ATE118208T1 - Chirale azabicycloheptanone und verfahren zu ihrer herstellung. - Google Patents

Chirale azabicycloheptanone und verfahren zu ihrer herstellung.

Info

Publication number
ATE118208T1
ATE118208T1 AT90311253T AT90311253T ATE118208T1 AT E118208 T1 ATE118208 T1 AT E118208T1 AT 90311253 T AT90311253 T AT 90311253T AT 90311253 T AT90311253 T AT 90311253T AT E118208 T1 ATE118208 T1 AT E118208T1
Authority
AT
Austria
Prior art keywords
chiral
azabicycloheptanones
production
lactamase
amino
Prior art date
Application number
AT90311253T
Other languages
English (en)
Inventor
Christopher Thomas Evans
Stanley Michael Roberts
Original Assignee
Chiroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898923278A external-priority patent/GB8923278D0/en
Priority claimed from GB898924209A external-priority patent/GB8924209D0/en
Priority claimed from GB909000995A external-priority patent/GB9000995D0/en
Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd
Application granted granted Critical
Publication of ATE118208T1 publication Critical patent/ATE118208T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/001Amines; Imines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/005Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/02Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10Nitrogen as only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT90311253T 1989-10-16 1990-10-15 Chirale azabicycloheptanone und verfahren zu ihrer herstellung. ATE118208T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898923278A GB8923278D0 (en) 1989-10-16 1989-10-16 Chiral compounds
GB898924209A GB8924209D0 (en) 1989-10-27 1989-10-27 Chiral compounds
GB909000995A GB9000995D0 (en) 1990-01-17 1990-01-17 Chiral compounds

Publications (1)

Publication Number Publication Date
ATE118208T1 true ATE118208T1 (de) 1995-02-15

Family

ID=27264742

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90311253T ATE118208T1 (de) 1989-10-16 1990-10-15 Chirale azabicycloheptanone und verfahren zu ihrer herstellung.

Country Status (8)

Country Link
US (2) US5498625A (de)
EP (1) EP0424064B1 (de)
JP (1) JP2648013B2 (de)
AT (1) ATE118208T1 (de)
DE (1) DE69016739T2 (de)
DK (1) DK0424064T3 (de)
ES (1) ES2067693T3 (de)
GR (1) GR3015887T3 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
GB9108384D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Bicycloheptanes
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
DE4420751A1 (de) 1994-06-15 1995-12-21 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Lactamen
EP0777651A1 (de) * 1994-08-19 1997-06-11 Chiroscience Limited Verfahren zur trennung der enantiomeren eines bicyclischen lactams
GB9618340D0 (en) * 1996-09-03 1996-10-16 Chiroscience Ltd Microorganism and its use
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers
GB9717928D0 (en) * 1997-08-22 1997-10-29 Glaxo Group Ltd Process for the enatioselective hydrolysis of n-derivatised lactams
US6136327A (en) 1997-12-01 2000-10-24 Alza Corporation Stereospecific delivery of a drug using electrotransport
US6529730B1 (en) * 1998-05-15 2003-03-04 Conexant Systems, Inc System and method for adaptive multi-rate (AMR) vocoder rate adaption
ATE258605T1 (de) * 1998-07-09 2004-02-15 Lonza Ag Verfahren zur herstellung von (1r,4s)-2- azabicyclo 2.2.1 hept-5-en-3-on-derivaten
GB9907415D0 (en) * 1999-03-31 1999-05-26 Chirotech Technology Ltd Biocatalyst and its use
KR20020013937A (ko) 1999-06-28 2002-02-21 다우 케네드 제이. (-)-(1에스,4알) 엔-프로텍티드4-아미노-2-시클로펜텐-1-카르복실레이트 에스테르의제조방법
DE19962543A1 (de) * 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
EP1334969A4 (de) 2000-10-18 2005-08-24 Kuraray Co VERFAHREN ZUR HERSTELLUNG VON 4-N-SUBSTITUIERTEN AMINO-2-AZA-1-OXABICYCLOç3.3.0!OCT-2-EN-6-CARBONSÄUREESTERN UND VERFAHREN ZUR HERSTELLUNG IHRER ZWISCHENPRODUKTE
US6780635B2 (en) 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
JP2005520239A (ja) * 2002-03-13 2005-07-07 オー−プン・アンパルトセルスカブ タッチパッド、タッチパッドを用いるスタイラス、及びタッチパッドを操作する方法
EP1348765B1 (de) * 2002-03-28 2006-05-24 Council of Scientific and Industrial Research Verfahren zur Herstellung von optisch aktiven Azabicycloheptanone-Derivaten
US7435940B2 (en) * 2003-03-12 2008-10-14 Flatfrog Laboratories Ab System and a method of determining the position of a radiation emitting element
WO2005026938A2 (en) 2003-09-12 2005-03-24 O-Pen Aps A system and method of determining a position of a radiation scattering/reflecting element
US7442914B2 (en) * 2003-09-12 2008-10-28 Flatfrog Laboratories Ab System and method of determining a position of a radiation emitting element
JO2934B1 (en) 2006-06-23 2015-09-15 سميث كلاين بيتشام كوربوريشن Prolyl hydroxylase inhibitors
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
SE533704C2 (sv) 2008-12-05 2010-12-07 Flatfrog Lab Ab Pekkänslig apparat och förfarande för drivning av densamma
US10168835B2 (en) 2012-05-23 2019-01-01 Flatfrog Laboratories Ab Spatial resolution in touch displays
US10019113B2 (en) 2013-04-11 2018-07-10 Flatfrog Laboratories Ab Tomographic processing for touch detection
US9874978B2 (en) 2013-07-12 2018-01-23 Flatfrog Laboratories Ab Partial detect mode
US10126882B2 (en) 2014-01-16 2018-11-13 Flatfrog Laboratories Ab TIR-based optical touch systems of projection-type
US10146376B2 (en) 2014-01-16 2018-12-04 Flatfrog Laboratories Ab Light coupling in TIR-based optical touch systems
WO2015199602A1 (en) 2014-06-27 2015-12-30 Flatfrog Laboratories Ab Detection of surface contamination
EP3250993B1 (de) 2015-01-28 2019-09-04 FlatFrog Laboratories AB Dynamische berührungsquarantänerahmen
US10318074B2 (en) 2015-01-30 2019-06-11 Flatfrog Laboratories Ab Touch-sensing OLED display with tilted emitters
EP3537269A1 (de) 2015-02-09 2019-09-11 FlatFrog Laboratories AB Optisches berührungssystem
CN107250855A (zh) 2015-03-02 2017-10-13 平蛙实验室股份公司 用于光耦合的光学部件
EP3387516B1 (de) 2015-12-09 2022-04-20 FlatFrog Laboratories AB Verbesserte stiftidentifizierung
WO2018096430A1 (en) 2016-11-24 2018-05-31 Flatfrog Laboratories Ab Automatic optimisation of touch signal
KR102629629B1 (ko) 2016-12-07 2024-01-29 플라트프로그 라보라토리즈 에이비 개선된 터치 장치
CN110300950B (zh) 2017-02-06 2023-06-16 平蛙实验室股份公司 触摸感测系统中的光学耦合
WO2018174786A1 (en) 2017-03-22 2018-09-27 Flatfrog Laboratories Pen differentiation for touch displays
WO2018182476A1 (en) 2017-03-28 2018-10-04 Flatfrog Laboratories Ab Touch sensing apparatus and method for assembly
CN111052058B (zh) 2017-09-01 2023-10-20 平蛙实验室股份公司 改进的光学部件
US11567610B2 (en) 2018-03-05 2023-01-31 Flatfrog Laboratories Ab Detection line broadening
CN112889016A (zh) 2018-10-20 2021-06-01 平蛙实验室股份公司 用于触摸敏感装置的框架及其工具
WO2020153890A1 (en) 2019-01-25 2020-07-30 Flatfrog Laboratories Ab A videoconferencing terminal and method of operating the same
EP4066089B1 (de) 2019-11-25 2024-09-25 FlatFrog Laboratories AB Ein berührungsempfindliches gerät
WO2021158164A1 (en) 2020-02-08 2021-08-12 Flatfrog Laboratories Ab Touch apparatus with low latency interactions
CN115039063B (zh) 2020-02-10 2026-02-13 平蛙实验室股份公司 改进的触摸感测设备

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5651470A (en) * 1979-09-13 1981-05-09 Wellcome Found Flavan derivative
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression

Also Published As

Publication number Publication date
JPH03218380A (ja) 1991-09-25
DE69016739D1 (de) 1995-03-23
JP2648013B2 (ja) 1997-08-27
EP0424064B1 (de) 1995-02-08
DE69016739T2 (de) 1995-06-14
ES2067693T3 (es) 1995-04-01
GR3015887T3 (en) 1995-07-31
US5688933A (en) 1997-11-18
US5498625A (en) 1996-03-12
DK0424064T3 (da) 1995-06-26
EP0424064A1 (de) 1991-04-24

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee