ES2067549T3 - Procedimiento quimico para la preparacion de derivados de purina. - Google Patents

Procedimiento quimico para la preparacion de derivados de purina.

Info

Publication number
ES2067549T3
ES2067549T3 ES89309463T ES89309463T ES2067549T3 ES 2067549 T3 ES2067549 T3 ES 2067549T3 ES 89309463 T ES89309463 T ES 89309463T ES 89309463 T ES89309463 T ES 89309463T ES 2067549 T3 ES2067549 T3 ES 2067549T3
Authority
ES
Spain
Prior art keywords
group
preparation
aciloximetilo
formula
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89309463T
Other languages
English (en)
Inventor
Graham Richard Beecham Ph Geen
John Christopher Beecha Hanson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of ES2067549T3 publication Critical patent/ES2067549T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE UN COMPUESTO DE LA FORMULA (I) CUYO PROCESO COMPRENDE REACCIONAR UN COMPUESTO DE FORMULA (II): EN DONDE EL GRUPO AMINO ESTA OPCIONALMENTE PROTEGIDO, CON UNA CADENA LATERAL INTERMEDIA DE FORMULA (III): EN DONDE Q ES UN GRUPO OMITIDO, RX Y RY SON HIDROXIMETILO O ACICLOXIMETILO PROTEGIDOS, O GRUPO (S) CONVERTIBLE(S) A HIDROXIMETILO O ACILOXIMETILO; Y RZ ES HIDROGENO O UN GRUPO CONVERTIBLE A EL; Y ADEMAS CONVERTIR LOS CLORO SUSTITUYENTES 6OR MEDIO DE REDUCCION; CONVERTIR RX Y RY CUANDO SEAN DISTINTOS DE HIDROXIMETILO O ACILOXIMETILO, A HIDROXIMETILO O ACILOXIMETILO, OPCIONALMENTE CONVERTIR RX/RY HIDROXIMETILO A ACILOXIMETILO O VICE VERSA, DESPROTEGER EL GRUPO 2-AMINO DONDE SEA NECESARIO Y CONVERTIR RZ, (CUANDO SEA DISTINTO DE HIDROGENO) A HIDROGENO; Y FORMAR OPCIONALMENTE UNA SAL FARMACEUTICAMENTE ACEPTABLE DE EL.
ES89309463T 1988-09-21 1989-09-18 Procedimiento quimico para la preparacion de derivados de purina. Expired - Lifetime ES2067549T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888822236A GB8822236D0 (en) 1988-09-21 1988-09-21 Chemical process

Publications (1)

Publication Number Publication Date
ES2067549T3 true ES2067549T3 (es) 1995-04-01

Family

ID=10644039

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89309463T Expired - Lifetime ES2067549T3 (es) 1988-09-21 1989-09-18 Procedimiento quimico para la preparacion de derivados de purina.

Country Status (8)

Country Link
US (1) US5138057A (es)
EP (1) EP0369583B1 (es)
JP (1) JP3089354B2 (es)
DE (1) DE68921153T2 (es)
ES (1) ES2067549T3 (es)
GB (1) GB8822236D0 (es)
GR (1) GR3015327T3 (es)
PT (1) PT91749B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) * 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
GB8829571D0 (en) * 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
GB9407698D0 (en) * 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals
US5606100A (en) * 1994-12-21 1997-02-25 Lonza Ltd. Process for the preparation of trialkyl ester derivatives
AT412211B (de) * 1996-07-20 2004-11-25 Novartis Int Pharm Ltd Verfahren zur herstellung von penciclovir und famciclovir
GB9615276D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GB9615275D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GB9615253D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
CA2251481A1 (en) 1997-11-12 1999-05-12 Junichi Yasuoka Purine derivatives having cyclopropane ring
WO1999051566A1 (de) * 1998-04-02 1999-10-14 Lonza Ag Carbonsäure-2-acyloxymethyl-4-aminobutylester und verfahren zu deren herstellung
KR100573859B1 (ko) * 2002-07-15 2006-04-25 경동제약 주식회사 9-[4-아세톡시-3-(아세톡시메틸)부트-1-일]-2-아미노푸린의제조방법
AU2003268213A1 (en) * 2002-08-26 2004-03-11 Teva Pharmaceutical Industries Ltd. Crystalline solid famciclovir forms i, ii, iii and preparation thereof
TW200510415A (en) * 2003-04-30 2005-03-16 Teva Pharma Process for the preparation of famciclovir
KR100573860B1 (ko) * 2003-06-13 2006-04-25 경동제약 주식회사 2-아미노-9-(2-치환에틸)푸린을 이용한 9-[4-아세톡시-3-(아세톡시메틸)부트-1-일]-2-아미노푸린의 제조방법
WO2005026167A1 (en) * 2003-09-04 2005-03-24 Teva Pharmaceutical Industries Ltd. Process for preparing famciclovir
EP1747223A1 (en) * 2004-05-18 2007-01-31 Teva Pharmaceutical Industries Ltd. Drying process for preparing crystalline solid famciclovir
JP4887500B2 (ja) * 2004-09-16 2012-02-29 国立大学法人岐阜大学 ヌクレオシド類似体またはその塩
GB2426247A (en) * 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir
EP2170840A1 (en) * 2007-06-21 2010-04-07 Aurobindo Pharma Ltd An improved process for preparing purine derivative

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347187A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
US4347185A (en) * 1980-10-20 1982-08-31 Syntex (U.S.A.) Inc. Processes for preparing 5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
EP0182024B1 (en) * 1984-09-20 1991-04-03 Beecham Group Plc Purine derivatives and their pharmaceutical use
GB8507606D0 (en) * 1985-03-23 1985-05-01 Beecham Group Plc Process
EP0302644B1 (en) * 1987-08-01 1997-01-29 Beecham Group Plc Purine compounds and their preparation
GB8817270D0 (en) * 1988-07-20 1988-08-24 Beecham Group Plc Novel process
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process

Also Published As

Publication number Publication date
EP0369583B1 (en) 1995-02-15
DE68921153D1 (de) 1995-03-23
PT91749A (pt) 1990-03-30
JP3089354B2 (ja) 2000-09-18
EP0369583A1 (en) 1990-05-23
DE68921153T2 (de) 1995-07-27
PT91749B (pt) 1995-05-31
GB8822236D0 (en) 1988-10-26
US5138057A (en) 1992-08-11
JPH02121992A (ja) 1990-05-09
GR3015327T3 (en) 1995-06-30

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