ATE118208T1 - Chirale azabicycloheptanone und verfahren zu ihrer herstellung. - Google Patents

Chirale azabicycloheptanone und verfahren zu ihrer herstellung.

Info

Publication number
ATE118208T1
ATE118208T1 AT90311253T AT90311253T ATE118208T1 AT E118208 T1 ATE118208 T1 AT E118208T1 AT 90311253 T AT90311253 T AT 90311253T AT 90311253 T AT90311253 T AT 90311253T AT E118208 T1 ATE118208 T1 AT E118208T1
Authority
AT
Austria
Prior art keywords
chiral
azabicycloheptanones
production
lactamase
amino
Prior art date
Application number
AT90311253T
Other languages
English (en)
Inventor
Christopher Thomas Evans
Stanley Michael Roberts
Original Assignee
Chiroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898923278A external-priority patent/GB8923278D0/en
Priority claimed from GB898924209A external-priority patent/GB8924209D0/en
Priority claimed from GB909000995A external-priority patent/GB9000995D0/en
Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd
Application granted granted Critical
Publication of ATE118208T1 publication Critical patent/ATE118208T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT90311253T 1989-10-16 1990-10-15 Chirale azabicycloheptanone und verfahren zu ihrer herstellung. ATE118208T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898923278A GB8923278D0 (en) 1989-10-16 1989-10-16 Chiral compounds
GB898924209A GB8924209D0 (en) 1989-10-27 1989-10-27 Chiral compounds
GB909000995A GB9000995D0 (en) 1990-01-17 1990-01-17 Chiral compounds

Publications (1)

Publication Number Publication Date
ATE118208T1 true ATE118208T1 (de) 1995-02-15

Family

ID=27264742

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90311253T ATE118208T1 (de) 1989-10-16 1990-10-15 Chirale azabicycloheptanone und verfahren zu ihrer herstellung.

Country Status (8)

Country Link
US (2) US5498625A (de)
EP (1) EP0424064B1 (de)
JP (1) JP2648013B2 (de)
AT (1) ATE118208T1 (de)
DE (1) DE69016739T2 (de)
DK (1) DK0424064T3 (de)
ES (1) ES2067693T3 (de)
GR (1) GR3015887T3 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
GB9108384D0 (en) * 1991-04-19 1991-06-05 Enzymatix Ltd Bicycloheptanes
GB9204015D0 (en) * 1992-02-25 1992-04-08 Wellcome Found Therapeutic nucleosides
DE4420751A1 (de) * 1994-06-15 1995-12-21 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Lactamen
AU3187495A (en) * 1994-08-19 1996-03-14 Chiroscience Limited Process for the separation of the enantiomers of a bicyclic lactam
GB9618340D0 (en) * 1996-09-03 1996-10-16 Chiroscience Ltd Microorganism and its use
GB9625455D0 (en) * 1996-12-07 1997-01-22 Glaxo Group Ltd Process for resolving mixtures of carbocyclic steroisomers
GB9717928D0 (en) 1997-08-22 1997-10-29 Glaxo Group Ltd Process for the enatioselective hydrolysis of n-derivatised lactams
US6136327A (en) 1997-12-01 2000-10-24 Alza Corporation Stereospecific delivery of a drug using electrotransport
US6529730B1 (en) * 1998-05-15 2003-03-04 Conexant Systems, Inc System and method for adaptive multi-rate (AMR) vocoder rate adaption
ATE258605T1 (de) * 1998-07-09 2004-02-15 Lonza Ag Verfahren zur herstellung von (1r,4s)-2- azabicyclo 2.2.1 hept-5-en-3-on-derivaten
GB9907415D0 (en) * 1999-03-31 1999-05-26 Chirotech Technology Ltd Biocatalyst and its use
CN1358170A (zh) 1999-06-28 2002-07-10 生物晶体药品股份有限公司 (一)-(1s,4r)n-保护4-氨基-2-环戊烯-1-羧酸酯的制备方法
DE19962543A1 (de) 1999-12-23 2001-07-05 Degussa Chromatographische Enantiomerentrennung von bicyclischen Lactamen
US7038059B2 (en) 2000-10-18 2006-05-02 Kuraray Co., Ltd. Process for preparation of 4-n-substituted amino-2-aza-1-oxabicyclo[3.3.0] oct-2-ene-6-carboxylic acid esters and process for preparation of their intermediates
US6780635B2 (en) 2001-12-27 2004-08-24 Council Of Scientific And Industrial Research Process for the preparation of optically active azabicyclo heptanone derivatives
EP1493124B1 (de) * 2002-03-13 2006-07-26 O-Pen ApS Berührungs-pad und verfahren zum betreiben des berührungs-pad
EP1348765B1 (de) * 2002-03-28 2006-05-24 Council of Scientific and Industrial Research Verfahren zur Herstellung von optisch aktiven Azabicycloheptanone-Derivaten
JP2006523869A (ja) * 2003-03-12 2006-10-19 オー−プン・アンパルトセルスカブ 放射線を放射する要素の位置を測定するシステム及び方法
WO2005026930A2 (en) * 2003-09-12 2005-03-24 O-Pen Aps A system and method of determining a position of a radiation emitting element
CN1867881B (zh) 2003-09-12 2010-08-18 平蛙实验室股份公司 确定辐射散射/反射件的位置的系统和方法
TWI394747B (zh) 2006-06-23 2013-05-01 Smithkline Beecham Corp 脯胺醯基羥化酶抑制劑
HU227663B1 (en) * 2007-07-09 2011-10-28 Univ Szegedi Resolution process
SE533704C2 (sv) 2008-12-05 2010-12-07 Flatfrog Lab Ab Pekkänslig apparat och förfarande för drivning av densamma
US10168835B2 (en) 2012-05-23 2019-01-01 Flatfrog Laboratories Ab Spatial resolution in touch displays
US10019113B2 (en) 2013-04-11 2018-07-10 Flatfrog Laboratories Ab Tomographic processing for touch detection
WO2015005847A1 (en) 2013-07-12 2015-01-15 Flatfrog Laboratories Ab Partial detect mode
WO2015108480A1 (en) 2014-01-16 2015-07-23 Flatfrog Laboratories Ab Improvements in tir-based optical touch systems of projection-type
US10146376B2 (en) 2014-01-16 2018-12-04 Flatfrog Laboratories Ab Light coupling in TIR-based optical touch systems
EP3161594A4 (de) 2014-06-27 2018-01-17 FlatFrog Laboratories AB Nachweis von oberflächenverschmutzung
US11182023B2 (en) 2015-01-28 2021-11-23 Flatfrog Laboratories Ab Dynamic touch quarantine frames
US10318074B2 (en) 2015-01-30 2019-06-11 Flatfrog Laboratories Ab Touch-sensing OLED display with tilted emitters
US10496227B2 (en) 2015-02-09 2019-12-03 Flatfrog Laboratories Ab Optical touch system comprising means for projecting and detecting light beams above and inside a transmissive panel
EP3265855A4 (de) 2015-03-02 2018-10-31 FlatFrog Laboratories AB Optische komponente zur lichtkopplung
JP2018536944A (ja) 2015-12-09 2018-12-13 フラットフロッグ ラボラトリーズ アーベーFlatFrog Laboratories AB 改善されたスタイラスの識別
EP3545392A4 (de) 2016-11-24 2020-07-29 FlatFrog Laboratories AB Automatische optimierung von berührungssignalen
CN116755580A (zh) 2016-12-07 2023-09-15 平蛙实验室股份公司 触摸感测装置
CN110300950B (zh) 2017-02-06 2023-06-16 平蛙实验室股份公司 触摸感测系统中的光学耦合
WO2018174787A1 (en) 2017-03-22 2018-09-27 Flatfrog Laboratories Eraser for touch displays
EP3602259A4 (de) 2017-03-28 2021-01-20 FlatFrog Laboratories AB Berührungssensor und verfahren zur montage
EP3676694A4 (de) 2017-09-01 2021-06-09 FlatFrog Laboratories AB Verbesserte optische komponente
US11567610B2 (en) 2018-03-05 2023-01-31 Flatfrog Laboratories Ab Detection line broadening
US12055969B2 (en) 2018-10-20 2024-08-06 Flatfrog Laboratories Ab Frame for a touch-sensitive device and tool therefor
WO2020153890A1 (en) 2019-01-25 2020-07-30 Flatfrog Laboratories Ab A videoconferencing terminal and method of operating the same
ES2991658T3 (es) 2019-11-25 2024-12-04 Flatfrog Lab Ab Un aparato táctil
US12282653B2 (en) 2020-02-08 2025-04-22 Flatfrog Laboratories Ab Touch apparatus with low latency interactions
EP4104042A1 (de) 2020-02-10 2022-12-21 FlatFrog Laboratories AB Verbesserte berührungsempfindliche vorrichtung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3069830D1 (en) * 1979-09-13 1985-01-31 Wellcome Found Benzopyran compounds, useful as chemotherapeutic agents
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression

Also Published As

Publication number Publication date
DE69016739D1 (de) 1995-03-23
JP2648013B2 (ja) 1997-08-27
EP0424064B1 (de) 1995-02-08
JPH03218380A (ja) 1991-09-25
US5498625A (en) 1996-03-12
GR3015887T3 (en) 1995-07-31
US5688933A (en) 1997-11-18
DK0424064T3 (da) 1995-06-26
DE69016739T2 (de) 1995-06-14
EP0424064A1 (de) 1991-04-24
ES2067693T3 (es) 1995-04-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
REN Ceased due to non-payment of the annual fee