NO891471L - Fremgangsmaate for fremstilling av spirocykliske forbindelser innbefattende fem-leddede ringer med to heteroatomer. - Google Patents

Fremgangsmaate for fremstilling av spirocykliske forbindelser innbefattende fem-leddede ringer med to heteroatomer.

Info

Publication number
NO891471L
NO891471L NO89891471A NO891471A NO891471L NO 891471 L NO891471 L NO 891471L NO 89891471 A NO89891471 A NO 89891471A NO 891471 A NO891471 A NO 891471A NO 891471 L NO891471 L NO 891471L
Authority
NO
Norway
Prior art keywords
preparation
represents hydrogen
alkyl
heteratomes
procedure
Prior art date
Application number
NO89891471A
Other languages
English (en)
Other versions
NO891471D0 (no
Inventor
Raymond Baker
Clare O Kneen
John Saunders
Christoper Swain
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of NO891471D0 publication Critical patent/NO891471D0/no
Publication of NO891471L publication Critical patent/NO891471L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Addiction (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Luminescent Compositions (AREA)

Abstract

Mye forbindelser av formel I. eller salter eller prolegenidler derav:. hvori den stiplede linje betegner en eventuelt kjemisk binding i en,av to muligs stillinger; A betegner en gruppe av forael II:hvori Rbetegner hydrogen, hydroxy, Cj^g-aikyl, C2_6-alkenyl, C_-alkynyl, Cg-aikoxy, benzyloxy, hydroxy(Cg)-alkyl, halogen, amino, cyano, nitro, -COeller -S6, hvori Rogbetegner hydrogen, Cg-alkyl, C2.g-alkenxl eller C_-alkynyl;betegner hydrogen, halogen, Cg-alkyl, Cg-alkoxy eller C.g-alkylcarbonyl;. V betegner nitrogen, -CH eller -C-; og W betegner oxygen, svovel eller -NR, hvori Rbetegner hydrogen, Cg-alkyl, C_g-alkenyl eller C_g-alkynyl; to av X, Y og Z er oxygen, svovel eller nitrogen, og den gjenværende er car-bon, eller Y er (C=0), og Q er resten av et azacyklisk eller azabicyklisk ringsystem, utvisar terapeutisk aktivitet. Fremstilling av forbind-elsene er beskrevet.
NO89891471A 1988-04-11 1989-04-10 Fremgangsmaate for fremstilling av spirocykliske forbindelser innbefattende fem-leddede ringer med to heteroatomer. NO891471L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888808433A GB8808433D0 (en) 1988-04-11 1988-04-11 Therapeutic agents

Publications (2)

Publication Number Publication Date
NO891471D0 NO891471D0 (no) 1989-04-10
NO891471L true NO891471L (no) 1989-10-12

Family

ID=10634939

Family Applications (1)

Application Number Title Priority Date Filing Date
NO89891471A NO891471L (no) 1988-04-11 1989-04-10 Fremgangsmaate for fremstilling av spirocykliske forbindelser innbefattende fem-leddede ringer med to heteroatomer.

Country Status (17)

Country Link
US (1) US4940703A (no)
EP (1) EP0337547B1 (no)
JP (1) JPH01305092A (no)
KR (1) KR900016202A (no)
AT (1) ATE102205T1 (no)
AU (1) AU617785B2 (no)
DE (1) DE68913327T2 (no)
DK (1) DK170489A (no)
ES (1) ES2061933T3 (no)
FI (1) FI891584A7 (no)
GB (1) GB8808433D0 (no)
IE (1) IE891137L (no)
IL (1) IL89822A0 (no)
NO (1) NO891471L (no)
NZ (1) NZ228583A (no)
PT (1) PT90223B (no)
ZA (1) ZA892587B (no)

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US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
IL97726A (en) * 1990-04-10 1994-12-29 Israel Inst Biolog Res Pharmaceutical compositions containing compounds with bridged and unbridged heterocyclic groups, spiro-connected with oxazoline and thiazoline groups, and some new such compounds
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
US6060473A (en) * 1993-04-01 2000-05-09 Ucb S.A. - Dtb 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
AU701227B2 (en) 1993-09-10 1999-01-21 Cytomed, Inc Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
ATE192157T1 (de) * 1994-08-24 2000-05-15 Astra Ab Therapeutisch verwendbare spiro-azabicyclische verbindungen
HUP9900606A2 (hu) * 1995-09-18 2000-03-28 Glaxo Group Limited 5-HT3 Receptor antagonisták mozgászavar kezelésére
US7863291B2 (en) * 2008-04-23 2011-01-04 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
US8309577B2 (en) 2008-04-23 2012-11-13 Bristol-Myers Squibb Company Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands
US9034891B2 (en) 2009-01-26 2015-05-19 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
KR20150116466A (ko) 2009-01-26 2015-10-15 이스라엘 인스티튜트 포 바이올로지컬 리서치 이환형 헤테로사이클릭 스피로 화합물
ES2432618T3 (es) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
DK2432467T3 (en) 2009-05-20 2018-04-16 Inst Nat Sante Rech Med SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS FOR USE IN TREATMENT OF VESTIBULAR DAMAGE LESSONS
US8278320B2 (en) 2009-10-28 2012-10-02 Bristol-Myers Squibb Company Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands
WO2011056573A1 (en) 2009-10-28 2011-05-12 Bristol-Myers Squibb Company Azabicyclic compounds as alpha-7 nicotinic acetylcholine receptor ligands
CN102791718B (zh) * 2009-10-29 2015-11-25 百时美施贵宝公司 作为α-7烟碱乙酰胆碱受体配体的奎宁环化合物
CN103025744A (zh) 2010-04-30 2013-04-03 百时美施贵宝公司 作为α-7烟碱乙酰胆碱受体配体前药的氮杂二环胺N-氧化物化合物
JP5714745B2 (ja) * 2014-04-28 2015-05-07 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ α７ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物
WO2020180876A1 (en) * 2019-03-04 2020-09-10 Beth Israel Deaconess Medical Center, Inc. Orai channel inhibitors
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds
KR20230152654A (ko) 2020-12-30 2023-11-03 타이라 바이오사이언시스, 인크. 키나아제 억제제로서의 인다졸 화합물

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Also Published As

Publication number Publication date
DE68913327T2 (de) 1994-07-28
DK170489D0 (da) 1989-04-10
AU617785B2 (en) 1991-12-05
DE68913327D1 (de) 1994-04-07
NO891471D0 (no) 1989-04-10
ES2061933T3 (es) 1994-12-16
JPH01305092A (ja) 1989-12-08
GB8808433D0 (en) 1988-05-11
IL89822A0 (en) 1989-12-15
FI891584A0 (fi) 1989-04-03
EP0337547A1 (en) 1989-10-18
US4940703A (en) 1990-07-10
PT90223A (pt) 1989-11-10
EP0337547B1 (en) 1994-03-02
KR900016202A (ko) 1990-11-12
IE891137L (en) 1989-10-11
NZ228583A (en) 1990-02-26
FI891584A7 (fi) 1989-10-12
ZA892587B (en) 1990-03-28
AU3263289A (en) 1989-10-12
DK170489A (da) 1989-10-12
ATE102205T1 (de) 1994-03-15
PT90223B (pt) 1994-07-29

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