ES2054825T3 - Compuestos heterociclicos terapeuticos. - Google Patents

Compuestos heterociclicos terapeuticos.

Info

Publication number
ES2054825T3
ES2054825T3 ES88309943T ES88309943T ES2054825T3 ES 2054825 T3 ES2054825 T3 ES 2054825T3 ES 88309943 T ES88309943 T ES 88309943T ES 88309943 T ES88309943 T ES 88309943T ES 2054825 T3 ES2054825 T3 ES 2054825T3
Authority
ES
Spain
Prior art keywords
compounds
rent
selected independently
heterociclicos
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88309943T
Other languages
English (en)
Inventor
Alan Duncan Robertson
Graeme Richard Martin
Janet Susan Buckingham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2054825T3 publication Critical patent/ES2054825T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA(I), EN LA QUE R1, Y R2 SE SELECCIONAN INDEPENDIENTEMENTE DE ENTRE H Y ALQUILO DE 1 A 4 C; R3 Y R4 SE SELCCIONAN INDEPENDIENTEMENTE DE H, ALQUILO DE 1 A 6 C O ARILO PUDIENDO ESTOS ESTAR SUSTITUIDOS POR UNO O MAS ATOMOS O GRUPOS HALOGENO, ALQUENILO DE 1 A 4 C O ARILO, (NO PUDIENDO R3 SE BENCILO CUANDO R4 ES H); M ES 0, 1 O 2; N ES 0, 1, 2 O 3; W ES UN GRUPO DE FORMULA (I), (II), (III) O (IV), (DONDE Y PUEDE SER O, METILENO Y = N - R5) R5 ES H, ALQUILO DE 1 A 4 C O BENCILO; Z Y Z''SE SELCCIONAN INDEPENDIENTEMENTE DE = C = O, = C = S Y METILENO Y EL CENTRO QUIRAL * ESTA EN FORMA (S), (R) O MEZCLA DE AMBAS); X ES UN GRUPO QUE SE SELECCIONA DE ARILO, XANTENILO O DIBENZOFURANILO Y PUEDE ESTAR SUSTITUIDO POR HALOGENO O DIVERSOS GRUPOS QUE SE ESPECIFICSAN. TAMBIEN SE REFIERE A LAS SALES Y SOLVATOS DE ESTOS COMPUESTOS, A FORMULACIONES FARMACEUTICAS QUE LOS CONTIENEN Y A SU EMPLEO EN MEDICINA, ESPECIALMENTE PARA EL TRATAMIENTO DE LA MIGRAÑA.
ES88309943T 1987-10-23 1988-10-21 Compuestos heterociclicos terapeuticos. Expired - Lifetime ES2054825T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878724912A GB8724912D0 (en) 1987-10-23 1987-10-23 Indole derivatives

Publications (1)

Publication Number Publication Date
ES2054825T3 true ES2054825T3 (es) 1994-08-16

Family

ID=10625806

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88309943T Expired - Lifetime ES2054825T3 (es) 1987-10-23 1988-10-21 Compuestos heterociclicos terapeuticos.

Country Status (18)

Country Link
EP (1) EP0313397B1 (es)
JP (1) JP2501631B2 (es)
CN (1) CN1035113A (es)
AT (1) ATE90089T1 (es)
AU (1) AU604165B2 (es)
DD (1) DD283140A5 (es)
DE (1) DE3881472T2 (es)
DK (1) DK586588A (es)
ES (1) ES2054825T3 (es)
FI (1) FI884879A7 (es)
GB (1) GB8724912D0 (es)
HU (1) HU202230B (es)
IL (1) IL88122A0 (es)
MC (1) MC1983A1 (es)
NZ (1) NZ226671A (es)
PL (1) PL158305B1 (es)
PT (1) PT88829B (es)
ZA (1) ZA887900B (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT95899A (pt) * 1989-11-17 1991-09-13 Glaxo Group Ltd Processo para a preparacao de derivados indole
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
KR100215627B1 (ko) * 1990-06-07 1999-08-16 레슬리 제인 에드워즈 치료용 헤테로사이클 화합물
EP0494774A1 (en) * 1991-01-11 1992-07-15 MERCK SHARP & DOHME LTD. Indazole-substituted fivemembered heteroaromatic compounds
US5317103A (en) * 1991-01-15 1994-05-31 Merck Sharp & Dohme Limited Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
TW263508B (es) * 1991-02-12 1995-11-21 Pfizer
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents
DE69230803T2 (de) * 1991-11-25 2000-12-07 Pfizer Inc., New York 5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten
EP0545478A1 (en) * 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclic compounds as tachykinin antagonists
US5409941A (en) * 1992-02-03 1995-04-25 Pfizer Inc. 5-heteroyl indole derivatives
TW288010B (es) * 1992-03-05 1996-10-11 Pfizer
DE69330713T2 (de) * 1992-03-13 2002-07-04 Merck Sharp & Dohme Ltd., Hoddesdon Imidazol-, triazol- und tetrazolderivate
GB9207396D0 (en) * 1992-04-03 1992-05-13 Merck Sharp & Dohme Therapeutic agents
PL172405B1 (en) * 1992-04-07 1997-09-30 Pfizer Derivatives of indole
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
UA34452C2 (uk) * 1992-04-10 2001-03-15 Пфайзер Інк. Похідні ациламіноіндолу, що проявляють серотонінову 5-нт1 агоністичну активність та похідні аміноіндолу як проміжні сполуки
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9208463D0 (en) * 1992-04-16 1992-06-03 Merck Sharp & Dohme Therapeutic agents
GB9210400D0 (en) * 1992-05-15 1992-07-01 Merck Sharp & Dohme Therapeutic agents
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
ES2116411T3 (es) * 1992-06-05 1998-07-16 Merck Sharp & Dohme La sal sulfato de un triazol sustituido, composiciones farmaceuticas de la misma y su uso en terapia
GB9215526D0 (en) * 1992-07-22 1992-09-02 Merck Sharp & Dohme Chemical process
CA2138649A1 (en) * 1992-07-24 1994-02-03 Raymond Baker Imidazole, triazole and tetrazole derivatives
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
TW251284B (es) * 1992-11-02 1995-07-11 Pfizer
GB9226537D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
LT3594B (en) 1993-07-29 1995-12-27 Merck Sharp & Dohme Imidazole,triazole and tetrazole derivatives
ES2070087B1 (es) * 1993-08-13 1996-02-16 Pfizer Derivados de indol
US6423731B2 (en) 1994-01-06 2002-07-23 Zeneca Limited Indole derivatives as prodrugs of 5-HT1-like receptor agonists
GB9401436D0 (en) * 1994-01-26 1994-03-23 Wellcome Found Therapeutic heterocyclic compounds
GB9407447D0 (en) * 1994-04-14 1994-06-08 Glaxo Group Ltd Chemical compounds
JP3262800B2 (ja) * 1994-06-01 2002-03-04 ゼネカ・リミテッド 療用複素環化合物
CA2194984C (en) * 1994-07-26 2002-07-02 John Eugene Macor 4-indole derivatives as serotonin agonists and antagonists
WO1996017842A1 (en) * 1994-12-06 1996-06-13 Merck Sharp & Dohme Limited Azetidine, pyrrolidine and piperidine derivatives as 5ht1 receptor agonists
GB9516145D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
US6909005B1 (en) 1995-08-07 2005-06-21 Astrazeneca Uk Limited One post synthesis of 2-oxazolidinone derivatives
GB9516143D0 (en) 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
US5998438A (en) * 1996-11-26 1999-12-07 Allelix Biopharmaceuticals, Inc. 5-cyclo indole compounds
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
WO2000000490A2 (en) * 1998-06-26 2000-01-06 Eli Lilly And Company 5-ht1f agonists
RU2320663C2 (ru) 2002-06-21 2008-03-27 Сувен Лайф Сайенсиз Лимитед Новые арилалкилиндолы с аффинностью к серотониновым рецепторам, пригодные в качестве лекарственных средств, способ их получения и содержащие их фармацевтические композиции
AU2003249582B2 (en) 2002-06-21 2006-08-03 Suven Life Sciences Limited Tetracyclic arylsulfonyl indoles having serotonin receptor affinity
PT1567492E (pt) 2002-11-28 2013-07-22 Suven Life Sciences Ltd N-arilsulfonil-3-aminoalcoxi-indóis
US7875605B2 (en) 2002-11-28 2011-01-25 Suven Life Sciences Limited N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
SI1581538T1 (sl) 2002-12-18 2007-08-31 Suven Life Sciences Ltd Tetraciklični 3-substituirani indoli z afiniteto za receptor serotonina
DE102005018191A1 (de) * 2005-04-19 2006-10-26 Grünenthal GmbH Substituierte zyklische Harnstoff-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
CA3010568C (en) 2016-01-27 2023-10-17 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment
CN112759550A (zh) * 2019-11-04 2021-05-07 上海科技大学 一种平滑受体拮抗剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4833153A (en) 1985-11-08 1989-05-23 Glaxo Group Limited Indole derivatives
GB8600397D0 (en) 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
DK586588D0 (da) 1988-10-21
DE3881472T2 (de) 1993-12-16
AU604165B2 (en) 1990-12-06
DD283140A5 (de) 1990-10-03
EP0313397A1 (en) 1989-04-26
GB8724912D0 (en) 1987-11-25
PL158305B1 (en) 1992-08-31
AU2418188A (en) 1989-04-27
PL275423A1 (en) 1989-08-07
ATE90089T1 (de) 1993-06-15
JP2501631B2 (ja) 1996-05-29
CN1035113A (zh) 1989-08-30
ZA887900B (en) 1990-06-27
DE3881472D1 (de) 1993-07-08
FI884879A0 (fi) 1988-10-21
PT88829B (pt) 1993-01-29
HUT50163A (en) 1989-12-28
NZ226671A (en) 1991-09-25
HU202230B (en) 1991-02-28
MC1983A1 (fr) 1989-11-23
IL88122A0 (en) 1989-06-30
EP0313397B1 (en) 1993-06-02
FI884879A7 (fi) 1989-04-24
DK586588A (da) 1989-04-24
JPH01146882A (ja) 1989-06-08

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