ES2062021T3 - Esteres monoyodopropargilicos de anhidridos dicarboxilicos y su uso como agentes antimicrobianos. - Google Patents
Esteres monoyodopropargilicos de anhidridos dicarboxilicos y su uso como agentes antimicrobianos.Info
- Publication number
- ES2062021T3 ES2062021T3 ES89308820T ES89308820T ES2062021T3 ES 2062021 T3 ES2062021 T3 ES 2062021T3 ES 89308820 T ES89308820 T ES 89308820T ES 89308820 T ES89308820 T ES 89308820T ES 2062021 T3 ES2062021 T3 ES 2062021T3
- Authority
- ES
- Spain
- Prior art keywords
- cycloalkenyl
- cycloalkyl
- alkenyl
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000004599 antimicrobial Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 7
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- -1 amino, carboxyl Chemical group 0.000 abstract 5
- 229930194542 Keto Natural products 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000000468 ketone group Chemical group 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 239000001301 oxygen Substances 0.000 abstract 4
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000004434 sulfur atom Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000003641 microbiacidal effect Effects 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- PAVNZLVXYJDFNR-UHFFFAOYSA-N 3,3-dimethyloxane-2,6-dione Chemical compound CC1(C)CCC(=O)OC1=O PAVNZLVXYJDFNR-UHFFFAOYSA-N 0.000 abstract 1
- GCQOAXGCHJTEBR-UHFFFAOYSA-N 4-(3-iodoprop-2-ynoxy)-4-oxobutanoic acid Chemical class OC(=O)CCC(=O)OCC#CI GCQOAXGCHJTEBR-UHFFFAOYSA-N 0.000 abstract 1
- POLIXZIAIMAECK-UHFFFAOYSA-N 4-[2-(2,6-dioxomorpholin-4-yl)ethyl]morpholine-2,6-dione Chemical compound C1C(=O)OC(=O)CN1CCN1CC(=O)OC(=O)C1 POLIXZIAIMAECK-UHFFFAOYSA-N 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N itaconic acid Chemical class OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 abstract 1
- 150000002688 maleic acid derivatives Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000005498 phthalate group Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
- C07C69/657—Maleic acid esters; Fumaric acid esters; Halomaleic acid esters; Halofumaric acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/80—Phthalic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LAS NUEVAS COMPOSICIONES CONTENIDAS DE LA PRESENTE INVENCION COMPRENDE COMPONENTE QUE TIENEN UNA DE LAS SIGUIENTES FORMULAS (I), (II): DONDE R ES HIDROGENO O METILO; N ES DE 1 A 16; R1 Y R2 ESTAN DEFINIDOS COMO R3 Y R4 O ESTAN UNIDOS PARA FORMAR UN CICLOALQUILO UN CICLOALQUENILO O UN ANILLO AROMATICO O HETEROCICLICO QUE CONTIENE UN ATOMO DE OXIGENO, NITROGENO O AZUFRE O UN DERIVADO DE ELLOS SUSTITUIDO DE ALCOXI AMINO, CARBOXILO, HALO, HIDROXIL, CETONA O TIOCARBOXILO; R3 Y R4 SON ELEGIDOS INDEPENDIENTEMENTE DE (A) HIDROGENO, ALQUILO, CICLOALQUILO, ALQUENILO, CIALOALQUENILO O UN ANILLO HETEROCICLICO QUE CONTIENE UN ATOMO DE OXIGENO, NITROGENO O AZUFRE, ALOXI, AMINO CARBOXILO, HALO, HIDROXILO, CETONA O UN TIOCARBOXILO, Y (B) DERIVADOS SUSTITUIDOS DE LAQUILO, CICLOALQUILO, ALQUENILO CICLOALQUENILO, ARILO Y EL ANILLO ETEROCICLICO DONDE LAS SUSTITUCIONES SON ALQUILO, CICLOALQUILO ALQUENILO, CICLOALQUENILO, ARILO, ALCOXI, AMINO, CARBOXILO, HALO, HIDROXILO, CETONA O UN TIOCARBOXILO; (W) PUEDE SER UN ENLACE SIMPLE OXIGENO, NR5 O (CR6R7)M, DONDE N5 ES HIDROGENO, ALQUILO, CICLOALQUILO, ALQUENILO, CICLOALQUENILO, ARILO O UN ANILLO HETOCICLICO QUE CONTIENE UN ATOMO DE OXIGENO NITROGENO O AZUFRE O UN DERIVADO SUSTITUIDO ALQUILO, CICLOALQUILO, ALQUENILO, CICLOALQUENILO, ARILO O UN ANILLO HETEROCICLICO QUE CONTIENE UN ATOMO DE OXIGENO NITROGENO O AZUFRE O UN DERIVADO SUSTITUIDO ALQUILO, CICLOALQUILO, ALQUENILO, CICLOALQUENILO, O GRUPOS ARILOS DONDE LAS SUSTITUCIONES SON ALQUILO, CICLOALQUILO - ALQUENILO, CICLOALQUENILO ARILO, ALCOXI, AMINO, CARBOXILO, HALO, HIDROXILO, CETONA O UN TIOCARBOXILO DONDE R6 Y R7 SE DEFINEN COMO R3 Y R4 Y M ES UN ENTERO DE 1 A 12; Y X ES HIDROGENO O UN CATION FORMADOR DE SAL. EJEMPLOS DE TALES COMPOSICIONES SON SUCCIONADOS DE MONO IODOPROPAUGIL - MALEATAS ITACONATAS DIGLICOLATAS Y TALATAS. OTROS COMPONENTES INCLUYEN ESTERES DE MONOIODOPROPANGIL DE ANHIDRIDOS TALES COMO EL DIMETILGLUTARICO Y EL DIANHIDRIDO ETILENODIAMINA TETRACETICO SON UTILIZADOS EN FORMULAS MICROBICIDAS EFECTIVOS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24406088A | 1988-09-14 | 1988-09-14 | |
| US07/311,523 US5073570A (en) | 1988-09-14 | 1989-02-16 | Mono-iodopropargyl esters of dicarboxylic anhydrides and their use as antimicrobial agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2062021T3 true ES2062021T3 (es) | 1994-12-16 |
Family
ID=26936297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES89308820T Expired - Lifetime ES2062021T3 (es) | 1988-09-14 | 1989-08-31 | Esteres monoyodopropargilicos de anhidridos dicarboxilicos y su uso como agentes antimicrobianos. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5073570A (es) |
| EP (1) | EP0359442B1 (es) |
| JP (1) | JPH0725720B2 (es) |
| AT (1) | ATE113026T1 (es) |
| CA (1) | CA1334977C (es) |
| DE (1) | DE68918910T2 (es) |
| ES (1) | ES2062021T3 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5209930A (en) * | 1990-12-10 | 1993-05-11 | Rohm And Haas Company | Preparation and use of n-iodopropargyl oxycarbonyl amino acid esters and derivatives as antimicrobial agents |
| US6143204A (en) * | 1998-06-19 | 2000-11-07 | Lonza Inc. | Stabilization of iodopropynl compounds |
| US6340384B1 (en) | 1999-05-24 | 2002-01-22 | Lonza Inc. | Copper/amine oxide wood preservatives |
| EP1185402B1 (en) | 1999-05-24 | 2005-03-02 | Lonza Inc. | Azole/amine oxide wood preservatives and fungicides |
| AU776264B2 (en) | 1999-05-24 | 2004-09-02 | Lonza Inc. | Isothiazolone/amine oxide wood preservatives |
| NZ516197A (en) | 1999-05-24 | 2004-05-28 | Lonza Ag | Amine oxide/iodine containing blends for wood preservation |
| CA2409295C (en) | 2000-05-24 | 2010-11-23 | Lonza, Inc. | Amine oxide wood preservatives |
| DE60127261T2 (de) | 2000-06-30 | 2008-01-17 | Lonza Inc. | Verwendung von Holzwasserdichtungs- und Holzkonservierungs-Zusammensetzungen, die eine Borverbindung und ein Aminoxid enthalten |
| WO2002067685A1 (en) * | 2001-02-26 | 2002-09-06 | Lonza Inc. | Stable preservative formulations comprising halopropynyl compounds and butoxydiglycol solvent |
| TW201002201A (en) | 2001-03-01 | 2010-01-16 | Lonza Ag | Preservative blends containing quaternary ammonium compounds |
| CA2439640A1 (en) | 2001-03-01 | 2002-09-12 | Lonza Inc. | Combination of an iodopropynyl derivative with a ketone acid or its salt and/or with an aromatic carboxylic acid or its salt |
| AU2002322720B2 (en) | 2001-07-25 | 2008-11-13 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| ITMI20040244A1 (it) * | 2004-02-13 | 2004-05-13 | Vama Farmacosmetica S R L | Sostanza batteriostatica per preparati ad uso topico in particolare per uso dermofarmaceutico e cosmetico e preparati comprendenti questa sostanza |
| CA2789262C (en) | 2005-04-28 | 2016-10-04 | Proteus Digital Health, Inc. | Pharma-informatics system |
| EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| TR201908314T4 (tr) | 2009-02-20 | 2019-06-21 | 2 Bbb Medicines B V | Glutatyon bazlı ilaç dağıtım sistemi. |
| KR101909711B1 (ko) | 2009-05-06 | 2018-12-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3796746A (en) * | 1968-12-19 | 1974-03-12 | Alelio G D | Unsaturated ester of halogenated alkenes |
| US3823183A (en) * | 1968-12-19 | 1974-07-09 | Alelio G D | Unsaturated ester of halogenated alkenes |
| US3793293A (en) * | 1971-08-04 | 1974-02-19 | Nat Starch Chem Corp | Electrophotographic coating compositions having bromine-containing polymer binders |
| US4107122A (en) * | 1975-12-22 | 1978-08-15 | Monsanto Company | Copolymer plasticizers comprising novel ω-bromoalkyl esters of acyclic unsaturated dicarboxylic acids |
| US4259350A (en) * | 1978-03-15 | 1981-03-31 | Sankyo Company Limited | Iodopropargyl derivatives, their use and preparation |
| DE3227220A1 (de) * | 1982-07-21 | 1984-02-02 | Bayer Ag, 5090 Leverkusen | Jodpropargylcarbonsaeureester |
-
1989
- 1989-02-16 US US07/311,523 patent/US5073570A/en not_active Expired - Fee Related
- 1989-08-31 EP EP89308820A patent/EP0359442B1/en not_active Expired - Lifetime
- 1989-08-31 ES ES89308820T patent/ES2062021T3/es not_active Expired - Lifetime
- 1989-08-31 AT AT89308820T patent/ATE113026T1/de not_active IP Right Cessation
- 1989-08-31 DE DE68918910T patent/DE68918910T2/de not_active Expired - Fee Related
- 1989-09-13 JP JP1235883A patent/JPH0725720B2/ja not_active Expired - Lifetime
- 1989-09-14 CA CA000611489A patent/CA1334977C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5073570A (en) | 1991-12-17 |
| DE68918910D1 (de) | 1994-11-24 |
| JPH02180848A (ja) | 1990-07-13 |
| ATE113026T1 (de) | 1994-11-15 |
| EP0359442B1 (en) | 1994-10-19 |
| DE68918910T2 (de) | 1995-03-16 |
| EP0359442A3 (en) | 1992-01-02 |
| EP0359442A2 (en) | 1990-03-21 |
| JPH0725720B2 (ja) | 1995-03-22 |
| CA1334977C (en) | 1995-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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