ES2069285T3 - Nuevo metodo para la preparacion de derivados del acido benzoico. - Google Patents

Nuevo metodo para la preparacion de derivados del acido benzoico.

Info

Publication number
ES2069285T3
ES2069285T3 ES91906248T ES91906248T ES2069285T3 ES 2069285 T3 ES2069285 T3 ES 2069285T3 ES 91906248 T ES91906248 T ES 91906248T ES 91906248 T ES91906248 T ES 91906248T ES 2069285 T3 ES2069285 T3 ES 2069285T3
Authority
ES
Spain
Prior art keywords
reaction
benzoic acid
preparation
reaction product
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91906248T
Other languages
English (en)
Inventor
Yoshinori Hamada
Isamu Yamada
Masaaki Uenaka
Teruo Sakata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2069285T3 publication Critical patent/ES2069285T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Paper (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE PRESENTA UN PROCESO INDUSTRIALMENTE VENTAJOSO PARA PRODUCIR UN DERIVADO DE ACIDO BENZOICO DE LA FORMULA GENERAL (V), QUE TIENE UNA BUENA ACTIVIDAD RETINOIDEA CON UNA ALTA SEGURIDAD, EL PROCESO COMPRENDE LOS PASOS DE LLEVAR A CABO UNA REACCION "FRIEDEL-CRAFTS" ENTRE ACETANILURO, EL CUAL ES FACIL DE ENCONTRAR Y DE TRABAJAR Y, 2,5-DIMETIL ENDO EL INTERCAMBIO DE AZIL ENTRE EL PRODUCTO DE REACCION Y EL CLORURO ESTER MONOMETIL DEL ACIDO TEREFTALICO, HIDROLIZANDO EL PRODUCTO DE REACCION, Y RECRISTALIZANDO EL HIDROLIZATO A PARTIR DEL METANOL/AGUA. LOS VARIOS PASOS DE LA REACCION TIENEN LUGAR EN UN UNICO VASO. LOS CRISTALES DEL COMPUESTO OBTENIDO SON ADECUADOS PARA LA PREPARACION FARMACEUTICA A CAUSA DE QUE CONTIENEN UNA CANTIDAD REDUCIDA DE SOLVENTE DE RECRISTALIZACION RESIDUAL Y PRESENTAN TAMAÑOS DE PARTICULAS UNIFORMES.
ES91906248T 1990-03-20 1991-03-15 Nuevo metodo para la preparacion de derivados del acido benzoico. Expired - Lifetime ES2069285T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7143390 1990-03-20

Publications (1)

Publication Number Publication Date
ES2069285T3 true ES2069285T3 (es) 1995-05-01

Family

ID=13460393

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91906248T Expired - Lifetime ES2069285T3 (es) 1990-03-20 1991-03-15 Nuevo metodo para la preparacion de derivados del acido benzoico.

Country Status (14)

Country Link
US (1) US5214202A (es)
EP (1) EP0478787B1 (es)
JP (2) JP3001632B2 (es)
KR (1) KR960014911B1 (es)
AT (1) ATE115946T1 (es)
AU (1) AU628732B2 (es)
DE (1) DE69106098T2 (es)
DK (1) DK0478787T3 (es)
ES (1) ES2069285T3 (es)
FI (1) FI915445A7 (es)
GR (1) GR3015138T3 (es)
HU (2) HU210300B (es)
NO (1) NO300206B1 (es)
WO (1) WO1991014673A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264578A (en) 1987-03-20 1993-11-23 Allergan, Inc. Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity
US5648514A (en) 1994-12-29 1997-07-15 Allergan Substituted acetylenes having retinoid-like biological activity
US5534641A (en) 1994-12-29 1996-07-09 Allergan Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity
US5675033A (en) 1995-06-06 1997-10-07 Allergan 2,4-pentadienoic acid derivatives having retinoid-like biological activity
US5917082A (en) 1995-06-06 1999-06-29 Allergan Sales, Inc. 2,4-pentadienoic acid derivatives having retinoid-like biological activity
US6008204A (en) 1995-09-01 1999-12-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5776699A (en) * 1995-09-01 1998-07-07 Allergan, Inc. Method of identifying negative hormone and/or antagonist activities
US5952345A (en) 1995-09-01 1999-09-14 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US6942980B1 (en) 1995-09-01 2005-09-13 Allergan, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US6218128B1 (en) 1997-09-12 2001-04-17 Allergan Sales, Inc. Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities
US5958954A (en) 1995-09-01 1999-09-28 Allergan Sales, Inc. Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities
US5675024A (en) 1995-11-22 1997-10-07 Allergan Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity
US6555690B2 (en) 1996-06-21 2003-04-29 Allergan, Inc. Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5763635A (en) 1996-06-21 1998-06-09 Allergan Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity
US5741896A (en) 1996-06-21 1998-04-21 Allergan O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5773594A (en) 1996-06-21 1998-06-30 Allergan Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5728846A (en) 1996-12-12 1998-03-17 Allergan Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
US6037488A (en) 1997-04-19 2000-03-14 Allergan Sales, Inc. Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity
US5919970A (en) 1997-04-24 1999-07-06 Allergan Sales, Inc. Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
ES2349461T3 (es) * 2000-09-01 2011-01-03 Toko Pharmaceutical Ind. Co. Ltd Procedimiento de producción de cristales de un derivado de acido benzoico.
US6620963B1 (en) 2002-09-19 2003-09-16 Allergan, Inc. TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-PHENYL AND TRICYCLO[6.2.202,7]DODECA-2(7),3,5-TRIEN-4-CARBONYLAMINO-HETEROARYL AND RELATED COMPOUNDS HAVING RARα RECEPTOR SELECTIVE BIOLOGICAL ACTIVITY
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
CN101200435B (zh) * 2006-12-12 2011-12-07 江苏恒瑞医药股份有限公司 他米巴罗汀ⅱ型结晶的制备方法
EP2143428B1 (en) 2007-03-30 2015-11-04 TMRC Co., Ltd. Tamibarotene capsule preparation
WO2009114966A1 (zh) * 2008-03-19 2009-09-24 江苏恒瑞医药股份有限公司 他米巴罗汀ii型结晶的制备方法
CN101665449B (zh) * 2009-09-24 2012-12-12 山东大学 他米巴罗汀的水溶性前药及其制备方法与应用
CN102633673A (zh) * 2012-03-30 2012-08-15 上海共价化学科技有限公司 他米巴罗汀的合成方法
WO2025018279A1 (ja) 2023-07-14 2025-01-23 国立大学法人 岡山大学 ヒト移植片対宿主病の治療薬およびその組合せ物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2500157C2 (de) * 1975-01-03 1983-09-15 Hoechst Ag, 6230 Frankfurt N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung
US4227014A (en) * 1978-02-27 1980-10-07 American Cyanamid Company 4-[(Cycloalkyl or cycloalkenyl substituted)amino, alkylamino or alkenylamino]benzoic acids and salts thereof
DK214679A (da) * 1978-06-09 1979-12-10 Chugai Pharmaceutical Co Ltd Terephthalsyremonoamid derivater fremgangsmaade til deres fremstilling samt antiallergiske midler indeholdende disse
JPS6176440A (ja) * 1984-09-19 1986-04-18 Koichi Shiyudo 安息香酸誘導体
US4808631A (en) * 1986-11-07 1989-02-28 Hoffmann-La Roche Inc. Aromatic acid derivatives
US4989090A (en) * 1989-04-05 1991-01-29 Yves C. Faroudja Television scan line doubler including temporal median filter

Also Published As

Publication number Publication date
AU7482691A (en) 1991-10-21
ATE115946T1 (de) 1995-01-15
DE69106098T2 (de) 1995-05-24
AU628732B2 (en) 1992-09-17
HU913801D0 (en) 1992-07-28
DE69106098D1 (de) 1995-02-02
HU208417B (en) 1993-10-28
FI915445A0 (fi) 1991-11-18
HU210300B (en) 1995-03-28
JP2000034262A (ja) 2000-02-02
HUT61270A (en) 1992-12-28
WO1991014673A1 (fr) 1991-10-03
GR3015138T3 (en) 1995-05-31
NO914519L (no) 1992-01-07
KR960014911B1 (ko) 1996-10-21
DK0478787T3 (da) 1995-02-20
JP3001632B2 (ja) 2000-01-24
US5214202A (en) 1993-05-25
JP3076569B2 (ja) 2000-08-14
KR920702342A (ko) 1992-09-03
EP0478787B1 (en) 1994-12-21
NO914519D0 (no) 1991-11-19
HUT61272A (en) 1992-12-28
EP0478787A4 (en) 1992-07-01
FI915445A7 (fi) 1991-11-18
EP0478787A1 (en) 1992-04-08
HU9202856D0 (en) 1992-11-30
NO300206B1 (no) 1997-04-28

Similar Documents

Publication Publication Date Title
ES2069285T3 (es) Nuevo metodo para la preparacion de derivados del acido benzoico.
HUT59376A (en) Process for producing r(+)-n-propargyl-1-aminoindane and pharmaceutical compositions comprising such compound
NO974967D0 (no) Fremgangsmåte for fremstilling av rene enantiomere av tropasyre-estere
ES8707514A1 (es) Procedimiento para preparar nuevos tetrahidro-benzotiazoles.
FI952230A0 (fi) Uusi aryylipropaanijohdannainen, menetelmä sen valmistamiseksi ja sen käyttö analgeettisena aineena
SE8406138L (sv) Nya retinoider
ES8305749A1 (es) "procedimiento para la preparacion de nuevas amidas de acidos carboxilicos".
ES8506031A1 (es) Un procedimiento para la preparacion de derivados de ergolina
CO4340619A1 (es) Derivados cristalinos del acido n-acetil neuramico y procesos para su preparacion
FI901150A0 (fi) Menetelmä terapeuttisesti käyttökelpoisen N-asetyylineuraminaattitrihydraatin valmistamiseksi
ES8304122A1 (es) "procedimiento para la preparacion de derivados triptaminicos sustituidos de tieniloxipropanolaminas, racemicos y opticamente activos".
KR900009677A (ko) 신규 화합물들
EE03822B1 (et) Meetod bensüülalkoholi valmistamiseks
JPS6492A (en) Novel glycerin derivative, production thereof, hypotensor containing said derivative
ES479576A1 (es) Un procedimiento para la preparacion de 4-aza-5-andostran-3 ona 17 sustituida.
ES2071843T3 (es) Derivado de acido d-2-(6-metoxi-2-naftil)-propionico opticamente activo y composiciones farmaceuticas que lo contienen.
IT1252228B (it) Procedimento per la produzione di neuraminidasi
ES8503005A1 (es) Un procedimiento para la preparacion de acido 6,a-metoxi-6,b-(2-(2-metilfenoxicarbonil)-2-(tien-3-il) acetamido) penicilanico
JPS57142946A (en) 3,7-dimethyl-6-hydroxy-2,4,7-octatrienoic ester and its preparation
IT1260996B (it) Fiala a soluzione per infusione di acido tiottico in forma di sale idrosolubile dell'acido tiottico.
JPS5452024A (en) Stereospecific synthesis of optically active compounds
JPS57131778A (en) Novel 7-oxabicyclo(4.1.0)heptane-3-carboxylic acid derivative
JPS6470429A (en) Reduction of ester compound
JPS5695197A (en) Aminobenzoic acid derivative and physiologically active agent containing the same
JPS5721371A (en) Quinolinoneiminecarboxylic ester derivative, its preparation and anti-inflammatory and analgesic agent composition containing the same

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 478787

Country of ref document: ES