ES2067693T3 - Azabicicloheptanona quiral y un procedimiento para su preparacion. - Google Patents

Azabicicloheptanona quiral y un procedimiento para su preparacion.

Info

Publication number
ES2067693T3
ES2067693T3 ES90311253T ES90311253T ES2067693T3 ES 2067693 T3 ES2067693 T3 ES 2067693T3 ES 90311253 T ES90311253 T ES 90311253T ES 90311253 T ES90311253 T ES 90311253T ES 2067693 T3 ES2067693 T3 ES 2067693T3
Authority
ES
Spain
Prior art keywords
azabicicloheptanone
chabal
procedure
preparation
lactamase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90311253T
Other languages
English (en)
Inventor
Christopher Thomas Evans
Stanley Michael Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chirotech Technology Ltd
Original Assignee
Chiroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898923278A external-priority patent/GB8923278D0/en
Priority claimed from GB898924209A external-priority patent/GB8924209D0/en
Priority claimed from GB909000995A external-priority patent/GB9000995D0/en
Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd
Application granted granted Critical
Publication of ES2067693T3 publication Critical patent/ES2067693T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PROVEE LACTAMASA DE COMPUESTOS CICLICOS DE ACIDO 1-AMINO-3-CARBOXILICO EN FORMA ENANTIOMERA, JUNTO CON UN ENANTIOMERO DEL CORRESPONDIENTE ESTER O AMINO ACIDO DE ANILLO ABIERTO, POR REACCION DE LA LACTAMA RACEMICA CON UNA NUEVA LACTAMASA. LOS PRODUCTOS SE USAN EN LA SINTESIS DE NUCLEOTIDOS CARBOCICLICOS TRIDIMENSIONALES.
ES90311253T 1989-10-16 1990-10-15 Azabicicloheptanona quiral y un procedimiento para su preparacion. Expired - Lifetime ES2067693T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898923278A GB8923278D0 (en) 1989-10-16 1989-10-16 Chiral compounds
GB898924209A GB8924209D0 (en) 1989-10-27 1989-10-27 Chiral compounds
GB909000995A GB9000995D0 (en) 1990-01-17 1990-01-17 Chiral compounds

Publications (1)

Publication Number Publication Date
ES2067693T3 true ES2067693T3 (es) 1995-04-01

Family

ID=27264742

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90311253T Expired - Lifetime ES2067693T3 (es) 1989-10-16 1990-10-15 Azabicicloheptanona quiral y un procedimiento para su preparacion.

Country Status (8)

Country Link
US (2) US5498625A (es)
EP (1) EP0424064B1 (es)
JP (1) JP2648013B2 (es)
AT (1) ATE118208T1 (es)
DE (1) DE69016739T2 (es)
DK (1) DK0424064T3 (es)
ES (1) ES2067693T3 (es)
GR (1) GR3015887T3 (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
GB9108384D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Bicycloheptanes
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
DE4420751A1 (de) 1994-06-15 1995-12-21 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Lactamen
EP0777651A1 (en) * 1994-08-19 1997-06-11 Chiroscience Limited Process for the separation of the enantiomers of a bicyclic lactam
GB9618340D0 (en) * 1996-09-03 1996-10-16 Chiroscience Ltd Microorganism and its use
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers
GB9717928D0 (en) * 1997-08-22 1997-10-29 Glaxo Group Ltd Process for the enatioselective hydrolysis of n-derivatised lactams
US6136327A (en) 1997-12-01 2000-10-24 Alza Corporation Stereospecific delivery of a drug using electrotransport
US6529730B1 (en) * 1998-05-15 2003-03-04 Conexant Systems, Inc System and method for adaptive multi-rate (AMR) vocoder rate adaption
ATE258605T1 (de) * 1998-07-09 2004-02-15 Lonza Ag Verfahren zur herstellung von (1r,4s)-2- azabicyclo 2.2.1 hept-5-en-3-on-derivaten
GB9907415D0 (en) * 1999-03-31 1999-05-26 Chirotech Technology Ltd Biocatalyst and its use
KR20020013937A (ko) 1999-06-28 2002-02-21 다우 케네드 제이. (-)-(1에스,4알) 엔-프로텍티드4-아미노-2-시클로펜텐-1-카르복실레이트 에스테르의제조방법
DE19962543A1 (de) * 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
EP1334969A4 (en) 2000-10-18 2005-08-24 Kuraray Co PROCESS FOR PREPARING 4-N-SUBSTITUTED AMINO-2-AZA-1-OXABICYCLOc3.3.0! OCT-2-EN-6-CARBOXYLIC ACID ESTERS AND METHOD FOR PRODUCING THEIR INTERMEDIATE PRODUCTS
US6780635B2 (en) 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
JP2005520239A (ja) * 2002-03-13 2005-07-07 オー−プン・アンパルトセルスカブ タッチパッド、タッチパッドを用いるスタイラス、及びタッチパッドを操作する方法
EP1348765B1 (en) * 2002-03-28 2006-05-24 Council of Scientific and Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
US7435940B2 (en) * 2003-03-12 2008-10-14 Flatfrog Laboratories Ab System and a method of determining the position of a radiation emitting element
WO2005026938A2 (en) 2003-09-12 2005-03-24 O-Pen Aps A system and method of determining a position of a radiation scattering/reflecting element
US7442914B2 (en) * 2003-09-12 2008-10-28 Flatfrog Laboratories Ab System and method of determining a position of a radiation emitting element
JO2934B1 (en) 2006-06-23 2015-09-15 سميث كلاين بيتشام كوربوريشن Prolyl hydroxylase inhibitors
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
SE533704C2 (sv) 2008-12-05 2010-12-07 Flatfrog Lab Ab Pekkänslig apparat och förfarande för drivning av densamma
US10168835B2 (en) 2012-05-23 2019-01-01 Flatfrog Laboratories Ab Spatial resolution in touch displays
US10019113B2 (en) 2013-04-11 2018-07-10 Flatfrog Laboratories Ab Tomographic processing for touch detection
US9874978B2 (en) 2013-07-12 2018-01-23 Flatfrog Laboratories Ab Partial detect mode
US10126882B2 (en) 2014-01-16 2018-11-13 Flatfrog Laboratories Ab TIR-based optical touch systems of projection-type
US10146376B2 (en) 2014-01-16 2018-12-04 Flatfrog Laboratories Ab Light coupling in TIR-based optical touch systems
WO2015199602A1 (en) 2014-06-27 2015-12-30 Flatfrog Laboratories Ab Detection of surface contamination
EP3250993B1 (en) 2015-01-28 2019-09-04 FlatFrog Laboratories AB Dynamic touch quarantine frames
US10318074B2 (en) 2015-01-30 2019-06-11 Flatfrog Laboratories Ab Touch-sensing OLED display with tilted emitters
EP3537269A1 (en) 2015-02-09 2019-09-11 FlatFrog Laboratories AB Optical touch system
CN107250855A (zh) 2015-03-02 2017-10-13 平蛙实验室股份公司 用于光耦合的光学部件
EP3387516B1 (en) 2015-12-09 2022-04-20 FlatFrog Laboratories AB Improved stylus identification
WO2018096430A1 (en) 2016-11-24 2018-05-31 Flatfrog Laboratories Ab Automatic optimisation of touch signal
KR102629629B1 (ko) 2016-12-07 2024-01-29 플라트프로그 라보라토리즈 에이비 개선된 터치 장치
CN110300950B (zh) 2017-02-06 2023-06-16 平蛙实验室股份公司 触摸感测系统中的光学耦合
WO2018174786A1 (en) 2017-03-22 2018-09-27 Flatfrog Laboratories Pen differentiation for touch displays
WO2018182476A1 (en) 2017-03-28 2018-10-04 Flatfrog Laboratories Ab Touch sensing apparatus and method for assembly
CN111052058B (zh) 2017-09-01 2023-10-20 平蛙实验室股份公司 改进的光学部件
US11567610B2 (en) 2018-03-05 2023-01-31 Flatfrog Laboratories Ab Detection line broadening
CN112889016A (zh) 2018-10-20 2021-06-01 平蛙实验室股份公司 用于触摸敏感装置的框架及其工具
WO2020153890A1 (en) 2019-01-25 2020-07-30 Flatfrog Laboratories Ab A videoconferencing terminal and method of operating the same
EP4066089B1 (en) 2019-11-25 2024-09-25 FlatFrog Laboratories AB A touch-sensing apparatus
WO2021158164A1 (en) 2020-02-08 2021-08-12 Flatfrog Laboratories Ab Touch apparatus with low latency interactions
CN115039063B (zh) 2020-02-10 2026-02-13 平蛙实验室股份公司 改进的触摸感测设备

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5651470A (en) * 1979-09-13 1981-05-09 Wellcome Found Flavan derivative
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression

Also Published As

Publication number Publication date
JPH03218380A (ja) 1991-09-25
DE69016739D1 (de) 1995-03-23
JP2648013B2 (ja) 1997-08-27
EP0424064B1 (en) 1995-02-08
DE69016739T2 (de) 1995-06-14
GR3015887T3 (en) 1995-07-31
US5688933A (en) 1997-11-18
US5498625A (en) 1996-03-12
ATE118208T1 (de) 1995-02-15
DK0424064T3 (da) 1995-06-26
EP0424064A1 (en) 1991-04-24

Similar Documents

Publication Publication Date Title
ES2067693T3 (es) Azabicicloheptanona quiral y un procedimiento para su preparacion.
ATE280240T1 (de) Enzymatische verfahren zur aüftrennüng von enantiomeren-mischungen nützlich als zwischenprodukte zur herstellung von taxanen
ATE93518T1 (de) Enantiomere derivate von aminosaeure, verfahren zu deren herstellung und deren therapeutische verwendung.
DE69031534D1 (de) Verfahren zur Herstellung von optisch aktiven Zyklobutannukleosiden
ATE138378T1 (de) Enantioselektive synthese von antifolaten
DK0423705T3 (da) Fremgangsmåde til stereokemisk inversion af (2S,3 S)-2-amino-3-phenyl-1,3-propandioler til deres tilsvarende (2R,3R)-enantiomerer
ES2065446T3 (es) Proceso para la preparacion de amino-compuestos ciclicos con actividad anticonvulsiva.
ATE76399T1 (de) Enantiomere glutaramide als harntreibende verbindungen.
ATE53989T1 (de) Verfahren zur optischen spaltung der razemischen gemische von alpha-naphthylpropionsaeuren.
PT84648B (pt) Processo para a preparacao de tia-ciclo alqueno 3,2-b piridinas substituidas e de composicoes farmaceuticas que as contem
PT81841A (de) Traegermatrix zur aufnahme von katalytisch wirkenden verbindungen verfahren zur herstellung der traeger matrix
ATE45572T1 (de) Verfahren zur herstellung substituierter oxazoline.
MX9204972A (es) Procedimiento para la separacion de enantiomeros de 5-hetaril-1,3,4-tiadiazinona.
DE68920265D1 (de) Verfahren zur Enantiomerentrennung von Cis-3-amino-4-[2-(2-furyl)vinyl]-1-methoxycarbonylmethyl-azetidin-2-on und deren Di-p-Toluoyl-Weinsäuresalze.
PT88142A (pt) Process for preparing a pharmaceutical compositions containing trapidil
ES2140925T3 (es) Procedimiento para la racemizacion de aminas opticamente activas.
GEP19991791B (en) Pharmacologically Active Enantiomers and Process for its Production
NZ239435A (en) Conversion of the r(-) isomer of ketoprofen to the s(+) isomer
DE3678734D1 (de) Verfahren zur chiralen synthese von 1-beta-methyl-carbapenem-zwischenprodukten.
DE68907771D1 (de) Pentafluorphenylderivate, verfahren zu deren herstellung einschliesslich der optisch aktiven derivate und verfahren zur optischen aufspaltung von chiralen carbonsaeuren.
DE3665569D1 (en) Process for the racemic resolution of d,l-2-aminobutan-1-ol
IT1190436B (it) Processo stereoselettivo per la preparazione di composti carbonilici alfa,beta-disostituiti otticamente attivi
DE68917251D1 (de) Cyclische Dihydroxyverbindungen.
ATE88701T1 (de) Zwischenprodukte und deren verwendung fuer die synthese von organischen verbindungen.
DK0416583T3 (da) Fremgangsmåde til fremstilling af crotonobetainhydrochlorid

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 424064

Country of ref document: ES