ATE118208T1 - Chirale azabicycloheptanone und verfahren zu ihrer herstellung. - Google Patents

Chirale azabicycloheptanone und verfahren zu ihrer herstellung.

Info

Publication number
ATE118208T1
ATE118208T1 AT90311253T AT90311253T ATE118208T1 AT E118208 T1 ATE118208 T1 AT E118208T1 AT 90311253 T AT90311253 T AT 90311253T AT 90311253 T AT90311253 T AT 90311253T AT E118208 T1 ATE118208 T1 AT E118208T1
Authority
AT
Austria
Prior art keywords
chiral
azabicycloheptanones
production
lactamase
amino
Prior art date
Application number
AT90311253T
Other languages
English (en)
Inventor
Christopher Thomas Evans
Stanley Michael Roberts
Original Assignee
Chiroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898923278A external-priority patent/GB8923278D0/en
Priority claimed from GB898924209A external-priority patent/GB8924209D0/en
Priority claimed from GB909000995A external-priority patent/GB9000995D0/en
Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd
Application granted granted Critical
Publication of ATE118208T1 publication Critical patent/ATE118208T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/001Amines; Imines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/005Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/02Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10Nitrogen as only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT90311253T 1989-10-16 1990-10-15 Chirale azabicycloheptanone und verfahren zu ihrer herstellung. ATE118208T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898923278A GB8923278D0 (en) 1989-10-16 1989-10-16 Chiral compounds
GB898924209A GB8924209D0 (en) 1989-10-27 1989-10-27 Chiral compounds
GB909000995A GB9000995D0 (en) 1990-01-17 1990-01-17 Chiral compounds

Publications (1)

Publication Number Publication Date
ATE118208T1 true ATE118208T1 (de) 1995-02-15

Family

ID=27264742

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90311253T ATE118208T1 (de) 1989-10-16 1990-10-15 Chirale azabicycloheptanone und verfahren zu ihrer herstellung.

Country Status (8)

Country Link
US (2) US5498625A (de)
EP (1) EP0424064B1 (de)
JP (1) JP2648013B2 (de)
AT (1) ATE118208T1 (de)
DE (1) DE69016739T2 (de)
DK (1) DK0424064T3 (de)
ES (1) ES2067693T3 (de)
GR (1) GR3015887T3 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
GB9108384D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Bicycloheptanes
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
DE4420751A1 (de) 1994-06-15 1995-12-21 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Lactamen
JPH10506384A (ja) * 1994-08-19 1998-06-23 カイロサイエンス・リミテッド 二環式ラクタム鏡像体の分離法
GB9618340D0 (en) * 1996-09-03 1996-10-16 Chiroscience Ltd Microorganism and its use
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers
GB9717928D0 (en) * 1997-08-22 1997-10-29 Glaxo Group Ltd Process for the enatioselective hydrolysis of n-derivatised lactams
US6136327A (en) 1997-12-01 2000-10-24 Alza Corporation Stereospecific delivery of a drug using electrotransport
US6529730B1 (en) * 1998-05-15 2003-03-04 Conexant Systems, Inc System and method for adaptive multi-rate (AMR) vocoder rate adaption
WO2000003032A1 (de) * 1998-07-09 2000-01-20 Lonza Ag Verfahren zur herstellung von (1r,4s)-2-azabicyclo[2.2.1]hept-5-en-3-on-derivaten
GB9907415D0 (en) * 1999-03-31 1999-05-26 Chirotech Technology Ltd Biocatalyst and its use
KR20020013937A (ko) * 1999-06-28 2002-02-21 다우 케네드 제이. (-)-(1에스,4알) 엔-프로텍티드4-아미노-2-시클로펜텐-1-카르복실레이트 에스테르의제조방법
DE19962543A1 (de) 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
WO2002032885A1 (en) * 2000-10-18 2002-04-25 Kuraray Co., Ltd. Process for preparation of 4-n-substituted amino-2-aza-1-oxabicyclo[3.3.0]oct-2-ene-6-carboxylic acid esters and process for preparation of their intermediates
US6780635B2 (en) 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
CN100511115C (zh) * 2002-03-13 2009-07-08 平蛙实验室股份公司 触摸板以及与触摸板一起使用的触笔和操作触摸板的方法
DE60211646T2 (de) * 2002-03-28 2007-05-24 Council Of Scientific And Industrial Research Verfahren zur Herstellung von optisch aktiven Azabicycloheptanone-Derivaten
CN1777859B (zh) * 2003-03-12 2010-04-28 平蛙实验室股份公司 确定射线发射单元位置的系统和方法
EP1665024B1 (de) 2003-09-12 2011-06-29 FlatFrog Laboratories AB System und verfahren zur bestimmung einer position eines strahlungsstreu-/-reflexionselements
US7442914B2 (en) * 2003-09-12 2008-10-28 Flatfrog Laboratories Ab System and method of determining a position of a radiation emitting element
JO2934B1 (en) 2006-06-23 2015-09-15 سميث كلاين بيتشام كوربوريشن Prolyl hydroxylase inhibitors
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
SE533704C2 (sv) 2008-12-05 2010-12-07 Flatfrog Lab Ab Pekkänslig apparat och förfarande för drivning av densamma
US10168835B2 (en) 2012-05-23 2019-01-01 Flatfrog Laboratories Ab Spatial resolution in touch displays
US10019113B2 (en) 2013-04-11 2018-07-10 Flatfrog Laboratories Ab Tomographic processing for touch detection
US9874978B2 (en) 2013-07-12 2018-01-23 Flatfrog Laboratories Ab Partial detect mode
US10126882B2 (en) 2014-01-16 2018-11-13 Flatfrog Laboratories Ab TIR-based optical touch systems of projection-type
WO2015108479A1 (en) 2014-01-16 2015-07-23 Flatfrog Laboratories Ab Light coupling in tir-based optical touch systems
US10161886B2 (en) 2014-06-27 2018-12-25 Flatfrog Laboratories Ab Detection of surface contamination
CN107209608A (zh) 2015-01-28 2017-09-26 平蛙实验室股份公司 动态触摸隔离帧
US10318074B2 (en) 2015-01-30 2019-06-11 Flatfrog Laboratories Ab Touch-sensing OLED display with tilted emitters
EP3256936A4 (de) 2015-02-09 2018-10-17 FlatFrog Laboratories AB Optisches berührungssystem mit mitteln zur projektion und detektion von lichtstrahlen über und in einer durchlässigen platte
WO2016140612A1 (en) 2015-03-02 2016-09-09 Flatfrog Laboratories Ab Optical component for light coupling
US10775937B2 (en) 2015-12-09 2020-09-15 Flatfrog Laboratories Ab Stylus identification
CN110100226A (zh) 2016-11-24 2019-08-06 平蛙实验室股份公司 触摸信号的自动优化
EP3667475B1 (de) 2016-12-07 2022-09-07 FlatFrog Laboratories AB Krumme berührungsvorrichtung
CN116679845A (zh) 2017-02-06 2023-09-01 平蛙实验室股份公司 触摸感测装置
WO2018174786A1 (en) 2017-03-22 2018-09-27 Flatfrog Laboratories Pen differentiation for touch displays
WO2018182476A1 (en) 2017-03-28 2018-10-04 Flatfrog Laboratories Ab Touch sensing apparatus and method for assembly
EP3676694A4 (de) 2017-09-01 2021-06-09 FlatFrog Laboratories AB Verbesserte optische komponente
US11567610B2 (en) 2018-03-05 2023-01-31 Flatfrog Laboratories Ab Detection line broadening
WO2020080992A1 (en) 2018-10-20 2020-04-23 Flatfrog Laboratories Ab Frame for a touch-sensitive device and tool therefor
WO2020153890A1 (en) 2019-01-25 2020-07-30 Flatfrog Laboratories Ab A videoconferencing terminal and method of operating the same
US12056316B2 (en) 2019-11-25 2024-08-06 Flatfrog Laboratories Ab Touch-sensing apparatus
EP4100822A4 (de) 2020-02-08 2024-02-28 FlatFrog Laboratories AB Berührungsgerät mit interaktionen mit niedriger latenzzeit
CN121614054A (zh) 2020-02-10 2026-03-06 平蛙实验室股份公司 触摸感测设备和制造触摸感测设备的框架元件的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3069830D1 (en) * 1979-09-13 1985-01-31 Wellcome Found Benzopyran compounds, useful as chemotherapeutic agents
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression

Also Published As

Publication number Publication date
DE69016739D1 (de) 1995-03-23
US5498625A (en) 1996-03-12
ES2067693T3 (es) 1995-04-01
EP0424064A1 (de) 1991-04-24
JP2648013B2 (ja) 1997-08-27
DK0424064T3 (da) 1995-06-26
US5688933A (en) 1997-11-18
EP0424064B1 (de) 1995-02-08
GR3015887T3 (en) 1995-07-31
DE69016739T2 (de) 1995-06-14
JPH03218380A (ja) 1991-09-25

Similar Documents

Publication Publication Date Title
DE69016739D1 (de) Chirale Azabicycloheptanone und Verfahren zu ihrer Herstellung.
ATE131161T1 (de) Substanz pf 1022, verfahren zu ihrer herstellung und diese substanz enthaltende anthelmintische zusammensetzung.
ATE195973T1 (de) Enzymatische verfahren zur resolution von enantiomeren-mischungen nützlich wie zwischenprodukte zur herstellung von taxanen
ATE234829T1 (de) Verfahren zu herstellung von enantiomerisch- anreicherte tetrahydrobenzothiepin oxyden
MX9203346A (es) (+)-1-(3-dimetilaminopropil)-1-(4'-fluorfenil)-1,3-dihidro-sobenofuran -5-carbonitrilo y sus sales de adicion de acido no toxicas farmaceuticamente utiles.
DE3855458D1 (de) Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden
ATE158798T1 (de) Verfahren zur herstellung von optisch aktiven zyklobutannukleosiden
CY1110919T1 (el) Μεθοδος για τον ενζυματικο διαχωρισμο εναντιομερων της 3(r)- kai 3(s)-υδροξυ-1-μεθυλο-4-(2,4,6-τριμεθοξυφαινυλο)-1,2,3,6-τετραϋδρο-πυριδινης ή των εστερων καρβοξυλικου οξεος αυτης.
ATE273952T1 (de) Verfahren und zwischenprodukte zur trennung von piperidylacetamid-stereoisomeren
DE69027063D1 (de) Enantioselektive Synthese von Antifolaten
DE69014480D1 (de) Verfahren zur Herstellung von antikonvulsanten cyclischen Aminosäureverbindungen.
DE69032341D1 (de) Verfahren zur Herstellung von optisch aktiven Verbindungen mit mehrfachen chiralen Mittelpunkten
ATE170173T1 (de) Verfahren zur enantioselektiven synthese alkylierter oxindole zur verwendung als zwischenprodukte bei der herstellung von physostigminen
DE68923312D1 (de) Verfahren zur Herstellung von Caprolactam mit hoher Reinheit.
PT81841A (de) Traegermatrix zur aufnahme von katalytisch wirkenden verbindungen verfahren zur herstellung der traeger matrix
ATE45572T1 (de) Verfahren zur herstellung substituierter oxazoline.
DE69424065D1 (de) Verfahren zur herstellung von zwischenprodukten, die für die herstellung von retroviral-protease hemmenden verbindungen verwendbar sind
DK0530657T3 (da) Fremgangsmåde til enantiomeradskillelse af 5-hetaryl-1,3,4-thiadiazinon
ATE132535T1 (de) Verfahren zur diskontinuierlichen herstellung von l-carnitin auf mikrobiologischem weg
DE3685337D1 (de) Verfahren zur herstellung von amiden unter verwendung von mikroorganismen.
ATE182140T1 (de) Optisch aktive 1,4-dihydropyridinderivate sowie verfahren zu ihrer herstellung
DE3777464D1 (de) Fluorine enthaltende vitamin-d3-derivate und verfahren zu ihrer herstellung.
ATE62674T1 (de) Verfahren zur herstellung von n-allylpiperidinderivaten.
ATE55769T1 (de) Substituierte dioxanone, verfahren zu deren herstellung und deren verwendung.
DE68907771D1 (de) Pentafluorphenylderivate, verfahren zu deren herstellung einschliesslich der optisch aktiven derivate und verfahren zur optischen aufspaltung von chiralen carbonsaeuren.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee