ES2061933T3 - Compuestos espirociclicos que incorporan anillos de cinco miembros con dos heteroatomos. - Google Patents

Compuestos espirociclicos que incorporan anillos de cinco miembros con dos heteroatomos.

Info

Publication number
ES2061933T3
ES2061933T3 ES89200862T ES89200862T ES2061933T3 ES 2061933 T3 ES2061933 T3 ES 2061933T3 ES 89200862 T ES89200862 T ES 89200862T ES 89200862 T ES89200862 T ES 89200862T ES 2061933 T3 ES2061933 T3 ES 2061933T3
Authority
ES
Spain
Prior art keywords
alkyl
nause
exp8
exp6
alquilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89200862T
Other languages
English (en)
Inventor
Raymond Baker
Clare O Kneen
John Saunders
Christopher Swain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Application granted granted Critical
Publication of ES2061933T3 publication Critical patent/ES2061933T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Luminescent Compositions (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA UN COMPUESTO DE FORMULA I O UNA SAL O PROFARMACO SUYO, EN EL QUE LA LINEA DISCONTINUA REPRESENTA UN ENLACE QUIMICO OPCIONAL EN UNA DE LAS DOS POSICIONES POSIBLES; A REPRESENTA UN GRUPO DE FORMULA II (EN EL QUE R EXP1 REPRESENTA H, OH, ALQUILO, ALQUENILO, ALQUINILO, ALCOXI, E HIDROXI - ALQUILO DE HASTA 6C, BENCILOXI, HALOGENO, AMINO, CIANO, NITRO, - CONR EXP6 R EXP7 (EN EL QUE R EXP6 Y R EXP7 SON INDEPENDIENTEMENTE H, ALQUILO, ALQUENILO O ALQUINILO DE HASTA 6C); R (AL CUADRADO) REPRESENTA H, HALOGENO, ALQUILO, ALCOXI O ALQUILCARBONILO DE HASTA 6C; V REPRESENTA N, - CH O - C -; Y W REPRESENTA O, S O - NR EXP8, SIENDO R EXP8 UN ATOMO DE H, O ALQUILO, ALQUENILO O ALQUINILO DE HASTA 6C); DE X, Y Y Z DOS SON IGUALES O DIFERENTES Y REPRESENTAN O, S, O N Y EL RESTANTE ES C, O Y ES CARBONILO (C = O); Y Q ES EL RESTO DE UN SISTEMA AZACICLICO O AZALICICLICO. LOS CITADOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ALTERACIONES PSICOTICAS (POR EJEMPLO ESQUIZOFRENIA YMANIA), ANSIEDAD, ABSTINENCIA O DEPENDENCIA DE DROGAS O ALCOHOL, DOLOR, ESTASIS GASTRICO, DISFUNCION GASTRICA, MIGRAÑA, NAUSEAS, VOMITOS, ALTERACIONES DEL MOVIMIENTO Y DEMENCIA SENIL Y PRESENIL.
ES89200862T 1988-04-11 1989-04-06 Compuestos espirociclicos que incorporan anillos de cinco miembros con dos heteroatomos. Expired - Lifetime ES2061933T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888808433A GB8808433D0 (en) 1988-04-11 1988-04-11 Therapeutic agents

Publications (1)

Publication Number Publication Date
ES2061933T3 true ES2061933T3 (es) 1994-12-16

Family

ID=10634939

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89200862T Expired - Lifetime ES2061933T3 (es) 1988-04-11 1989-04-06 Compuestos espirociclicos que incorporan anillos de cinco miembros con dos heteroatomos.

Country Status (17)

Country Link
US (1) US4940703A (es)
EP (1) EP0337547B1 (es)
JP (1) JPH01305092A (es)
KR (1) KR900016202A (es)
AT (1) ATE102205T1 (es)
AU (1) AU617785B2 (es)
DE (1) DE68913327T2 (es)
DK (1) DK170489A (es)
ES (1) ES2061933T3 (es)
FI (1) FI891584A7 (es)
GB (1) GB8808433D0 (es)
IE (1) IE891137L (es)
IL (1) IL89822A0 (es)
NO (1) NO891471L (es)
NZ (1) NZ228583A (es)
PT (1) PT90223B (es)
ZA (1) ZA892587B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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US5053412A (en) * 1990-04-10 1991-10-01 Israel Institute For Biological Research Spiro nitrogen-bridged heterocyclic compounds
EP0445974A3 (en) * 1990-03-05 1992-04-29 Merck Sharp & Dohme Ltd. Spirocyclic antipsychotic agents
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
IL97726A (en) * 1990-04-10 1994-12-29 Israel Inst Biolog Res Pharmaceutical compositions containing compounds with bridged and unbridged heterocyclic groups, spiro-connected with oxazoline and thiazoline groups, and some new such compounds
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
US6060473A (en) * 1993-04-01 2000-05-09 Ucb S.A. - Dtb 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
AU701227B2 (en) 1993-09-10 1999-01-21 Cytomed, Inc Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
ATE192157T1 (de) * 1994-08-24 2000-05-15 Astra Ab Therapeutisch verwendbare spiro-azabicyclische verbindungen
HUP9900606A2 (hu) * 1995-09-18 2000-03-28 Glaxo Group Limited 5-HT3 Receptor antagonisták mozgászavar kezelésére
US7863291B2 (en) * 2008-04-23 2011-01-04 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
US8309577B2 (en) 2008-04-23 2012-11-13 Bristol-Myers Squibb Company Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands
US9034891B2 (en) 2009-01-26 2015-05-19 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
KR20150116466A (ko) 2009-01-26 2015-10-15 이스라엘 인스티튜트 포 바이올로지컬 리서치 이환형 헤테로사이클릭 스피로 화합물
ES2432618T3 (es) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
DK2432467T3 (en) 2009-05-20 2018-04-16 Inst Nat Sante Rech Med SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS FOR USE IN TREATMENT OF VESTIBULAR DAMAGE LESSONS
US8278320B2 (en) 2009-10-28 2012-10-02 Bristol-Myers Squibb Company Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands
WO2011056573A1 (en) 2009-10-28 2011-05-12 Bristol-Myers Squibb Company Azabicyclic compounds as alpha-7 nicotinic acetylcholine receptor ligands
CN102791718B (zh) * 2009-10-29 2015-11-25 百时美施贵宝公司 作为α-7烟碱乙酰胆碱受体配体的奎宁环化合物
CN103025744A (zh) 2010-04-30 2013-04-03 百时美施贵宝公司 作为α-7烟碱乙酰胆碱受体配体前药的氮杂二环胺N-氧化物化合物
JP5714745B2 (ja) * 2014-04-28 2015-05-07 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ α７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物
WO2020180876A1 (en) * 2019-03-04 2020-09-10 Beth Israel Deaconess Medical Center, Inc. Orai channel inhibitors
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
KR20230152654A (ko) 2020-12-30 2023-11-03 타이라 바이오사이언시스, 인크. 키나아제 억제제로서의 인다졸 화합물

Family Cites Families (19)

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Publication number Priority date Publication date Assignee Title
US3646053A (en) * 1970-05-18 1972-02-29 American Cyanamid Co Certain-(2-amino-4-thiazolyl)indoles
JPS4917534B1 (es) * 1970-10-06 1974-05-01
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US4029655A (en) * 1975-04-11 1977-06-14 Eli Lilly And Company Method of preparing stable sterile crystalline cephalosporins for parenteral administration
IL48452A (en) * 1975-11-11 1979-07-25 Purdue Frederick Co Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them
AT357555B (de) * 1975-11-11 1980-07-25 Mundipharma Ag Verfahren zum herstellen von neuen spiro-(1,3- dioxolan-4,3')chinuclidinen, ihren salzen und isomeren
US4342769A (en) * 1978-10-02 1982-08-03 Schering Corporation 2-[(Methylsulfinyl)acetyl]-3-heterocyclicindoles and derivatives thereof as immunosuppressants
US4203990A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
DE3164982D1 (de) * 1980-04-10 1984-08-30 Sandoz Ag Isoxazolyl indolamines
US4332804A (en) * 1981-03-23 1982-06-01 Syntex (U.S.A.) Inc. 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones
DE3218172A1 (de) * 1982-05-14 1983-11-17 Hoechst Ag, 6230 Frankfurt Polyalkyldiazaspirodecanderivate, verfahren zu ihrer herstellung und ihre verwendung als stabilisatoren
DE3504286A1 (de) * 1985-02-08 1986-08-14 Sandoz-Patent-GmbH, 7850 Lörrach Spiro-oxothiolane, ihre herstellung und verwendung
DE3504284A1 (de) * 1985-02-08 1986-08-14 Sandoz-Patent-GmbH, 7850 Lörrach Spiro-dithiolane, ihre herstellung und verwendung
DE3501225A1 (de) * 1985-01-16 1986-07-24 Sandoz-Patent-GmbH, 7850 Lörrach Spirodioxolane, ihre herstellung und verwendung
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
ES2061502T3 (es) * 1986-06-27 1994-12-16 Beecham Group Plc Nuevos n-heterociclos biciclicos puenteados.
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
US4707484A (en) * 1986-11-25 1987-11-17 Hoffmann-La Roche Inc. Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
DE68913327T2 (de) 1994-07-28
DK170489D0 (da) 1989-04-10
AU617785B2 (en) 1991-12-05
DE68913327D1 (de) 1994-04-07
NO891471D0 (no) 1989-04-10
JPH01305092A (ja) 1989-12-08
GB8808433D0 (en) 1988-05-11
IL89822A0 (en) 1989-12-15
FI891584A0 (fi) 1989-04-03
EP0337547A1 (en) 1989-10-18
US4940703A (en) 1990-07-10
PT90223A (pt) 1989-11-10
EP0337547B1 (en) 1994-03-02
NO891471L (no) 1989-10-12
KR900016202A (ko) 1990-11-12
IE891137L (en) 1989-10-11
NZ228583A (en) 1990-02-26
FI891584A7 (fi) 1989-10-12
ZA892587B (en) 1990-03-28
AU3263289A (en) 1989-10-12
DK170489A (da) 1989-10-12
ATE102205T1 (de) 1994-03-15
PT90223B (pt) 1994-07-29

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