ES2066842T3 - Virus recombinante de la enfermedad de marek y vacuna. - Google Patents

Virus recombinante de la enfermedad de marek y vacuna.

Info

Publication number
ES2066842T3
ES2066842T3 ES89302485T ES89302485T ES2066842T3 ES 2066842 T3 ES2066842 T3 ES 2066842T3 ES 89302485 T ES89302485 T ES 89302485T ES 89302485 T ES89302485 T ES 89302485T ES 2066842 T3 ES2066842 T3 ES 2066842T3
Authority
ES
Spain
Prior art keywords
marek
disease
present
vaccine
recombinant virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89302485T
Other languages
English (en)
Inventor
Toyokazu Ishikawa
Sadao Manabe
Chisato Mori
Akihisa Takamizawa
Iwao Yoshida
Juichiro Osame
Keisuke Takaku
Konosuke Fukai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation for Microbial Diseases of Osaka University
Original Assignee
Research Foundation for Microbial Diseases of Osaka University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation for Microbial Diseases of Osaka University filed Critical Research Foundation for Microbial Diseases of Osaka University
Application granted granted Critical
Publication of ES2066842T3 publication Critical patent/ES2066842T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE PROPORCIONA UN VIRUS RECOMBINANTE DE LA ENFERMEDAD DE MAREK QUE COMPRENDE EL DNA GENOMICO DE UN VIRUS ATENUADO DE LA ENFERMEDAD DE MAREK Y UN GEN EXTRAÑO DE OTRA FUENTE. EL PRESENTE VIRUS RECOMBINANTE SE PUEDE USAR DE FORMA VENTAJOSA COMO INGREDIENTE ACTIVO PARA UNA VACUNA VIVA MULTIFUNCIONAL, QUE EXHIBE NO SOLO LA ANTIGENICIDAD E INMUNOGENICIDAD DEL VIRUS DE LA ENFERMEDAD DE MAREK, SINO TAMBIEN LAS PROPIEDADES ADSCRITAS AL GEN EXTRAÑO. COMO LA CELULA HUESPED ADECUADA PARA EL VIRUS RECOMBINANTE DE LA PRESENTE INVENCION ES UNA CELULA AVIAR ACCESIBLE EN GRAN CANTIDAD Y NO CARA, EL VIRUS RECOMBINANTE DE LA PRESENTE INVENCION PUEDE SER PRODUCTO DE FORMA EFICIENTE A UN COSTE BAJO, A ESCALA COMERCIAL.
ES89302485T 1988-03-20 1989-03-14 Virus recombinante de la enfermedad de marek y vacuna. Expired - Lifetime ES2066842T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6697388 1988-03-20
JP63230851A JP2779447B2 (ja) 1988-03-20 1988-09-14 弱毒マレック病ウイルス・ベクターを用いる組換え遺伝子作成法、及び該ウイルスの組換え体

Publications (1)

Publication Number Publication Date
ES2066842T3 true ES2066842T3 (es) 1995-03-16

Family

ID=26408175

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89302485T Expired - Lifetime ES2066842T3 (es) 1988-03-20 1989-03-14 Virus recombinante de la enfermedad de marek y vacuna.

Country Status (12)

Country Link
US (1) US5650153A (es)
EP (1) EP0334530B1 (es)
JP (1) JP2779447B2 (es)
KR (1) KR920000116B1 (es)
AT (1) ATE117369T1 (es)
AU (1) AU619812B2 (es)
CA (1) CA1340243C (es)
DE (1) DE68920610T2 (es)
ES (1) ES2066842T3 (es)
HU (1) HUT52555A (es)
MY (1) MY103854A (es)
NZ (1) NZ228409A (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2583115B2 (ja) * 1988-09-10 1997-02-19 財団法人化学及血清療法研究所 組換えマレック病ウイルスおよびその製法
GB8821441D0 (en) * 1988-09-13 1988-10-12 Animal Health Inst Viral vectors
EP0423869B1 (en) * 1989-10-20 1995-07-12 Akzo Nobel N.V. Infectious bronchitis virus vaccine
ES2070997T3 (es) * 1989-12-04 1995-06-16 Akzo Nobel Nv Virus de herpes recombinante de pavos y vacunas vector vivas derivadas de los mismos.
EP0473210B1 (en) * 1990-07-30 1994-04-13 Akzo Nobel N.V. Recombinant Marek's disease virus
US5231023A (en) * 1990-07-30 1993-07-27 Akzo N.V. Recombinant Marek's disease virus
FR2666589B1 (fr) * 1990-09-07 1994-08-05 Rhone Merieux Nouveaux virus herpes recombinants, vaccin a base de ces recombinants, leur procede de preparation, genes, vecteurs et plasmides utilises dans ce procede.
US5690939A (en) * 1991-05-14 1997-11-25 Akzo Nobel N.V. Recombinant vaccine against marek's disease
ZA923041B (en) * 1991-05-14 1993-04-28 Akzo Nv Recombinant vaccine against marek's disease
AU657144B2 (en) * 1991-07-09 1995-03-02 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Recombinant Marek's disease virus, process for preparing the same and vaccine containing the same
ZA93216B (en) * 1992-01-17 1993-08-18 Solvay Animal Health Inc Vaccine containing acemannan as an adjuvant.
CA2158935A1 (en) * 1993-10-12 1995-04-20 Chiron Viagene, Inc. Methods for preserving recombinant viruses
EP0745127A4 (en) * 1994-01-11 1999-10-20 Cornell Res Foundation Inc CONTROLLING MARE'S DISEASE BY PREVENTING LATENCY AND DEVELOPING TUMOR CELLS
JPH1084969A (ja) * 1996-09-19 1998-04-07 Chemo Sero Therapeut Res Inst ヘモフィルス・パラガリナルム由来新規ポリペプチド及びその製法
GB9808922D0 (en) * 1998-04-24 1998-06-24 Cantab Pharmaceuticals Res Ltd Virus preparations
EP1038952A3 (en) * 1998-12-09 2001-06-27 Pfizer Products Inc. Processes for preparation of Marek's Disease Virus using continuous avian cell lines
HRP20190525T4 (hr) 2011-11-30 2023-01-20 Boehringer Ingelheim Animal Health USA Inc. Rekombinantni vektori gallid herpesvirusa 3 (mdv serotip 2) koji eksprimiraju antigene ptičjih patogena i njihove uporabe
US9114108B2 (en) 2011-11-30 2015-08-25 Merial, Inc. Recombinant HVT vectors expressing antigens of avian pathogens and uses thereof
RU2752836C2 (ru) 2016-12-14 2021-08-09 БЁРИНГЕР ИНГЕЛЬХАЙМ ЭНИМАЛ ХЕЛТ ЮЭсЭй ИНК. Рекомбинантные hvt-векторы, экспрессирующие множественные антигены патогенов птиц, и содержащие их вакцины
CN114616325A (zh) 2019-09-11 2022-06-10 硕腾服务有限责任公司 表达禽病原体抗原的重组火鸡疱疹病毒载体和其用途
US20240252624A1 (en) 2020-06-17 2024-08-01 Teshome Mebatsion Recombinant hvt vectors expressing influenza hemagglutinin and immunogenic compositions, and production and uses thereof
CN119842637A (zh) * 2025-03-18 2025-04-18 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 表达IBDV VP2和FAdV-4 Fiber2基因的重组马立克氏病病毒及其构建方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH666035A5 (de) * 1984-12-24 1988-06-30 Sandoz Ag 8-alpha-acylaminoergolene.
EP0231209B1 (en) * 1985-07-29 1991-02-06 The Upjohn Company Virus vaccine
AU623333B2 (en) * 1986-01-27 1992-05-14 Syntro Corporation Attenuated herpesviruses, herpesviruses which include foreign dna encoding an amino acid sequence and vaccine containing same
DE3853819T2 (de) * 1987-03-19 1995-09-21 Synergen Inc Virales vektorsystem zum einführen fremder dns-expressionserzeugnisse in gallinaceenvögeln.
DE3853088T2 (de) * 1987-03-27 1995-10-19 Nippon Zeon Co Rekombinantes Avipoxvirus.
FR2632863B2 (fr) * 1987-10-29 1990-08-31 Transgene Sa Virus du fowlpox recombinant et vaccins derives de ces virus

Also Published As

Publication number Publication date
EP0334530A1 (en) 1989-09-27
DE68920610D1 (de) 1995-03-02
KR890014740A (ko) 1989-10-25
EP0334530B1 (en) 1995-01-18
ATE117369T1 (de) 1995-02-15
CA1340243C (en) 1998-12-15
AU619812B2 (en) 1992-02-06
JP2779447B2 (ja) 1998-07-23
NZ228409A (en) 1990-09-26
AU3142889A (en) 1989-09-21
JPH02291277A (ja) 1990-12-03
HUT52555A (en) 1990-07-28
MY103854A (en) 1993-09-30
KR920000116B1 (ko) 1992-01-09
DE68920610T2 (de) 1995-08-31
US5650153A (en) 1997-07-22

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