ES2055686T3 - Procedimiento para preparar proteinas con factor de granulocitos-macrofagos "estimulador de colonias". - Google Patents

Procedimiento para preparar proteinas con factor de granulocitos-macrofagos "estimulador de colonias".

Info

Publication number
ES2055686T3
ES2055686T3 ES86117484T ES86117484T ES2055686T3 ES 2055686 T3 ES2055686 T3 ES 2055686T3 ES 86117484 T ES86117484 T ES 86117484T ES 86117484 T ES86117484 T ES 86117484T ES 2055686 T3 ES2055686 T3 ES 2055686T3
Authority
ES
Spain
Prior art keywords
macrophagus
factor
granulocyt
procedure
colony stimulator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86117484T
Other languages
English (en)
Inventor
Paul Habermann
Hubert Muellner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2055686T3 publication Critical patent/ES2055686T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

POR EXPRESION EN BACTERIAS DE UN GEN QUE CODIFICA EL FACTOR ESTIMULANTE DE COLONIAS (CSF) MACROFAGO DE GRANULOCITOS (GM) SE OBTIENEN PROTEINAS CON ACTIVIDAD BIOLOGICA. POR VARIACION DE UNA ESTRUCTURA NATURAL O SINTETICA DEL GEN SE OBTIENEN DERIVADOS BIOLOGICAMENTE ACTIVOS CON UNA SECUENCIA MODIFICADA DE AMINOACIDOS.
ES86117484T 1985-12-21 1986-12-16 Procedimiento para preparar proteinas con factor de granulocitos-macrofagos "estimulador de colonias". Expired - Lifetime ES2055686T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853545568 DE3545568A1 (de) 1985-12-21 1985-12-21 Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung

Publications (1)

Publication Number Publication Date
ES2055686T3 true ES2055686T3 (es) 1994-09-01

Family

ID=6289242

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86117484T Expired - Lifetime ES2055686T3 (es) 1985-12-21 1986-12-16 Procedimiento para preparar proteinas con factor de granulocitos-macrofagos "estimulador de colonias".

Country Status (17)

Country Link
EP (1) EP0228018B1 (es)
JP (1) JP2575367B2 (es)
KR (1) KR940005585B1 (es)
AT (1) ATE71144T1 (es)
AU (2) AU601959B2 (es)
CA (1) CA1341197C (es)
DE (2) DE3545568A1 (es)
DK (1) DK170346B1 (es)
ES (1) ES2055686T3 (es)
FI (1) FI91168C (es)
GR (1) GR3003999T3 (es)
HU (1) HU202584B (es)
IE (1) IE59779B1 (es)
IL (1) IL81020A (es)
NO (1) NO177270C (es)
PT (1) PT83972B (es)
ZA (1) ZA869557B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5078996A (en) * 1985-08-16 1992-01-07 Immunex Corporation Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
WO1987002060A1 (en) * 1985-10-03 1987-04-09 Biogen N.V. Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells
DE3712985A1 (de) * 1987-04-16 1988-11-03 Hoechst Ag Bifunktionelle proteine
US5359035A (en) * 1985-12-21 1994-10-25 Hoechst Aktiengesellschaft Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF)
JP2583770B2 (ja) * 1986-09-17 1997-02-19 大塚製薬株式会社 遺伝子
JPS6420097A (en) * 1987-03-02 1989-01-24 Sumitomo Chemical Co Human granulocyte-macrophage colony stimulating factor
PT87133B (pt) * 1987-04-02 1992-07-31 Amrad Corp Ltd Metodo de purificacao do factor inibidor da leucemia (lif) e de composicoes farmaceuticas contendo polipeptidos com actividade do lif
AU609128B2 (en) * 1987-04-02 1991-04-26 Amrad Operations Pty. Limited Leukaemia-inhibitory factor
AU602097B2 (en) * 1987-06-25 1990-09-27 Immunex Corporation Bovine granulocyte-macrophage colony stimulating factor
IL88344A (en) * 1987-11-12 1994-06-24 Schering Corp Accelerating bone formation using a factor that accelerates colonies of granulocyte macrophages
GB2212159B (en) * 1987-11-13 1992-01-22 British Bio Technology Synthetic gene for human granulocyte/macrophage colony stimulating factor.
JPH03503897A (ja) * 1988-04-21 1991-08-29 メドベット・サイエンス・プロプライアテリー・リミテッド ひとｇｍ‐ｃｓｆ変異形類
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
EP0489116B1 (en) * 1989-08-22 1994-04-06 Immunex Corporation Fusion proteins comprising gm-csf and il-3
NZ236819A (en) * 1990-02-03 1993-07-27 Max Planck Gesellschaft Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions
US5270181A (en) * 1991-02-06 1993-12-14 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
US6060258A (en) * 1995-09-28 2000-05-09 Otsuka Pharmaceutical Co., Ltd. Neutrophil chemotactic lymphokine, and method for the diagnosis of drug hypersensitive granulocytopenia using the same
RU2144083C1 (ru) * 1998-03-13 2000-01-10 Государственный научный центр вирусологии и биотехнологии "Вектор" Способ промышленного получения рекомбинантного гранулоцит-макрофаг-колониестимулирующего фактора человека
KR100448021B1 (ko) * 2001-12-28 2004-09-08 크레아젠 주식회사 마우스 과립구 대식세포 콜로니 촉진인자 발현벡터 ｐＧＭ-ＣＳＦ로 형질전환된 대장균 및 상기 마우스 과립구 대식세포 콜로니 촉진인자의 대량생산방법
CN108295087B (zh) 2009-12-23 2021-01-15 格兰达利斯有限公司 弗林蛋白酶敲减和gm-csf增强的(fang)癌症疫苗
SG181881A1 (en) 2009-12-23 2012-07-30 Gradalis Inc Furin-knockdown bi-functional rna

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
SE8300693L (sv) * 1983-02-09 1984-08-10 Sven Lofdahl Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta
IL71991A (en) * 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
AU594014B2 (en) * 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
ES8701226A1 (es) * 1984-07-06 1986-11-16 Sandoz Ag Procedimiento de obtencion de una proteina de factor estimu-lante de colonias (csf) en primates
ZA856108B (en) * 1984-10-29 1986-10-29 Immunex Corp Cloning of human granulocyte-macrophage colony simulating factor gene
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
IE59581B1 (en) * 1984-11-20 1994-03-09 Schering Biotech Corp Cdna clones coding for polypeptides exhibiting human granulocyte macrophage and eosinophil cellular growth factor activity
WO1987002060A1 (en) * 1985-10-03 1987-04-09 Biogen N.V. Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells
DE3636903A1 (de) * 1985-12-21 1987-07-02 Hoechst Ag Fusionsproteine mit eukaryotischem ballastanteil
DE3541856A1 (de) * 1985-11-27 1987-06-04 Hoechst Ag Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens

Also Published As

Publication number Publication date
JPS62164695A (ja) 1987-07-21
FI865186L (fi) 1987-06-22
IE863335L (en) 1987-06-21
EP0228018B1 (de) 1992-01-02
GR3003999T3 (es) 1993-03-16
DK170346B1 (da) 1995-08-07
NO177270B (no) 1995-05-08
HU202584B (en) 1991-03-28
KR870006188A (ko) 1987-07-09
CA1341197C (en) 2001-03-06
NO865191D0 (no) 1986-12-19
NO865191L (no) 1987-06-22
JP2575367B2 (ja) 1997-01-22
NO177270C (no) 1995-08-16
PT83972B (pt) 1989-07-31
DK619086D0 (da) 1986-12-19
IL81020A (en) 1995-11-27
ATE71144T1 (de) 1992-01-15
DE3545568A1 (de) 1987-07-16
HUT44615A (en) 1988-03-28
FI865186A0 (fi) 1986-12-18
PT83972A (de) 1987-01-01
AU6675686A (en) 1987-06-25
EP0228018A2 (de) 1987-07-08
DE3683267D1 (de) 1992-02-13
FI91168B (fi) 1994-02-15
KR940005585B1 (ko) 1994-06-21
AU6268390A (en) 1990-12-13
IE59779B1 (en) 1994-04-06
AU601959B2 (en) 1990-09-27
IL81020A0 (en) 1987-03-31
AU637139B2 (en) 1993-05-20
ZA869557B (en) 1987-10-28
FI91168C (fi) 1994-05-25
DK619086A (da) 1987-06-22
EP0228018A3 (en) 1987-12-02

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