ATE353225T1 - Öladjuvierter impfstoff und verfahren zu seiner herstellung - Google Patents
Öladjuvierter impfstoff und verfahren zu seiner herstellungInfo
- Publication number
- ATE353225T1 ATE353225T1 AT96308676T AT96308676T ATE353225T1 AT E353225 T1 ATE353225 T1 AT E353225T1 AT 96308676 T AT96308676 T AT 96308676T AT 96308676 T AT96308676 T AT 96308676T AT E353225 T1 ATE353225 T1 AT E353225T1
- Authority
- AT
- Austria
- Prior art keywords
- weight
- oil
- water
- oil adjuvant
- adjuvant vaccine
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title abstract 5
- 239000002671 adjuvant Substances 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 239000008346 aqueous phase Substances 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 239000003995 emulsifying agent Substances 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 239000002736 nonionic surfactant Substances 0.000 abstract 2
- 239000012071 phase Substances 0.000 abstract 2
- 150000005846 sugar alcohols Polymers 0.000 abstract 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000016784 immunoglobulin production Effects 0.000 abstract 1
- -1 polyoxyethylene Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31196595 | 1995-11-30 | ||
| JP31196495 | 1995-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353225T1 true ATE353225T1 (de) | 2007-02-15 |
Family
ID=26566969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96308676T ATE353225T1 (de) | 1995-11-30 | 1996-11-29 | Öladjuvierter impfstoff und verfahren zu seiner herstellung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5814321A (de) |
| EP (1) | EP0781559B1 (de) |
| KR (1) | KR100512030B1 (de) |
| CN (1) | CN1196473C (de) |
| AT (1) | ATE353225T1 (de) |
| DE (1) | DE69636889T2 (de) |
| DK (1) | DK0781559T3 (de) |
| ES (1) | ES2277339T3 (de) |
| TW (1) | TW410158B (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9626865D0 (en) * | 1996-12-24 | 1997-02-12 | Cyanamid Websters Pty Limited | Veterinary vaccines |
| IS4518A (is) | 1997-07-09 | 1999-01-10 | Lyfjathroun Hf, The Icelandic Bio Pharmaceutical Group | Nýtt lyfjaform fyrir bóluefni |
| EP1023083A4 (de) * | 1997-10-17 | 2006-06-14 | Wyeth Corp | Veterinär-impfstoffe |
| US6225289B1 (en) | 1998-12-10 | 2001-05-01 | Genvec, Inc. | Methods and compositions for preserving adenoviral vectors |
| AU769539B2 (en) | 1999-01-29 | 2004-01-29 | Zoetis Services Llc | Adjuvants for use in vaccines |
| JP2001131087A (ja) * | 1999-11-05 | 2001-05-15 | Chemo Sero Therapeut Res Inst | オイルアジュバントワクチン |
| EP1104767A1 (de) | 1999-11-30 | 2001-06-06 | Stichting Dienst Landbouwkundig Onderzoek | Mono- und Disaccharidederivate die sowohl Fettsäureestern als Sulfatestern enthalten |
| DE50012404D1 (de) * | 2000-08-11 | 2006-05-11 | Lohmann Animal Health Gmbh | W/o Emulsion Adjuvanszuzammensetzungen für Impstoffen |
| DE10113284A1 (de) * | 2001-03-16 | 2002-10-02 | Heinrich Exner | Adjuvans-Emulsion und Verfahren zu deren Verwendung |
| IL142536A0 (en) * | 2001-04-11 | 2002-03-10 | Yeda Res & Dev | Carriers for therapeutic preparations for treatment of t-cell mediated diseases |
| JP2005509598A (ja) * | 2001-08-16 | 2005-04-14 | リュフヤトルン・エイチエフ,バイオファーマシューティカルズ | エクスビボで抗体を産生する方法 |
| UY27412A1 (es) * | 2002-08-12 | 2003-06-30 | Carlson Internat Inc | Un nuevo producto para el combate de garrapatas y el proceso para la prepaacinn. |
| DE10351644A1 (de) * | 2003-11-05 | 2005-06-09 | Bayer Technology Services Gmbh | Verfahren zur Herstellung von lagerstabilen multiplen Emulsionen |
| CU23476A1 (es) * | 2004-01-29 | 2009-12-17 | Ct Ingenieria Genetica Biotech | Formulación adyuvante conteniendo una emulsión oleosa con aceite de jojoba |
| FR2878746B1 (fr) | 2004-12-02 | 2007-02-23 | Vetoquinol Sa Sa | Nouvelle composition pharmaceutique utilisable dans le domaine des vaccins |
| CN1320924C (zh) * | 2005-01-07 | 2007-06-13 | 邢为藩 | 一种自乳化疫苗佐剂及其制备方法 |
| ES2507097T3 (es) * | 2005-01-19 | 2014-10-14 | Sumitomo Dainippon Pharma Co., Ltd. | Composición emulsionada para dilución y composición de vacuna contra el cáncer |
| MX2008001527A (es) * | 2005-08-02 | 2008-04-04 | Novartis Vaccines & Diagnostic | Reduccion de interferencia entre adyuvantes que contienen aceite y antigenos que contienen agentes tensioactivos. |
| CN101313216A (zh) * | 2005-09-22 | 2008-11-26 | 普洛茨股份有限公司 | 酵母突变体中产生的糖基化多肽及其使用方法 |
| US20070292521A1 (en) * | 2006-06-20 | 2007-12-20 | Schwitzer Co., Ltd | Oral Encapsulated Preparation for Aquatic Animals |
| JP5135852B2 (ja) * | 2007-03-30 | 2013-02-06 | 日油株式会社 | 可溶化用組成物 |
| US8735359B2 (en) | 2012-05-24 | 2014-05-27 | Orban Biotech Llc | Combinations of modalities for the treatment of diabetes |
| MX377570B (es) | 2012-06-27 | 2025-03-10 | Orban Biotech Llc | Proteínas de fusión ctla4 para el tratamiento de la diabetes. |
| CN103223164B (zh) * | 2013-04-15 | 2014-08-20 | 华南农业大学 | 一种水包油包水型佐剂疫苗及其制备方法 |
| GB2523399B (en) | 2014-02-25 | 2019-03-13 | Orban Tihamer | A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence |
| JP6789631B2 (ja) | 2015-12-22 | 2020-11-25 | ロレアル | Spf及びレオロジーを改善するための高内相エマルション組成物 |
| CN108578688B (zh) * | 2018-04-03 | 2022-02-11 | 武汉轻工大学 | 多重纳米乳疫苗佐剂的制备方法 |
| EP4473960A1 (de) * | 2023-06-06 | 2024-12-11 | Vaxxinova Nederland BV | Impfstoffformulierung mit einem tensid ohne esterbindung |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2313078A1 (fr) * | 1975-02-07 | 1976-12-31 | Anvar | Composition a base d'huile vegetale metabolisable et d'eau, utilisable notamment pour la constitution de preparations adjuvantes, ces preparations adjuvantes et leur procede d'obtention |
| US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
| US4933179A (en) * | 1983-08-22 | 1990-06-12 | Syntex (U.S.A.) Inc. | Feline leukemia virus antigen vaccines |
| JPS60199833A (ja) * | 1984-03-26 | 1985-10-09 | Meiji Milk Prod Co Ltd | 医薬品、化粧品等用w/o/w型複合エマルジヨンの製造法 |
| JPH0647533B2 (ja) * | 1984-08-10 | 1994-06-22 | 裕 水島 | 4−ビフエニリル酢酸系化合物含有脂肪乳剤 |
| SE8505047L (sv) * | 1985-10-25 | 1987-04-26 | Nutritional Int Res Inst | Fettemulsion |
| FR2649012B1 (fr) * | 1989-07-03 | 1991-10-25 | Seppic Sa | Emulsions multiphasiques injectables |
| FR2649013B1 (fr) | 1989-07-03 | 1991-10-25 | Seppic Sa | Vaccins et vecteurs de principes actifs fluides contenant une huile metabolisable |
| AU668509B2 (en) * | 1991-04-19 | 1996-05-09 | Affinity Biotech, Inc. | Convertible microemulsion formulations |
| JP2913229B2 (ja) * | 1991-10-21 | 1999-06-28 | 塩野義製薬株式会社 | 油性アジュバントワクチン製剤 |
| JPH0681731A (ja) * | 1992-03-31 | 1994-03-22 | Frontier Maaketeingu:Kk | 内燃機関等の燃焼用空気の改質装置 |
| JP3095537B2 (ja) * | 1992-07-27 | 2000-10-03 | 松下電工株式会社 | 汚水処理装置 |
| JPH06172216A (ja) * | 1992-12-04 | 1994-06-21 | Norin Suisanshiyou Kachiku Eisei Shikenjo | 乳液状オイルアジュバント |
| FR2702373B1 (fr) * | 1993-03-08 | 1996-06-07 | Rhone Merieux | Emulsions vaccinales fluides eau-dans-l'huile contenant une huile métabolisable. |
-
1996
- 1996-11-29 AT AT96308676T patent/ATE353225T1/de not_active IP Right Cessation
- 1996-11-29 DK DK96308676T patent/DK0781559T3/da active
- 1996-11-29 US US08/758,374 patent/US5814321A/en not_active Expired - Fee Related
- 1996-11-29 EP EP96308676A patent/EP0781559B1/de not_active Expired - Lifetime
- 1996-11-29 DE DE69636889T patent/DE69636889T2/de not_active Expired - Fee Related
- 1996-11-29 ES ES96308676T patent/ES2277339T3/es not_active Expired - Lifetime
- 1996-11-29 TW TW085114738A patent/TW410158B/zh not_active IP Right Cessation
- 1996-11-30 CN CNB961231009A patent/CN1196473C/zh not_active Expired - Fee Related
- 1996-11-30 KR KR1019960060481A patent/KR100512030B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1159914A (zh) | 1997-09-24 |
| EP0781559A2 (de) | 1997-07-02 |
| DE69636889T2 (de) | 2007-12-06 |
| KR970025624A (ko) | 1997-06-24 |
| KR100512030B1 (ko) | 2005-11-24 |
| EP0781559B1 (de) | 2007-02-07 |
| CN1196473C (zh) | 2005-04-13 |
| US5814321A (en) | 1998-09-29 |
| DE69636889D1 (de) | 2007-03-22 |
| EP0781559A3 (de) | 1998-12-16 |
| TW410158B (en) | 2000-11-01 |
| ES2277339T3 (es) | 2007-07-01 |
| DK0781559T3 (da) | 2007-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |