ES2055193T3 - Nuevo epimero de 1 alfa-hidroxi-vitamina d2 y derivados. - Google Patents

Nuevo epimero de 1 alfa-hidroxi-vitamina d2 y derivados.

Info

Publication number
ES2055193T3
ES2055193T3 ES90104564T ES90104564T ES2055193T3 ES 2055193 T3 ES2055193 T3 ES 2055193T3 ES 90104564 T ES90104564 T ES 90104564T ES 90104564 T ES90104564 T ES 90104564T ES 2055193 T3 ES2055193 T3 ES 2055193T3
Authority
ES
Spain
Prior art keywords
vitamin
cenulas
new
epimeral
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90104564T
Other languages
English (en)
Inventor
Hector F Deluca
Heinrich K Schnoes
Kato L Perlman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of ES2055193T3 publication Critical patent/ES2055193T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

EL INVENTO PROVEE UN NUEVO COMPONENTE D2 VITAMIN, D2 VITAMIN-EPI-24-HIDROXI-1A Y CIERTOS DERIVADOS DE ELLO PROTEGIDOS DE HIDROXI. LOS NUEVOS COMPONENTES EXHIBEN UN MODELO DE ACTIVIDAD DISTINTIVA COMPRENDIENDO ALTA POTENCIA EN ESTIMULAR EL TRANSPORTE DE CALCIO INTESTINAL Y PEQUEÑA O NINGUNA ACTIVIDAD EN INDUCIR LA MOVILIZACION DE CALCIO DE HUESO O LA DIFERENCIACION DE CELULAS INDIFERENCIADAS EN CULTIVO, POR LO CUAL MOSTRAR UTILIDAD EN EL TRATAMIENTO DE ENFERMEDADES CARACTERIZADAS POR LA PERDIDA DE MASA OSEA.
ES90104564T 1989-03-09 1990-03-09 Nuevo epimero de 1 alfa-hidroxi-vitamina d2 y derivados. Expired - Lifetime ES2055193T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/321,254 US4973584A (en) 1989-03-09 1989-03-09 Novel 1α-hydroxyvitamin D2 epimer and derivatives

Publications (1)

Publication Number Publication Date
ES2055193T3 true ES2055193T3 (es) 1994-08-16

Family

ID=23249837

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90104564T Expired - Lifetime ES2055193T3 (es) 1989-03-09 1990-03-09 Nuevo epimero de 1 alfa-hidroxi-vitamina d2 y derivados.

Country Status (15)

Country Link
US (1) US4973584A (es)
EP (1) EP0386793B1 (es)
JP (1) JPH0737443B2 (es)
KR (1) KR950005776B1 (es)
AT (1) ATE90342T1 (es)
AU (1) AU631618B2 (es)
CA (1) CA1335105C (es)
DE (1) DE69001839T2 (es)
DK (1) DK0386793T3 (es)
ES (1) ES2055193T3 (es)
HU (1) HU207040B (es)
IL (1) IL93456A (es)
NZ (1) NZ232735A (es)
RU (1) RU2065851C1 (es)
WO (1) WO1990010619A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5756783A (en) * 1990-09-21 1998-05-26 Bone Care International, Inc. 1α-Hydroxy-24-EPI-vitamin D4
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
US6251883B1 (en) 1991-01-08 2001-06-26 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US5789397A (en) * 1991-01-08 1998-08-04 Bone Care International, Inc. Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2
US5182396A (en) * 1991-03-29 1993-01-26 Nisshin Flour Milling Co., Ltd. 1-hydroxyvitamin d derivatives
AU656829B2 (en) * 1991-12-26 1995-02-16 Wisconsin Alumni Research Foundation 26, 27-dimethylene-1 alpha, 25-dihydroxyvitamin D2 and 26,27-dihydroxyvitamin D2 and methods for preparing same
AU682817B2 (en) * 1992-01-29 1997-10-23 Bone Care International, Inc. 1alpha-hydroxy-24-(epi)-vitamin D4
US5194431A (en) * 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives
DE69325253T2 (de) * 1992-08-28 1999-12-02 Bone Care International Inc., Madison 1alpha,24(s)-dihydroxy vitamin d2, seine synthese und verwendung
TW267161B (es) * 1992-11-20 1996-01-01 Hoffmann La Roche
JPH0753384A (ja) * 1993-07-13 1995-02-28 Wisconsin Alumni Res Found ２４−エピ−１α−ヒドロキシビタミンＤ２ を含んでなる骨粗鬆症治療剤
US5565589A (en) * 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
US5373004A (en) * 1993-11-24 1994-12-13 Wisconsin Alumni Research Foundation 26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds
US5661140A (en) * 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
US6416737B1 (en) 1998-11-19 2002-07-09 Board Of Trustees Of The University Of Arkansas Increasing bone strength with selected bisphosphonates
WO2000059513A1 (en) * 1999-04-01 2000-10-12 Johns Hopkins University NON-CALCEMIC, ANTIPROLIFERATIVE, TRANSCRIPTIONALLY ACTIVE SULFUR-CONTAINING ANALOGS OF 1α, 25-DIHYDROXY VITAMIN D¿3?
US6479474B2 (en) 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
ATE428692T1 (de) * 2001-08-22 2009-05-15 Univ Johns Hopkins 24-schwefel-substituierte 1-alpha-25-dihydroxy- vitamin-d3-analogen
WO2003106411A1 (en) 2002-06-13 2003-12-24 Johns Hopkins University 24-sulfoximine vitamin d3 compounds
WO2004054968A2 (en) 2002-12-18 2004-07-01 Johns Hopkins University 25-so2-substituted analogs of 1alpha, 25-dihydroxyvitamin d3 (calcitriol)
JP5009617B2 (ja) * 2003-08-20 2012-08-22 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１９−ノル−ビタミンｄ２化合物
AU2010208323B2 (en) 2009-01-27 2016-03-10 Berg Llc Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (en) 2009-08-14 2019-05-22 Berg LLC Vitamin d3 and analogs thereof for treating alopecia
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
US3907843A (en) * 1974-06-14 1975-09-23 Wisconsin Alumni Res Found 1{60 -Hydroxyergocalciferol and processes for preparing same
NL193245C (nl) * 1983-05-09 1999-04-02 Wisconsin Alumni Res Found Aan 1Ó,25-dihydroxyvitamine D2 verwante verbinding en farmaceutisch preparaat met een het calciummetabolisme regulerende werking dat een dergelijke verbinding bevat.
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4717721A (en) * 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity

Also Published As

Publication number Publication date
US4973584A (en) 1990-11-27
HU207040B (en) 1993-03-01
DK0386793T3 (da) 1993-08-02
HU902288D0 (en) 1991-07-29
JPH0737443B2 (ja) 1995-04-26
JPH03504508A (ja) 1991-10-03
DE69001839D1 (de) 1993-07-15
AU631618B2 (en) 1992-12-03
EP0386793A1 (en) 1990-09-12
EP0386793B1 (en) 1993-06-09
ATE90342T1 (de) 1993-06-15
DE69001839T2 (de) 1993-09-16
KR950005776B1 (ko) 1995-05-30
IL93456A0 (en) 1990-11-29
KR920700201A (ko) 1992-02-19
NZ232735A (en) 1992-07-28
RU2065851C1 (ru) 1996-08-27
IL93456A (en) 1994-02-27
WO1990010619A1 (en) 1990-09-20
CA1335105C (en) 1995-04-04
AU5192590A (en) 1990-10-09

Similar Documents

Publication Publication Date Title
MX9101913A (es) Derivados de quinazolinas para potenciar la actividad antitumoral
AP2000001947A0 (en) Novel crystalline forms of an antiviral benzidazole compound.
ATE114113T1 (de) Verwendung von droloxifen bei der behandlung von knochenerkrankungen.
MX9102353A (es) N,o-sulfados de heparosanos, su procedimiento de preparacion y las composiciones farmaceuticas que contienen.
SE9701398D0 (sv) Novel compounds
IL113462A0 (en) Substituted pyridylpyrazoles, their preparation and pesticidal compositions containing them
DE69401204D1 (de) Gonadotropin enthaltende gefriergetrocknete troepfen
IL93456A0 (en) 1alpha-hydroxyvitamin d2 epimer and pharmaceutical compositions containing it
ATE231872T1 (de) Thiazolopyrimidinderivate
ATE204297T1 (de) Peptidanaloge des lh-rh, ihre verwendungen und die sie enthaltenden pharmazeutischen zusammensetzungen
DE58906239D1 (de) Einrichtung zur Behandlung von Erkrankungen, insbesondere der Sehbahn.
ATE103918T1 (de) 5,11-dihydro-6h-dipyrido(3,2-b:2',3'e>(1,4>diazepin-6-one und -thione und ihre verwendung bei der aids-vorbeugung oder behandlung.
DE3867659D1 (de) 1,5-diphenyl-1h-1,2,4-triazol-3-carboxamid-derivate und diese enthaltende herbizide zusammensetzungen.
MX9301789A (es) Nuevos oligopeptidos lipofilicos con actividad inmunomoduladora.
TR200100637T2 (tr) Yeni doğal ürün türevleri
ES2068714T3 (es) Derivados de pirimidina para aumentar la actividad antitumoral.
ES2173911T3 (es) Uso de glicosidos en vitamina d para el tratamiento o prevencion de la osteoporosis.
NO995685L (no) Nye glycosylerte ginkgolidderivater, anvendelse derav som medikamenter og farmasoeytiske blandinger
ZA923935B (en) New 2-amino-5-cyano-1,4-dihydropyridines,processes for their preparation and their use in medicaments
DE68905973D1 (de) Synergistische suessungsmittel-zusammensetzungen, enthaltend chlorodeoxysucrase, und diese enthaltende zusammensetzungen.
GB9505082D0 (en) Medicament
ATE311399T1 (de) 2'-deoxy-4'-thioribonucleoside als antivirale und antikrebsmittel
NO900926D0 (no) Substituerte (kinolin-2-yl-metoksy)fenyl-n,n'-sulfonylurinstoffer, deres fremstilling og anvendelse i legemidler.
IT8721540A0 (it) Composizioni farmaceutiche contenenti trapidil, loro procedimento di preparazione erelativo impiego terapeutico.
RO103683A2 (en) Treatment medicine for eczema

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 386793

Country of ref document: ES