ES2062010T3 - Proceso para la cloracion de azucares. - Google Patents

Proceso para la cloracion de azucares.

Info

Publication number
ES2062010T3
ES2062010T3 ES89307933T ES89307933T ES2062010T3 ES 2062010 T3 ES2062010 T3 ES 2062010T3 ES 89307933 T ES89307933 T ES 89307933T ES 89307933 T ES89307933 T ES 89307933T ES 2062010 T3 ES2062010 T3 ES 2062010T3
Authority
ES
Spain
Prior art keywords
sugar
reaction
protected
persulphite
thionyl chloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89307933T
Other languages
English (en)
Inventor
Nigel John Homer
Graham Jackson
George Henry Sankey
Philip John Simpson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tate and Lyle PLC
Original Assignee
Tate and Lyle PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tate and Lyle PLC filed Critical Tate and Lyle PLC
Application granted granted Critical
Publication of ES2062010T3 publication Critical patent/ES2062010T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Glass Compositions (AREA)

Abstract

LOS AZUCARES Y DERIVADOS DE AZUCARES PARCIALMENTE PROTEGIDOS SE CLORAN POR REACCION DE GRUPOS HIDROXILO SIN PROTEGER CON CLORURO DE TIONILO PARA FORMAR UN PERSULFITO, SEGUIDA DE DESCOMPOSICION DEL GRUPO SULFITO PARA FORMAR CLOROSULFITOS, DESPLAZAMIENTO DE LOS GRUPOS CLOROSULFITO E INSERCION DE LOS ATOMOS DE CLORO EN UNA O MAS POSICIONES, CARACTERIZADA PORQUE LA FORMACION Y DESPLAZAMIENTO DE LOS GRUPOS CLOROSULFITO Y LA INSERCION DE LOS ATOMOS DE CLORO SE EFECTUA POR REACCION CON CLORURO DE TIONILO EN UN DISOLVENTE INERTE EN PRESENCIA DE UNA SAL CUATERNARIA DE FORMLA GENERAL (I), EN DONDE R1, R2 Y R3, QUE PUEDEN SER EL MISMO O DIFERENTES, SON UN GRUPO ALQUILO INFERIOR, Y R4 ES UN GRUPO HIDROCARBONADO CON 7 ATOMOS DE CARBONO POR LO MENOS, Y CUANDO EL AZUCAR O DERIVADO DE AZUCAR PARCIALMENTE PROTEGIDO TIENE MAS QUE 3 GRUPOS HIDROXI NO PROTEGIDOS, EL PROCESO CONSTA DE LAS SIGUIENTES ETAPAS: (A) REACCION DEL AZUCAR O DERIVADO DE AZUCAR PARCIALMENTE PROTEGIDO CON CLORURO DE TIONILO EN PRESENCIADE PIRIDINA PARA FORMAR UN PERSULFITO; (B) SEPARACION DEL PERSULFITO PARA ELIMINAR PIRIDINA LIBRE; Y (C) REACCION DEL POLISULFITO SEPARADO CON CLORURO DE TIONILO EN UN DISOLVENTE O MEDIO DE SUSPENSION INERTE, EN PRESENCIA DE UNA SAL CUATERNARIA DE FORMULA GENERAL (I).
ES89307933T 1988-08-03 1989-08-03 Proceso para la cloracion de azucares. Expired - Lifetime ES2062010T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888818430A GB8818430D0 (en) 1988-08-03 1988-08-03 Process

Publications (1)

Publication Number Publication Date
ES2062010T3 true ES2062010T3 (es) 1994-12-16

Family

ID=10641538

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89307933T Expired - Lifetime ES2062010T3 (es) 1988-08-03 1989-08-03 Proceso para la cloracion de azucares.

Country Status (13)

Country Link
US (1) US4977254A (es)
EP (1) EP0354050B1 (es)
JP (1) JP3055910B2 (es)
KR (1) KR0137951B1 (es)
AT (1) ATE99317T1 (es)
CA (1) CA1316532C (es)
DE (1) DE68911788T2 (es)
DK (1) DK170805B1 (es)
ES (1) ES2062010T3 (es)
GB (2) GB8818430D0 (es)
IE (1) IE61917B1 (es)
PT (1) PT91357B (es)
RU (1) RU1836375C (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0373118A3 (de) * 1988-12-07 1991-10-16 Ciba-Geigy Ag Verfahren zur Herstellung von geschützten Mono- und Oligozuckerhalogeniden
US5136031A (en) * 1990-07-09 1992-08-04 Tate & Lyle Public Limited Company Chlorination of sugars
DE4227752A1 (de) * 1992-08-21 1994-02-24 Basf Ag Verfahren zur Herstellung von Alkylglykosiden
US6555677B2 (en) * 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole
CA2429228C (en) 2000-11-17 2008-08-26 Mcneil-Ppc, Inc. Improved sucralose composition and process for the crystallization thereof
US6943248B2 (en) * 2003-04-30 2005-09-13 Tate & Lyle Public Limited Company Crystalline form of sucralose, and method for producing it
US20050214425A1 (en) * 2004-03-23 2005-09-29 Roma Vazirani Sugar substitute prepared with nutritive and high-intensity sweeteners
GB2417555A (en) * 2004-07-28 2006-03-01 John Charles Fry Sucralose analysis
US20060247180A1 (en) * 2005-04-29 2006-11-02 Bergey James L Purgative composition and uses thereof
CN101253187A (zh) * 2005-08-30 2008-08-27 法马德医疗保险私人有限公司 含有蔗糖酯的反应物中吡啶及其类似物的除去方法
US7741477B2 (en) * 2006-01-10 2010-06-22 Alembic Limited Process for purification of sucralose
CN1814609B (zh) * 2006-03-06 2010-11-10 盐城捷康三氯蔗糖制造有限公司 一种提高三氯蔗糖合成收率的方法
WO2008004246A1 (en) * 2006-07-06 2008-01-10 Alembic Limited An improved process for the preparation of sucralose of high purity
US20080103295A1 (en) * 2006-10-25 2008-05-01 David Losan Ho Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst
US8258291B2 (en) * 2006-10-25 2012-09-04 Mamtek International Limited Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC)
CN101626997B (zh) * 2006-12-05 2013-01-09 塔特和莱利技术有限公司 三苯甲基氯的回收
CN100591684C (zh) * 2006-12-27 2010-02-24 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖结晶方法
KR20080073879A (ko) * 2007-02-07 2008-08-12 주식회사 일신케미칼 수크랄로오스의 제조방법
CN101260126B (zh) * 2007-03-06 2010-12-22 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖的结晶方法
US20080300401A1 (en) * 2007-06-04 2008-12-04 Polymed Therapeutics, Inc. Novel chlorination process for preparing sucralose
US20080300392A1 (en) * 2007-06-04 2008-12-04 Polymed Therapeutics, Inc. Novel chlorination process for preparing sucralose
US7932380B2 (en) * 2008-03-06 2011-04-26 Wanhe International (Group) Co. Ltd. Process for the preparation of sucralose
US20100022765A1 (en) * 2008-07-23 2010-01-28 David Losan Ho Methods for extracting and purifying sucralose intermediate
CN102241708B (zh) * 2011-05-10 2013-10-30 山东大学 一种半乳糖苷化合物及其制备方法
CN105153247B (zh) * 2015-08-28 2017-11-21 山东康宝生化科技有限公司 一种解决固体光气法合成三氯蔗糖酯时蔗糖酯结块的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2036007A (en) * 1978-10-18 1980-06-25 Tate & Lyle Ltd A Method for the Preparation of 2-chloro-2-deoxy Saccharides
EP0031651B1 (en) * 1979-12-20 1983-03-23 TATE & LYLE PUBLIC LIMITED COMPANY Process for the preparation of 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose
DE3165986D1 (en) * 1980-07-08 1984-10-18 Tate & Lyle Plc Process for the preparation of 4, 1',6'-trichloro-4,1',6'-trideoxygalactosucrose (tgs)
DE3102516A1 (de) * 1981-01-27 1982-08-12 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von optisch aktiven 2-chlorpropionsaeureestern
GB2104063B (en) * 1981-08-21 1985-11-06 Tate And Lyle Plc 4-halo-substituted sucrose derivatives
US4605784A (en) 1984-12-19 1986-08-12 Eastman Kodak Company Process for the preparation of ether-containing chlorides
GB8500862D0 (en) * 1985-01-14 1985-02-20 Tate & Lyle Plc Composition
GB8525871D0 (en) * 1985-10-21 1985-11-27 Tate & Lyle Plc Chemical compound
GB8525954D0 (en) * 1985-10-21 1985-11-27 Mcneilab Inc Chlorination of carbohydrates &c alcohols

Also Published As

Publication number Publication date
PT91357B (pt) 1995-05-04
DK379389D0 (da) 1989-08-02
GB8818430D0 (en) 1988-09-07
DE68911788D1 (de) 1994-02-10
RU1836375C (ru) 1993-08-23
JPH02160796A (ja) 1990-06-20
EP0354050A3 (en) 1991-09-04
IE892498L (en) 1990-02-03
GB2221462B (en) 1992-04-22
US4977254A (en) 1990-12-11
KR900003190A (ko) 1990-03-26
KR0137951B1 (ko) 1998-04-30
EP0354050B1 (en) 1993-12-29
GB8917468D0 (en) 1989-09-13
DK170805B1 (da) 1996-01-22
PT91357A (pt) 1990-03-08
DE68911788T2 (de) 1994-04-14
JP3055910B2 (ja) 2000-06-26
GB2221462A (en) 1990-02-07
IE61917B1 (en) 1994-11-30
ATE99317T1 (de) 1994-01-15
DK379389A (da) 1990-02-04
EP0354050A2 (en) 1990-02-07
CA1316532C (en) 1993-04-20

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