ES2065181T3 - Dispositivo de suministro iontoforetico y procedimiento para su fabricacion. - Google Patents

Dispositivo de suministro iontoforetico y procedimiento para su fabricacion.

Info

Publication number
ES2065181T3
ES2065181T3 ES92908542T ES92908542T ES2065181T3 ES 2065181 T3 ES2065181 T3 ES 2065181T3 ES 92908542 T ES92908542 T ES 92908542T ES 92908542 T ES92908542 T ES 92908542T ES 2065181 T3 ES2065181 T3 ES 2065181T3
Authority
ES
Spain
Prior art keywords
agent
vol
typically
case
iontophoretical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92908542T
Other languages
English (en)
Inventor
Robert M Myers
Felix A Landrau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ES2065181T3 publication Critical patent/ES2065181T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE PRESENTA UN DISPOSITIVO DE SUMINISTRO IONTOFORETICO, TRANSDERMICO, ELECTRICAMENTE ALIMENTADO (10, 20) Y UN METODO PARA FABRICAR EL MISMO. EL DISPOSITIVO UTILIZA UNOS ELECTRODOS (8, 9) COMPUESTOS DE UNA MEZCLA SUBSTANCIALMENTE HOMOGENEA DE UNA MATRIZ POLIMERICA QUE CONTIENE ALREDEDOR DE UN 5 Y UN 50% DE SU VOLUMEN DE UN RELLENO CONDUCTOR QUE FORMA UNA RED CONDUCTORA A TRAVES DE LA MATRIZ Y HASTA ALREDEDOR DE UN 50% DEL VOLUMEN DE UN AGENTE QUE SERA IONTOFORETICAMENTE SUMINISTRADO A TRAVES DE LA PIEL. EN EL CASO DEL ELECTRODO DONANTE, EL AGENTE ES TIPICAMENTE UNA DROGA Y PREFERIBLEMENTE UNA SAL DE UNA DROGA SOLUBLE EN AGUA. EN EL CASO DEL ELECTRODO CONTRARIO, EL AGENTE ES TIPICAMENTE UNA SAL DE ELECTROLITO. LA MEZCLA HOMOGENEA ELIMINA LA NECESIDAD DE ELECTRODOS SEPARADOS Y AGENTES QUE CONTENGAN CAPAS QUE REQUIERAN LAMINACION.
ES92908542T 1991-03-11 1992-03-09 Dispositivo de suministro iontoforetico y procedimiento para su fabricacion. Expired - Lifetime ES2065181T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66771491A 1991-03-11 1991-03-11

Publications (1)

Publication Number Publication Date
ES2065181T3 true ES2065181T3 (es) 1995-02-01

Family

ID=24679337

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92908542T Expired - Lifetime ES2065181T3 (es) 1991-03-11 1992-03-09 Dispositivo de suministro iontoforetico y procedimiento para su fabricacion.

Country Status (13)

Country Link
US (2) US5543098A (es)
EP (1) EP0575508B1 (es)
JP (1) JPH06505413A (es)
AT (1) ATE112496T1 (es)
AU (1) AU1586692A (es)
DE (1) DE69200506T2 (es)
DK (1) DK0575508T3 (es)
ES (1) ES2065181T3 (es)
IE (1) IE920763A1 (es)
MX (1) MX9201029A (es)
PT (1) PT100215A (es)
WO (1) WO1992015365A1 (es)
ZA (1) ZA921736B (es)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5322520A (en) * 1992-11-12 1994-06-21 Implemed, Inc. Iontophoretic structure for medical devices
US6060000A (en) * 1992-11-12 2000-05-09 Implemed, Inc. Iontophoretic material containing carbon and metal granules
FR2722993B1 (fr) * 1994-07-26 1996-09-27 Elf Aquitaine Dispositif d'ionophorese comportant au moins un ensemble electrode a electrode composite reversible
JPH08155041A (ja) * 1994-12-05 1996-06-18 Advance Co Ltd イオントフォレシス用新規高能率電極システム
ATE263597T1 (de) * 1995-06-05 2004-04-15 Alza Corp Vorrichtung zur transdermalen iontophoretischen verabreichung von fentanyl und sufentanil
EP1762268A1 (en) * 1995-09-29 2007-03-14 Vyteris, Inc. Low-cost electrodes for an iontophoretic device
CA2242753A1 (en) 1996-01-30 1997-08-07 Novagent Oy Composition for transdermal delivery of drugs
JP3459724B2 (ja) * 1996-03-17 2003-10-27 久光製薬株式会社 イオントフォレーシス用電極デバイス
DK0898467T3 (da) * 1996-04-16 2004-11-29 Pathagon Inc Iontoforetisk struktur
FI962461A7 (fi) * 1996-06-13 1997-12-14 Novagent Oy Menetelmä ja farmaseuttinen kompositio ihon läpi tehtävään lääkkeen antoon
US6246904B1 (en) * 1996-12-17 2001-06-12 Alza Corporation Electrotransport drug delivery reservoirs containing inert fillers
EP1030560B1 (en) 1997-10-09 2007-09-26 Emory University Method and devices for transdermal delivery of lithium
ATE274973T1 (de) * 1998-01-28 2004-09-15 Alza Corp Electrochemisch reaktive kathode für elektrotransport gerät
EP0962233A1 (fr) * 1998-06-03 1999-12-08 Sport-Elec S.A. Dispositif d'electrode pour electrotherapie
US6192270B1 (en) 1998-08-14 2001-02-20 Genetronics, Inc. Apparatus and method for the delivery of drugs and genes into tissue
US6424862B1 (en) 1999-02-10 2002-07-23 Gmp Drug Delivery, Inc. Iontophoresis electroporation and combination patches for local drug delivery to body tissues
KR20020048425A (ko) * 1999-09-30 2002-06-22 해리 제이. 레온 하르트 마이크로전자 어레이 상의 생체분자 부착 부위
US6303082B1 (en) * 1999-12-15 2001-10-16 Nanogen, Inc. Permeation layer attachment chemistry and method
US6629968B1 (en) * 2000-06-30 2003-10-07 Vyteris, Inc. Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode
DE20109614U1 (de) 2001-03-05 2001-09-06 Zimmermann, Johann, Dipl.-Ing., 88281 Schlier Elektrode für das Sammeln von Körpersäften und dem Verabreichen von Wirkstoffen/Arzneien durch die Haut,transdermal ohne die Haut zu penetrieren, und dies bei Mensch und Tier
US20140163060A1 (en) * 2001-10-12 2014-06-12 Monosol Rx, Llc Films and Drug Delivery Systems Made Therefrom
IL161529A0 (en) * 2001-10-31 2004-09-27 R & R Ventures Inc Iontophoresis device
US7349733B2 (en) * 2001-11-02 2008-03-25 Ceramatel, Inc. Iontophoretic drug delivery systems
US6960298B2 (en) 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
US6998193B2 (en) 2001-12-28 2006-02-14 Policell Technologies, Inc. Microporous membrane and its uses thereof
US6527955B1 (en) * 2001-12-28 2003-03-04 Policell Technologies, Inc. Heat-activatable microporous membrane and its uses in batteries
US6815123B2 (en) * 2001-12-28 2004-11-09 Policell Technologies, Inc. Lithium-ion battery using heat-activatable microporous membrane
US6775570B2 (en) 2002-02-04 2004-08-10 Ceramatec, Inc. Iontophoretic treatment device
US7047069B2 (en) 2002-02-04 2006-05-16 Ceramatec, Inc. Iontophoretic fluid delivery device
DE10205373B4 (de) * 2002-02-09 2007-07-19 Aloys Wobben Brandschutz
US20040009398A1 (en) * 2002-06-19 2004-01-15 Dorfman Jay Robert Zinc polymer thick film composition
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
US8133505B2 (en) 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152573A (en) * 2002-10-31 2009-11-18 Transpharma Medical Ltd A system for the transmission through the skin of a medical preparation against vomiting and nausea
IL152575A (en) * 2002-10-31 2008-12-29 Transpharma Medical Ltd A skin-to-skin transmission system of water-insoluble drugs
US7383084B2 (en) * 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US7662404B2 (en) * 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
IL159273A0 (en) * 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
JP4728631B2 (ja) * 2004-11-30 2011-07-20 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
US7590444B2 (en) * 2004-12-09 2009-09-15 Tti Ellebeau, Inc. Iontophoresis device
JP4731931B2 (ja) * 2005-02-03 2011-07-27 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
JP4793806B2 (ja) * 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
JP2006346368A (ja) * 2005-06-20 2006-12-28 Transcutaneous Technologies Inc イオントフォレーシス装置及びその製造方法
US20070027426A1 (en) * 2005-06-24 2007-02-01 Transcutaneous Technologies Inc. Iontophoresis device to deliver active agents to biological interfaces
EP1905433A1 (en) * 2005-07-15 2008-04-02 Transcu Ltd. Percutaneous absorption patch with application position indicating function, and iontophoresis device
JP2007037868A (ja) * 2005-08-05 2007-02-15 Transcutaneous Technologies Inc 経皮投与装置及びその制御方法
US8295922B2 (en) 2005-08-08 2012-10-23 Tti Ellebeau, Inc. Iontophoresis device
US8386030B2 (en) 2005-08-08 2013-02-26 Tti Ellebeau, Inc. Iontophoresis device
US20070060860A1 (en) * 2005-08-18 2007-03-15 Transcutaneous Technologies Inc. Iontophoresis device
US20070088331A1 (en) * 2005-08-18 2007-04-19 Transcutaneous Technologies Inc. Method and apparatus for managing active agent usage, and active agent injecting device
WO2007023907A1 (ja) * 2005-08-24 2007-03-01 Transcu Ltd. 冷凍型イオントフォレーシス用電極構造体
JPWO2007026671A1 (ja) * 2005-08-29 2009-03-05 Ｔｔｉ・エルビュー株式会社 センサからの情報により投与すべき薬剤の選定を行うイオントフォレーシス装置
US20100030128A1 (en) * 2005-09-06 2010-02-04 Kazuma Mitsuguchi Iontophoresis device
KR20080047600A (ko) 2005-09-15 2008-05-29 티티아이 엘뷰 가부시키가이샤 로드형 이온토포레시스 장치
BRPI0616166A2 (pt) * 2005-09-16 2011-06-07 Tti Ellebeau Inc dispositivo de iontoforese do tipo de cateter
US20090299265A1 (en) * 2005-09-30 2009-12-03 Tti Ellebeau, Inc. Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same
US20070093787A1 (en) * 2005-09-30 2007-04-26 Transcutaneous Technologies Inc. Iontophoresis device to deliver multiple active agents to biological interfaces
JP2009509657A (ja) 2005-09-30 2009-03-12 Ｔｔｉ・エルビュー株式会社 生体界面への活性物質の送達のイオントフォレーシス装置及び方法
WO2007041526A2 (en) * 2005-09-30 2007-04-12 Transcutaneous Technologies Inc. Iontophoresis apparatus and method to deliver antibiotics to biological interfaces
JPWO2007037476A1 (ja) * 2005-09-30 2009-04-16 Ｔｔｉ・エルビュー株式会社 睡眠導入剤と興奮剤の投与量および投与時期を制御するイオントフォレーシス装置
US20070197955A1 (en) * 2005-10-12 2007-08-23 Transcutaneous Technologies Inc. Mucous membrane adhesion-type iontophoresis device
JP4804904B2 (ja) * 2005-12-09 2011-11-02 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置包装品
WO2007079116A1 (en) * 2005-12-28 2007-07-12 Tti Ellebeau, Inc. Electroosmotic pump apparatus and method to deliver active agents to biological interfaces
US7744591B2 (en) * 2005-12-29 2010-06-29 Boston Scientific Scimed, Inc. Foam electrode and method of use thereof during tissue resection
WO2007079190A2 (en) * 2005-12-29 2007-07-12 Tti Ellebeau, Inc. Device and method for enhancing immune response by electrical stimulation
WO2007123707A1 (en) * 2006-03-30 2007-11-01 Tti Ellebeau, Inc. Controlled release membrane and methods of use
WO2007142579A1 (en) * 2006-06-05 2007-12-13 Bactiguard Ab A polymer matrix, uses thereof and a method of manufacturing the same
US20080058701A1 (en) * 2006-07-05 2008-03-06 Transcutaneous Technologies Inc. Delivery device having self-assembling dendritic polymers and method of use thereof
US7687103B2 (en) * 2006-08-31 2010-03-30 Gamida For Life B.V. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
WO2008030497A2 (en) * 2006-09-05 2008-03-13 Tti Ellebeau, Inc. Transdermal drug delivery systems, devices, and methods using inductive power supplies
TW200838576A (en) 2006-12-01 2008-10-01 Transcu Ltd Systems, devices and methods for powering and/or controlling transdermal delivery devices
US20080177219A1 (en) * 2007-01-23 2008-07-24 Joshi Ashok V Method for Iontophoretic Fluid Delivery
US20080188791A1 (en) * 2007-02-02 2008-08-07 Difiore Attilio E Active iontophoresis delivery system
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
CN102159205A (zh) * 2008-06-25 2011-08-17 Fe3医学有限公司 用于经皮递送治疗有效量的铁的贴片和方法
AR074047A1 (es) * 2008-09-09 2010-12-22 Transcu Ltd Sistemas, dispositivos, y metodos para suministrar energia a dispositivos, por ejemplo dispositivos de administracion transdermica y/o para controlarlos
JP2012501801A (ja) * 2008-09-10 2012-01-26 トランスキュー リミテッド ヒドロキシプロピルセルロース（ｈｐｃ）をベースにした粘性液体を多孔質基材に薬剤投与する装置および方法、例えば連続ウェブをベースにしたプロセス
WO2010050510A1 (ja) * 2008-10-28 2010-05-06 大塚製薬株式会社 羅漢果抽出物及びスクラロースを含有する低カロリー飲料組成物
KR101674904B1 (ko) 2009-02-26 2016-11-10 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 중재형 약물전달 시스템과 그 방법
US8821945B2 (en) * 2009-04-25 2014-09-02 Fe3 Medical, Inc. Method for transdermal iontophoretic delivery of chelated agents
EP2440694A4 (en) * 2009-06-09 2012-12-19 Tti Ellebeau Inc DURABLE HIGH-CAPACITY ELECTRODE AND METHOD OF MANUFACTURING THEREOF
FR2983075B1 (fr) * 2011-11-24 2014-08-15 Ab7 Innovation Procede de chargement de plaquette polymere en solution medicamenteuse ionisee amphiphile pour administration transdermique par iontophorese
US9949935B2 (en) 2014-04-08 2018-04-24 Teikoku Pharma Usa, Inc. Rivastigmine transdermal compositions and methods of using the same
JP2018024608A (ja) * 2016-08-10 2018-02-15 株式会社リコー 生体組織貼付用電極シート

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE410009C (de) * 1923-12-25 1925-02-21 Willi Reiche Dipl Ing Sprungwellenschutz fuer die Induktionswicklungen elektrischer Apparate und Maschinen
BE399044A (es) * 1933-09-09
CA1008623A (en) * 1972-02-11 1977-04-19 Gould Inc. Process and apparatus for manufacture of an electrode
US3991755A (en) * 1973-07-27 1976-11-16 Medicon, Inc. Iontophoresis apparatus for applying local anesthetics
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
JPS56501274A (es) * 1979-10-10 1981-09-10
DE2941774C2 (de) * 1979-10-16 1985-03-21 Varta Batterie Ag, 3000 Hannover Verfahren und Vorrichtung zur Herstellung einer kunststoffgebundenen Aktivkohleschicht für dünne Gasdiffusionselektroden
US4367745A (en) * 1980-05-27 1983-01-11 Minnesota Mining And Manufacturing Company Conformable electrically conductive compositions
US4383529A (en) * 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
US5087240A (en) * 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4640689A (en) * 1983-08-18 1987-02-03 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4921475A (en) * 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
CA1262564A (en) * 1983-09-01 1989-10-31 Minoru Sasaki Iontophoresis device
US4904247A (en) * 1984-08-31 1990-02-27 Kendall Company Pressure-sensitive hydrophilic laminate structures for use in wound dressing, transdermal and topical drug delivery
US4747819A (en) * 1984-10-29 1988-05-31 Medtronic, Inc. Iontophoretic drug delivery
US4744787A (en) * 1984-10-29 1988-05-17 Medtronic, Inc. Iontophoresis apparatus and methods of producing same
US4702732A (en) * 1984-12-24 1987-10-27 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands
US4752285B1 (en) * 1986-03-19 1995-08-22 Univ Utah Res Found Methods and apparatus for iontophoresis application of medicaments
IE60941B1 (en) * 1986-07-10 1994-09-07 Elan Transdermal Ltd Transdermal drug delivery device
US4731049A (en) * 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
US5032109A (en) * 1987-02-10 1991-07-16 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US4957593A (en) * 1989-03-07 1990-09-18 University Of Connecticut Modified composite electrodes with renewable surface for electrochemical applications and method of making same
US5084006A (en) * 1990-03-30 1992-01-28 Alza Corporation Iontopheretic delivery device
US5147297A (en) * 1990-05-07 1992-09-15 Alza Corporation Iontophoretic delivery device
US5236647A (en) * 1992-05-11 1993-08-17 E. I. Du Pont De Nemours And Company Electrostatic dissipative material and process relating thereto

Also Published As

Publication number Publication date
DK0575508T3 (da) 1994-11-14
EP0575508B1 (en) 1994-10-05
DE69200506T2 (de) 1995-02-02
PT100215A (pt) 1994-04-29
EP0575508A1 (en) 1993-12-29
DE69200506D1 (de) 1994-11-10
WO1992015365A1 (en) 1992-09-17
IE920763A1 (en) 1992-09-23
US5543098A (en) 1996-08-06
JPH06505413A (ja) 1994-06-23
MX9201029A (es) 1992-09-01
ZA921736B (en) 1992-11-25
ATE112496T1 (de) 1994-10-15
US5618265A (en) 1997-04-08
AU1586692A (en) 1992-10-06

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