ES2060442T3 - Procedimiento para la preparacion de pentaalquilcromenos sustituidos. - Google Patents

Procedimiento para la preparacion de pentaalquilcromenos sustituidos.

Info

Publication number
ES2060442T3
ES2060442T3 ES92119637T ES92119637T ES2060442T3 ES 2060442 T3 ES2060442 T3 ES 2060442T3 ES 92119637 T ES92119637 T ES 92119637T ES 92119637 T ES92119637 T ES 92119637T ES 2060442 T3 ES2060442 T3 ES 2060442T3
Authority
ES
Spain
Prior art keywords
preparation
substituted
pentaalkylchrones
procedure
pentaalkylchromenes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92119637T
Other languages
English (en)
Inventor
David Dr Laffan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Sankyo Co Ltd
Original Assignee
Lonza AG
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG, Sankyo Co Ltd filed Critical Lonza AG
Application granted granted Critical
Publication of ES2060442T3 publication Critical patent/ES2060442T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C07C46/08—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring with molecular oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/24—Quinones containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA OBTENCION DE PENTAALQUILCROMENOS SUBSTITUIDOS DE LA FORMULA GENERAL. EN EL SE TRANSFORMA UNA TRIALQUILOQUINONA CON UN BUTENOL HALOGENADO, EN UNA TETRAALQUILOHIDROQUINONA, ESTA OXIDA A CONTINUACION EL ATOMO DE HALOGENO, CON UN NUCLEOFILO SUSTITUIDO, Y FINALMENTE SE CICLA EN PRODUCTO FINAL. LOS PENTAALQUILOCROMENOS SON PRODUCTOS INTERMEDIOS ADECUADOS PARA LA OBTENCION DE FARMACOS REDUCTORES DE LIPIDOS.
ES92119637T 1991-11-20 1992-11-17 Procedimiento para la preparacion de pentaalquilcromenos sustituidos. Expired - Lifetime ES2060442T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH339291 1991-11-20

Publications (1)

Publication Number Publication Date
ES2060442T3 true ES2060442T3 (es) 1994-11-16

Family

ID=4254987

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92119637T Expired - Lifetime ES2060442T3 (es) 1991-11-20 1992-11-17 Procedimiento para la preparacion de pentaalquilcromenos sustituidos.

Country Status (10)

Country Link
US (2) US5364946A (es)
EP (1) EP0543346B1 (es)
JP (1) JPH0680658A (es)
KR (1) KR930010022A (es)
AT (1) ATE111095T1 (es)
CA (1) CA2082003A1 (es)
DE (1) DE59200472D1 (es)
DK (1) DK0543346T3 (es)
ES (1) ES2060442T3 (es)
TW (1) TW213457B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2947503B2 (ja) * 1994-03-02 1999-09-13 エーザイ株式会社 アリルキノン誘導体の製造方法および中間体
EP0916665A1 (de) * 1997-11-11 1999-05-19 Lonza A.G. Verfahren zur Herstellung von Chromanderivaten
EP4330242A1 (en) * 2021-04-28 2024-03-06 DSM IP Assets B.V. Ring closure of benzoquinones containing an unsaturated side chain using a base in two-phase system

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS567737A (en) * 1979-07-02 1981-01-27 Takeda Chem Ind Ltd Physiologically active quinone and its preparation
DE3010505A1 (de) * 1980-03-19 1981-10-01 Basf Ag, 6700 Ludwigshafen Chromanderivate, verfahren zu ihrer herstellung, ihre verwendung als stabilisatoren von organischen materialien sowie diese stabilisatoren enthaltende organische materialien
DE3044109A1 (de) * 1980-11-24 1982-06-24 Basf Ag, 6700 Ludwigshafen Chromanderivate sowie verfahren zu deren herstellung
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
DK173350B1 (da) * 1985-02-26 2000-08-07 Sankyo Co Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem

Also Published As

Publication number Publication date
EP0543346B1 (de) 1994-09-07
US5304663A (en) 1994-04-19
KR930010022A (ko) 1993-06-21
DE59200472D1 (de) 1994-10-13
EP0543346A1 (de) 1993-05-26
ATE111095T1 (de) 1994-09-15
JPH0680658A (ja) 1994-03-22
CA2082003A1 (en) 1993-05-21
TW213457B (es) 1993-09-21
DK0543346T3 (da) 1994-10-17
US5364946A (en) 1994-11-15

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