ES2058070T3 - Utilizacion de monosacaridos especificos para la preparacion de un medicamento para impedir metastasis de tumores malignos. - Google Patents

Utilizacion de monosacaridos especificos para la preparacion de un medicamento para impedir metastasis de tumores malignos.

Info

Publication number
ES2058070T3
ES2058070T3 ES87105548T ES87105548T ES2058070T3 ES 2058070 T3 ES2058070 T3 ES 2058070T3 ES 87105548 T ES87105548 T ES 87105548T ES 87105548 T ES87105548 T ES 87105548T ES 2058070 T3 ES2058070 T3 ES 2058070T3
Authority
ES
Spain
Prior art keywords
preparation
malignant tumors
medicinal product
prevent metastasis
specific monosaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87105548T
Other languages
English (en)
Inventor
Gerhard Prof Dr Dr H Pulverer
Kurt Prof Dr Med Oette
Gerd Prof Dr Med Uhlenbruck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2058070T3 publication Critical patent/ES2058070T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid Fuels And Fuel-Associated Substances (AREA)

Abstract

MEDIOS Y PROCEDIMIENTO PARA EVITAR LAS METASTASIS DE LOS TUMORES MALIGNOS, CON LA UTILIZACION DE MONOSACARIDOS ESPECIFICOS PARA ORGANOCELULOLECTINA, Y/O PREFERENTEMENTE LOS GLICOCONJUGADOS RESULTANTES, CONTENIENDO ESTOS MONOSACARIDOS, ESPECIALMENTE LA (BETA) OS, QUE CONTIENEN (BETA) - D - GALACTOSA.
ES87105548T 1986-05-09 1987-04-14 Utilizacion de monosacaridos especificos para la preparacion de un medicamento para impedir metastasis de tumores malignos. Expired - Lifetime ES2058070T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3615621 1986-05-09

Publications (1)

Publication Number Publication Date
ES2058070T3 true ES2058070T3 (es) 1994-11-01

Family

ID=6300445

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87105548T Expired - Lifetime ES2058070T3 (es) 1986-05-09 1987-04-14 Utilizacion de monosacaridos especificos para la preparacion de un medicamento para impedir metastasis de tumores malignos.

Country Status (6)

Country Link
US (1) US4946830A (es)
EP (1) EP0249008B1 (es)
JP (1) JPH07100658B2 (es)
AT (1) ATE94395T1 (es)
DE (1) DE3787403D1 (es)
ES (1) ES2058070T3 (es)

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EP0521692A3 (en) * 1991-07-02 1993-02-03 The Biomembrane Institute Inhibition of tumor cell metastasis potential and invasiveness by chemically-defined oligosaccharides, their derivatives, mimetics and antibodies directed to them
US5760008A (en) * 1991-11-04 1998-06-02 Co Enzyme Technology Ltd. Method and compositions for treating malignant tumors and inhibiting metastases of malignant tumors
US5639737A (en) * 1991-11-04 1997-06-17 Co Enzyme Technology Ltd. Method and compositions for treating malignant tumors and inhibiting growth and metastases of malignant tumors
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DE69329425T2 (de) * 1992-12-16 2001-01-18 Basf Ag Dolastatin analog
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US5654273A (en) * 1994-09-22 1997-08-05 Children's Medical Center Corporation Synducin mediated modulation of tissue repair
JP5183010B2 (ja) 2002-05-16 2013-04-17 グリコミメティクス， インコーポレイテッド セレクチンによって媒介される機能を阻害するための化合物および方法
AU2003245595A1 (en) * 2002-07-03 2004-01-23 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
US20050043272A1 (en) * 2003-07-11 2005-02-24 Pro-Pharmaceuticals, Inc. Compositions and methods for hydrophobic drug delivery
US20050053664A1 (en) * 2003-09-08 2005-03-10 Eliezer Zomer Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer
AU2003271016A1 (en) * 2003-09-17 2005-04-06 Bio-Wave Institute Of Suzhou Hi-Tech New District Corporation, Ltd. Use of n-acetyl-d-aminoglycosamine in preparation of drugs for the treatment of cacer and metastasis
CA2546784A1 (en) * 2003-11-19 2005-06-16 Glycomimetics, Inc. Glycomimetic antagonists for both e- and p-selectins
DE602004011272T2 (de) * 2003-11-19 2008-12-24 Glycomimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
US20070078109A1 (en) * 2004-02-13 2007-04-05 David Platt Compositions and methods used to treat acne and candida
JP2007529554A (ja) * 2004-03-19 2007-10-25 プロ−ファーマシューティカルズ，インク． 多価リガンド結合糖質ポリマーを用いた組成物、および該組成物による転移腫瘍の標的療法
WO2006017417A2 (en) * 2004-08-02 2006-02-16 Pro-Pharmaceuticals, Inc. Compositions and methods for the enhancement of chemotherapy with microbial cytotoxins
US8201377B2 (en) * 2004-11-05 2012-06-19 Faus Group, Inc. Flooring system having multiple alignment points
US20090036386A1 (en) * 2005-05-25 2009-02-05 Glycomimetics, Inc Heterobifunctional compounds for selectin inhibition
WO2007021721A2 (en) * 2005-08-09 2007-02-22 Glycomimetics, Inc. Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
SI2264043T1 (en) 2005-09-02 2018-01-31 Glycomimetics, Inc. HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS
US20090176717A1 (en) * 2006-06-01 2009-07-09 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
US7964569B2 (en) * 2006-10-12 2011-06-21 Glycomimetics, Inc. Glycomimetic replacements for hexoses and N-acetyl hexosamines
WO2008100453A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
US8039442B2 (en) * 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
US8895510B2 (en) * 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
US8518896B2 (en) * 2008-06-13 2013-08-27 Glycomimetics, Inc. Treatment of cancers of the blood using selected glycomimetic compounds
AU2010241807B2 (en) * 2009-05-01 2014-08-14 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
EP2794626B3 (en) 2011-12-22 2020-08-05 GlycoMimetics, Inc. E-selectin antagonist compounds
HUE038423T2 (hu) 2012-12-07 2018-10-29 Glycomimetics Inc E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára
CN107108679B (zh) 2014-12-03 2020-10-23 糖模拟物有限公司 E-选择蛋白和cxcr4趋化因子受体的异双官能抑制剂
WO2017127422A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
BR112019006642A2 (pt) 2016-10-07 2019-07-02 Glycomimetics Inc antagonistas multiméricos de e-selectina altamente potentes
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3717013A1 (en) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
US11548908B2 (en) 2017-12-29 2023-01-10 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
AU2019230013A1 (en) 2018-03-05 2020-09-10 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
US12642809B2 (en) * 2019-08-16 2026-06-02 H. Lee Moffitt Cancer Center And Research Institute Fucosylation and immune modulation in cancer

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IT1168205B (it) * 1983-07-21 1987-05-20 Wellcome Italia Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione
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US4742046A (en) * 1984-08-03 1988-05-03 Medisearch S.A. Methods and compositions for inhibiting the infectious activity of viruses
JPS6183125A (ja) * 1984-09-28 1986-04-26 Kanto Ishi Pharma Co Ltd 癌転移阻害剤
US4656159A (en) * 1984-10-31 1987-04-07 Georgetown University Galactose-C-6 nitrogen mustard compounds and their uses

Also Published As

Publication number Publication date
DE3787403D1 (de) 1993-10-21
US4946830A (en) 1990-08-07
JPH07100658B2 (ja) 1995-11-01
JPS62267234A (ja) 1987-11-19
ATE94395T1 (de) 1993-10-15
EP0249008A2 (de) 1987-12-16
EP0249008B1 (de) 1993-09-15
EP0249008A3 (en) 1989-09-27

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