ES2054825T3 - Compuestos heterociclicos terapeuticos. - Google Patents

Compuestos heterociclicos terapeuticos.

Info

Publication number
ES2054825T3
ES2054825T3 ES88309943T ES88309943T ES2054825T3 ES 2054825 T3 ES2054825 T3 ES 2054825T3 ES 88309943 T ES88309943 T ES 88309943T ES 88309943 T ES88309943 T ES 88309943T ES 2054825 T3 ES2054825 T3 ES 2054825T3
Authority
ES
Spain
Prior art keywords
compounds
rent
selected independently
heterociclicos
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88309943T
Other languages
English (en)
Inventor
Alan Duncan Robertson
Graeme Richard Martin
Janet Susan Buckingham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2054825T3 publication Critical patent/ES2054825T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA(I), EN LA QUE R1, Y R2 SE SELECCIONAN INDEPENDIENTEMENTE DE ENTRE H Y ALQUILO DE 1 A 4 C; R3 Y R4 SE SELCCIONAN INDEPENDIENTEMENTE DE H, ALQUILO DE 1 A 6 C O ARILO PUDIENDO ESTOS ESTAR SUSTITUIDOS POR UNO O MAS ATOMOS O GRUPOS HALOGENO, ALQUENILO DE 1 A 4 C O ARILO, (NO PUDIENDO R3 SE BENCILO CUANDO R4 ES H); M ES 0, 1 O 2; N ES 0, 1, 2 O 3; W ES UN GRUPO DE FORMULA (I), (II), (III) O (IV), (DONDE Y PUEDE SER O, METILENO Y = N - R5) R5 ES H, ALQUILO DE 1 A 4 C O BENCILO; Z Y Z''SE SELCCIONAN INDEPENDIENTEMENTE DE = C = O, = C = S Y METILENO Y EL CENTRO QUIRAL * ESTA EN FORMA (S), (R) O MEZCLA DE AMBAS); X ES UN GRUPO QUE SE SELECCIONA DE ARILO, XANTENILO O DIBENZOFURANILO Y PUEDE ESTAR SUSTITUIDO POR HALOGENO O DIVERSOS GRUPOS QUE SE ESPECIFICSAN. TAMBIEN SE REFIERE A LAS SALES Y SOLVATOS DE ESTOS COMPUESTOS, A FORMULACIONES FARMACEUTICAS QUE LOS CONTIENEN Y A SU EMPLEO EN MEDICINA, ESPECIALMENTE PARA EL TRATAMIENTO DE LA MIGRAÑA.
ES88309943T 1987-10-23 1988-10-21 Compuestos heterociclicos terapeuticos. Expired - Lifetime ES2054825T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878724912A GB8724912D0 (en) 1987-10-23 1987-10-23 Indole derivatives

Publications (1)

Publication Number Publication Date
ES2054825T3 true ES2054825T3 (es) 1994-08-16

Family

ID=10625806

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88309943T Expired - Lifetime ES2054825T3 (es) 1987-10-23 1988-10-21 Compuestos heterociclicos terapeuticos.

Country Status (18)

Country Link
EP (1) EP0313397B1 (es)
JP (1) JP2501631B2 (es)
CN (1) CN1035113A (es)
AT (1) ATE90089T1 (es)
AU (1) AU604165B2 (es)
DD (1) DD283140A5 (es)
DE (1) DE3881472T2 (es)
DK (1) DK586588A (es)
ES (1) ES2054825T3 (es)
FI (1) FI884879A7 (es)
GB (1) GB8724912D0 (es)
HU (1) HU202230B (es)
IL (1) IL88122A0 (es)
MC (1) MC1983A1 (es)
NZ (1) NZ226671A (es)
PL (1) PL158305B1 (es)
PT (1) PT88829B (es)
ZA (1) ZA887900B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT95899A (pt) * 1989-11-17 1991-09-13 Glaxo Group Ltd Processo para a preparacao de derivados indole
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
CZ288351B6 (en) * 1990-06-07 2001-05-16 Astrazeneca Ab Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof
EP0494774A1 (en) * 1991-01-11 1992-07-15 MERCK SHARP & DOHME LTD. Indazole-substituted fivemembered heteroaromatic compounds
US5317103A (en) * 1991-01-15 1994-05-31 Merck Sharp & Dohme Limited Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
TW263508B (es) * 1991-02-12 1995-11-21 Pfizer
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents
CA2124206C (en) * 1991-11-25 2001-02-27 John Eugene Macor Indole derivatives
EP0545478A1 (en) * 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclic compounds as tachykinin antagonists
US5409941A (en) * 1992-02-03 1995-04-25 Pfizer Inc. 5-heteroyl indole derivatives
TW288010B (es) * 1992-03-05 1996-10-11 Pfizer
US5510362A (en) * 1992-03-13 1996-04-23 Merck, Sharp And Dohme Limited Imidazole, triazole and tetrazole derivatives
GB9207396D0 (en) * 1992-04-03 1992-05-13 Merck Sharp & Dohme Therapeutic agents
AU670579B2 (en) 1992-04-07 1996-07-25 Pfizer Inc. Indole derivatives as 5-HT1 agonists
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
EP0635015B1 (en) * 1992-04-10 1997-01-29 Pfizer Inc. Acylaminoindole derivatives as 5-ht1 agonists
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9208463D0 (en) * 1992-04-16 1992-06-03 Merck Sharp & Dohme Therapeutic agents
GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
CA2097208C (en) * 1992-06-05 2005-02-08 Raymond Baker The sulphate salt of a substituted triazole, pharmaceutical compositions thereof, and their use in therapy
GB9215526D0 (en) * 1992-07-22 1992-09-02 Merck Sharp & Dohme Chemical process
CA2138649A1 (en) * 1992-07-24 1994-02-03 Raymond Baker Imidazole, triazole and tetrazole derivatives
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
TW251284B (es) * 1992-11-02 1995-07-11 Pfizer
GB9226537D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
LT3594B (en) 1993-07-29 1995-12-27 Merck Sharp & Dohme Imidazole,triazole and tetrazole derivatives
ES2070087B1 (es) * 1993-08-13 1996-02-16 Pfizer Derivados de indol
US6423731B2 (en) 1994-01-06 2002-07-23 Zeneca Limited Indole derivatives as prodrugs of 5-HT1-like receptor agonists
GB9401436D0 (en) * 1994-01-26 1994-03-23 Wellcome Found Therapeutic heterocyclic compounds
GB9407447D0 (en) * 1994-04-14 1994-06-08 Glaxo Group Ltd Chemical compounds
JP3262800B2 (ja) * 1994-06-01 2002-03-04 ゼネカ・リミテッド 療用複素環化合物
CA2194984C (en) * 1994-07-26 2002-07-02 John Eugene Macor 4-indole derivatives as serotonin agonists and antagonists
US6025374A (en) * 1994-12-06 2000-02-15 Merck Sharp & Dohme, Ltd. Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor agonists
GB9516143D0 (en) 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
GB9516145D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
US6909005B1 (en) 1995-08-07 2005-06-21 Astrazeneca Uk Limited One post synthesis of 2-oxazolidinone derivatives
US5998438A (en) * 1996-11-26 1999-12-07 Allelix Biopharmaceuticals, Inc. 5-cyclo indole compounds
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
AU4961499A (en) * 1998-06-26 2000-01-17 Eli Lilly And Company 5-HT1f agonists
ES2297216T3 (es) 2002-06-21 2008-05-01 Suven Life Sciences Limited Indoles tetraciclicos arilsulfonil que tienen afinidad con el receptor de la serotonina.
BR0312175A (pt) 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmacêutica, uso de um composto, método para o tratamento e método para reduzir a morbidez e a mortalidade associadas com o excesso de peso
US7507835B2 (en) 2002-11-28 2009-03-24 Suven Life Sciences Ltd. N-arylsulfonyl-3-aminoalkoxyindoles
ATE401307T1 (de) 2002-11-28 2008-08-15 Suven Life Sciences Ltd N-arylsulfonyl-2-substituierte indole mit affinität zum serotonin rezeptor, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
JP4571507B2 (ja) 2002-12-18 2010-10-27 スベン ライフ サイエンシズ リミティド セロトニン受容体親和性を有する四環系３−置換インドール
DE102005018191A1 (de) 2005-04-19 2006-10-26 Grünenthal GmbH Substituierte zyklische Harnstoff-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
CN108697637A (zh) 2016-01-27 2018-10-23 因斯塔尔科技股份公司 用于治疗性处理的口腔粘膜纳米纤维载体
CN112759550A (zh) * 2019-11-04 2021-05-07 上海科技大学 一种平滑受体拮抗剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0225726B1 (en) 1985-11-08 1991-04-17 Glaxo Group Limited Indole derivatives
GB8600397D0 (en) 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
AU2418188A (en) 1989-04-27
FI884879A7 (fi) 1989-04-24
DD283140A5 (de) 1990-10-03
CN1035113A (zh) 1989-08-30
JPH01146882A (ja) 1989-06-08
DE3881472T2 (de) 1993-12-16
MC1983A1 (fr) 1989-11-23
AU604165B2 (en) 1990-12-06
PL158305B1 (en) 1992-08-31
ZA887900B (en) 1990-06-27
JP2501631B2 (ja) 1996-05-29
GB8724912D0 (en) 1987-11-25
DE3881472D1 (de) 1993-07-08
ATE90089T1 (de) 1993-06-15
IL88122A0 (en) 1989-06-30
EP0313397A1 (en) 1989-04-26
PT88829B (pt) 1993-01-29
NZ226671A (en) 1991-09-25
DK586588D0 (da) 1988-10-21
HU202230B (en) 1991-02-28
FI884879A0 (fi) 1988-10-21
PL275423A1 (en) 1989-08-07
EP0313397B1 (en) 1993-06-02
DK586588A (da) 1989-04-24
HUT50163A (en) 1989-12-28

Similar Documents

Publication Publication Date Title
ES2118457T3 (es) Derivados de piridina, composiciones farmaceuticas que comprenden los mismos, el uso de los mismos para la fabricacion de medicamentos que tienen valor terapeutico o preventivo, y un proceso para preparar los mismos.
ES2058527T3 (es) Derivados de pirimidina condensados procedimiento y compuestos intermedios para su preparacion y composiciones farmaceuticas que los contienen.
ES2031876T3 (es) Un procedimiento para la preparacion de 5,6-dihidro-2-(fenil sustituido)-1,2,4,-triazin-3,5(2h,4h)-dionas.
PA8431301A1 (es) Inhibidores de metaloproteinasas, composiciones farmaceuticas que los contienen y sus usos farmaceuticos y los metodos e intermedios utiles para su preparacion
MX9303263A (es) Antagonistas de la angiotensina ii, procedimiento para su preparacion y formulaciones farmaceuticas que los contienen
ES2121896T3 (es) Derivados de acido hidroxamico como inhibidores de colagenasa.
DK0447285T3 (da) Nephtalenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem
EA200000592A1 (ru) Азаполициклические соединения, конденсированные с арилом
ES2058292T3 (es) Derivados de indol.
PE20010211A1 (es) Compuestos de tiazol y composiciones farmaceuticas para inhibir las quinasas de proteina
ES2164758T3 (es) Derivados de morfolina sustituidos y su uso como agentes terapeuticos.
ES2059335T3 (es) Derivados de pirido(3,2,1-ij)-1,3,4-benzoxadiazina, procedimiento para su obtencion, preparados farmaceuticos correspondientes y productos intermedios utilizables en el procedimiento.
ES2071666T3 (es) Derivados de pirazoloisoquinolina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ES2118203T3 (es) Nuevos derivados benzopiranicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ES2038707T3 (es) Procedimiento para la obtencion de enantiomeros (+) y (-) de derivados de la 3,4-dihidro-2h-(1)-benzopiran-3-amina.
PT97047A (pt) Processo de preparacao de compostos de 1-carboxialquilquinoxalina-2,3(1h,4h)-diona e de composicoes farmaceuticas que os contem
AR007108A1 (es) Agentes antitumorales y antivirales alquilantes, procedimiento para su preparacion, utilizacion de los mismos para la fabricacion de un medicamento y composicion farmaceutica que contiene a dichos agentes.
ATE27456T1 (de) Kristallinische aenderungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate.
ES2045083T3 (es) Un procedimiento para preparar un compuesto quimico.
ES2109276T3 (es) Derivados de tropolona y composicion farmaceutica de los mismos para prevenir y tratar enfermedades isquemicas.
ES2056073T3 (es) Aril-aralquil-eteres, procedimientos para su preparacion y composicion farmaceutica que los comprende.
ES2029879T3 (es) Procedimiento para producir derivados de aminas sustituidas.
ES2064361T3 (es) Nuevos compuestos.
ES2055717T3 (es) Derivados de benzo- y tieno-3,4-dihidro-piridina, procedimientos para su preparacion y medicamentos que contienen estos compuestos.
MX9306394A (es) Derivados de benzofurano, proceso para su preparacion y composicion farmaceutica que los contiene

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 313397

Country of ref document: ES