ES2062671T3 - Un proceso para la preparacion de un derivado de tetrahidropiridinildibenzazepina. - Google Patents

Un proceso para la preparacion de un derivado de tetrahidropiridinildibenzazepina.

Info

Publication number
ES2062671T3
ES2062671T3 ES91201688T ES91201688T ES2062671T3 ES 2062671 T3 ES2062671 T3 ES 2062671T3 ES 91201688 T ES91201688 T ES 91201688T ES 91201688 T ES91201688 T ES 91201688T ES 2062671 T3 ES2062671 T3 ES 2062671T3
Authority
ES
Spain
Prior art keywords
sub
sesic
hydrogen
lower alkyl
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91201688T
Other languages
English (en)
Inventor
James Cairns
Samuel George Gibson
Duncan Robertson Rae
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Application granted granted Critical
Publication of ES2062671T3 publication Critical patent/ES2062671T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS TETRAHIDROPIRIDINILDIBENZACEPINOS DE LA FORMULA I DONDE R SUB 1 ES UN SUSTITUYENTE SELECCIONADO DEL GRUPO QUE CONSISTE EN HIDROGENO, HALOGENO, Y ALQUILO INFERIOR; R SUB 2 SE SELECCIONA DE HIDROGENO Y ALQUILO INFERIOR SUSTITUIDO POR HIDROXI O NO SUSTITUIDO O ALQUENILO INFERIOR; X ES O, S, O CH SUB 2; Y ES HC = CH O S; O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES. ESTOS COMPUESTOS SON ANTAGONISTAS DE LA DOPAMINA Y POR LO TANTO UTILES PARA EL TRATAMIENTO DE TRANSTORNOS SICOTICOS TALES COMO ESQUIZOFRENIA, TRANSTORNOS ESQUIZOFRENIFORMES, TRANSTORNO DELUSIONAL, ESTADOS MANIACOS AGUDOS, SENILES Y ESTADOS SICOTICOS PRESENILES, SICOSIS TOXICA, SICOSIS INDUCIDA POR UNA SUSTANCIA SICOACTIVA, SINTOMAS SEVEROS DE INSOMNIO, HIPEREXCITABILIDAD Y ANSIEDAD, TRANSTORNOS MOTORES, ENTRE LOS CUALES ESTA EL TRANSTORNO DE TOURETTE Y RUTINA DE HUNTINGTON, NAUSEAS Y VOMITOS Y VERTIGOS.
ES91201688T 1990-07-24 1991-07-02 Un proceso para la preparacion de un derivado de tetrahidropiridinildibenzazepina. Expired - Lifetime ES2062671T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90308071 1990-07-24

Publications (1)

Publication Number Publication Date
ES2062671T3 true ES2062671T3 (es) 1994-12-16

Family

ID=8205498

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91201688T Expired - Lifetime ES2062671T3 (es) 1990-07-24 1991-07-02 Un proceso para la preparacion de un derivado de tetrahidropiridinildibenzazepina.

Country Status (13)

Country Link
EP (1) EP0468562B1 (es)
JP (1) JPH04234384A (es)
KR (1) KR920002595A (es)
AT (1) ATE98240T1 (es)
AU (1) AU640799B2 (es)
CA (1) CA2046488A1 (es)
DE (1) DE69100741T2 (es)
ES (1) ES2062671T3 (es)
FI (1) FI913495A7 (es)
IE (1) IE912239A1 (es)
NZ (1) NZ239052A (es)
PT (1) PT98421A (es)
ZA (1) ZA915128B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9988377B2 (en) 2011-08-24 2018-06-05 The Trustees Of Columbia University In The City Of New York Small molecule inducers of GDNF as potential new therapeutics for neuropsychiatric disorders
EP4487913A3 (en) * 2014-11-26 2025-04-16 The Trustees Of Columbia University In The City Of New York Opioid receptor modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1184251A (en) * 1966-04-15 1970-03-11 American Cyanamid Co Oxazepines and Thiazepines
US4221714A (en) * 1979-08-03 1980-09-09 American Cyanamid Company 11-(1,2,3,6-Tetrahydro-substituted-4-pyridyl)-dibenz[b,f][1,4]oxazepines
US4798841A (en) * 1987-03-31 1989-01-17 Warner-Lambert Company Tetrahydropyridine oxime cholinergic agents and method of treatment
DE3726908A1 (de) * 1987-08-13 1989-02-23 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3735895A1 (de) * 1987-10-23 1989-05-03 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
FI913495L (fi) 1992-01-25
EP0468562B1 (en) 1993-12-08
JPH04234384A (ja) 1992-08-24
ZA915128B (en) 1992-05-27
CA2046488A1 (en) 1992-01-25
NZ239052A (en) 1992-11-25
IE912239A1 (en) 1992-01-29
FI913495A7 (fi) 1992-01-25
DE69100741D1 (de) 1994-01-20
FI913495A0 (fi) 1991-07-19
PT98421A (pt) 1992-05-29
KR920002595A (ko) 1992-02-28
AU640799B2 (en) 1993-09-02
AU8038591A (en) 1992-01-30
EP0468562A1 (en) 1992-01-29
DE69100741T2 (de) 1994-04-28
ATE98240T1 (de) 1993-12-15

Similar Documents

Publication Publication Date Title
ES2113368T3 (es) Antagonistas de serotonina.
ES2094843T3 (es) Bencisotiazol- y bencisoxazol-3-carboxamidas, un procedimiento para su preparacion y su empleo como medicamentos antipsicoticos.
ES2164758T3 (es) Derivados de morfolina sustituidos y su uso como agentes terapeuticos.
ES2094653T3 (es) Derivados de indol como antagonistas de tipo 5-ht1 para uso en la migraña.
PE20020721A1 (es) Derivados de quinuclidina como agentes antimuscarinicos m3
PE20060336A1 (es) Compuestos derivados de 1-amino-ftalazina como moduladores de mch1
ES2149215T3 (es) Bencilaminoquinuclidinas sustituidas como antagonistas de la sustancia p.
DE60313634D1 (de) Piperazinsubstituierte arylbenzodiazepine
ES2185665T3 (es) Derivados de benzofurano como antagonistas de taquicininas.
ES2127919T3 (es) 4-amino-piridinas, procedimiento para su preparacion, asi como medicamentos que contienen estos compuestos.
ES2038707T3 (es) Procedimiento para la obtencion de enantiomeros (+) y (-) de derivados de la 3,4-dihidro-2h-(1)-benzopiran-3-amina.
ES2133416T3 (es) Ligandos de subtipos de receptores de dopamina.
AR009413A1 (es) Un compuesto, el cual es un derivado de distamicina benzoheterociclico, su utilizacion, un procedimiento para producirlo y una composicionfarmaceutica que lo comprende
ES2169248T3 (es) Compuestos aromaticos y composiciones farmaceuticas que los contienen.
ES2037208T3 (es) Un metodo para preparar derivados 3-aminometilicos de indano, indolina, dihidrobenzofurano y dihidrobenzotiofeno.
ES2106616T3 (es) Derivados de 11,21-bisfenilo-19-nor-pregnanos.
AR079467A1 (es) Derivados heterociclicos nitrogenados de etinilo, composiciones farmaceuticas que los contienen, proceso para prepararlos y uso de los mismos para tratar y/o prevenir enfermedades cognitivas o esquizofrenia.
ES2107212T3 (es) Derivados de 1,4-benzoxazina como abridores de los canales de potasio.
ES2123873T3 (es) Pirrolocarbazol.
ES2132761T3 (es) Derivados del acido piperidin acetico utiles como antagonistas del fibrinogeno.
MX9306528A (es) Derivados de sulfonamida de compuestos anulares de cicloalquilo-heterociclico substituidos con hidroxi, de benceno fundido.
ES2062455T3 (es) Nuevos derivados de benzonaftiridina-1,8, su preparacion y las composiciones que les contienen.
ES2122253T3 (es) Derivados (arilalcoxibencil)aminopropanamidicos sustituidos, su preparacion y su utilizacion como agentes antiepilepticos, neuroprotectores y antidepresivos.
ES2029879T3 (es) Procedimiento para producir derivados de aminas sustituidas.
ES2152682T3 (es) Derivados de indolina utiles como antagonistas del receptor 5ht-2c.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 468562

Country of ref document: ES