ES2061054T3 - Emulsiones multifasicas inyectables. - Google Patents

Emulsiones multifasicas inyectables.

Info

Publication number
ES2061054T3
ES2061054T3 ES90910772T ES90910772T ES2061054T3 ES 2061054 T3 ES2061054 T3 ES 2061054T3 ES 90910772 T ES90910772 T ES 90910772T ES 90910772 T ES90910772 T ES 90910772T ES 2061054 T3 ES2061054 T3 ES 2061054T3
Authority
ES
Spain
Prior art keywords
pct
formula
sec
active substances
representing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90910772T
Other languages
English (en)
Inventor
Bernard Brancq
Gerard Trouve
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
Original Assignee
Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA filed Critical Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
Application granted granted Critical
Publication of ES2061054T3 publication Critical patent/ES2061054T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Colloid Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A EMULSIONES INYECTABLES MULTIFASICAS DE TIPO E/H/E UTILIZABLES COMO VACUNAS, O VEHICULOS DE PRINCIPIOS ACTIVOS EN MEDICINA VETERINARIA O HUMANA, FARMACEUTICAMENTE ACEPTABLES PARA CADA UNO DE SUS COMPONENTES, ESTABLES AL MENOS DURANTE 12 MESES EN ALMACENAMIENTO A 4 C, DE VISCOSIDAD INFERIOR A 300 MLAS Y QUE COMPRENDE AL MENOS LOS SIGUIENTES COMPONENTES: UN ADYACENTE ACEITOSO COMPUESTO DE: UNA FASE ACEITOSA INMUSCIBLE EN AGUA QUE REPRESENTA 20 A 70% DE LA FORMULA, UN SISTEMA EMULGENTE ELEGIDO DE TAL MANERA QUE EL PUNTO DE INVERSION OBTENIDO ESTA COMPRENDIDO ENTRE 25 Y 45 Y QUE REPRESENTA DE 2 A 10% DE LA FORMULA, UNA FASE ACUOSA QUE CONTIENE LOS ANTIGENOS O LOS PRINCIPIOS ACTIVOS Y QUE REPRESENTA DE 20 A 78% DE LA FORMULA Y QUE SE OBTIENE EN UNA SOLA OPERACION DE MEZCLA.
ES90910772T 1989-07-03 1990-06-29 Emulsiones multifasicas inyectables. Expired - Lifetime ES2061054T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8908917A FR2649012B1 (fr) 1989-07-03 1989-07-03 Emulsions multiphasiques injectables

Publications (1)

Publication Number Publication Date
ES2061054T3 true ES2061054T3 (es) 1994-12-01

Family

ID=9383409

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90910772T Expired - Lifetime ES2061054T3 (es) 1989-07-03 1990-06-29 Emulsiones multifasicas inyectables.

Country Status (12)

Country Link
US (1) US5424067A (es)
EP (1) EP0480981B1 (es)
JP (1) JP2851422B2 (es)
AT (1) ATE96037T1 (es)
AU (1) AU643690B2 (es)
BR (1) BR9007501A (es)
DE (1) DE69004094T2 (es)
DK (1) DK0480981T3 (es)
ES (1) ES2061054T3 (es)
FR (1) FR2649012B1 (es)
NZ (1) NZ234336A (es)
WO (1) WO1991000106A1 (es)

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FR2681246B1 (fr) * 1991-04-05 1995-02-10 Oreal Composition cosmetique sous forme d'emulsion triple.
CA2083553A1 (en) * 1991-11-25 1993-05-26 Kuniharu Seki Immunogen composition
FR2702373B1 (fr) * 1993-03-08 1996-06-07 Rhone Merieux Emulsions vaccinales fluides eau-dans-l'huile contenant une huile métabolisable.
FR2717694B1 (fr) * 1994-03-22 1996-05-03 Seppic Sa Une composition comprenant un plasmide recombinant et ses utilisations comme vaccin et médicament.
US5690942A (en) † 1995-06-02 1997-11-25 American Home Products Corporation Adjuvants for viral vaccines
ATE353225T1 (de) * 1995-11-30 2007-02-15 Chemo Sero Therapeut Res Inst Öladjuvierter impfstoff und verfahren zu seiner herstellung
GB9626865D0 (en) * 1996-12-24 1997-02-12 Cyanamid Websters Pty Limited Veterinary vaccines
AU776364B2 (en) * 1996-12-24 2004-09-09 Zoetis Services Llc Veterinary vaccines
US6524592B2 (en) 1997-10-17 2003-02-25 American Home Products Corporation Veterinary vaccines
WO1999020305A1 (en) 1997-10-17 1999-04-29 Fort Dodge Australia Pty. Limited Veterinary vaccines
AU769539B2 (en) * 1999-01-29 2004-01-29 Zoetis Services Llc Adjuvants for use in vaccines
FR2800280B1 (fr) * 1999-10-29 2003-09-19 Seppic Sa Nouvelle composition vaccinale et utilisation d'agents tensioactifs comme adjuvants d'immunite
JP2001131087A (ja) * 1999-11-05 2001-05-15 Chemo Sero Therapeut Res Inst オイルアジュバントワクチン
WO2001045670A2 (en) * 1999-12-23 2001-06-28 Aphton Corporation A stable immunogenic composition for frozen storage
FR2814956B1 (fr) * 2000-10-06 2003-01-24 Seppic Sa Nouvelle composition vaccinale, procede pour sa preparation, utilisation comme composition injectale en medecine humaine ou veterinaire et nouveau procede de conservation
SI2266603T1 (sl) 2000-10-18 2012-12-31 Glaxosmithkline Biologicals S.A. Tumorska cepiva
FR2823119B1 (fr) * 2001-04-05 2004-02-20 Seppic Sa Adjuvant d'immunite contenant un cation metallique complexe et vaccin le contenant
FR2824279B1 (fr) * 2001-05-04 2004-05-28 Seppic Sa Emulsion e/h concentree
FR2824269B1 (fr) * 2001-09-03 2012-03-02 Seppic Sa Composition adjuvante constituee de 1% a 15% de tensioactifs a hlb global compris entre 5 et 8 et de 85% a 99% de corps gras
US20050158329A1 (en) * 2004-01-21 2005-07-21 Ghosh Swapan K. Novel phytol derived immunoadjuvants and their use in vaccine formulations
GB0409940D0 (en) * 2004-05-04 2004-06-09 Glaxosmithkline Biolog Sa Vaccine
KR101515078B1 (ko) 2005-12-22 2015-04-24 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
EP2476433A1 (en) 2006-03-30 2012-07-18 GlaxoSmithKline Biologicals S.A. Immunogenic composition
US20070292521A1 (en) * 2006-06-20 2007-12-20 Schwitzer Co., Ltd Oral Encapsulated Preparation for Aquatic Animals
PL2068918T5 (pl) 2006-09-26 2024-12-02 Access To Advanced Health Institute Kompozycja szczepionki zawierająca syntetyczny adiuwant
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
CA2690708A1 (en) 2007-06-26 2008-12-31 Glaxosmithkline Biologicals S.A. Vaccine
TWI551295B (zh) 2008-04-18 2016-10-01 英特威特國際股份有限公司 防備胞內勞森菌（Ｌａｗｓｏｎｉａ ｉｎｔｒａｃｅｌｌｕｌａｒｉｓ）用疫苗
CA2764374C (en) 2009-06-05 2019-11-19 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
GB0913680D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
EP2353609A1 (en) 2010-02-04 2011-08-10 Sanofi Pasteur Immunization compositions and methods
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
EA027236B1 (ru) 2011-04-08 2017-07-31 Иммьюн Дизайн Корп. Иммуногенные композиции и способы применения таких композиций для индукции гуморального и клеточного иммунного ответа
WO2013083753A2 (en) 2011-12-07 2013-06-13 Institut Pasteur Identification of a swine parecho-like virus and applications
ES2729967T3 (es) 2012-02-07 2019-11-07 Infectious Disease Res Inst Formulaciones de adyuvante mejoradas que comprenden agonistas de TLR4 y métodos para usar las mismas
HRP20181102T1 (hr) 2012-05-16 2018-09-07 Immune Design Corp Cjepiva za hsv-2
SG10201912291YA (en) 2012-07-24 2020-02-27 Sanofi Pasteur Vaccine compositions
AU2013295016A1 (en) 2012-07-24 2015-01-29 Sanofi Pasteur Vaccine compositions for prevention against dengue virus infection
BR112015012515B1 (pt) 2012-11-30 2023-04-11 Sanofi Pasteur Uso de antígenos, construções de ácido nucleico ou vetores virais capazes de expressar uma partícula do tipo vírus (vlp) da dengue e de uma vacina contra sarampo, uma vacina contra caxumba e uma vacina contra rubéola
MX370573B (es) 2013-04-18 2019-12-17 Immune Design Corp Monoterapia con glucopiranosil lipido a para usarse en el tratamiento del cancer.
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
IL310015B2 (en) 2013-12-31 2026-02-01 Access To Advanced Health Inst Single vial formulation
WO2015112485A1 (en) 2014-01-21 2015-07-30 Immune Design Corp. Compositions for use in the treatment of allergic conditions
US20150359880A1 (en) * 2014-06-16 2015-12-17 Biomune Company Dual adjuvant vaccine compositions, preparation and uses
AR102547A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso
AU2015252119A1 (en) 2014-11-07 2016-05-26 Takeda Vaccines, Inc. Hand, foot, and mouth vaccines and methods of manufacture and use thereof
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
CN106267184B (zh) * 2016-03-03 2020-01-21 彭建彪 一种水包油包水型乳化剂及其用途和使用方法
AU2018283973B2 (en) 2017-06-11 2025-04-24 Molecular Express, Inc. Methods and compositions for substance use disorder vaccine formulations and uses thereof
KR20200117981A (ko) 2017-11-03 2020-10-14 다케다 백신즈 인코포레이티드 지카 백신 및 면역원성 조성물, 그리고 이를 이용하는 방법들
CA3141577A1 (en) 2019-05-25 2020-12-03 Infectious Disease Research Institute Composition and method for spray drying an adjuvant vaccine emulsion
CN115089702B (zh) * 2022-07-05 2026-02-13 天康制药股份有限公司 W/o/w转相疫苗佐剂、制备方法及应用

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* Cited by examiner, † Cited by third party
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FR1408437A (fr) * 1963-10-14 1965-08-13 Lummus Co Procédé de récupération du potentiel calorique d'un gaz liquéfié pendant la regazéification
GB1080994A (en) * 1963-10-25 1967-08-31 Nat Res Dev Injectable emulsions containing antigens
GB1408437A (en) * 1972-10-16 1975-10-01 C Vet Ltd Vaccines
US3983228A (en) * 1973-08-28 1976-09-28 Merck & Co., Inc. Water-in-oil adjuvant composition
US4069313A (en) * 1974-11-19 1978-01-17 Merck & Co., Inc. Water-in-oil adjuvant composition
JPS60199833A (ja) * 1984-03-26 1985-10-09 Meiji Milk Prod Co Ltd 医薬品、化粧品等用ｗ／ｏ／ｗ型複合エマルジヨンの製造法
IL74289A (en) * 1985-02-10 1989-02-28 Israel State Vaccine system comprising a live-non-virulent vaccine and an adjuvant
US4803070A (en) * 1986-04-15 1989-02-07 Ribi Immunochem Research Inc. Immunological emulsion adjuvants for polysaccharide vaccines
AU614465B2 (en) * 1989-04-05 1991-08-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
JPH07501259A (ja) * 1990-06-01 1995-02-09 リサーチ　コーポレイション　テクノロジーズ，インコーポレイテッド 自己乳化型ガラス

Also Published As

Publication number Publication date
NZ234336A (en) 1992-07-28
BR9007501A (pt) 1992-06-23
EP0480981A1 (fr) 1992-04-22
JPH04507405A (ja) 1992-12-24
DK0480981T3 (da) 1993-11-29
AU5961090A (en) 1991-01-17
US5424067A (en) 1995-06-13
WO1991000106A1 (fr) 1991-01-10
AU643690B2 (en) 1993-11-25
FR2649012B1 (fr) 1991-10-25
ATE96037T1 (de) 1993-11-15
DE69004094D1 (de) 1993-11-25
EP0480981B1 (fr) 1993-10-20
DE69004094T2 (de) 1994-02-17
FR2649012A1 (fr) 1991-01-04
JP2851422B2 (ja) 1999-01-27

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