NO178260C - Indolderivater, mellomproduktforbindelser for deres fremstilling, anvendelse derav samt farmasöytisk preparat - Google Patents

Indolderivater, mellomproduktforbindelser for deres fremstilling, anvendelse derav samt farmasöytisk preparat

Info

Publication number
NO178260C
NO178260C NO921141A NO921141A NO178260C NO 178260 C NO178260 C NO 178260C NO 921141 A NO921141 A NO 921141A NO 921141 A NO921141 A NO 921141A NO 178260 C NO178260 C NO 178260C
Authority
NO
Norway
Prior art keywords
alkyl
alkylamino
phenyl
benzyl
optionally substituted
Prior art date
Application number
NO921141A
Other languages
English (en)
Other versions
NO178260B (no
NO921141L (no
NO921141D0 (no
Inventor
Didier Festal
Denis Descours
Robert Bellemin
Jacques Decerprit
Original Assignee
Lipha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha filed Critical Lipha
Publication of NO921141D0 publication Critical patent/NO921141D0/no
Publication of NO921141L publication Critical patent/NO921141L/no
Publication of NO178260B publication Critical patent/NO178260B/no
Publication of NO178260C publication Critical patent/NO178260C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16Tryptamines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO921141A 1991-03-26 1992-03-24 Indolderivater, mellomproduktforbindelser for deres fremstilling, anvendelse derav samt farmasöytisk preparat NO178260C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9103618A FR2674522B1 (fr) 1991-03-26 1991-03-26 Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.

Publications (4)

Publication Number Publication Date
NO921141D0 NO921141D0 (no) 1992-03-24
NO921141L NO921141L (no) 1992-09-28
NO178260B NO178260B (no) 1995-11-13
NO178260C true NO178260C (no) 1996-02-21

Family

ID=9411107

Family Applications (1)

Application Number Title Priority Date Filing Date
NO921141A NO178260C (no) 1991-03-26 1992-03-24 Indolderivater, mellomproduktforbindelser for deres fremstilling, anvendelse derav samt farmasöytisk preparat

Country Status (25)

Country Link
US (1) US5219859A (no)
EP (1) EP0506532B1 (no)
JP (1) JPH0597802A (no)
KR (1) KR950007753B1 (no)
AT (1) ATE111078T1 (no)
AU (1) AU658609B2 (no)
CA (1) CA2063170A1 (no)
CS (1) CS89592A3 (no)
DE (1) DE69200378T2 (no)
DK (1) DK0506532T3 (no)
ES (1) ES2064149T3 (no)
FR (1) FR2674522B1 (no)
HU (1) HUT65489A (no)
IE (1) IE65366B1 (no)
IL (1) IL101248A (no)
MA (1) MA22474A1 (no)
MX (1) MX9201365A (no)
NO (1) NO178260C (no)
NZ (1) NZ242078A (no)
OA (1) OA09573A (no)
RU (1) RU2074179C1 (no)
SI (1) SI9210305A (no)
TN (1) TNSN92022A1 (no)
YU (1) YU30592A (no)
ZA (1) ZA922163B (no)

Families Citing this family (34)

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FR2687402B1 (fr) * 1992-02-14 1995-06-30 Lipha Nouveaux azaindoles, procedes de preparation et medicaments les contenant.
WO1993024458A1 (en) * 1992-05-28 1993-12-09 Pfizer Inc. New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase (acat)
NZ250916A (en) * 1993-02-27 1995-08-28 Nihon Nohyaku Co Ltd N-heteroaryl-n'-phenylureas, their use as acat inhibitors
IL109568A0 (en) * 1993-05-19 1994-08-26 Fujisawa Pharmaceutical Co Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
US5952354A (en) * 1993-07-21 1999-09-14 American Home Products Corporation Tris carbamic acid esters: inhibitors of cholesterol absorption
DE4401893A1 (de) * 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe
JP3720395B2 (ja) 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
KR100241643B1 (ko) * 1995-06-06 2000-03-02 디. 제이. 우드 당뇨병치료제인 치환된 N-(인돌-2-카르보닐)-β-알라님아미드 및 그의 유도체
CA2224062C (en) * 1995-06-06 2001-09-04 Pfizer Limited Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors
FI974437A7 (fi) 1995-06-06 1997-12-05 Pfizer Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogee nifosforylaasi-inhibiittoreina
NZ299242A (en) * 1995-09-11 1997-12-19 Nihon Nohyaku Co Ltd N-phenyl-n'-(phenyl substituted imidazol-5-yl, -oxazol-4-yl, and -thiazol-4-yl)urea derivatives
ATE210116T1 (de) 1995-10-05 2001-12-15 Kyoto Pharma Ind Neue heterozyklische derivate und ihre medizinische anwendung
EP0773218A1 (en) * 1995-11-13 1997-05-14 Mitsubishi Chemical Corporation N-(Piperazinylalkoxyphenyl)-N'phenylalkylurea derivatives as ACAT inhibitors for the treatment of atheroschlerosis
DE19616486C5 (de) * 1996-04-25 2016-06-30 Royalty Pharma Collection Trust Verfahren zur Senkung des Blutglukosespiegels in Säugern
FR2763334A1 (fr) * 1997-05-13 1998-11-20 Lipha Derives anthraniliques
SI1045839T1 (en) * 1997-12-16 2004-06-30 Warner-Lambert Company Llc Novel amines as pharmaceutical agents
CN1131855C (zh) * 1997-12-16 2003-12-24 沃尼尔·朗伯公司 1-取代-1-氨基甲基-环烷衍生物(=加巴喷丁类似物)、其制备及其在治疗神经病方面的用途
CA2304967C (en) * 1997-12-16 2005-06-14 Warner-Lambert Company 4(3)substituted-4(3)-aminomethyl-(thio)pyran or -piperidine derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
SK282727B6 (sk) 1997-12-19 2002-11-06 Slovakofarma, A. S. 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
US7153882B2 (en) 2000-11-02 2006-12-26 The United States Of America As Represented By The Department Of Health And Human Services Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof
MXPA04010780A (es) * 2002-05-03 2005-03-07 Warner Lambert Co Antagonistas de bombesina.
RU2318808C2 (ru) * 2002-07-17 2008-03-10 Киото Фармасьютикал Индастриз, Лтд. Новое соединение индолина и его применение в медицине
EP1615900A1 (en) * 2003-04-01 2006-01-18 Eli Lilly And Company Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors
KR20060111898A (ko) * 2003-08-29 2006-10-30 교와 가부시키가이샤 지질-풍부-플라크의 안정화 방법 및 파열 예방방법
ATE442368T1 (de) 2005-11-30 2009-09-15 Hoffmann La Roche 3-amino-2-arylpropylazaindole und anwendungen davon
JP2009517430A (ja) 2005-11-30 2009-04-30 エフ.ホフマン−ラ ロシュ アーゲー 3−アミノ−1−アリールプロピルインドール類及びアザ置換インドール類
RU2361581C2 (ru) * 2007-09-14 2009-07-20 Закрытое Акционерное Общество "Мастерклон" Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний
SK287385B6 (sk) 2007-11-27 2010-08-09 Hameln-Rds, A. S. 1,3-Disubstituované močoviny, spôsob ich prípravy a použitia
CN104628621A (zh) * 2015-01-22 2015-05-20 湖南华腾制药有限公司 一种氟取代吲哚衍生物的制备方法
WO2018064465A1 (en) 2016-09-29 2018-04-05 The Regents Of The University Of California Compounds for increasing neural plasticity
RU2020102908A (ru) 2017-06-26 2021-07-27 Лунелла Байотек, Инк. Митокетосцины: митохондриальная терапия, нацеленная на кетоновый метаболизм в раковых клетках
CN113784962B (zh) 2019-02-27 2025-04-25 加利福尼亚大学董事会 用于治疗脑部疾病的氮杂环庚三烯并-吲哚类和其他杂环
TW202333668A (zh) 2021-12-15 2023-09-01 美商德利克斯醫療公司 經苯氧基及苄氧基取代之精神成形素(psychoplastogen)及其用途

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Publication number Priority date Publication date Assignee Title
JPS55151505A (en) * 1979-05-14 1980-11-26 Kuraray Co Ltd Indole agricultural and horticultural fungicide
IL85189A (en) * 1987-02-02 1992-06-21 Lilly Co Eli Beta-alkyl substituted melatonins,their preparation and pharmaceutical compositions containing them
EP0375133A1 (en) * 1988-11-14 1990-06-27 The Upjohn Company Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
IE903206A1 (en) * 1989-09-07 1991-03-13 Abbott Lab Indole-, benzofuran-, and benzothiophene-containing¹lipoxygenase-inhibiting compounds
WO1991004027A1 (en) * 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
ATE130002T1 (de) * 1990-08-13 1995-11-15 Hoechst Roussel Pharma 1-(pyridinylalkyl)-1h-indole, -indoline und analoge.
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
WO1993005020A1 (en) * 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase

Also Published As

Publication number Publication date
MA22474A1 (fr) 1992-10-01
DK0506532T3 (da) 1995-02-20
IL101248A0 (en) 1992-11-15
CA2063170A1 (en) 1992-09-27
OA09573A (fr) 1993-01-31
HUT65489A (en) 1994-06-28
DE69200378D1 (de) 1994-10-13
EP0506532A1 (fr) 1992-09-30
DE69200378T2 (de) 1995-03-09
YU30592A (sh) 1994-12-28
ES2064149T3 (es) 1995-01-16
AU658609B2 (en) 1995-04-27
CS89592A3 (en) 1992-10-14
EP0506532B1 (fr) 1994-09-07
US5219859A (en) 1993-06-15
FR2674522B1 (fr) 1993-07-16
KR920018022A (ko) 1992-10-21
MX9201365A (es) 1992-10-01
FR2674522A1 (fr) 1992-10-02
IE65366B1 (en) 1995-10-18
IE920937A1 (en) 1992-10-07
NO178260B (no) 1995-11-13
ATE111078T1 (de) 1994-09-15
NO921141L (no) 1992-09-28
NO921141D0 (no) 1992-03-24
TNSN92022A1 (fr) 1993-06-08
JPH0597802A (ja) 1993-04-20
IL101248A (en) 1996-12-05
AU1309492A (en) 1992-10-01
NZ242078A (en) 1994-10-26
SI9210305A (en) 1996-02-29
ZA922163B (en) 1993-09-27
RU2074179C1 (ru) 1997-02-27
HU9200997D0 (en) 1992-05-28
KR950007753B1 (ko) 1995-07-14

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