1984-12-25 Syntex (U.S.A.) Inc. Acid stabilized compositions of thieno-pyridine derived compounds
JPS57145659A (en) * 1981-03-06 1982-09-08 Chugai Pharmaceutical Co Ltd Production of tablet
US4382091A (en) * 1981-04-30 1983-05-03 Syntex (U.S.A.) Inc. Stabilization of 1-substituted imidazole derivatives in talc
JPS5839618A (ja) * 1981-09-04 1983-03-08 Chugai Pharmaceut Co Ltd 持続性積層錠剤
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
JPH0653658B2 (ja) * 1984-12-17 1994-07-20 中外製薬株式会社 安定な錠剤の製造法
US5188840A (en) * 1985-09-26 1993-02-23 Chugai Seiyaku Kabushiki Kaisha Slow-release pharmaceutical agent

Also Published As

Publication number Publication date
AU6764887A (en) 1987-07-23
NO870212L (no) 1987-07-20
NZ218917A (en) 1989-10-27
KR870006894A (ko) 1987-08-13
MX167912B (es) 1993-04-22
DK19187D0 (da) 1987-01-15
PT84124A (en) 1987-02-01
EG18088A (en) 1992-08-30
CS8700282A2 (en) 1991-07-16
HU196705B (en) 1989-01-30
CA1285486C (en) 1991-07-02
EP0230932A2 (en) 1987-08-05
AU591958B2 (en) 1989-12-21
FI87043B (fi) 1992-08-14
FI870131L (fi) 1987-07-18
CN87100285A (zh) 1987-08-19
CS276587B6 (en) 1992-07-15
DE3769662D1 (de) 1991-06-06
PT84124B (pt) 1989-02-28
SG64893G (en) 1993-08-06
US4822808A (en) 1989-04-18
KR940000232B1 (ko) 1994-01-12
NO173590B (no) 1993-09-27
FI87043C (fi) 1992-11-25
DK174918B1 (da) 2004-02-23
GR3002288T3 (en) 1992-12-30
EP0230932A3 (en) 1987-12-09
HK66193A (en) 1993-07-16
CN1009525B (zh) 1990-09-12
HUT44435A (en) 1988-03-28
AR241514A1 (es) 1992-08-31
DK19187A (da) 1987-07-18
NO870212D0 (no) 1987-01-19
FI870131A0 (fi) 1987-01-14
NO173590C (no) 1994-01-05
EP0230932B1 (en) 1991-05-02

Similar Documents

Publication Publication Date Title
ES2054623T3 (es) Un procedimiento para producir una preparacion farmaceutica estable que contiene nicorandil.
UY23804A1 (es) Procedimiento de preparacion de medicamentos en forma de comprimidos con liberacion retardada de sustancia activa.
IT1042715B (it) Procedimento per la produzione di alcool da materiali cellulosici
ES2067159T3 (es) Proceso para la preparacion de nitrilos.
DK165447C (da) 2-pyrimidinyl-1-piperazin-derivater, fremgangsmaader til deres fremstilling og laegemidler indeholdende dem
IT1145695B (it) Procedimento per la produzione di alcool butilico terziario
IT1154024B (it) Derivati pridinici e procedimento per la loro produzione
ES2054643T3 (es) Un procedimiento para la despolimerizacion controlada de polisacaridos.
ES442215A1 (es) Procedimiento para la preparacion de nuevos derivados de a- cido 1-(bis-trifluorometilfenil)-2-oxo-pirrolidin-4-carboxi-lico.
MX9204110A (es) Derivados del acido quinolonacarboxilico y procedimiento para su preparacion.
ES8609193A1 (es) Procedimiento para preparar analogos de mevalonolactona y derivados de los mismos
ES8703447A1 (es) Procedimiento para la preparacion de una (2-3-trans)-lactona
ES8201167A1 (es) Procedimiento para la obtencion de derivados de cefalospori-nas
DK546489D0 (da) Thienopyridin-mevalonolactoner, fremgangsmaade til fremstilling heraf og farmaceutisk praeparat omfattende samme
IL61285A (en) 2-hydroxyalkyl-3,4,5-trihydroxy-piperidine compounds,their production and pharmaceutical compositions containing them
SE7610595L (sv) Forfarande for framstellning av en farmaceutisk komposition av insulinŸfor rektal anvendning
ES2044970T3 (es) Procedimiento para la obtencion de compuestos hidrogenados del acido 1-benzooxacicloalquil-piridincarboxilico.
IT7921788A0 (it) Composizione farmaceutica contenente un derivato di acido para-amminobenzoico come ingrediente attivo.
ES2060127T3 (es) Halogenoalquilfenil-alcoholes-cetonas y sus hidratos.
ES2028838T3 (es) Procedimiento para la obtencion de nuevos derivados de 4,5-hidro-oxazoles.
DK156474C (da) S-(carbamoylphenylselenyl)-derivater af mercaptaner, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
ES8105997A1 (es) Un procedimiento para la preparacion de fenil-quinolicidinas
ES8304978A1 (es) "procedimiento para la preparacion de derivados triptaminicos sustituidos de tieniloxipropanolaminas, racemicos y opticamente activos".
ES8801615A1 (es) Un procedimiento para preparar esteres de acidos ciclopropanocarboxolico que contienen fluor.
ES8705463A1 (es) Un procedimiento para la preparacion de 1-metil-4,5-dihi- droorotil-histidil-prolinamida

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 230932

Country of ref document: ES