ES2061607T3 - Capsula de liberacion oral instantanea, con contenido de nifedipina. - Google Patents
Capsula de liberacion oral instantanea, con contenido de nifedipina.Info
- Publication number
- ES2061607T3 ES2061607T3 ES88118596T ES88118596T ES2061607T3 ES 2061607 T3 ES2061607 T3 ES 2061607T3 ES 88118596 T ES88118596 T ES 88118596T ES 88118596 T ES88118596 T ES 88118596T ES 2061607 T3 ES2061607 T3 ES 2061607T3
- Authority
- ES
- Spain
- Prior art keywords
- solution
- nifedipine
- release capsule
- instant oral
- oral release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002775 capsule Substances 0.000 title abstract 3
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001597 nifedipine Drugs 0.000 title abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 229920001515 polyalkylene glycol Polymers 0.000 abstract 1
- -1 polyoxyethylene Polymers 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
LA INVENCION CONCIERNE A UNA CAPSULA DE LIBERACION ORAL INSTANTANEA QUE CONTIENE UNA SOLUCION ACUOSA O HIDRO - ALCOHOLICA DE NIFEDIPINA QUE CONTIENE UN POLIALQUILEN GLICOL Y UN COMPONENTE DE ESTER DE POLIOXIETILENO, SIENDO LA CANTIDAD DE ESTER SUFICIENTE PARA PREVENIR LA PRECIPITACION DE NIFEDIPINA EN LA BOCA DE UN PACIENTE DESPUES DE LA LIBERACION DE LA SOLUCION DE LA CAPSULA. PREFERIBLEMENTE EL COMPONENTE ESTER ES UN ACEITE DE RICINO HIDROGENADO ETOXILADO CREMOPHOR RH40. LA SOLUCION PUEDE CONTENER UN SEGUNDO COMPONENTE GLICOL, ESPECIALMENTE GLICEROL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873738236 DE3738236A1 (de) | 1987-11-11 | 1987-11-11 | Beisskapsel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2061607T3 true ES2061607T3 (es) | 1994-12-16 |
Family
ID=6340247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88118596T Expired - Lifetime ES2061607T3 (es) | 1987-11-11 | 1988-11-09 | Capsula de liberacion oral instantanea, con contenido de nifedipina. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5200192A (es) |
| EP (1) | EP0315960B1 (es) |
| JP (1) | JPH01238528A (es) |
| AT (1) | ATE101516T1 (es) |
| AU (1) | AU616693B2 (es) |
| CA (1) | CA1312549C (es) |
| DE (2) | DE3738236A1 (es) |
| ES (1) | ES2061607T3 (es) |
| IE (1) | IE63182B1 (es) |
| ZA (1) | ZA888441B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3121080B2 (ja) * | 1991-12-19 | 2000-12-25 | アール・ピー・シーラー コーポレイション | カプセル封入用溶液 |
| IT1263840B (it) * | 1993-03-30 | 1996-09-04 | Giuseppe Furiosi | Formulazioni orali di ubidecarenone in forma di capsule |
| GB9325445D0 (en) | 1993-12-13 | 1994-02-16 | Cortecs Ltd | Pharmaceutical formulations |
| ES2234010T3 (es) * | 1996-04-12 | 2005-06-16 | Novadel Pharma Inc. | Aerosol bucal polar. |
| IT1284604B1 (it) * | 1996-09-27 | 1998-05-21 | Roberto Valducci | Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva |
| EP1952802A3 (en) | 1997-10-01 | 2009-06-17 | Novadel Pharma Inc. | Buccal, polar and non-polar spray or capsule |
| US20030077227A1 (en) | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system |
| US20030185761A1 (en) | 1997-10-01 | 2003-10-02 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing drugs for treating pain |
| US7632517B2 (en) | 1997-10-01 | 2009-12-15 | Novadel Pharma Inc. | Buccal, polar and non-polar spray containing zolpidem |
| US20040136914A1 (en) | 1997-10-01 | 2004-07-15 | Dugger Harry A. | Buccal, polar and non-polar spray containing ondansetron |
| US6168806B1 (en) | 1999-03-05 | 2001-01-02 | Fang-Yu Lee | Orally administrable nifedipine pellet and process for the preparation thereof |
| DE19922537A1 (de) * | 1999-05-10 | 2000-11-16 | Roland Bodmeier | Darreichungsform zur Applikation in Körperöffnungen |
| US20040115134A1 (en) * | 1999-06-22 | 2004-06-17 | Elan Pharma International Ltd. | Novel nifedipine compositions |
| SE9902742D0 (sv) * | 1999-07-20 | 1999-07-20 | Astra Ab | New pharmaceutical formultion |
| AU2001270891A1 (en) * | 2000-08-17 | 2002-03-04 | Machines Industrielles Etablissements | Consumable container |
| US20030003144A1 (en) * | 2001-05-01 | 2003-01-02 | Keller Brian C. | Sustained release formulations for nifedipine, dextromethorphan, and danazol |
| DE10142416A1 (de) * | 2001-08-31 | 2003-03-20 | Molecular And Clinical Drug Re | Verfahren zur Herstellung von Lösungen |
| DE10142417A1 (de) * | 2001-08-31 | 2003-03-20 | Molecular And Clinical Drug Re | Arzneimittel |
| CA2563533C (en) | 2004-04-15 | 2013-10-01 | Shmuel A. Ben-Sasson | Compositions capable of facilitating penetration across a biological barrier |
| US20070219131A1 (en) * | 2004-04-15 | 2007-09-20 | Ben-Sasson Shmuel A | Compositions capable of facilitating penetration across a biological barrier |
| US7530804B2 (en) * | 2004-12-07 | 2009-05-12 | Mcneil-Ppc, Inc. | System and process for providing at least one opening in dosage forms |
| WO2009091622A1 (en) * | 2008-01-18 | 2009-07-23 | Dow Global Technologies Inc. | Method to enhance aqueous solubility of poorly soluble actives using methoxypolyethylene glycol |
| KR101814186B1 (ko) | 2008-09-17 | 2018-03-14 | 키아스마 인코포레이티드 | 약제학적 조성물 및 연관된 투여방법 |
| BR112013031406B1 (pt) * | 2011-06-08 | 2022-02-22 | Lts Lohmann Therapie-Systeme Ag | Tira de filme oral comestível e seu método de preparação |
| WO2016126830A1 (en) | 2015-02-03 | 2016-08-11 | Chiasma Inc. | Method of treating diseases |
| US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU432703A3 (es) * | 1971-08-24 | 1974-06-15 | Фридрих Боссерт, Вульф Фатер, Курт Бауер | |
| DE2209526C3 (de) * | 1972-02-29 | 1980-02-28 | Bayer Ag, 5090 Leverkusen | Coronartherapeutlkum in Form von Gelatine-BeiBkapseln |
| DE3237814A1 (de) * | 1982-10-12 | 1984-04-12 | Warner-Lambert Co., 07950 Morris Plains, N.J. | Wasserfreie emulsionen und verwendung derselben |
| DE3307422A1 (de) * | 1983-03-03 | 1984-09-06 | Bayer Ag, 5090 Leverkusen | Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen |
| DE3437599C2 (de) * | 1984-10-13 | 1987-04-16 | Dolorgiet GmbH & Co KG, 5205 St Augustin | Ibuprofen enthaltende Weichgelatinekapseln |
| US4689233A (en) * | 1986-01-06 | 1987-08-25 | Siegfried Aktiengesellschaft | Coronary therapeutic agent in the form of soft gelatin capsules |
| SE8601624D0 (sv) * | 1986-04-11 | 1986-04-11 | Haessle Ab | New pharmaceutical preparations |
| GB8629761D0 (en) * | 1986-12-12 | 1987-01-21 | Harris Pharma Ltd | Capsules |
| EP0272336B1 (de) * | 1986-12-18 | 1991-10-23 | Kurt H. Prof. Dr. Bauer | Gegenüber Lichteinfluss stabilisiertes Nifedipin-Konzentrat und Verfahren zu seiner Herstellung |
-
1987
- 1987-11-11 DE DE19873738236 patent/DE3738236A1/de not_active Withdrawn
-
1988
- 1988-11-09 EP EP88118596A patent/EP0315960B1/en not_active Revoked
- 1988-11-09 ES ES88118596T patent/ES2061607T3/es not_active Expired - Lifetime
- 1988-11-09 DE DE3887826T patent/DE3887826T2/de not_active Revoked
- 1988-11-09 AT AT88118596T patent/ATE101516T1/de not_active IP Right Cessation
- 1988-11-10 AU AU24993/88A patent/AU616693B2/en not_active Ceased
- 1988-11-10 IE IE337888A patent/IE63182B1/en not_active IP Right Cessation
- 1988-11-11 ZA ZA888441A patent/ZA888441B/xx unknown
- 1988-11-11 JP JP63286611A patent/JPH01238528A/ja active Pending
- 1988-11-14 CA CA000583042A patent/CA1312549C/en not_active Expired - Fee Related
- 1988-11-14 US US07/270,957 patent/US5200192A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01238528A (ja) | 1989-09-22 |
| AU616693B2 (en) | 1991-11-07 |
| AU2499388A (en) | 1989-05-11 |
| US5200192A (en) | 1993-04-06 |
| IE63182B1 (en) | 1995-03-22 |
| CA1312549C (en) | 1993-01-12 |
| ZA888441B (en) | 1989-08-30 |
| DE3738236A1 (de) | 1989-05-24 |
| EP0315960B1 (en) | 1994-02-16 |
| EP0315960A1 (en) | 1989-05-17 |
| IE883378L (en) | 1989-05-11 |
| ATE101516T1 (de) | 1994-03-15 |
| DE3887826T2 (de) | 1994-09-22 |
| DE3887826D1 (de) | 1994-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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