ES2056936T3 - Conjugado bidentado y metodo de utilizacion del mismo. - Google Patents

Conjugado bidentado y metodo de utilizacion del mismo.

Info

Publication number
ES2056936T3
ES2056936T3 ES88309004T ES88309004T ES2056936T3 ES 2056936 T3 ES2056936 T3 ES 2056936T3 ES 88309004 T ES88309004 T ES 88309004T ES 88309004 T ES88309004 T ES 88309004T ES 2056936 T3 ES2056936 T3 ES 2056936T3
Authority
ES
Spain
Prior art keywords
bidentate
members
conjugate
specific binding
spacer moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88309004T
Other languages
English (en)
Inventor
Paul C Harris
Chan S Oh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Instruments Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22294106&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2056936(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Beckman Instruments Inc filed Critical Beckman Instruments Inc
Application granted granted Critical
Publication of ES2056936T3 publication Critical patent/ES2056936T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

UN NUEVO CONJUGADO BIDENTADO TIENE DOS PARTES QUIMICAS O MIEMBROS BIDENTADOS DIFERENTES, UNIDOS A TRAVES DE UNA PARTE ESPACIADORA ADECUADA. CADA MIEMBRO BIDENTADO ACTUA COMO UNA PEQUEÑA MOLECULA LIGANDO, Y ES CAPAZ DE UNIRSE ESPECIFICAMENTE A UNA SUSTANCIA MACROMOLECULAR. LOS MIEMBROS BIDENTADOS SON MOLECULAS RELATIVAMENTE PEQUEÑAS, HABITUALMENTE DE TAMAÑOS MENORES QUE 7000 DALTONS APROXIMADAMENTE. LA PARTE ESPACIADORA SE ELIGE DE MODO QUE AMBOS MIEMBROS BIDENTADOS SE PUEDAN UNIR SIMULTANEAMENTE A SU RESPECTIVA PAREJA ENLAZANTE ESPECIFICA. CUANDO LAS PAREJAS ENLAZANTES ESPECIFICAS SON MULTIVALENTES, SE PUEDEN FORMAR GRANDES COMPLEJOS. LA FORMACION DE ESTOS COMPLEJOS SE PUEDE INHIBIR POR LA PRESENCIA DE UN MIEMBRO BIDENTADO MONOVALENTE NO CONJUGADO, TAL COMO UN ANALITO LIBRE DE UNA MUESTRA DE ENSAYO. EL BIDENTADO ES DE USO PARTICULAR EN PROCEDIMIENTOS DE ENSAYO DE INHIBICION TURBIDIMETRICOS O NEFELOMETRICOS.
ES88309004T 1987-09-30 1988-09-29 Conjugado bidentado y metodo de utilizacion del mismo. Expired - Lifetime ES2056936T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10323787A 1987-09-30 1987-09-30

Publications (1)

Publication Number Publication Date
ES2056936T3 true ES2056936T3 (es) 1994-10-16

Family

ID=22294106

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88309004T Expired - Lifetime ES2056936T3 (es) 1987-09-30 1988-09-29 Conjugado bidentado y metodo de utilizacion del mismo.

Country Status (7)

Country Link
EP (1) EP0315317B2 (es)
JP (1) JP2670696B2 (es)
AT (1) ATE92632T1 (es)
AU (1) AU621321B2 (es)
DE (1) DE3882904T2 (es)
ES (1) ES2056936T3 (es)
WO (1) WO1989003042A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534620A (en) * 1987-09-30 1996-07-09 Beckman Instruments, Inc. Method of heterogenous purification using a bidentate conjugate
GB8916859D0 (en) * 1989-07-24 1989-09-06 Dynal As Hapten linking
DE4011601A1 (de) * 1990-04-10 1991-10-17 Boehringer Mannheim Gmbh Hapten-biotin-konjugate und ihre verwendung
US5371021A (en) * 1992-07-17 1994-12-06 Beckman Instruments, Inc. Initial rate photometric method for immunoassay
US5440023A (en) * 1992-09-18 1995-08-08 Beckman Instruments, Inc. Method for making valproic acid derivatives
DE69331570T2 (de) * 1992-10-21 2002-10-02 Dade Behring Inc., Deerfield Agglutinationstest unter Anwendung eines multivalenten Liganden
JPH07504756A (ja) * 1993-01-06 1995-05-25 ベックマン　インスツルメンツ　インコーポレーテッド プレコンジュゲートの製造方法
US5728589A (en) * 1993-08-24 1998-03-17 Wako Pure Chemical Industries, Ltd. Immunoassay method
EP0656422B1 (en) * 1993-11-05 2000-04-26 Amersham Pharmacia Biotech UK Limited Chloramphenicol acetyl transferase (CAT) assay
DE69424132T2 (de) * 1993-11-05 2000-09-21 Amersham Pharmacia Biotech Uk Ltd., Little Chalfont Chloramphenicol Acetyl Transferase (CAT) Nachweis
US5747352A (en) * 1994-05-23 1998-05-05 Beckman Instruments, Inc. Reagents and methods for the rapid and quantitative assay of pharmacological agents
US5627080A (en) * 1994-07-29 1997-05-06 Beckman Instruments, Inc. Detergent-facilitated immunoassay for the rapid and quantitative assay of pharmacological agents
US6656694B2 (en) * 2001-01-11 2003-12-02 Theravance, Inc. Method for identifying a ligand for a biological substrate
GB0303919D0 (en) * 2003-02-20 2003-03-26 Purely Proteins Ltd Methods for investigating the specificity of compounds that interact with receptors
JP4780405B2 (ja) * 2006-08-29 2011-09-28 アイシン精機株式会社 結合親和性を利用する被検物質の測定方法、及び被検物質の測定のための結合親和性解析の制御方法
CN113030463B (zh) * 2021-02-04 2023-08-11 北京邦腾生物科技有限公司 一种检测疫苗中蛋白a等杂质的试纸条及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2029011B (en) * 1978-09-01 1983-02-02 Coulson W Use of a synthetic bifunctional ligand for the immunimetric determination of the concentration ratio of two solutes
EP0183901B1 (de) * 1984-11-27 1992-07-08 BEHRINGWERKE Aktiengesellschaft Bifunktionelle Haptene, Verfahren zu ihrer Herstellung und ihre Verwendung
US4680338A (en) * 1985-10-17 1987-07-14 Immunomedics, Inc. Bifunctional linker

Also Published As

Publication number Publication date
DE3882904T2 (de) 1993-11-18
EP0315317A3 (en) 1989-05-24
ATE92632T1 (de) 1993-08-15
JPH02501410A (ja) 1990-05-17
AU621321B2 (en) 1992-03-12
EP0315317B2 (en) 2000-05-10
AU2603288A (en) 1989-04-18
WO1989003042A1 (en) 1989-04-06
JP2670696B2 (ja) 1997-10-29
EP0315317B1 (en) 1993-08-04
DE3882904D1 (de) 1993-09-09
EP0315317A2 (en) 1989-05-10

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