ES2059831T3 - Producto radiofarmaceutico que tiene principalmente un tropismo cardiaco que comprende un complejo nitruro de un metal de transicion, y su procedimiento de preparacion. - Google Patents

Producto radiofarmaceutico que tiene principalmente un tropismo cardiaco que comprende un complejo nitruro de un metal de transicion, y su procedimiento de preparacion.

Info

Publication number
ES2059831T3
ES2059831T3 ES89913235T ES89913235T ES2059831T3 ES 2059831 T3 ES2059831 T3 ES 2059831T3 ES 89913235 T ES89913235 T ES 89913235T ES 89913235 T ES89913235 T ES 89913235T ES 2059831 T3 ES2059831 T3 ES 2059831T3
Authority
ES
Spain
Prior art keywords
complex
nitrid
transitional metal
mainly
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89913235T
Other languages
English (en)
Inventor
Roberto Pasqualini
Luciano Magon
Andre Bardy
Adriano Duatti
Andrea Marchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIS Bio International SA
Original Assignee
CIS Bio International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8815415A external-priority patent/FR2639542B1/fr
Priority claimed from FR898907731A external-priority patent/FR2648049B1/fr
Application filed by CIS Bio International SA filed Critical CIS Bio International SA
Application granted granted Critical
Publication of ES2059831T3 publication Critical patent/ES2059831T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN PRODUCTO RADIOFARMACEUTICO QUE TIENE, EN PARTICULAR, UN TROPISMO CARDIACO, QUE COMPRENDE UN COMPLEJO NITRURO DE UN METAL DE TRANSICION, Y SU PROCESO DE PREPARACION. ESTE COMPLEJO RESPONDE A LA FORMULA (M=N) L ELEVADO 1 L ELEVADO 2 (I) EN LA QUE M ES UN METAL DE TRANSICION, POR EJEMPLO TC 99M, RE 188, Y L ELEVADO 1 Y L ELEVADO 2 QUE PUEDEN SER IDENTICOS O DIFERENTES, RESPONDEN A LA FORMULA (II) EN LA QUE R ELEVADO 1 Y R (AL CUADRADO) PUEDEN SER RADICALES ALQUILO, V Y W PUEDEN SER O, S O SE , N=O O 1, M=O O 1, Y REPRESENTA N, P O AS.
ES89913235T 1988-11-25 1989-11-24 Producto radiofarmaceutico que tiene principalmente un tropismo cardiaco que comprende un complejo nitruro de un metal de transicion, y su procedimiento de preparacion. Expired - Lifetime ES2059831T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8815415A FR2639542B1 (fr) 1988-11-25 1988-11-25 Produit radiopharmaceutique a tropisme cardiaque comportant un complexe nitrido d'un metal de transition, et son procede de preparation
FR898907731A FR2648049B1 (fr) 1989-06-12 1989-06-12 Produit radiopharmaceutique a tropisme cardiaque comportant un complexe nitruro d'un metal de transition, et son procede de preparation

Publications (1)

Publication Number Publication Date
ES2059831T3 true ES2059831T3 (es) 1994-11-16

Family

ID=26227009

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89913235T Expired - Lifetime ES2059831T3 (es) 1988-11-25 1989-11-24 Producto radiofarmaceutico que tiene principalmente un tropismo cardiaco que comprende un complejo nitruro de un metal de transicion, y su procedimiento de preparacion.

Country Status (9)

Country Link
US (1) US5288476A (es)
EP (1) EP0445190B1 (es)
JP (1) JP3015970B2 (es)
AU (1) AU623204B2 (es)
CA (1) CA2003880C (es)
DE (1) DE68909245T2 (es)
ES (1) ES2059831T3 (es)
RU (1) RU2049789C1 (es)
WO (1) WO1990006137A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2664166A1 (fr) * 1990-07-04 1992-01-10 Cis Bio Int Procede de preparation de complexes nitruro de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques.
WO1992010214A1 (en) * 1990-12-12 1992-06-25 Mallinckrodt Medical, Inc. Method of radioactive labelling of blood cells and kit therefor
FR2679452B1 (fr) * 1991-07-22 1993-11-12 Cis Bio International Produit radiopharmaceutique ayant notamment un tropisme cerebral, comportant un complexe nitruro d'un metal de transition, et son procede de preparation.
FR2698272B1 (fr) * 1992-11-20 1994-12-30 Cis Bio Int Procédé de marquage cellulaire au moyen de complexes nitruro-bis (dithiocarbamato)Tc-99m et trousse pour la mise en Óoeuvre de ce procédé.
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
FR2736834B1 (fr) * 1995-07-17 1997-08-29 Cis Bio Int Produits radiopharmaceutiques a tropisme cardiaque comportant un complexe nitruro d'un metal de transition et ayant une clairance myocardique rapide
ES2315295T3 (es) * 2000-07-28 2009-04-01 Nihon Medi-Physics Co., Ltd. Radiofarmaco para obtencion de imagenes diagnosticas que contiene un heterocomplejo de nitruro de tecnecio-99m.
JP5027144B2 (ja) 2006-01-20 2012-09-19 日本メジフィジックス株式会社 放射性画像診断のための窒化テクネチウム錯体の中間体化合物
MD3995C2 (ro) * 2009-05-11 2010-07-31 Государственный Университет Молд0 Utilizare a di(µ-Ofenoxi)-di{[2-(4-aminobenzensulfamido)-5-etil-1,3,4-tiadiazol]-3,5-dibromosalicilidentiosemicarbazonato(-1)-cupru} în calitate de inhibitor al proliferării celulelor T-47D ale cancerului mamar

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5361234A (en) * 1976-11-12 1978-06-01 Matsushita Electric Ind Co Ltd Memory unit
US4247534A (en) * 1978-07-31 1981-01-27 The Procter & Gamble Company Radiographic scanning agent
JPS55160382A (en) * 1979-05-31 1980-12-13 Toshiba Corp Memory unit
JPS5786959A (en) * 1980-11-19 1982-05-31 Matsushita Electric Ind Co Ltd Data transfer control system
JPS6059461A (ja) * 1983-09-13 1985-04-05 Matsushita Electric Ind Co Ltd プログラムメモリ装置
JPS61501087A (ja) * 1983-12-29 1986-05-29 オ−ストラリア国 テクネチウム−９９ｍ−標識放射医薬の製造
US4925925A (en) * 1988-06-15 1990-05-15 University Of Cincinnati Radioactive rhenium ligated to 2-hydroxy isobutyric acid and method of use

Also Published As

Publication number Publication date
WO1990006137A1 (fr) 1990-06-14
CA2003880C (fr) 2002-01-08
CA2003880A1 (fr) 1990-05-25
RU2049789C1 (ru) 1995-12-10
DE68909245D1 (de) 1993-10-21
AU623204B2 (en) 1992-05-07
US5288476A (en) 1994-02-22
JP3015970B2 (ja) 2000-03-06
AU4639289A (en) 1990-06-26
EP0445190A1 (fr) 1991-09-11
DE68909245T2 (de) 1994-03-17
EP0445190B1 (fr) 1993-09-15
JPH04506653A (ja) 1992-11-19

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