ES2086346T3 - Derivados de acido quinoloncarboxilico, procedimiento para su fabricacion asi como su uso como agentes antiviricos. - Google Patents

Derivados de acido quinoloncarboxilico, procedimiento para su fabricacion asi como su uso como agentes antiviricos.

Info

Publication number
ES2086346T3
ES2086346T3 ES90118898T ES90118898T ES2086346T3 ES 2086346 T3 ES2086346 T3 ES 2086346T3 ES 90118898 T ES90118898 T ES 90118898T ES 90118898 T ES90118898 T ES 90118898T ES 2086346 T3 ES2086346 T3 ES 2086346T3
Authority
ES
Spain
Prior art keywords
agents
derivatives
quinoloncarboxilico
antiviric
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90118898T
Other languages
English (en)
Inventor
Klaus Dr Grohe
Wolfgang Dr Dummer
Kai Dr Rossen
Arnold Dr Paessens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2086346T3 publication Critical patent/ES2086346T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

EL INVENTO SE REFIERE A UN NUEVO DERIVADO DE ACIDO QUINOLOCARBONICO DE FORMULA (I). TRATA DE UN PROCEDIMIENTO PARA LA PRODUCCION DE UN COMPUESTO DE FORMULA (I) Y DESCRIBE LA APLICACION COMO MEDICAMENTO POR SU ACCION ANTIVIRAL. TENIENDO A, R, R1, R (AL CUADRADO) , R3 Y R5 UN SIGNIFICADO DESCRITO EN LA PATENTE.
ES90118898T 1989-10-12 1990-10-03 Derivados de acido quinoloncarboxilico, procedimiento para su fabricacion asi como su uso como agentes antiviricos. Expired - Lifetime ES2086346T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3934082A DE3934082A1 (de) 1989-10-12 1989-10-12 Chinoloncarbonsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung als antivirale mittel

Publications (1)

Publication Number Publication Date
ES2086346T3 true ES2086346T3 (es) 1996-07-01

Family

ID=6391329

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90118898T Expired - Lifetime ES2086346T3 (es) 1989-10-12 1990-10-03 Derivados de acido quinoloncarboxilico, procedimiento para su fabricacion asi como su uso como agentes antiviricos.

Country Status (9)

Country Link
US (2) US5217972A (es)
EP (1) EP0422485B1 (es)
JP (1) JPH03133960A (es)
AT (1) ATE136298T1 (es)
CA (1) CA2027204A1 (es)
DE (2) DE3934082A1 (es)
DK (1) DK0422485T3 (es)
ES (1) ES2086346T3 (es)
GR (1) GR3019796T3 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05117150A (ja) * 1991-10-25 1993-05-14 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
WO1993025545A1 (en) * 1992-06-09 1993-12-23 Korea Research Institute Of Chemical Technology Novel quinoline derivatives and processes for preparing the same
DE4303657A1 (de) * 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate
DE4425660A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 7-substituierte 1-[4-(1H-1,2,4-triazol-1-yl-methyl)phenyl] substituierte Chinoloncarbonsäuren
DE4425659A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Neue N1-diverse 6-Fluor-8-difluormethoxy substituierte Chinoloncarbonsäuren
DE4425648A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Neue 6 und 6,8-substituierte 1-[4-(1H-1,2,4-triazol-l-yl-methyl)phenyl] Chinoloncarbonsäuren
DE4425650A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Substituierte Triazolylmethylphenylnaphthyridone
DE4425647A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Heterocyclyl-1-phenyl substituierte Chinoloncarbonsäuren
DE69531305T2 (de) * 1994-10-20 2004-05-13 Wakunaga Seiyaku K.K. Pyridoncarboxylat- derivate oder salze davon und antibakterielle zusammensetzungen die diese als aktiven bestandteil enthalten
KR100499366B1 (ko) * 1995-01-30 2005-09-08 와쿠나가 세이야쿠 가부시키 가이샤 신규피리돈카르복실산유도체또는그염및그물질을유효성분으로하는항균제
EP0945435B1 (en) * 1996-11-28 2003-08-13 Wakunaga Pharmaceutical Co., Ltd. Novel pyridonecarboxylic acid derivatives or salts thereof and drugs containing the same as the active ingredient
US6309662B1 (en) 1999-09-23 2001-10-30 Janet Buchanan Use of anti-inflammatory drugs for treatment of dermatological conditions
DE10005280A1 (de) * 2000-02-07 2001-08-09 Bayer Ag Partikuläre Zusammensetzung, Verfahren zu ihrer Herstellung und deren Verwendung
EP2161258A3 (en) * 2002-11-20 2010-04-07 Japan Tabacco Inc. 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
WO2005028467A1 (en) * 2003-09-15 2005-03-31 Anadys Pharmaceuticals, Inc. Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds
DE602005023717D1 (de) * 2004-03-10 2010-11-04 Usa Chinolin-4-one als inhibitoren der retroviralen integrase zur behandlung von hiv, aids und aids-related complex (arc)
WO2005113509A1 (en) * 2004-05-20 2005-12-01 Japan Tobacco Inc. Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
IN2014CN00532A (es) * 2006-03-06 2015-04-03 Japan Tobacco Inc
RS54047B1 (sr) 2006-03-06 2015-10-30 Japan Tobacco Inc. Postupak za dobijanje jedinjenja 4-oksohinolina
EP3183258A1 (en) * 2014-08-19 2017-06-28 Straitmark Holding AG Method for the synthesis of heterocyclic hydrogen phosphine oxide
TW201841911A (zh) 2017-03-31 2018-12-01 日商富士軟片股份有限公司 ４－吡啶酮化合物或其鹽、包含４－吡啶酮化合物之藥物組成物及劑

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
EP0154780B1 (en) * 1984-01-26 1990-04-11 Abbott Laboratories Quinoline antibacterial compounds
JPS60228479A (ja) * 1984-04-26 1985-11-13 Toyama Chem Co Ltd １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩
US4851535A (en) * 1985-01-23 1989-07-25 Toyama Chemical Co., Ltd. Nicotinic acid derivatives
AT392789B (de) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd Verfahren zur herstellung von 1-substituierten aryl-1,4-dihydro-4-oxonaphthyridinderivaten
IE62600B1 (en) * 1987-08-04 1995-02-22 Abbott Lab Naphtyridine antianaerobic compounds
US4920120A (en) * 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents

Also Published As

Publication number Publication date
EP0422485B1 (de) 1996-04-03
EP0422485A2 (de) 1991-04-17
ATE136298T1 (de) 1996-04-15
DE3934082A1 (de) 1991-04-18
CA2027204A1 (en) 1991-04-13
DE59010254D1 (de) 1996-05-09
JPH03133960A (ja) 1991-06-07
US5217972A (en) 1993-06-08
GR3019796T3 (en) 1996-07-31
US5300643A (en) 1994-04-05
DK0422485T3 (da) 1996-08-19
EP0422485A3 (en) 1991-08-14

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