ES2062406T3 - Nuevos compuestos de morfolinol, su preparacion y uso. - Google Patents

Nuevos compuestos de morfolinol, su preparacion y uso.

Info

Publication number
ES2062406T3
ES2062406T3 ES90311851T ES90311851T ES2062406T3 ES 2062406 T3 ES2062406 T3 ES 2062406T3 ES 90311851 T ES90311851 T ES 90311851T ES 90311851 T ES90311851 T ES 90311851T ES 2062406 T3 ES2062406 T3 ES 2062406T3
Authority
ES
Spain
Prior art keywords
compounds
morfolinol
preparation
new
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90311851T
Other languages
English (en)
Inventor
James Leroy Kelley
David Lee Musso
Grady Evan Boswell
Barrett Randolph Cooper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2062406T3 publication Critical patent/ES2062406T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NUEVOS (25, 35, 5R) MORFOLINOLES QUE TIENEN LA FORMULA (I) JUNTO CON LAS RAMIFICACIONES (+-) *, 5S ELEVADO *) DEL MISMO Y SUS SALES, EN DONDE X ES UN HIDROGENO, UN ALQUILO DE 1 A 6 ATOMOS DE CARBONO, UN CICLOALQUILO DE 3 A 6 ATOMOS DE CARBONO O UN GRUPO -CH SUB 2DE X ELEVADO 1 ES UN CICLOALQUILO DE 3 A 6 ATOMOS DE CARBONO. EL COMPUESTO TIENE VARIAS APLICACIONES MEDICAS, SOBRE TODO EN EL TRATAMIENTO DE ENFERMEDADES MENTALES DE LAS PERSONAS COMO POR EJEMPLO LA DEPRESION.
ES90311851T 1989-10-31 1990-10-30 Nuevos compuestos de morfolinol, su preparacion y uso. Expired - Lifetime ES2062406T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898924528A GB8924528D0 (en) 1989-10-31 1989-10-31 Heterocyclic pharmaceutical compounds,preparation and use

Publications (1)

Publication Number Publication Date
ES2062406T3 true ES2062406T3 (es) 1994-12-16

Family

ID=10665482

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90311851T Expired - Lifetime ES2062406T3 (es) 1989-10-31 1990-10-30 Nuevos compuestos de morfolinol, su preparacion y uso.

Country Status (19)

Country Link
US (1) US5104870A (es)
EP (1) EP0426416B1 (es)
JP (1) JP2873076B2 (es)
AT (1) ATE101604T1 (es)
AU (1) AU645763B2 (es)
CA (1) CA2028893C (es)
DE (1) DE69006682T2 (es)
DK (1) DK0426416T3 (es)
ES (1) ES2062406T3 (es)
FI (1) FI94753C (es)
GB (1) GB8924528D0 (es)
HU (2) HU207304B (es)
IE (1) IE66115B1 (es)
LV (1) LV11030B (es)
MX (1) MX9203219A (es)
NZ (1) NZ235882A (es)
PT (1) PT95735B (es)
SG (1) SG28347G (es)
ZA (1) ZA908696B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9108629D0 (en) * 1991-04-23 1991-06-12 Wellcome Found Heterocyclic pharmaceutical compounds,preparation and use
WO1999025355A1 (en) * 1997-11-14 1999-05-27 Glaxo Group Ltd. Method of treating addiction to nicotine products
MA26693A1 (fr) * 1998-09-28 2004-12-20 Glaxo Group Ltd Compositions pour administration par voie buccale
EP1220673A2 (en) * 1999-10-13 2002-07-10 Glaxo Group Limited Morpholinol derivatives for the treatment of obesity
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
CA2635261A1 (en) * 2006-01-03 2007-07-12 Algebra, Inc. Therapeutic amine-arylsulfonamide conjugate compounds
EP2419400A1 (en) 2009-04-15 2012-02-22 Research Triangle Institute Monoamine reuptake inhibitors
CA2800219C (en) 2010-05-21 2019-03-12 Research Triangle Institute 1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence
JP2013526583A (ja) 2010-05-21 2013-06-24 リサーチ・トライアングル・インスティチュート フェニルモルホリンおよびその類似体
CN105949142B (zh) * 2016-05-21 2018-03-27 南华大学 具有抗抑郁活性的单一手性化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3117967A (en) * 1962-04-02 1964-01-14 Smith Kline French Lab 2-biphenylyl-2-hydroxy-morpholinium halides
FR2553413B1 (fr) * 1983-10-17 1986-03-21 Lafon Labor Derives de 4-alkyl-2-hydroxy-3-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique
GB8417170D0 (en) * 1984-07-05 1984-08-08 Wellcome Found Heterocyclic pharmaceutical compounds

Also Published As

Publication number Publication date
ZA908696B (en) 1992-07-29
HU906935D0 (en) 1991-05-28
AU6563990A (en) 1991-05-09
HU207304B (en) 1993-03-29
DE69006682D1 (de) 1994-03-24
JP2873076B2 (ja) 1999-03-24
JPH03206084A (ja) 1991-09-09
FI94753C (fi) 1995-10-25
DK0426416T3 (da) 1994-03-14
FI905356A0 (fi) 1990-10-30
ATE101604T1 (de) 1994-03-15
IE66115B1 (en) 1995-12-13
HU211304A9 (en) 1995-11-28
HUT57748A (en) 1991-12-30
AU645763B2 (en) 1994-01-27
NZ235882A (en) 1993-05-26
FI94753B (fi) 1995-07-14
PT95735B (pt) 1998-01-30
CA2028893C (en) 2000-10-10
LV11030A (lv) 1996-02-20
EP0426416B1 (en) 1994-02-16
PT95735A (pt) 1991-09-13
MX9203219A (es) 1992-07-01
LV11030B (en) 1996-08-20
SG28347G (en) 1995-09-18
EP0426416A1 (en) 1991-05-08
GB8924528D0 (en) 1989-12-20
IE903888A1 (en) 1991-05-08
DE69006682T2 (de) 1994-08-04
CA2028893A1 (en) 1991-05-01
US5104870A (en) 1992-04-14

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