ES2064149T3 - Nuevos derivados del indol, procedimiento de preparacion y medicamentos que los contienen. - Google Patents

Nuevos derivados del indol, procedimiento de preparacion y medicamentos que los contienen.

Info

Publication number
ES2064149T3
ES2064149T3 ES92400764T ES92400764T ES2064149T3 ES 2064149 T3 ES2064149 T3 ES 2064149T3 ES 92400764 T ES92400764 T ES 92400764T ES 92400764 T ES92400764 T ES 92400764T ES 2064149 T3 ES2064149 T3 ES 2064149T3
Authority
ES
Spain
Prior art keywords
indol
alkyl
represent
new derivatives
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92400764T
Other languages
English (en)
Inventor
Didier Festal
Denis Descours
Robert Bellemin
Jacques Decerprit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA SAS, LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA SAS
Application granted granted Critical
Publication of ES2064149T3 publication Critical patent/ES2064149T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NUEVOS DERIVADOS DEL INDOL, PROCESO DE PREPARACION Y MEDICAMENTOS QUE LOS CONTIENEN. LA INVENCION SE REFIERE A DERIVADOS DEL INDOL DE FORMULA, EN LA QUE R1 Y R2 REPRESENTAN H, ALQUILO, ALCENILO, CICLOALQUILO, N-ALQUILAMINO LMETILO O FENILO EVENTUALMENTE SUSTITUIDOS, R3 Y R4 REPRESENTAN H, HALOGENO, ALQUILO, ALCOXI, ALQUILTIO, CF3, NO2, N-ALQUILAMINO O N,N-DIALQUILAMINO, BENCILO O FENILO EVENTUALMENTE SUSTITUIDOS, R5 REPRESENTA H, ALQUILO, CICLOALQUILO O BENCILO EVENTUALMENTE SUSTITUIDO. R6 DESIGNA UN RADICAL ALQUILO, FENILO O HETEROCICLICO EVENTUALMENTE SUSTITUIDOS, Z DESIGNA LOS BIRRADICALES: -(CH2)N N=0-2, P=0-2 Y N + P MENOR O IGUAL A 2, R7 Y R8 REPRESENTAN H, ALQUILO, ALCENILO, CICLOALQUILO, N-ALQUILAMINO, N,N-DIALQUILAMINO, N-ALIKILAMINO PUEDEN ESTAR SUSTITUIDOS, O FORMAN JUNTOS CADENAS POLIMETILENA U OXA-, TIA SUS PROCESOS DE PREPARACION Y APLICACION COMO MEDICAMENTOS HIPOLIPIDEMIANTES, ANTIATEROMATOSOS Y ANTIDIABETICOS
ES92400764T 1991-03-26 1992-03-20 Nuevos derivados del indol, procedimiento de preparacion y medicamentos que los contienen. Expired - Lifetime ES2064149T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9103618A FR2674522B1 (fr) 1991-03-26 1991-03-26 Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.

Publications (1)

Publication Number Publication Date
ES2064149T3 true ES2064149T3 (es) 1995-01-16

Family

ID=9411107

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92400764T Expired - Lifetime ES2064149T3 (es) 1991-03-26 1992-03-20 Nuevos derivados del indol, procedimiento de preparacion y medicamentos que los contienen.

Country Status (25)

Country Link
US (1) US5219859A (es)
EP (1) EP0506532B1 (es)
JP (1) JPH0597802A (es)
KR (1) KR950007753B1 (es)
AT (1) ATE111078T1 (es)
AU (1) AU658609B2 (es)
CA (1) CA2063170A1 (es)
CS (1) CS89592A3 (es)
DE (1) DE69200378T2 (es)
DK (1) DK0506532T3 (es)
ES (1) ES2064149T3 (es)
FR (1) FR2674522B1 (es)
HU (1) HUT65489A (es)
IE (1) IE65366B1 (es)
IL (1) IL101248A (es)
MA (1) MA22474A1 (es)
MX (1) MX9201365A (es)
NO (1) NO178260C (es)
NZ (1) NZ242078A (es)
OA (1) OA09573A (es)
RU (1) RU2074179C1 (es)
SI (1) SI9210305A (es)
TN (1) TNSN92022A1 (es)
YU (1) YU30592A (es)
ZA (1) ZA922163B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687402B1 (fr) * 1992-02-14 1995-06-30 Lipha Nouveaux azaindoles, procedes de preparation et medicaments les contenant.
EP0642498A1 (en) * 1992-05-28 1995-03-15 Pfizer Inc. NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT)
NZ250916A (en) * 1993-02-27 1995-08-28 Nihon Nohyaku Co Ltd N-heteroaryl-n'-phenylureas, their use as acat inhibitors
IL109568A0 (en) * 1993-05-19 1994-08-26 Fujisawa Pharmaceutical Co Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
US5952354A (en) * 1993-07-21 1999-09-14 American Home Products Corporation Tris carbamic acid esters: inhibitors of cholesterol absorption
DE4401893A1 (de) * 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe
JP3720395B2 (ja) 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
FI974437A0 (fi) 1995-06-06 1997-12-05 Pfizer Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogeenifosforylaasi-inhibiittoreina
KR100241643B1 (ko) * 1995-06-06 2000-03-02 디. 제이. 우드 당뇨병치료제인 치환된 N-(인돌-2-카르보닐)-β-알라님아미드 및 그의 유도체
JP3314938B2 (ja) * 1995-06-06 2002-08-19 ファイザー・インコーポレーテッド グリコーゲンホスホリラーゼ抑制剤としての置換されたｎ−（インドール−２−カルボニル）−グリシンアミド類および誘導体
NZ299242A (en) * 1995-09-11 1997-12-19 Nihon Nohyaku Co Ltd N-phenyl-n'-(phenyl substituted imidazol-5-yl, -oxazol-4-yl, and -thiazol-4-yl)urea derivatives
CZ292632B6 (cs) * 1995-10-05 2003-11-12 Kyoto Pharmaceutical Industries, Ltd. Indolinový, indolový nebo tetrahydrochinolinový derivát a farmaceutický přípravek s jeho obsahem
EP0773218A1 (en) * 1995-11-13 1997-05-14 Mitsubishi Chemical Corporation N-(Piperazinylalkoxyphenyl)-N'phenylalkylurea derivatives as ACAT inhibitors for the treatment of atheroschlerosis
DE122010000020I1 (de) * 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern
FR2763334A1 (fr) * 1997-05-13 1998-11-20 Lipha Derives anthraniliques
WO1999031075A1 (en) * 1997-12-16 1999-06-24 Warner-Lambert Company 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
KR20010033153A (ko) * 1997-12-16 2001-04-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 4(3)-치환-4(3)-아미노메틸-(티오)피란 또는 -피페리딘유도체(=가바펜틴 동족체), 그의 제법 및 신경 질환 치료용도
ES2216338T3 (es) * 1997-12-16 2004-10-16 Warner-Lambert Company Llc Aminas novedosas como agentes farmaceuticos.
SK282727B6 (sk) 1997-12-19 2002-11-06 Slovakofarma, A. S. 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
EP1349858B1 (en) 2000-11-02 2008-08-27 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof
JP2005538047A (ja) * 2002-05-03 2005-12-15 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ボンベシンアンタゴニスト
EP1541553B1 (en) * 2002-07-17 2010-06-02 Kyoto Pharmaceutical Industries, Ltd. Indoline compound and medicinal use thereof
US7595403B2 (en) 2003-04-01 2009-09-29 Eli Lilly And Company Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors
NZ544803A (en) * 2003-08-29 2009-11-27 Kowa Co Method of stabilizing lipid-rich plaque and method of preventing rupture thereof
AU2006319231A1 (en) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
JP2009517432A (ja) 2005-11-30 2009-04-30 エフ．ホフマン−ラ ロシュ アーゲー ３−アミノ−２−アリールプロピルアザインドールおよびその使用
RU2361581C2 (ru) * 2007-09-14 2009-07-20 Закрытое Акционерное Общество "Мастерклон" Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний
SK287385B6 (sk) 2007-11-27 2010-08-09 Hameln-Rds, A. S. 1,3-Disubstituované močoviny, spôsob ich prípravy a použitia
CN104628621A (zh) * 2015-01-22 2015-05-20 湖南华腾制药有限公司 一种氟取代吲哚衍生物的制备方法
WO2018064465A1 (en) 2016-09-29 2018-04-05 The Regents Of The University Of California Compounds for increasing neural plasticity
CU20190106A7 (es) 2017-06-26 2020-11-30 Lunella Biotech Inc Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas
JP7770673B2 (ja) 2019-02-27 2025-11-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 脳障害を治療するためのアゼピノ－インドール及び他の複素環化合物
AU2022416279A1 (en) 2021-12-15 2024-07-25 Delix Therapeutics, Inc. Phenoxy and benzyloxy substituted psychoplastogens and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151505A (en) * 1979-05-14 1980-11-26 Kuraray Co Ltd Indole agricultural and horticultural fungicide
CA1299174C (en) * 1987-02-02 1992-04-21 Michael Edward Flaugh Alkylmelatonins
EP0375133A1 (en) * 1988-11-14 1990-06-27 The Upjohn Company Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
IL95584A (en) * 1989-09-07 1995-03-15 Abbott Lab Indole-, benzoporene- and benzothiophene compounds including lipoxygenase-inhibiting compounds and pharmaceutical compounds containing them
WO1991004027A1 (en) * 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
EP0471296B1 (en) * 1990-08-13 1995-11-08 Hoechst-Roussel Pharmaceuticals Incorporated 1-(Pyridinylalkyl)-1H-indoles, indolines and related analogs
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
WO1993005020A1 (en) * 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase

Also Published As

Publication number Publication date
DE69200378T2 (de) 1995-03-09
DK0506532T3 (da) 1995-02-20
FR2674522B1 (fr) 1993-07-16
NO178260C (no) 1996-02-21
JPH0597802A (ja) 1993-04-20
AU1309492A (en) 1992-10-01
OA09573A (fr) 1993-01-31
ATE111078T1 (de) 1994-09-15
HUT65489A (en) 1994-06-28
KR920018022A (ko) 1992-10-21
IE65366B1 (en) 1995-10-18
IL101248A (en) 1996-12-05
EP0506532B1 (fr) 1994-09-07
MX9201365A (es) 1992-10-01
MA22474A1 (fr) 1992-10-01
ZA922163B (en) 1993-09-27
TNSN92022A1 (fr) 1993-06-08
NO921141D0 (no) 1992-03-24
HU9200997D0 (en) 1992-05-28
IL101248A0 (en) 1992-11-15
AU658609B2 (en) 1995-04-27
EP0506532A1 (fr) 1992-09-30
SI9210305A (en) 1996-02-29
IE920937A1 (en) 1992-10-07
NO921141L (no) 1992-09-28
NZ242078A (en) 1994-10-26
YU30592A (sh) 1994-12-28
CA2063170A1 (en) 1992-09-27
RU2074179C1 (ru) 1997-02-27
KR950007753B1 (ko) 1995-07-14
FR2674522A1 (fr) 1992-10-02
DE69200378D1 (de) 1994-10-13
CS89592A3 (en) 1992-10-14
NO178260B (no) 1995-11-13
US5219859A (en) 1993-06-15

Similar Documents

Publication Publication Date Title
ES2062460T3 (es) Nuevos derivados de la isoindolona, su preparacion y las composiciones farmaceuticas que les contienen.
CO4520184A1 (es) Nuevos taxoides, su preparacion y composiciones farmaceuticas que les contienen
ES2118067T3 (es) Derivados de acido acetico provistos de enlaces peptidicos.
ES2040276T3 (es) Derivados de la indolizina, procedimiento para su preparacion y composiciones que los contienen.
ES2173899T3 (es) Acetales de bis (3,4-dialquil bencilideno) sorbitol y composiciones que los contienen.
DK51986A (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som insecticide midler
ES2166379T3 (es) 2-aminotetralinas sustituidas.
YU30592A (sh) Novi derivati indola i postupci dobijanja
CO4410331A1 (es) Derivados triciclicos del pirazol
DE3881483D1 (de) Photographisches element, das gelbe filterfarbstoffe mit tricyanvinylgruppen enthaelt.
ES487677A1 (es) Procedimiento para la preparacion de derivados de aril-ete- res
IT1125795B (it) Apparecchio a fibre cave per il frazionamento di fluido,utilizzabile in particolare come rene artificiale
DE3778396D1 (de) 1h-imidazol-5-carbonsaeurederivate.
FI851934L (fi) Kefalosporinderivat.
ES2108595B1 (es) Derivados de la 3(2h)-piridacinona y procedimiento para su preparacion.
FR2558837B1 (fr) Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
ES8706690A1 (es) Un procedimiento para la preparacion de nuevos derivados de penem.
ES2081858T3 (es) Compuestos de beta-fenoxinitrilo.
BG92842A (bg) Метод за получаване на бета-карбонил-карбоксиамиди на 1,3-тиазолидини
ES8304933A1 (es) Procedimiento para preparar derivados de sulfonilurea de efecto antidoto contra herbicidas del tipo tiolcarbamato.
NO880143D0 (no) Soetemiddel.
ES2061530T3 (es) 9-amino-1,4-etano-1,2,3,4-tetrahidroacridina y compuestos afines, intermediarios y un procedimiento para la preparacion de los mismos y su uso como medicamentos.
DK0457215T3 (da) 3-deamino-4-desoxy-4-amino-8-fluoranthracycliner samt fremgangsmåder til fremstilling deraf
DE68922571D1 (de) N-Sulfenylierte und N-acylierte Pyrazoline.
ES2058557T3 (es) Monoesteres de un acido arilacetico, su produccion y uso.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 506532

Country of ref document: ES