ES2056928T3 - Compuestos heterociclicos. - Google Patents

Compuestos heterociclicos.

Info

Publication number
ES2056928T3
ES2056928T3 ES88304899T ES88304899T ES2056928T3 ES 2056928 T3 ES2056928 T3 ES 2056928T3 ES 88304899 T ES88304899 T ES 88304899T ES 88304899 T ES88304899 T ES 88304899T ES 2056928 T3 ES2056928 T3 ES 2056928T3
Authority
ES
Spain
Prior art keywords
acch
formula
cyclic compounds
hetero cyclic
hetero
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88304899T
Other languages
English (en)
Inventor
Klaus Peter Bogeso
Klaus Gundertofte Jensen
Ejner Knud Moltzen
Pedersen Henrik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Application granted granted Critical
Publication of ES2056928T3 publication Critical patent/ES2056928T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTOS HETEROCICLICOS DE LA FORMULA (I) DONDE LA LINEA DE PUNTOS DESIGNA UN ENLACE OPCIONAL Y "HET", R1, R2, R3, R4 Y R5 SON COMO SE REDEFINEN EN LA REIVINDICACION 1 ASI COMO ESTEREOISOMEROS INDIVIDUALES Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS QUE SON NUEVAS Y SE DESCRIBEN COMO POSEEDORAS DE UNA POTENTE ACTIVIDAD AGONISTA DE LA ACETILCOLINA (ACCH) INDICANDO UTILIDAD EN EL TRATAMIENTO DE ENFERMEDADES CAUSADAS POR LA REDUCCION DE LA FUNCION DE LA ACCH EN EL CEREBRO. SE DESCRIBEN COMPOSICIONES FARMACEUTICAS QUE CONTIENEN UN COMPUESTO DE LA FORMULA (I) Y METODOS PARA LA PREPARACION DE ESTOS.
ES88304899T 1987-06-24 1988-05-27 Compuestos heterociclicos. Expired - Lifetime ES2056928T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878714789A GB8714789D0 (en) 1987-06-24 1987-06-24 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ES2056928T3 true ES2056928T3 (es) 1994-10-16

Family

ID=10619472

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88304899T Expired - Lifetime ES2056928T3 (es) 1987-06-24 1988-05-27 Compuestos heterociclicos.

Country Status (19)

Country Link
US (3) US4866077A (es)
EP (1) EP0296721B1 (es)
JP (1) JP2703268B2 (es)
AU (1) AU615917B2 (es)
BR (1) BR1100658A (es)
CA (1) CA1340458C (es)
DE (1) DE3881970T2 (es)
DK (1) DK168600B1 (es)
ES (1) ES2056928T3 (es)
FI (1) FI93356C (es)
GB (1) GB8714789D0 (es)
HK (1) HK84194A (es)
HU (1) HU210809A9 (es)
IE (1) IE61694B1 (es)
IL (1) IL86618A (es)
NO (1) NO174051C (es)
NZ (1) NZ224868A (es)
PT (1) PT87820B (es)
ZA (1) ZA884339B (es)

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IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
ATE87918T1 (de) * 1988-02-19 1993-04-15 Lilly Co Eli Tetrazolverbindungen als antagonisten der excitatorischen aminosaeurerezeptoren.
DK162892C (da) * 1988-07-04 1992-05-11 Novo Nordisk As 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
IT1229491B (it) * 1988-12-28 1991-09-03 Roussel Maestretti S P A Ora R Derivati della 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro impiego come sostanze medicinali
JP3003148B2 (ja) * 1989-01-05 2000-01-24 藤沢薬品工業株式会社 チアゾール化合物、その製造法およびそれを含有する医薬組成物
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5264444A (en) * 1989-02-22 1993-11-23 Novo Nordisk A/S Piperidine compounds and use
US5260311A (en) * 1989-02-22 1993-11-09 Novo Nordisk A/S Piperidine compounds and their use
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
US5328925A (en) * 1989-02-22 1994-07-12 Novo Nordisk A/S Piperidine compounds and their use
EP0402056A3 (en) * 1989-06-06 1991-09-04 Beecham Group p.l.c. Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
EP0427390B1 (en) * 1989-10-07 1996-03-27 Beecham Group Plc Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them
US5200419A (en) * 1990-05-21 1993-04-06 Warner-Lambert Company Substituted tetrazoles and derivatives thereof acting at muscarinic receptors
IE911994A1 (en) * 1990-07-03 1992-01-15 Akzo Nv 5-isothiazolamine derivatives
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US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
DK198390D0 (da) 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
USRE35822E (en) * 1990-08-21 1998-06-09 Novo Nordisk A/S Heterocyclic compounds
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
AU656547B2 (en) * 1990-11-29 1995-02-09 Allergan, Inc. Use of pyridine derivatives in the treatment of ocular hypertension
AU654013B2 (en) * 1991-03-13 1994-10-20 Regents Of The University Of Minnesota 2-hydroxy-3(4-iodophenyl)-1-(4-phenylpiperidinyl) propane
IE922270A1 (en) * 1991-07-26 1993-01-27 Akzo Nv Pyrazole derivatives
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
US5175166A (en) * 1991-08-27 1992-12-29 The University Of Toledo Muscarinic agonists
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5330994A (en) * 1992-03-24 1994-07-19 Warner-Lambert Company Tetrahydropyridine isoxazoline derivatives
JPH08502508A (ja) * 1992-10-23 1996-03-19 メルク シヤープ エンド ドーム リミテツド ドーパミンレセプターサブタイプリガンド
US5753683A (en) * 1993-08-19 1998-05-19 Novo Nordisk A/S Antipsychotic method
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
US5668148A (en) * 1995-04-20 1997-09-16 Merck & Co., Inc. Alpha1a adrenergic receptor antagonists
JPH11508539A (ja) * 1995-06-29 1999-07-27 ノボ ノルディスク アクティーゼルスカブ 新規の置換アザ環式化合物
CZ287441B6 (en) * 1995-11-06 2000-11-15 Lundbeck & Co As H Pharmaceutical preparation for treating traumatic lesion of brain
DE69724967D1 (de) * 1996-04-24 2003-10-23 Novo Nordisk As Heterozyklische verbindungen, ihre herstellung und ihre anwendung
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
WO1998053820A1 (en) * 1997-05-29 1998-12-03 H. Lundbeck A/S Treatment of schizophrenia and psychosis
AR013096A1 (es) * 1997-07-01 2000-12-13 Lundbeck & Co As H Sal de adicion de acido maleico de 5-(2-etil-2-h-tetrazol-5-il)-1-metil- 1,2,3,6-tetrahidropiridina, composicion farmaceutica que la contiene, su usoen terapia y metodo de preparacion de la misma.
EP1017386A1 (en) * 1997-10-02 2000-07-12 H. Lundbeck A/S GRANULAR PREPARATIONS OF 5-(2-ETHYL- 2$i(H)-TETRAZOL- 5-YL)-1-METHYL-1, 2,3,6-TETRAHYDROPYRIDINE
EA200100182A1 (ru) * 1998-07-27 2001-08-27 Эли Лилли Энд Компани Лечение состояний тревожности
WO2001013918A1 (en) * 1999-08-23 2001-03-01 H. Lundbeck A/S Treatment of urinary incontinence
AU2001253418A1 (en) * 2000-04-12 2001-10-30 Smith Kline Beecham Corporation Compounds and methods
KR100785109B1 (ko) * 2001-04-05 2007-12-12 토렌트 파마슈티칼스 리미티드 노화 관련 및 당뇨병 혈관성 합병증에 사용되는 헤테로사이클릭 화합물
US20030069597A1 (en) * 2001-10-10 2003-04-10 Scimed Life Systems, Inc. Loading tool
JP2005514362A (ja) 2001-11-19 2005-05-19 イーラン ファーマスーティカルズ、インコーポレイテッド ３，４二置換、３，５二置換、及び３，４，５置換ピペリジン及びピペラジン
BR0317324A (pt) 2002-12-18 2005-11-16 Fmc Corp N-(arilmetil substituìdo)-4-(metil dissubstituìdo) piperidinas e piridinas
JP2006516140A (ja) * 2002-12-20 2006-06-22 メルク　エンド　カムパニー　インコーポレーテッド 有糸分裂キネシン阻害剤
WO2005080394A1 (en) * 2004-02-24 2005-09-01 Bioaxone Therapeutique Inc. 4-substituted piperidine derivatives
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JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
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US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
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US8084473B2 (en) 2007-04-24 2011-12-27 Solvay Pharmaceuticals B.V. Heterocyclic compounds with affinity to muscarinic receptors
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BR112013000925A2 (pt) 2010-07-15 2020-12-01 Bayer Intellectual Property Gmbh compostos heterocíclicos como pesticidas
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US10857157B2 (en) 2015-01-26 2020-12-08 BioAxone BioSciences, Inc. Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors
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Also Published As

Publication number Publication date
US4925858A (en) 1990-05-15
BR1100658A (pt) 1999-08-31
JP2703268B2 (ja) 1998-01-26
DK321688D0 (da) 1988-06-13
PT87820A (pt) 1989-05-31
FI883064A7 (fi) 1988-12-25
NZ224868A (en) 1990-07-26
ZA884339B (en) 1989-05-30
HK84194A (en) 1994-08-26
IL86618A0 (en) 1988-11-30
IE61694B1 (en) 1994-11-16
EP0296721A3 (en) 1990-04-25
HU210809A9 (en) 1995-08-28
FI93356C (fi) 1995-03-27
DK168600B1 (da) 1994-05-02
PT87820B (pt) 1992-10-30
EP0296721B1 (en) 1993-06-23
USRE36374E (en) 1999-11-02
IL86618A (en) 1992-07-15
DK321688A (da) 1988-12-25
FI883064A0 (fi) 1988-06-23
JPS6422869A (en) 1989-01-25
GB8714789D0 (en) 1987-07-29
EP0296721A2 (en) 1988-12-28
NO882799L (no) 1988-12-27
IE881631L (en) 1988-12-24
NO174051C (no) 1994-03-09
AU1828288A (en) 1989-01-05
NO174051B (no) 1993-11-29
DE3881970D1 (de) 1993-07-29
NO882799D0 (no) 1988-06-23
FI93356B (fi) 1994-12-15
DE3881970T2 (de) 1993-11-11
US4866077A (en) 1989-09-12
AU615917B2 (en) 1991-10-17
CA1340458C (en) 1999-03-23

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