ATE112496T1 - Iontophoretisches verabreichungssystem und verfahren zu seiner herstellung. - Google Patents

Iontophoretisches verabreichungssystem und verfahren zu seiner herstellung.

Info

Publication number
ATE112496T1
ATE112496T1 AT92908542T AT92908542T ATE112496T1 AT E112496 T1 ATE112496 T1 AT E112496T1 AT 92908542 T AT92908542 T AT 92908542T AT 92908542 T AT92908542 T AT 92908542T AT E112496 T1 ATE112496 T1 AT E112496T1
Authority
AT
Austria
Prior art keywords
agent
vol
typically
iontophoretic delivery
case
Prior art date
Application number
AT92908542T
Other languages
English (en)
Inventor
Robert M Myers
Felix A Landrau
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ATE112496T1 publication Critical patent/ATE112496T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/0436Material of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448Drug reservoir

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Electrotherapy Devices (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Peptides Or Proteins (AREA)
AT92908542T 1991-03-11 1992-03-09 Iontophoretisches verabreichungssystem und verfahren zu seiner herstellung. ATE112496T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66771491A 1991-03-11 1991-03-11

Publications (1)

Publication Number Publication Date
ATE112496T1 true ATE112496T1 (de) 1994-10-15

Family

ID=24679337

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92908542T ATE112496T1 (de) 1991-03-11 1992-03-09 Iontophoretisches verabreichungssystem und verfahren zu seiner herstellung.

Country Status (13)

Country Link
US (2) US5543098A (de)
EP (1) EP0575508B1 (de)
JP (1) JPH06505413A (de)
AT (1) ATE112496T1 (de)
AU (1) AU1586692A (de)
DE (1) DE69200506T2 (de)
DK (1) DK0575508T3 (de)
ES (1) ES2065181T3 (de)
IE (1) IE920763A1 (de)
MX (1) MX9201029A (de)
PT (1) PT100215A (de)
WO (1) WO1992015365A1 (de)
ZA (1) ZA921736B (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5322520A (en) * 1992-11-12 1994-06-21 Implemed, Inc. Iontophoretic structure for medical devices
US6060000A (en) * 1992-11-12 2000-05-09 Implemed, Inc. Iontophoretic material containing carbon and metal granules
FR2722993B1 (fr) * 1994-07-26 1996-09-27 Elf Aquitaine Dispositif d'ionophorese comportant au moins un ensemble electrode a electrode composite reversible
JPH08155041A (ja) * 1994-12-05 1996-06-18 Advance Co Ltd イオントフォレシス用新規高能率電極システム
EP0836511B1 (de) * 1995-06-05 2004-04-07 Alza Corporation Vorrichtung zur transdermalen iontophoretischen verabreichung von fentanyl und sufentanil
WO1997011744A1 (en) * 1995-09-29 1997-04-03 Becton Dickinson And Company Low-cost electrodes for an iontophoretic device
EP0942716B1 (de) 1996-01-30 2005-05-11 Novagent Oy Mittel zur transdermalen verabreichung von arzneistoffen
JP3459724B2 (ja) * 1996-03-17 2003-10-27 久光製薬株式会社 イオントフォレーシス用電極デバイス
ATE271839T1 (de) * 1996-04-16 2004-08-15 Pathagon Inc Iontophoretische struktur
FI962461A7 (fi) * 1996-06-13 1997-12-14 Novagent Oy Menetelmä ja farmaseuttinen kompositio ihon läpi tehtävään lääkkeen antoon
US6246904B1 (en) * 1996-12-17 2001-06-12 Alza Corporation Electrotransport drug delivery reservoirs containing inert fillers
CA2308489A1 (en) 1997-10-09 1999-04-22 Emory University Method and devices for transdermal delivery of lithium
DK1051219T3 (da) * 1998-01-28 2005-01-10 Alza Corp Elektrokemisk reaktive katoder for en elektrotransportanordning
EP0962233A1 (de) * 1998-06-03 1999-12-08 Sport-Elec S.A. Elektrodeneinheit zur Elektrotherapie
US6192270B1 (en) 1998-08-14 2001-02-20 Genetronics, Inc. Apparatus and method for the delivery of drugs and genes into tissue
JP2002536133A (ja) 1999-02-10 2002-10-29 ジーエムピー ドラッグ デリバリー インコーポレイテッド 局所薬物送達用のイオン導入パッチ、電気穿孔パッチおよび併用パッチ
WO2001023082A2 (en) * 1999-09-30 2001-04-05 Nanogen, Inc. Biomolecular attachment sites on microelectronic arrays
US6303082B1 (en) * 1999-12-15 2001-10-16 Nanogen, Inc. Permeation layer attachment chemistry and method
US6629968B1 (en) * 2000-06-30 2003-10-07 Vyteris, Inc. Shelf storage stable iontophoresis reservoir-electrode and iontophoretic system incorporating the reservoir-electrode
DE20109614U1 (de) 2001-03-05 2001-09-06 Zimmermann, Johann, Dipl.-Ing., 88281 Schlier Elektrode für das Sammeln von Körpersäften und dem Verabreichen von Wirkstoffen/Arzneien durch die Haut,transdermal ohne die Haut zu penetrieren, und dies bei Mensch und Tier
US20140163060A1 (en) * 2001-10-12 2014-06-12 Monosol Rx, Llc Films and Drug Delivery Systems Made Therefrom
SK2312004A3 (en) * 2001-10-31 2004-10-05 R & R Ventures Inc Iontophoresis device
US7349733B2 (en) * 2001-11-02 2008-03-25 Ceramatel, Inc. Iontophoretic drug delivery systems
US6960298B2 (en) * 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
US6527955B1 (en) * 2001-12-28 2003-03-04 Policell Technologies, Inc. Heat-activatable microporous membrane and its uses in batteries
US6998193B2 (en) 2001-12-28 2006-02-14 Policell Technologies, Inc. Microporous membrane and its uses thereof
US6815123B2 (en) * 2001-12-28 2004-11-09 Policell Technologies, Inc. Lithium-ion battery using heat-activatable microporous membrane
US6775570B2 (en) 2002-02-04 2004-08-10 Ceramatec, Inc. Iontophoretic treatment device
US7047069B2 (en) 2002-02-04 2006-05-16 Ceramatec, Inc. Iontophoretic fluid delivery device
DE10205373B4 (de) * 2002-02-09 2007-07-19 Aloys Wobben Brandschutz
US20040009398A1 (en) * 2002-06-19 2004-01-15 Dorfman Jay Robert Zinc polymer thick film composition
IL152575A (en) * 2002-10-31 2008-12-29 Transpharma Medical Ltd A skin-to-skin transmission system of water-insoluble drugs
IL152574A (en) * 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
US7662404B2 (en) * 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
US8133505B2 (en) 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152573A (en) * 2002-10-31 2009-11-18 Transpharma Medical Ltd A system for the transmission through the skin of a medical preparation against vomiting and nausea
US7383084B2 (en) * 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL159273A0 (en) * 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
JP4728631B2 (ja) * 2004-11-30 2011-07-20 Tti・エルビュー株式会社 イオントフォレーシス装置
US7590444B2 (en) * 2004-12-09 2009-09-15 Tti Ellebeau, Inc. Iontophoresis device
JP4731931B2 (ja) * 2005-02-03 2011-07-27 Tti・エルビュー株式会社 イオントフォレーシス装置
JP4793806B2 (ja) * 2005-03-22 2011-10-12 Tti・エルビュー株式会社 イオントフォレーシス装置
JP2006346368A (ja) * 2005-06-20 2006-12-28 Transcutaneous Technologies Inc イオントフォレーシス装置及びその製造方法
US20070027426A1 (en) * 2005-06-24 2007-02-01 Transcutaneous Technologies Inc. Iontophoresis device to deliver active agents to biological interfaces
US20090214625A1 (en) * 2005-07-15 2009-08-27 Mizuo Nakayama Drug delivery patch
JP2007037868A (ja) * 2005-08-05 2007-02-15 Transcutaneous Technologies Inc 経皮投与装置及びその制御方法
US8295922B2 (en) 2005-08-08 2012-10-23 Tti Ellebeau, Inc. Iontophoresis device
US8386030B2 (en) 2005-08-08 2013-02-26 Tti Ellebeau, Inc. Iontophoresis device
US20070060860A1 (en) * 2005-08-18 2007-03-15 Transcutaneous Technologies Inc. Iontophoresis device
US20070088331A1 (en) * 2005-08-18 2007-04-19 Transcutaneous Technologies Inc. Method and apparatus for managing active agent usage, and active agent injecting device
JPWO2007023907A1 (ja) * 2005-08-24 2009-02-26 Tti・エルビュー株式会社 冷凍型イオントフォレーシス用電極構造体
JPWO2007026671A1 (ja) * 2005-08-29 2009-03-05 Tti・エルビュー株式会社 センサからの情報により投与すべき薬剤の選定を行うイオントフォレーシス装置
US20100030128A1 (en) * 2005-09-06 2010-02-04 Kazuma Mitsuguchi Iontophoresis device
CN101252968A (zh) 2005-09-15 2008-08-27 Tti优而美株式会社 棒式离子电渗疗装置
AU2006289888B2 (en) * 2005-09-16 2010-12-02 Tti Ellebeau, Inc. Catheter type iontophoresis apparatus
WO2007037475A1 (ja) * 2005-09-30 2007-04-05 Tti Ellebeau, Inc. 形状記憶セパレータを有するイオントフォレーシス用電極構造体およびそれを用いたイオントフォレーシス装置
EP1944057A4 (de) * 2005-09-30 2009-02-18 Tti Ellebeau Inc Iontophorese-gerät zur kontrolle der dosis und zeit der verabreichung eines schlafinduzierenden und analeptischen mittels
RU2008117153A (ru) * 2005-09-30 2009-11-10 ТиТиАй ЭЛЛЕБО, ИНК. (JP) Аппарат для ионтофореза, доставляющий множество активных агентов к биологическим барьерам
WO2007041526A2 (en) * 2005-09-30 2007-04-12 Transcutaneous Technologies Inc. Iontophoresis apparatus and method to deliver antibiotics to biological interfaces
CA2664589A1 (en) 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Iontophoretic device and method of delivery of active agents to biological interface
US20070197955A1 (en) * 2005-10-12 2007-08-23 Transcutaneous Technologies Inc. Mucous membrane adhesion-type iontophoresis device
JP4804904B2 (ja) * 2005-12-09 2011-11-02 Tti・エルビュー株式会社 イオントフォレーシス装置包装品
US20080033338A1 (en) * 2005-12-28 2008-02-07 Smith Gregory A Electroosmotic pump apparatus and method to deliver active agents to biological interfaces
WO2007092101A2 (en) * 2005-12-29 2007-08-16 Boston Scientific Limited Foam electrode for tissue resection
WO2007079190A2 (en) * 2005-12-29 2007-07-12 Tti Ellebeau, Inc. Device and method for enhancing immune response by electrical stimulation
US20080004564A1 (en) * 2006-03-30 2008-01-03 Transcutaneous Technologies Inc. Controlled release membrane and methods of use
US8497017B2 (en) * 2006-06-05 2013-07-30 Bactiguard Ab Polymer matrix, uses thereof and a method of manufacturing the same
MX2008016186A (es) * 2006-07-05 2009-01-20 Tti Ellebeau Inc Dispositivo de suministro que tiene polimeros dendriticos autoensamblables y metodo de uso del mismo.
US7687103B2 (en) * 2006-08-31 2010-03-30 Gamida For Life B.V. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
WO2008030497A2 (en) * 2006-09-05 2008-03-13 Tti Ellebeau, Inc. Transdermal drug delivery systems, devices, and methods using inductive power supplies
BRPI0719353A2 (pt) 2006-12-01 2014-01-07 Titi Ellebeau Inc Sistemas, dispositivos e métodos para dispositivos de energização e/ou controle, por exemplo, dispositivos de distribuição transdérmicos
US20080177219A1 (en) * 2007-01-23 2008-07-24 Joshi Ashok V Method for Iontophoretic Fluid Delivery
US20080188791A1 (en) * 2007-02-02 2008-08-07 Difiore Attilio E Active iontophoresis delivery system
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
WO2009158032A1 (en) * 2008-06-25 2009-12-30 Fe2, Inc. Patches and methods for the transdermal delivery of a therapeutically effective amount of iron
AR074047A1 (es) * 2008-09-09 2010-12-22 Transcu Ltd Sistemas, dispositivos, y metodos para suministrar energia a dispositivos, por ejemplo dispositivos de administracion transdermica y/o para controlarlos
US20100069877A1 (en) * 2008-09-10 2010-03-18 Smith Gregory A Apparatus and method to dispense hpc-based viscous liquids into porous substrates, e.g., continuous web-based process
EP2345337B1 (de) * 2008-10-28 2016-06-01 Otsuka Pharmaceutical Co., Ltd. Kalorienarme getränkezusammensetzung mit luo-han-guo-extrakt und sucralose
KR101674904B1 (ko) 2009-02-26 2016-11-10 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 중재형 약물전달 시스템과 그 방법
US8821945B2 (en) * 2009-04-25 2014-09-02 Fe3 Medical, Inc. Method for transdermal iontophoretic delivery of chelated agents
EP2440694A4 (de) * 2009-06-09 2012-12-19 Tti Ellebeau Inc Langlebige elektrode von hoher kapazität und herstellungsverfahren dafür
FR2983075B1 (fr) * 2011-11-24 2014-08-15 Ab7 Innovation Procede de chargement de plaquette polymere en solution medicamenteuse ionisee amphiphile pour administration transdermique par iontophorese
WO2015156990A1 (en) 2014-04-08 2015-10-15 Teikoku Pharma Usa, Inc. Rivastigmine transdermal compositions and methods of using the same
JP2018024608A (ja) * 2016-08-10 2018-02-15 株式会社リコー 生体組織貼付用電極シート

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE410009C (de) * 1923-12-25 1925-02-21 Willi Reiche Dipl Ing Sprungwellenschutz fuer die Induktionswicklungen elektrischer Apparate und Maschinen
BE399044A (de) * 1933-09-09
CA1008623A (en) * 1972-02-11 1977-04-19 Gould Inc. Process and apparatus for manufacture of an electrode
US3991755A (en) * 1973-07-27 1976-11-16 Medicon, Inc. Iontophoresis apparatus for applying local anesthetics
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
BR8008859A (pt) * 1979-10-10 1981-08-25 Cyclotech Med Ind Bandagem bloqueadora de dor
DE2941774C2 (de) * 1979-10-16 1985-03-21 Varta Batterie Ag, 3000 Hannover Verfahren und Vorrichtung zur Herstellung einer kunststoffgebundenen Aktivkohleschicht für dünne Gasdiffusionselektroden
US4367745A (en) * 1980-05-27 1983-01-11 Minnesota Mining And Manufacturing Company Conformable electrically conductive compositions
US4383529A (en) * 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
US4640689A (en) * 1983-08-18 1987-02-03 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4921475A (en) * 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US5087240A (en) * 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
CA1262564A (en) * 1983-09-01 1989-10-31 Minoru Sasaki Iontophoresis device
US4904247A (en) * 1984-08-31 1990-02-27 Kendall Company Pressure-sensitive hydrophilic laminate structures for use in wound dressing, transdermal and topical drug delivery
US4744787A (en) * 1984-10-29 1988-05-17 Medtronic, Inc. Iontophoresis apparatus and methods of producing same
US4747819A (en) * 1984-10-29 1988-05-31 Medtronic, Inc. Iontophoretic drug delivery
US4702732A (en) * 1984-12-24 1987-10-27 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands
US4752285B1 (en) * 1986-03-19 1995-08-22 Univ Utah Res Found Methods and apparatus for iontophoresis application of medicaments
IE60941B1 (en) * 1986-07-10 1994-09-07 Elan Transdermal Ltd Transdermal drug delivery device
US4731049A (en) * 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
US5032109A (en) * 1987-02-10 1991-07-16 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US4957593A (en) * 1989-03-07 1990-09-18 University Of Connecticut Modified composite electrodes with renewable surface for electrochemical applications and method of making same
US5084006A (en) * 1990-03-30 1992-01-28 Alza Corporation Iontopheretic delivery device
US5147297A (en) * 1990-05-07 1992-09-15 Alza Corporation Iontophoretic delivery device
US5236647A (en) * 1992-05-11 1993-08-17 E. I. Du Pont De Nemours And Company Electrostatic dissipative material and process relating thereto

Also Published As

Publication number Publication date
US5543098A (en) 1996-08-06
AU1586692A (en) 1992-10-06
ZA921736B (en) 1992-11-25
WO1992015365A1 (en) 1992-09-17
US5618265A (en) 1997-04-08
EP0575508A1 (de) 1993-12-29
DK0575508T3 (da) 1994-11-14
EP0575508B1 (de) 1994-10-05
JPH06505413A (ja) 1994-06-23
DE69200506D1 (de) 1994-11-10
IE920763A1 (en) 1992-09-23
ES2065181T3 (es) 1995-02-01
DE69200506T2 (de) 1995-02-02
MX9201029A (es) 1992-09-01
PT100215A (pt) 1994-04-29

Similar Documents

Publication Publication Date Title
DE69200506D1 (de) Iontophoretisches verabreichungssystem und verfahren zu seiner herstellung.
US6635045B2 (en) Electrodes and method for manufacturing electrodes for electrically assisted drug delivery
EP0612258B1 (de) Vorrichtung zur verabreichung von heilmitteln
KR970004037B1 (ko) 폴리펩티드의 전해식 경피투여
US6064908A (en) Device for ionophoresis comprising at least a membrane electrode assembly, for the transcutaneous administration of active principles to a subject
US5443441A (en) Apparatus and method for transdermal delivery of cosmetic compositions
Bommannan et al. Effect of electroporation on transdermal lontophoretic delivery of luteinizing hormone releasing hormone (LHRH) in vitro
DE69031083T2 (de) Gerät zur iontophoretischen verabreichung von medikamenten
US5445606A (en) Indicator for iontophoresis system
US5084008A (en) Iontophoresis electrode
DE3225748C2 (de)
JP3343348B2 (ja) イオン電気導入薬剤投与中の刺激を軽減させるためのデバイス
US5203768A (en) Transdermal delivery device
US5464387A (en) Transdermal delivery device
RU2269366C2 (ru) Аппарат для ионтофореза
AU6747194A (en) Iontophoretic drug delivery electrode and method of hydrating the same
CH690751A5 (de) Vorrichtung zur transdermalen Elektrotransport-Abgabe von Fentanyl und Sufentanil.
Sanderson et al. Iontophoretic delivery of nonpeptide drugs: formulation optimization for maximum skin permeability
NZ237560A (en) An iontophoretic device in which the agent reservoir comprises a hydrophilic polymer and a hydrophobic polymer
EP0400118A1 (de) Elektrode für IONTOPHORESE.
DE19681421B4 (de) Vorrichtung und Bereitstellungsverfahren für eine transdermale Elektrotransport-Abgabe von Fentanyl und Sufentanil
JPH04297277A (ja) 電気泳動による薬剤浸透装置
Slough et al. Transdermal delivery of etidronate (EHDP) in the pig via iontophoresis
Numajiri et al. Comparison of depolarizing and direct current systems on iontophoretic enhancement of transport of sodium benzoate through human and hairless rat skin
FI962461A0 (fi) Menetelmä ja farmaseuttinen kompositio ihon läpi tMenetelmä ja farmaseuttinen kompositio ihon läpi tehtävään lääkkeen antoon ehtävään lääkkeen antoon

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee