ES2057876T3 - Procedimiento para la obtencion de un intermedio de sultamicilina. - Google Patents

Procedimiento para la obtencion de un intermedio de sultamicilina.

Info

Publication number
ES2057876T3
ES2057876T3 ES91906121T ES91906121T ES2057876T3 ES 2057876 T3 ES2057876 T3 ES 2057876T3 ES 91906121 T ES91906121 T ES 91906121T ES 91906121 T ES91906121 T ES 91906121T ES 2057876 T3 ES2057876 T3 ES 2057876T3
Authority
ES
Spain
Prior art keywords
sulbactam
salt
iodocloromethane
chlorometil
bromocloromethane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91906121T
Other languages
English (en)
Inventor
Dennis Michael Godek
Thomas Arthus Morris Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2057876T3 publication Critical patent/ES2057876T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

SE PRESENTA UN METODO SIMPLIFICADO PARA FABRICAR EL ETER DE CLOROMETIL DE SULBACTAM EN EL CUAL LA SAL DE SULBACTAM DE TETRAALQUILAMONIO NO SE SECA Y SE AISLA ANTES DE LA ALQUILACION. EL METODO COMPRENDE LA REACCION DE UNA SAL DE TETRAALQUILAMONIO Y UNA SAL DE SULBACTAM EN UNA SOLUCION ACUOSA PARA FORMAR UNA SOLUCION ACUOSA DE SULBACTAM DE TETRAALQUILAMONIO. EL SULBACTAM DE TETRAALQUILAMONIO SE EXTRAE EN BROMOCLOROMETANO O IODOCLOROMETANO, Y DICHA AGUA SE SEPARA DE LA CAPA ORGANICA PARA MEJORAR LA FORMACION DEL ESTER DE CLOROMETIL DEL SULBACTA. EL SULBACTAM DE TETRAALQUILAMONIO SE HACE REACCIONAR CON BROMOCLOROMETANO O IODOCLOROMETANO EN LA CAPA ORGANICA PARA FORMAR EL ESTER DE CLOROMETIL DE SULBACTAM.
ES91906121T 1990-04-13 1991-03-15 Procedimiento para la obtencion de un intermedio de sultamicilina. Expired - Lifetime ES2057876T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50925690A 1990-04-13 1990-04-13

Publications (1)

Publication Number Publication Date
ES2057876T3 true ES2057876T3 (es) 1994-10-16

Family

ID=24025883

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91906121T Expired - Lifetime ES2057876T3 (es) 1990-04-13 1991-03-15 Procedimiento para la obtencion de un intermedio de sultamicilina.

Country Status (14)

Country Link
US (1) US5399678A (es)
EP (1) EP0524959B1 (es)
JP (1) JPH06104671B2 (es)
KR (1) KR0164866B1 (es)
AT (1) ATE108797T1 (es)
CA (1) CA2078217C (es)
DE (1) DE69103003T2 (es)
DK (1) DK0524959T3 (es)
ES (1) ES2057876T3 (es)
FI (1) FI100971B (es)
HU (2) HU913930D0 (es)
IE (1) IE63599B1 (es)
PT (1) PT97324B (es)
WO (1) WO1991016326A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR035533A1 (es) * 2001-01-26 2004-06-02 Schering Corp Uso de por lo menos un inhibidor de la absorcion de los esteroles o sus sales, solvatos, prodrogas farmaceuticamente aceptables o mezclas de los mismos para la preparacion de un medicamento para el tratamiento de la sitosterolemia, composiciones farmaceuticas, el uso de dichas composiciones para la

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
HU196412B (en) * 1981-03-23 1988-11-28 Pfizer Process for production of penicillin-acid-penicillakiroloximethil-esthers
US4381263A (en) * 1981-03-23 1983-04-26 Pfizer Inc. Process for the preparation of penicillanic acid esters
US4428935A (en) * 1982-05-24 1984-01-31 Pfizer Inc. Penicillanic acid dioxide prodrug
US4530792A (en) * 1982-11-01 1985-07-23 Pfizer Inc. Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate
US4704456A (en) * 1985-11-22 1987-11-03 Pfizer Inc. Process for sultamicillin intermediate
JPH01139584A (ja) * 1987-11-25 1989-06-01 Yoshitomi Pharmaceut Ind Ltd ペニシラン酸化合物の製造法

Also Published As

Publication number Publication date
JPH06104671B2 (ja) 1994-12-21
DE69103003D1 (de) 1994-08-25
PT97324B (pt) 1998-08-31
HU913930D0 (en) 1992-09-28
ATE108797T1 (de) 1994-08-15
EP0524959B1 (en) 1994-07-20
PT97324A (pt) 1991-12-31
CA2078217C (en) 2000-02-22
EP0524959A1 (en) 1993-02-03
FI924608A0 (fi) 1992-10-12
IE911238A1 (en) 1991-10-23
JPH05502450A (ja) 1993-04-28
IE63599B1 (en) 1995-05-17
DE69103003T2 (de) 1994-11-03
CA2078217A1 (en) 1991-10-14
KR0164866B1 (ko) 1999-01-15
WO1991016326A1 (en) 1991-10-31
DK0524959T3 (da) 1994-09-12
US5399678A (en) 1995-03-21
HU212413B (en) 1996-06-28
HUT62591A (en) 1993-05-28
FI924608L (fi) 1992-10-12
FI100971B (fi) 1998-03-31

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