ES2077559T3 - Estabilizacion de proteinas terapeuticamente activas en preparados farmaceuticos. - Google Patents

Estabilizacion de proteinas terapeuticamente activas en preparados farmaceuticos.

Info

Publication number
ES2077559T3
ES2077559T3 ES88114944T ES88114944T ES2077559T3 ES 2077559 T3 ES2077559 T3 ES 2077559T3 ES 88114944 T ES88114944 T ES 88114944T ES 88114944 T ES88114944 T ES 88114944T ES 2077559 T3 ES2077559 T3 ES 2077559T3
Authority
ES
Spain
Prior art keywords
stabilization
pharmaceutical preparations
therapeutically active
active proteins
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88114944T
Other languages
English (en)
Inventor
Traute Dr Mundorf
Kurt Dr Schnecker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Application granted granted Critical
Publication of ES2077559T3 publication Critical patent/ES2077559T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

CNFORME A LA INVENCION SON PREPARADOS FARMACE=EUTICOS PARA APLICACION TOPICA, QUE CONTIENEN UNA O MAS PROTEINAS TERAPEUTICAS ESTABLES ASI COMO EN SU CASO LOS CORRIENTES ADITIVOS, SUSTANCIAS PORTADORAS Y AUXILIARES, ASI COMO UN PROCEDIMIENTO PARA LA PRODUCCION TANTO DE PREPARADOS FARMACEUTICOS ASI COMO LA UTILIZACION DE SUSTANCIAS HIDROFOBAS DE TRATAMIENTO FISIOLOGICO PARA LA ESTABILIZACION DE PROTEINAS.
ES88114944T 1987-09-17 1988-09-13 Estabilizacion de proteinas terapeuticamente activas en preparados farmaceuticos. Expired - Lifetime ES2077559T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873731255 DE3731255A1 (de) 1987-09-17 1987-09-17 Stabilisierung von therapeutisch wirksamen proteinen in pharmazeutischen zubereitungen

Publications (1)

Publication Number Publication Date
ES2077559T3 true ES2077559T3 (es) 1995-12-01

Family

ID=6336244

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88114944T Expired - Lifetime ES2077559T3 (es) 1987-09-17 1988-09-13 Estabilizacion de proteinas terapeuticamente activas en preparados farmaceuticos.

Country Status (20)

Country Link
EP (1) EP0307857B1 (es)
JP (1) JP2783552B2 (es)
KR (1) KR970008112B1 (es)
AT (1) ATE126063T1 (es)
AU (1) AU615473B2 (es)
CA (1) CA1329121C (es)
DD (1) DD274562A5 (es)
DE (2) DE3731255A1 (es)
DK (1) DK516288A (es)
ES (1) ES2077559T3 (es)
FI (1) FI95770C (es)
GR (1) GR3017432T3 (es)
HU (1) HU203045B (es)
IE (1) IE70908B1 (es)
IL (1) IL87778A (es)
NO (1) NO179436C (es)
NZ (1) NZ226209A (es)
PT (1) PT88539B (es)
RU (1) RU2093145C1 (es)
ZA (1) ZA886903B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5241925A (en) * 1988-12-27 1993-09-07 Dermamed Apparatus and techniques for administering veterinary medicaments
US5332577A (en) * 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5324521A (en) * 1989-12-18 1994-06-28 Dermamed Systems for transdermal administration of medicaments
JPH0776527A (ja) * 1993-06-28 1995-03-20 Hayashibara Biochem Lab Inc 半固形製剤とその製造方法
RU2132184C1 (ru) * 1998-12-16 1999-06-27 Краснодарская научно-исследовательская ветеринарная станция Способ получения препарата "жироформ-плюс" для лечения и профилактики эндометритов у коров
CA2416169C (en) * 2000-07-14 2008-09-23 Allergan, Inc. Compositions containing therapeutically active components having enhanced solubility
RU2216313C2 (ru) * 2000-12-25 2003-11-20 Савченков Сергей Николаевич Лечебно-профилактическое косметическое средство
RU2188665C1 (ru) * 2001-04-09 2002-09-10 Щербакова Элеонора Григорьевна Противовирусное и антибактериальное средство "интерлизин"
ITMI20031640A1 (it) * 2003-08-08 2005-02-09 Mipharm S P A Base per gel bioadesivi.
CU23432B6 (es) * 2005-11-02 2009-10-16 Ct Ingenieria Genetica Biotech Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras
KR20130091663A (ko) * 2010-05-04 2013-08-19 비스코겔 에이비 키토산 조성물
RU2431489C1 (ru) * 2010-05-25 2011-10-20 Федеральное государственное учреждение "Российский научный центр рентгенорадиологии Федерального агентства по высокотехнологичной медицинской помощи" (ФГУ "РНЦРР Росмедтехнологий") Способ лечения хронических воспалительных заболеваний толстого кишечника
FI3638251T3 (fi) 2017-06-12 2024-04-29 Lakewood Amedex Inc Bisfosfosiinin geeliformulaatioita ja niiden käyttötapoja

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5413223A (en) * 1977-07-01 1979-01-31 Ricoh Co Ltd Printer unit
GB2016015B (en) * 1978-01-22 1982-05-06 Hayashibara Co Method of preparing interferon and preparations containing interferon
JPS5598118A (en) * 1979-01-18 1980-07-25 Hayashibara Takeshi Preparation of type-2 interferon and drug containing the same
FR2513124B1 (fr) * 1981-07-21 1989-11-17 Hayashibara Biochem Lab Production et applications du facteur de lyse des cellules-cibles
CA1190148A (en) * 1981-10-13 1985-07-09 Samuel S. Asculai Interferon-containing compositions
JPS5892622A (ja) * 1981-11-28 1983-06-02 Sunstar Inc インタ−フエロン安定配合製剤
US4659696A (en) * 1982-04-30 1987-04-21 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its nasal or vaginal use
JPS5910524A (ja) * 1982-07-08 1984-01-20 Toray Ind Inc インタ−フエロン組成物およびその製造法
JPS6061535A (ja) * 1983-08-24 1985-04-09 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト 製薬学的組成物
EP0177342A3 (en) * 1984-10-04 1987-12-02 Genentech, Inc. Oral formulation of therapeutic proteins
DE3603444A1 (de) * 1986-02-05 1987-08-06 Thomae Gmbh Dr K Pharmazeutische zubereitungsformen zur stabilisierung von interferon alpha
US4822605A (en) * 1986-02-18 1989-04-18 Exovir, Inc. Compositions and methods employing the same for the treatment of viral and cancerous skin lesions and the like

Also Published As

Publication number Publication date
FI884240A0 (fi) 1988-09-15
FI884240L (fi) 1989-03-18
HU203045B (en) 1991-05-28
FI95770B (fi) 1995-12-15
DK516288D0 (da) 1988-09-16
AU2231688A (en) 1989-03-23
JP2783552B2 (ja) 1998-08-06
GR3017432T3 (en) 1995-12-31
HUT47436A (en) 1989-03-28
FI95770C (fi) 1996-03-25
PT88539B (pt) 1992-11-30
JPH01102029A (ja) 1989-04-19
EP0307857B1 (de) 1995-08-09
NO884123D0 (no) 1988-09-16
IE882812L (en) 1989-03-17
NO884123L (no) 1989-03-20
ZA886903B (en) 1990-05-30
CA1329121C (en) 1994-05-03
NO179436B (no) 1996-07-01
DD274562A5 (de) 1989-12-27
EP0307857A1 (de) 1989-03-22
IL87778A (en) 1993-05-13
IL87778A0 (en) 1989-03-31
AU615473B2 (en) 1991-10-03
NZ226209A (en) 1991-06-25
PT88539A (pt) 1988-10-01
ATE126063T1 (de) 1995-08-15
DE3854290D1 (de) 1995-09-14
RU2093145C1 (ru) 1997-10-20
DK516288A (da) 1989-03-18
KR890004719A (ko) 1989-05-09
DE3731255A1 (de) 1989-04-06
NO179436C (no) 1996-10-09
KR970008112B1 (ko) 1997-05-21
IE70908B1 (en) 1997-01-15

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