ES2064361T3 - Nuevos compuestos. - Google Patents

Nuevos compuestos.

Info

Publication number
ES2064361T3
ES2064361T3 ES88311252T ES88311252T ES2064361T3 ES 2064361 T3 ES2064361 T3 ES 2064361T3 ES 88311252 T ES88311252 T ES 88311252T ES 88311252 T ES88311252 T ES 88311252T ES 2064361 T3 ES2064361 T3 ES 2064361T3
Authority
ES
Spain
Prior art keywords
compounds
phenyl
amino
formula
new compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88311252T
Other languages
English (en)
Inventor
Michael Raymond Harnden
David Malcolm Duckworth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878727988A external-priority patent/GB8727988D0/en
Priority claimed from GB888811575A external-priority patent/GB8811575D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of ES2064361T3 publication Critical patent/ES2064361T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electrically Driven Valve-Operating Means (AREA)
  • Piezo-Electric Or Mechanical Vibrators, Or Delay Or Filter Circuits (AREA)
  • Liquid Crystal (AREA)
  • Sub-Exchange Stations And Push- Button Telephones (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Jib Cranes (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA(I) Y SALES ACEPTABLES FARMACEUTICAMENTE DE ESTOS COMPUESTOS, SIENDO R1 HIDROXI, AMINO, CLORO O OR7 (EN EL QUE R7 ES ALQUILO, FENILO, ALQUIL( DE 1 O 2 C) - FENILO PUDIENDO ESTAR LOS FENIULOS SUSTITUIDOS POR HALOALQUILO O ALCOXI DE 1 A 4 C); R2 ES AMINO O CUANDO R1 ES AMINO R2 PUEDE SER H; R3 ES H, HIDROXIMETILO O ACILIMETILO; R4 ES UN GRUPO DE FORMULA(II) (DONDE R5 Y R6 SE SELECCIONAN INDEPENDIENTEMENTE DE H, ALQUILO DE 1 A 6 C O FENILO QUE PUEDE ESTAR SUSTITUIDO) O R3 Y R4 JUNTOS FORMAN EL GRUPO DE FORMULA(III) (SIENDO R6 EL ANTES DEFINIDO). LOS COMPUESTOS DE LA INVENCION TIENEN ACTIVIDAD ANTIVIRICA. TAMBIEN TRATA LA INVENCION DE PROCEDIMIENTOS PARA SU PREPARACION Y DE SU EMPLEO COMO PRODUCTOS FARMACEUTICOS.
ES88311252T 1987-11-30 1988-11-28 Nuevos compuestos. Expired - Lifetime ES2064361T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878727988A GB8727988D0 (en) 1987-11-30 1987-11-30 Novel compounds
GB888811575A GB8811575D0 (en) 1988-05-16 1988-05-16 Novel compounds

Publications (1)

Publication Number Publication Date
ES2064361T3 true ES2064361T3 (es) 1995-02-01

Family

ID=26293121

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88311252T Expired - Lifetime ES2064361T3 (es) 1987-11-30 1988-11-28 Nuevos compuestos.

Country Status (20)

Country Link
EP (1) EP0319228B1 (es)
JP (1) JPH02293A (es)
KR (1) KR890008141A (es)
AT (1) ATE113601T1 (es)
AU (1) AU617724B2 (es)
DE (1) DE3852008T2 (es)
DK (1) DK663588A (es)
ES (1) ES2064361T3 (es)
FI (1) FI885544A7 (es)
GR (1) GR3014910T3 (es)
HU (1) HU202244B (es)
IE (1) IE883550L (es)
IL (1) IL88518A (es)
MA (1) MA21450A1 (es)
MY (1) MY103502A (es)
NO (1) NO885313L (es)
NZ (1) NZ227104A (es)
PH (1) PH26927A (es)
PL (3) PL158762B1 (es)
PT (1) PT89098B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5247085A (en) * 1987-11-30 1993-09-21 Beecham Group P.L.C. Antiviral purine compounds
EP0353955A3 (en) * 1988-08-02 1991-08-14 Beecham Group Plc Novel compounds
GB8907173D0 (en) * 1989-03-30 1989-05-10 Beecham Group Plc Novel compounds
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
EP0405748A1 (en) * 1989-05-30 1991-01-02 Beecham Group p.l.c. Phosphonoderivative of purine with antiviral activity
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
GB9205917D0 (en) * 1992-03-18 1992-04-29 Smithkline Beecham Plc Pharmaceuticals
EP0719274A1 (en) * 1993-09-17 1996-07-03 Gilead Sciences, Inc. Method for dosing therapeutic compounds
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
GB9821058D0 (en) 1998-09-28 1998-11-18 Univ Cardiff Chemical compound

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3646049A (en) * 1970-03-05 1972-02-29 Merck & Co Inc Acylaminobenzimidazole derivatives
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation

Also Published As

Publication number Publication date
FI885544A0 (fi) 1988-11-29
IE883550L (en) 1989-05-30
PL158762B1 (en) 1992-10-30
DK663588D0 (da) 1988-11-28
PT89098B (pt) 1993-03-31
EP0319228A2 (en) 1989-06-07
MY103502A (en) 1993-06-30
PL276046A1 (en) 1990-01-08
PL160924B1 (en) 1993-05-31
HU202244B (en) 1991-02-28
PT89098A (pt) 1988-12-01
IL88518A (en) 1994-02-27
IL88518A0 (en) 1989-06-30
PH26927A (en) 1992-12-02
PL281367A1 (en) 1990-05-28
PL281368A1 (en) 1990-05-28
ATE113601T1 (de) 1994-11-15
DE3852008T2 (de) 1995-03-23
PL160927B1 (pl) 1993-05-31
DE3852008D1 (de) 1994-12-08
EP0319228A3 (en) 1990-05-16
GR3014910T3 (en) 1995-05-31
NO885313D0 (no) 1988-11-29
FI885544A7 (fi) 1989-05-31
JPH02293A (ja) 1990-01-05
NO885313L (no) 1989-05-31
HUT50352A (en) 1990-01-29
AU2631188A (en) 1989-06-15
AU617724B2 (en) 1991-12-05
KR890008141A (ko) 1989-07-10
DK663588A (da) 1989-05-31
EP0319228B1 (en) 1994-11-02
MA21450A1 (fr) 1989-07-01
NZ227104A (en) 1991-11-26

Similar Documents

Publication Publication Date Title
ES2094721T3 (es) Analogos de la camptotecina solubles en agua.
ES2100907T3 (es) Bencimidazoles, medicamentos que contienen estos compuestos y proced imiento para su preparacion.
ES2061606T3 (es) Compuestos de quinoxalina y su preparacion y empleo.
ES2079694T3 (es) Derivados de bifenilo, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
DE3263734D1 (en) Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (z), their preparation and their use as medicines in the treatment of disorders of the central nervous system
ES2058527T3 (es) Derivados de pirimidina condensados procedimiento y compuestos intermedios para su preparacion y composiciones farmaceuticas que los contienen.
ES2081302T3 (es) Aril- y heteroaril-piperazinil carboxamidas que tienen actividad sobre el sistema nervioso central.
ES2118095T3 (es) Bencimidazoles, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
ES2152444T3 (es) Derivados de acido benzazepin-, benzoxazepin- y benzotiazepin-n-acetico, asi como procedimiento para su preparacion y medicamentos que contienen a estos compuestos.
ES2053508T3 (es) Compuestos de acidos 3-pirrolidinil-tio-1-azabiciclo(3.2.0)hept-2-eno-2-carboxilicos.
ES2076253T3 (es) N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos.
FI831009L (fi) Spiro/4(3+n)/-2-aza-3-karboxylsyra-derivat, foerfarande foer deras framstaellning, dessa innehaollaaemnen och deras anvaendning
ES2051843T3 (es) Un proceso para la preparacion de un derivado del acido benzoilaminofenoxibutanico.
ES2141727T3 (es) Derivados de 10-desacetoxitaxol.
ES2064361T3 (es) Nuevos compuestos.
ES2038172T3 (es) Procedimiento para preparar carboxamidas heterociclicas.
ES2104841T3 (es) Fosfono-aminoacidos bencimidazolicos.
ES2063756T3 (es) Derivados de acido benzoilaminofenoxibutanoico.
ES2029879T3 (es) Procedimiento para producir derivados de aminas sustituidas.
ES2056073T3 (es) Aril-aralquil-eteres, procedimientos para su preparacion y composicion farmaceutica que los comprende.
ES2080726T3 (es) Compuestos aromaticos o heteroaromaticos nitrosustituidos para su utilizacion en el tratamiento del cancer.
ES482285A1 (es) Procedimiento de preparacion de compuestos de benzofurano.
ES2183492T3 (es) Nuevos derivados de nitrono,su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ES2055717T3 (es) Derivados de benzo- y tieno-3,4-dihidro-piridina, procedimientos para su preparacion y medicamentos que contienen estos compuestos.
ES8700242A1 (es) Un procedimiento para preparar un derivado de dihidropirida-zinona

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 319228

Country of ref document: ES