ES2057592T3 - Procedimiento para la preparacion de soluciones acuosas de micelas mixtas. - Google Patents

Procedimiento para la preparacion de soluciones acuosas de micelas mixtas.

Info

Publication number
ES2057592T3
ES2057592T3 ES90915080T ES90915080T ES2057592T3 ES 2057592 T3 ES2057592 T3 ES 2057592T3 ES 90915080 T ES90915080 T ES 90915080T ES 90915080 T ES90915080 T ES 90915080T ES 2057592 T3 ES2057592 T3 ES 2057592T3
Authority
ES
Spain
Prior art keywords
water
soluble
freezing
preparation
aqueous solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90915080T
Other languages
English (en)
Inventor
Georg Rossling
Detlef Goritz
Heinrich Michel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6393595&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2057592(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2057592T3 publication Critical patent/ES2057592T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Mushroom Cultivation (AREA)
  • Colloid Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

SE DESCRIBE UN METODO DE PRODUCIR SOLUCIONES ACUOSAS CONTENIENDO MICELAS MEZCLADAS FORMADAS DE LIPIDOS Y SALES DE ACIDOS GALICOS Y EN EL CUAL, SI SE NECESITA, PUEDEN SOLUBILIZARSE, SUSTANCIAS ACTIVAS INDISOLUBLES O POCO SOLUBLES EN AGUA. EL METODO SE CARACTERIZA EN QUE SE PREPARAN, MEZCLAS DE (A) SOLUCIONES CONTENIENDO, EN UN DISOLVENTE SOLUBLE EN AGUA, LOS LIPIDOS, LOS ACIDOS GALICOS LIBRES Y OPCIONALMENTE, LAS SUSTANCIAS ACTIVAS QUE SON INDISOLUBLES O SOLAMENTE UN POCO SOLUBLES EN AGUA Y (B) DISOLUCIONES CONTENIENDO 0.05-3 EQUIVALENTES, RELATIVOS A LOS ACIDOS GALLICOS, DE BASES Y, OPCIONALMENTE ADITIVOS ISOTONIZADORES Y/O SUSTANCIAS ACTIVAS SOLUBLES EN AGUA, EXTRAYENDOSE EL DISOLVENTE ORGANICO POR ULTRAFILTRACION , CONGELACION EN SECO, DESTILACION AL VACIO U OSMOSIS REVERSA, Y SI ES NECESARIO, DILUYENDOSE CON FASE ACUOSA LA MEZCLA ASI OBTENIDA.
ES90915080T 1989-11-13 1990-10-11 Procedimiento para la preparacion de soluciones acuosas de micelas mixtas. Expired - Lifetime ES2057592T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3938030A DE3938030A1 (de) 1989-11-13 1989-11-13 Verfahren zur herstellung waessriger mischmicelloesungen

Publications (1)

Publication Number Publication Date
ES2057592T3 true ES2057592T3 (es) 1994-10-16

Family

ID=6393595

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90915080T Expired - Lifetime ES2057592T3 (es) 1989-11-13 1990-10-11 Procedimiento para la preparacion de soluciones acuosas de micelas mixtas.

Country Status (15)

Country Link
EP (1) EP0453525B1 (es)
JP (1) JPH04505018A (es)
AT (1) ATE88632T1 (es)
AU (1) AU648050B2 (es)
CA (1) CA2029673C (es)
DE (2) DE3938030A1 (es)
DK (1) DK0453525T3 (es)
ES (1) ES2057592T3 (es)
FI (1) FI913235A7 (es)
GR (1) GR900100798A (es)
HU (1) HUT57577A (es)
IE (1) IE66507B1 (es)
NO (1) NO912748D0 (es)
PT (1) PT95853B (es)
WO (1) WO1991007170A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6663885B1 (en) 1993-03-15 2003-12-16 A. Natterman & Cie Gmbh Aqueous liposome system and a method for the preparation of such a liposome system
JP2740153B2 (ja) * 1995-03-07 1998-04-15 エフ・ホフマン−ラ ロシユ アーゲー 混合ミセル
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
WO2008040799A2 (en) * 2006-10-06 2008-04-10 Boehringer Ingelheim International Gmbh Process for preparing instant forms of aqueous mixed micellar solutions as physiological buffer systems for use in the analysis of in vitro release
EP2201935B1 (en) * 2008-12-26 2020-07-08 Samyang Biopharmaceuticals Corporation Polymeric micelle composition containing a poorly soluble drug and preparation method of the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1289401A (fr) * 1953-03-07 1962-04-06 Merck & Co Inc Procédé de stabilisation de solutions huileuses de vitamines
IT1202370B (it) * 1976-07-12 1989-02-09 Hoffmann La Roche Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti
EP0252004A1 (de) * 1986-06-26 1988-01-07 Ciba-Geigy Ag Pharmazeutische Zusammensetzungen für die parenterale Applikation
CA1319886C (en) * 1987-02-03 1993-07-06 Alberto Ferro Mixed micelle solutions

Also Published As

Publication number Publication date
FI913235A0 (fi) 1991-07-03
DK0453525T3 (da) 1993-08-23
PT95853B (pt) 1999-02-26
IE66507B1 (en) 1996-01-10
FI913235A7 (fi) 1991-07-03
HUT57577A (en) 1991-12-30
JPH04505018A (ja) 1992-09-03
CA2029673A1 (en) 1991-05-14
AU648050B2 (en) 1994-04-14
PT95853A (pt) 1991-09-13
CA2029673C (en) 2000-09-19
IE904088A1 (en) 1991-05-22
WO1991007170A1 (de) 1991-05-30
EP0453525A1 (de) 1991-10-30
ATE88632T1 (de) 1993-05-15
DE59001318D1 (de) 1993-06-03
DE3938030A1 (de) 1991-05-16
NO912748L (no) 1991-07-12
GR900100798A (el) 1992-04-17
NO912748D0 (no) 1991-07-12
HU907430D0 (en) 1991-11-28
AU6658790A (en) 1991-05-16
EP0453525B1 (de) 1993-04-28

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