ES2067693T3 - Azabicicloheptanona quiral y un procedimiento para su preparacion. - Google Patents

Azabicicloheptanona quiral y un procedimiento para su preparacion.

Info

Publication number
ES2067693T3
ES2067693T3 ES90311253T ES90311253T ES2067693T3 ES 2067693 T3 ES2067693 T3 ES 2067693T3 ES 90311253 T ES90311253 T ES 90311253T ES 90311253 T ES90311253 T ES 90311253T ES 2067693 T3 ES2067693 T3 ES 2067693T3
Authority
ES
Spain
Prior art keywords
azabicicloheptanone
chabal
procedure
preparation
lactamase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90311253T
Other languages
English (en)
Inventor
Christopher Thomas Evans
Stanley Michael Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chirotech Technology Ltd
Original Assignee
Chiroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898923278A external-priority patent/GB8923278D0/en
Priority claimed from GB898924209A external-priority patent/GB8924209D0/en
Priority claimed from GB909000995A external-priority patent/GB9000995D0/en
Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd
Application granted granted Critical
Publication of ES2067693T3 publication Critical patent/ES2067693T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PROVEE LACTAMASA DE COMPUESTOS CICLICOS DE ACIDO 1-AMINO-3-CARBOXILICO EN FORMA ENANTIOMERA, JUNTO CON UN ENANTIOMERO DEL CORRESPONDIENTE ESTER O AMINO ACIDO DE ANILLO ABIERTO, POR REACCION DE LA LACTAMA RACEMICA CON UNA NUEVA LACTAMASA. LOS PRODUCTOS SE USAN EN LA SINTESIS DE NUCLEOTIDOS CARBOCICLICOS TRIDIMENSIONALES.
ES90311253T 1989-10-16 1990-10-15 Azabicicloheptanona quiral y un procedimiento para su preparacion. Expired - Lifetime ES2067693T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898923278A GB8923278D0 (en) 1989-10-16 1989-10-16 Chiral compounds
GB898924209A GB8924209D0 (en) 1989-10-27 1989-10-27 Chiral compounds
GB909000995A GB9000995D0 (en) 1990-01-17 1990-01-17 Chiral compounds

Publications (1)

Publication Number Publication Date
ES2067693T3 true ES2067693T3 (es) 1995-04-01

Family

ID=27264742

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90311253T Expired - Lifetime ES2067693T3 (es) 1989-10-16 1990-10-15 Azabicicloheptanona quiral y un procedimiento para su preparacion.

Country Status (8)

Country Link
US (2) US5498625A (es)
EP (1) EP0424064B1 (es)
JP (1) JP2648013B2 (es)
AT (1) ATE118208T1 (es)
DE (1) DE69016739T2 (es)
DK (1) DK0424064T3 (es)
ES (1) ES2067693T3 (es)
GR (1) GR3015887T3 (es)

Families Citing this family (47)

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Publication number Priority date Publication date Assignee Title
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
GB9108384D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Bicycloheptanes
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
DE4420751A1 (de) 1994-06-15 1995-12-21 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Lactamen
JPH10506384A (ja) * 1994-08-19 1998-06-23 カイロサイエンス・リミテッド 二環式ラクタム鏡像体の分離法
GB9618340D0 (en) * 1996-09-03 1996-10-16 Chiroscience Ltd Microorganism and its use
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers
GB9717928D0 (en) * 1997-08-22 1997-10-29 Glaxo Group Ltd Process for the enatioselective hydrolysis of n-derivatised lactams
US6136327A (en) 1997-12-01 2000-10-24 Alza Corporation Stereospecific delivery of a drug using electrotransport
US6529730B1 (en) * 1998-05-15 2003-03-04 Conexant Systems, Inc System and method for adaptive multi-rate (AMR) vocoder rate adaption
WO2000003032A1 (de) * 1998-07-09 2000-01-20 Lonza Ag Verfahren zur herstellung von (1r,4s)-2-azabicyclo[2.2.1]hept-5-en-3-on-derivaten
GB9907415D0 (en) * 1999-03-31 1999-05-26 Chirotech Technology Ltd Biocatalyst and its use
KR20020013937A (ko) * 1999-06-28 2002-02-21 다우 케네드 제이. (-)-(1에스,4알) 엔-프로텍티드4-아미노-2-시클로펜텐-1-카르복실레이트 에스테르의제조방법
DE19962543A1 (de) 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
WO2002032885A1 (en) * 2000-10-18 2002-04-25 Kuraray Co., Ltd. Process for preparation of 4-n-substituted amino-2-aza-1-oxabicyclo[3.3.0]oct-2-ene-6-carboxylic acid esters and process for preparation of their intermediates
US6780635B2 (en) 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
CN100511115C (zh) * 2002-03-13 2009-07-08 平蛙实验室股份公司 触摸板以及与触摸板一起使用的触笔和操作触摸板的方法
DE60211646T2 (de) * 2002-03-28 2007-05-24 Council Of Scientific And Industrial Research Verfahren zur Herstellung von optisch aktiven Azabicycloheptanone-Derivaten
CN1777859B (zh) * 2003-03-12 2010-04-28 平蛙实验室股份公司 确定射线发射单元位置的系统和方法
EP1665024B1 (en) 2003-09-12 2011-06-29 FlatFrog Laboratories AB A system and method of determining a position of a radiation scattering/reflecting element
US7442914B2 (en) * 2003-09-12 2008-10-28 Flatfrog Laboratories Ab System and method of determining a position of a radiation emitting element
JO2934B1 (en) 2006-06-23 2015-09-15 سميث كلاين بيتشام كوربوريشن Prolyl hydroxylase inhibitors
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
SE533704C2 (sv) 2008-12-05 2010-12-07 Flatfrog Lab Ab Pekkänslig apparat och förfarande för drivning av densamma
US10168835B2 (en) 2012-05-23 2019-01-01 Flatfrog Laboratories Ab Spatial resolution in touch displays
US10019113B2 (en) 2013-04-11 2018-07-10 Flatfrog Laboratories Ab Tomographic processing for touch detection
US9874978B2 (en) 2013-07-12 2018-01-23 Flatfrog Laboratories Ab Partial detect mode
US10126882B2 (en) 2014-01-16 2018-11-13 Flatfrog Laboratories Ab TIR-based optical touch systems of projection-type
WO2015108479A1 (en) 2014-01-16 2015-07-23 Flatfrog Laboratories Ab Light coupling in tir-based optical touch systems
US10161886B2 (en) 2014-06-27 2018-12-25 Flatfrog Laboratories Ab Detection of surface contamination
CN107209608A (zh) 2015-01-28 2017-09-26 平蛙实验室股份公司 动态触摸隔离帧
US10318074B2 (en) 2015-01-30 2019-06-11 Flatfrog Laboratories Ab Touch-sensing OLED display with tilted emitters
EP3256936A4 (en) 2015-02-09 2018-10-17 FlatFrog Laboratories AB Optical touch system comprising means for projecting and detecting light beams above and inside a transmissive panel
WO2016140612A1 (en) 2015-03-02 2016-09-09 Flatfrog Laboratories Ab Optical component for light coupling
US10775937B2 (en) 2015-12-09 2020-09-15 Flatfrog Laboratories Ab Stylus identification
CN110100226A (zh) 2016-11-24 2019-08-06 平蛙实验室股份公司 触摸信号的自动优化
EP3667475B1 (en) 2016-12-07 2022-09-07 FlatFrog Laboratories AB A curved touch device
CN116679845A (zh) 2017-02-06 2023-09-01 平蛙实验室股份公司 触摸感测装置
WO2018174786A1 (en) 2017-03-22 2018-09-27 Flatfrog Laboratories Pen differentiation for touch displays
WO2018182476A1 (en) 2017-03-28 2018-10-04 Flatfrog Laboratories Ab Touch sensing apparatus and method for assembly
EP3676694A4 (en) 2017-09-01 2021-06-09 FlatFrog Laboratories AB IMPROVED OPTICAL COMPONENT
US11567610B2 (en) 2018-03-05 2023-01-31 Flatfrog Laboratories Ab Detection line broadening
WO2020080992A1 (en) 2018-10-20 2020-04-23 Flatfrog Laboratories Ab Frame for a touch-sensitive device and tool therefor
WO2020153890A1 (en) 2019-01-25 2020-07-30 Flatfrog Laboratories Ab A videoconferencing terminal and method of operating the same
US12056316B2 (en) 2019-11-25 2024-08-06 Flatfrog Laboratories Ab Touch-sensing apparatus
EP4100822A4 (en) 2020-02-08 2024-02-28 FlatFrog Laboratories AB TOUCH DEVICE WITH LOW LATENCY INTERACTIONS
CN121614054A (zh) 2020-02-10 2026-03-06 平蛙实验室股份公司 触摸感测设备和制造触摸感测设备的框架元件的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
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DE3069830D1 (en) * 1979-09-13 1985-01-31 Wellcome Found Benzopyran compounds, useful as chemotherapeutic agents
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression

Also Published As

Publication number Publication date
DE69016739D1 (de) 1995-03-23
US5498625A (en) 1996-03-12
ATE118208T1 (de) 1995-02-15
EP0424064A1 (en) 1991-04-24
JP2648013B2 (ja) 1997-08-27
DK0424064T3 (da) 1995-06-26
US5688933A (en) 1997-11-18
EP0424064B1 (en) 1995-02-08
GR3015887T3 (en) 1995-07-31
DE69016739T2 (de) 1995-06-14
JPH03218380A (ja) 1991-09-25

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