ES2055438T3 - Nuevos analogos de vitamina d. - Google Patents
Nuevos analogos de vitamina d.Info
- Publication number
- ES2055438T3 ES2055438T3 ES90910609T ES90910609T ES2055438T3 ES 2055438 T3 ES2055438 T3 ES 2055438T3 ES 90910609 T ES90910609 T ES 90910609T ES 90910609 T ES90910609 T ES 90910609T ES 2055438 T3 ES2055438 T3 ES 2055438T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compounds
- hydroxyl group
- carbons
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
ESTA INVENCION DESCRIBE COMPUESTOS DE LA FORMULA (I), EN CUYA FORMULA, N ES 0 O 1, M ES 0 O UN ENTERO DE 1-7, R ELEVADO 1 Y R (AL CUADRADO) (QUE PUEDEN SER LO MISMO O DIFERENTE) DESIGNAN HIDROGENO O HIDROCARBILO-C SUB 1 EL CARBONO SOPORTANDO EL GRUPO HIDROXIL (CON ASTERISCO EN LA FORMULA I), R ELEVADO 1 Y R (AL CUADRADO) PUEDEN FORMAR UN ANILLO CARBOCICLICO C SUB 3 AS, R ELEVADO 1 Y/O R (AL CUADRADO) Y/O UNO DE LOS CARBONES DESIGNADOS POR EL "O" PUEDEN SER OPCIONALMENTE SUSTITUIDOS POR UN GRUPO HIDROXIL O UNO O MAS ATOMOS(S) DE FLUOR O CLORO; Y FINALMENTE UNO DE LOS CARBONES DESIGNADOS CON "O" PUEDE SER OPCIONALMENTE SUSTITUIDO POR UNO O DOS GRUPO(S) ALQUILOS C SUB 1 SUB 2; Y DERIVADOS DE LOS COMPUESTOS DE LA FORMULA I EN LA QUE UNO O MAS HIDROXI SE HA TRANSFORMADO EN ACILO-OO GRUPOS ESTER FOSFATO; SIENDO HIDROLIZABLES "IN VIVO" TALES GRUPOS ENMASCARADOS. ESTOS COMPUESTOS TIENEN UTILIDAD EN PRACTICAS HUMANAS Y VETERINARIAS PARA EL TRATAMIENTO Y PROFILAXIS DE ENFERMEDADES AUTOINMUNES (INCLUYENDO DIABETES MELLITUS), HIPERTENSION, ACNE, ALOECIA, ENVEJECIMIENTO DE LA PIEL, DESEQUILIBRIO EN EL SISTEMA INMUNOLOGICO, ENFERMEDADES INFLAMATORIAS TALES COMO ARTRITIS REUMATOIDE Y ASMA, ASI COMO ENFERMEDADES CARACTERIZADAS POR LA DIFERENCIACION ANORMAL DE LAS CELULAS Y/O PROLIFERACION CELULAR, TALES COMO POR EJ., SORIASIS Y CANCER.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898914963A GB8914963D0 (en) | 1989-06-29 | 1989-06-29 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2055438T3 true ES2055438T3 (es) | 1994-08-16 |
Family
ID=10659278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90910609T Expired - Lifetime ES2055438T3 (es) | 1989-06-29 | 1990-06-19 | Nuevos analogos de vitamina d. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0479871B1 (es) |
| JP (1) | JP2807086B2 (es) |
| KR (1) | KR100195573B1 (es) |
| AT (1) | ATE88465T1 (es) |
| AU (1) | AU629666B2 (es) |
| CA (1) | CA2051418C (es) |
| DE (1) | DE69001437T2 (es) |
| DK (1) | DK0479871T3 (es) |
| ES (1) | ES2055438T3 (es) |
| FI (1) | FI93723C (es) |
| GB (1) | GB8914963D0 (es) |
| IE (1) | IE63665B1 (es) |
| NZ (1) | NZ234216A (es) |
| WO (1) | WO1991000271A1 (es) |
| ZA (1) | ZA905043B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8915770D0 (en) * | 1989-07-10 | 1989-08-31 | Leo Pharm Prod Ltd | Chemical compounds |
| US5260290A (en) * | 1990-02-14 | 1993-11-09 | Wisconsin Alumni Research Foundation | Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives |
| US5030772A (en) * | 1990-02-14 | 1991-07-09 | Deluca Hector F | Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives |
| GB9017890D0 (en) * | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
| CA2062520C (en) * | 1991-03-11 | 1998-08-11 | Hector F. Deluca | Synthesis of 1-alpha-hydroxy-secosterol compounds |
| US5486509A (en) * | 1991-06-28 | 1996-01-23 | University Of Miami | Method of preventing and treating chemotherapy-induced alopecia |
| DE69326972T2 (de) * | 1992-04-14 | 2000-05-18 | Kuraray Co., Ltd | Verfahren zur Herstellung eines optisch aktiven Olefins |
| AU666563B2 (en) * | 1992-08-07 | 1996-02-15 | Wisconsin Alumni Research Foundation | Preparation of 19-nor-vitamin D compounds |
| IL107185A (en) * | 1992-10-06 | 1998-02-22 | Schering Ag | Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same |
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| GB9524812D0 (en) * | 1995-12-05 | 1996-02-07 | Leo Pharm Prod Ltd | Chemical compounds |
| SG70009A1 (en) * | 1996-05-23 | 2000-01-25 | Hoffmann La Roche | Vitamin d3 analogs |
| US5939408A (en) * | 1996-05-23 | 1999-08-17 | Hoffman-La Roche Inc. | Vitamin D3 analogs |
| GB9622590D0 (en) * | 1996-10-30 | 1997-01-08 | Leo Pharm Prod Ltd | Chemical compounds |
| US20030018017A1 (en) * | 2001-01-25 | 2003-01-23 | Deluca Hector F. | Method of treatment of type I diabetes |
| US8377913B2 (en) * | 2007-11-20 | 2013-02-19 | Abbvie Inc. | Vitamin D receptor activators and methods of making |
| CN102264751A (zh) * | 2008-11-26 | 2011-11-30 | 赛特克罗公司 | 合成维生素d类似物的方法 |
| ES2674336B1 (es) * | 2016-12-28 | 2019-04-11 | Laboratorios Vinas S A | Procedimiento para reducir derivados carbonilicos de vitamina d y uso correspondiente |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH665834A5 (de) * | 1983-05-09 | 1988-06-15 | Wisconsin Alumni Res Found | Verfahren zur herstellung von 1alpha,25-dihydroxyliertem vitamin d(2) und verwandten verbindungen. |
| NL8920392A (nl) * | 1988-04-29 | 1990-04-02 | Wisconsin Alumni Res Found | 1alfa-hydroxyvitamine d-homologen met onverzadigde zijketen. |
| US4851401A (en) * | 1988-07-14 | 1989-07-25 | Wisconsin Alumni Research Foundation | Novel cyclopentano-vitamin D analogs |
-
1989
- 1989-06-29 GB GB898914963A patent/GB8914963D0/en active Pending
-
1990
- 1990-06-06 IE IE202790A patent/IE63665B1/en not_active IP Right Cessation
- 1990-06-19 AT AT90910609T patent/ATE88465T1/de not_active IP Right Cessation
- 1990-06-19 WO PCT/DK1990/000156 patent/WO1991000271A1/en not_active Ceased
- 1990-06-19 JP JP2509936A patent/JP2807086B2/ja not_active Expired - Fee Related
- 1990-06-19 EP EP90910609A patent/EP0479871B1/en not_active Expired - Lifetime
- 1990-06-19 DK DK90910609.8T patent/DK0479871T3/da active
- 1990-06-19 CA CA002051418A patent/CA2051418C/en not_active Expired - Fee Related
- 1990-06-19 DE DE9090910609T patent/DE69001437T2/de not_active Expired - Fee Related
- 1990-06-19 AU AU59637/90A patent/AU629666B2/en not_active Ceased
- 1990-06-19 ES ES90910609T patent/ES2055438T3/es not_active Expired - Lifetime
- 1990-06-25 NZ NZ234216A patent/NZ234216A/xx unknown
- 1990-06-28 ZA ZA905043A patent/ZA905043B/xx unknown
-
1991
- 1991-11-07 KR KR1019910701542A patent/KR100195573B1/ko not_active Expired - Fee Related
- 1991-12-27 FI FI916150A patent/FI93723C/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04506351A (ja) | 1992-11-05 |
| JP2807086B2 (ja) | 1998-09-30 |
| ATE88465T1 (de) | 1993-05-15 |
| FI93723B (fi) | 1995-02-15 |
| WO1991000271A1 (en) | 1991-01-10 |
| IE63665B1 (en) | 1995-05-31 |
| EP0479871B1 (en) | 1993-04-21 |
| KR920701147A (ko) | 1992-08-11 |
| KR100195573B1 (en) | 1999-06-15 |
| GB8914963D0 (en) | 1989-08-23 |
| CA2051418C (en) | 2002-02-05 |
| EP0479871A1 (en) | 1992-04-15 |
| FI93723C (fi) | 1995-05-26 |
| DK0479871T3 (da) | 1993-06-14 |
| IE902027L (en) | 1990-12-29 |
| FI916150A0 (fi) | 1991-12-27 |
| ZA905043B (en) | 1991-05-29 |
| NZ234216A (en) | 1993-03-26 |
| CA2051418A1 (en) | 1990-12-30 |
| DE69001437T2 (de) | 1993-08-19 |
| DE69001437D1 (de) | 1993-05-27 |
| IE902027A1 (en) | 1991-06-19 |
| AU629666B2 (en) | 1992-10-08 |
| AU5963790A (en) | 1991-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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