KR920700201A - 신규 1α-히드록시비타민D 2 에피머 및 유도체 - Google Patents

신규 1α-히드록시비타민D 2 에피머 및 유도체

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Publication number
KR920700201A
KR920700201A KR1019900702409A KR900702409A KR920700201A KR 920700201 A KR920700201 A KR 920700201A KR 1019900702409 A KR1019900702409 A KR 1019900702409A KR 900702409 A KR900702409 A KR 900702409A KR 920700201 A KR920700201 A KR 920700201A
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KR
South Korea
Prior art keywords
hydroxyvitamin
epimers
derivatives
new
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
KR1019900702409A
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English (en)
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KR950005776B1 (ko
Inventor
헥터 에프. 델루카
하인리히 케이. 쉬노에스
카토 엘. 펄만
Original Assignee
원본미기재
위스콘신 알럼나이 리써취 파운데이션
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Publication of KR920700201A publication Critical patent/KR920700201A/ko
Application granted granted Critical
Publication of KR950005776B1 publication Critical patent/KR950005776B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

신규 1α－히드록시비타민D2에피머 및 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음 구조식으로 표시되는 화합물.
    식중, X1및 X2는 수소원자, 아실 및 알킬실릴로 구성된 군 중에서 선택될 수 있다.
  2. 제1항에 있어서, X1및 X2가 수소 원자인 것이 특징인 화합물.
  3. 제약학상 허용되는 부형제와 제1항의 화합물을 함유하는 것이 특징인 제약학적 제제.
  4. 제약학상 허용되는 부형제와 제2항의 화합물을 함유하는 것이 특징인 제약학적 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900702409A 1989-03-09 1990-02-16 신규 1α-히드록시비타민D_2에피머 및 유도체 Expired - Fee Related KR950005776B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US321,254 1989-03-09
US07/321,254 US4973584A (en) 1989-03-09 1989-03-09 Novel 1α-hydroxyvitamin D2 epimer and derivatives
PCT/US1990/000952 WO1990010619A1 (en) 1989-03-09 1990-02-16 NOVEL 1α-HYDROXYVITAMIN D2 EPIMER AND DERIVATIVES
US321254 1994-10-11

Publications (2)

Publication Number Publication Date
KR920700201A true KR920700201A (ko) 1992-02-19
KR950005776B1 KR950005776B1 (ko) 1995-05-30

Family

ID=23249837

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900702409A Expired - Fee Related KR950005776B1 (ko) 1989-03-09 1990-02-16 신규 1α-히드록시비타민D_2에피머 및 유도체

Country Status (15)

Country Link
US (1) US4973584A (ko)
EP (1) EP0386793B1 (ko)
JP (1) JPH0737443B2 (ko)
KR (1) KR950005776B1 (ko)
AT (1) ATE90342T1 (ko)
AU (1) AU631618B2 (ko)
CA (1) CA1335105C (ko)
DE (1) DE69001839T2 (ko)
DK (1) DK0386793T3 (ko)
ES (1) ES2055193T3 (ko)
HU (1) HU207040B (ko)
IL (1) IL93456A (ko)
NZ (1) NZ232735A (ko)
RU (1) RU2065851C1 (ko)
WO (1) WO1990010619A1 (ko)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5030772A (en) * 1990-02-14 1991-07-09 Deluca Hector F Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives
US5756783A (en) * 1990-09-21 1998-05-26 Bone Care International, Inc. 1α-Hydroxy-24-EPI-vitamin D4
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
US6251883B1 (en) 1991-01-08 2001-06-26 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxy vitamin D2
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US5789397A (en) * 1991-01-08 1998-08-04 Bone Care International, Inc. Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2
US5182396A (en) * 1991-03-29 1993-01-26 Nisshin Flour Milling Co., Ltd. 1-hydroxyvitamin d derivatives
AU656829B2 (en) * 1991-12-26 1995-02-16 Wisconsin Alumni Research Foundation 26, 27-dimethylene-1 alpha, 25-dihydroxyvitamin D2 and 26,27-dihydroxyvitamin D2 and methods for preparing same
AU682817B2 (en) * 1992-01-29 1997-10-23 Bone Care International, Inc. 1alpha-hydroxy-24-(epi)-vitamin D4
US5194431A (en) * 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives
DE69325253T2 (de) * 1992-08-28 1999-12-02 Bone Care International Inc., Madison 1alpha,24(s)-dihydroxy vitamin d2, seine synthese und verwendung
TW267161B (ko) * 1992-11-20 1996-01-01 Hoffmann La Roche
JPH0753384A (ja) * 1993-07-13 1995-02-28 Wisconsin Alumni Res Found ２４−エピ−１α−ヒドロキシビタミンＤ２ を含んでなる骨粗鬆症治療剤
US5565589A (en) * 1993-11-03 1996-10-15 Wisconsin Alumni Research Foundation 17-formyl-5,6-trans-vitamin D compounds
US5373004A (en) * 1993-11-24 1994-12-13 Wisconsin Alumni Research Foundation 26,28-methylene-1α, 25-dihydroxyvitamin D2 compounds
US5661140A (en) * 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
US5716946A (en) * 1996-02-13 1998-02-10 Wisconsin Alumni Research Foundation Multiple sclerosis treatment
US6416737B1 (en) 1998-11-19 2002-07-09 Board Of Trustees Of The University Of Arkansas Increasing bone strength with selected bisphosphonates
WO2000059513A1 (en) * 1999-04-01 2000-10-12 Johns Hopkins University NON-CALCEMIC, ANTIPROLIFERATIVE, TRANSCRIPTIONALLY ACTIVE SULFUR-CONTAINING ANALOGS OF 1α, 25-DIHYDROXY VITAMIN D¿3?
US6479474B2 (en) 1999-07-08 2002-11-12 Wisconsin Alumni Research Foundation Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis
ATE428692T1 (de) * 2001-08-22 2009-05-15 Univ Johns Hopkins 24-schwefel-substituierte 1-alpha-25-dihydroxy- vitamin-d3-analogen
WO2003106411A1 (en) 2002-06-13 2003-12-24 Johns Hopkins University 24-sulfoximine vitamin d3 compounds
WO2004054968A2 (en) 2002-12-18 2004-07-01 Johns Hopkins University 25-so2-substituted analogs of 1alpha, 25-dihydroxyvitamin d3 (calcitriol)
JP5009617B2 (ja) * 2003-08-20 2012-08-22 ウイスコンシン アラムニ リサーチ ファンデーション ２−メチレン−１９−ノル−ビタミンｄ２化合物
AU2010208323B2 (en) 2009-01-27 2016-03-10 Berg Llc Vitamin D3 and analogs thereof for alleviating side effects associated with chemotherapy
EP2464357B1 (en) 2009-08-14 2019-05-22 Berg LLC Vitamin d3 and analogs thereof for treating alopecia
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
US3907843A (en) * 1974-06-14 1975-09-23 Wisconsin Alumni Res Found 1{60 -Hydroxyergocalciferol and processes for preparing same
NL193245C (nl) * 1983-05-09 1999-04-02 Wisconsin Alumni Res Found Aan 1Ó,25-dihydroxyvitamine D2 verwante verbinding en farmaceutisch preparaat met een het calciummetabolisme regulerende werking dat een dergelijke verbinding bevat.
US4769181A (en) * 1983-11-07 1988-09-06 Wisconsin Alumni Research Foundation 1,25-dihydroxyvitamin D2 compounds
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4717721A (en) * 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity

Also Published As

Publication number Publication date
US4973584A (en) 1990-11-27
HU207040B (en) 1993-03-01
DK0386793T3 (da) 1993-08-02
HU902288D0 (en) 1991-07-29
JPH0737443B2 (ja) 1995-04-26
JPH03504508A (ja) 1991-10-03
DE69001839D1 (de) 1993-07-15
AU631618B2 (en) 1992-12-03
EP0386793A1 (en) 1990-09-12
EP0386793B1 (en) 1993-06-09
ATE90342T1 (de) 1993-06-15
DE69001839T2 (de) 1993-09-16
ES2055193T3 (es) 1994-08-16
KR950005776B1 (ko) 1995-05-30
IL93456A0 (en) 1990-11-29
NZ232735A (en) 1992-07-28
RU2065851C1 (ru) 1996-08-27
IL93456A (en) 1994-02-27
WO1990010619A1 (en) 1990-09-20
CA1335105C (en) 1995-04-04
AU5192590A (en) 1990-10-09

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