ES2069836T3 - Sulfato de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida(2:1). - Google Patents

Sulfato de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida(2:1).

Info

Publication number
ES2069836T3
ES2069836T3 ES91311583T ES91311583T ES2069836T3 ES 2069836 T3 ES2069836 T3 ES 2069836T3 ES 91311583 T ES91311583 T ES 91311583T ES 91311583 T ES91311583 T ES 91311583T ES 2069836 T3 ES2069836 T3 ES 2069836T3
Authority
ES
Spain
Prior art keywords
indol
dimethylamine
ethyl
methyl
methanosulfonamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91311583T
Other languages
English (en)
Inventor
Joanne Craig
Derek Leslie Crookes
Stephen John Skittrall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ES2069836T3 publication Critical patent/ES2069836T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)

Abstract

SE REVELA UNA SAL DE SULFATO 3-(2-DIMETILAMINO)ETIL)-N-METIL-1H-INDOL-5 -METANOSULFONAMIDA (2:1) Y SOLVATADOS FARMACEUTICAMENTE ACEPTABLE DE LO MISMO. EL COMPUESTO ES DE UTILIDAD EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS, PARTICULARMENTE PARA FORMULACIONES INTRANASALES, PARA UTILIZAR EN EL TRATAMIENTO DE CONDICIONES ASOCIADAS CON DOLOR DE CABEZA, EN PARTICULAR MIGRAÑA.
ES91311583T 1990-12-12 1991-12-12 Sulfato de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida(2:1). Expired - Lifetime ES2069836T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026998A GB9026998D0 (en) 1990-12-12 1990-12-12 Medicaments

Publications (1)

Publication Number Publication Date
ES2069836T3 true ES2069836T3 (es) 1995-05-16

Family

ID=10686904

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91311583T Expired - Lifetime ES2069836T3 (es) 1990-12-12 1991-12-12 Sulfato de 3-(2-(dimetilamino)etil)-n-metil-1h-indol-5-metanosulfonamida(2:1).

Country Status (36)

Country Link
US (2) US5554639A (es)
EP (1) EP0490689B1 (es)
JP (1) JP2994037B2 (es)
KR (1) KR100211479B1 (es)
CN (2) CN1030890C (es)
AP (1) AP230A (es)
AT (1) ATE119881T1 (es)
AU (1) AU650706B2 (es)
BE (1) BE1005085A3 (es)
CA (1) CA2098302C (es)
CH (1) CH684192A5 (es)
CY (1) CY2005A (es)
CZ (1) CZ281931B6 (es)
DE (1) DE69108200T2 (es)
DK (1) DK0490689T3 (es)
EG (1) EG20219A (es)
ES (1) ES2069836T3 (es)
FR (1) FR2670487B1 (es)
GB (2) GB9026998D0 (es)
GR (1) GR3015430T3 (es)
HK (1) HK82697A (es)
HU (1) HU211937A9 (es)
IE (1) IE62894B1 (es)
IL (1) IL100330A (es)
IS (1) IS1706B (es)
IT (1) IT1252868B (es)
MX (1) MX9102501A (es)
MY (1) MY109265A (es)
NL (1) NL9102071A (es)
NZ (1) NZ240942A (es)
PT (1) PT99757B (es)
RU (1) RU2108328C1 (es)
TW (2) TW300886B (es)
WO (1) WO1992010477A1 (es)
YU (1) YU48926B (es)
ZA (1) ZA919750B (es)

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US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6187790B1 (en) 1999-03-04 2001-02-13 Neal R. Cutler Use of cilostazol for treatment of sexual dysfunction
US6132757A (en) 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6426084B1 (en) 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
US6610271B2 (en) * 2000-05-10 2003-08-26 University Of Kentucky Research Foundation System and method for intranasal administration of lorazepam
US20040115133A1 (en) * 2000-05-10 2004-06-17 Wermeling Daniel P. Intranasal opioid compositions
US6562838B2 (en) * 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US20040176359A1 (en) * 2001-02-20 2004-09-09 University Of Kentucky Research Foundation Intranasal Benzodiazepine compositions
US20030096748A1 (en) * 2001-06-04 2003-05-22 The Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
US20030013753A1 (en) * 2001-06-05 2003-01-16 Ronald Aung-Din Transdermal migraine therapy
US8329734B2 (en) * 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US7208628B2 (en) * 2002-05-13 2007-04-24 Kansas State University Research Foundation Compositions and methods for the treatment of hepatitis C virus infection
US7074893B2 (en) * 2002-06-03 2006-07-11 Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
ES2380827T3 (es) * 2002-12-26 2012-05-18 Pozen, Inc. Formas de dosificación con múltiples capas que contienen naproxeno y triptanes
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
WO2004076403A1 (en) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Sumatriptan crystalline forms, pharmaceutical compositions and methods
EP1644004A4 (en) 2003-06-20 2010-10-06 Ronald Aung-Din LOCAL THERAPY FOR THE TREATMENT OF MIGRAINS, MUSCLE CLARIFICATIONS, MUSCLE SPASMS, SPASTICITY AND RELATED CONDITIONS
US20050089558A1 (en) * 2003-10-28 2005-04-28 Alamo Pharmaceuticals, Llc Compositions and methods for the co-formulation and administration of tramadol and propoxyphene
US20050269402A1 (en) * 2004-06-03 2005-12-08 Tyfone, Inc. System and method for securing financial transactions
US20060002989A1 (en) * 2004-06-10 2006-01-05 Ahmed Salah U Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
CA2609185A1 (en) 2005-05-20 2006-11-30 Ahmed F. Abdel-Magid Process for preparation of sulfamide derivatives
WO2007070504A2 (en) * 2005-12-13 2007-06-21 Morton Grove Pharmaceuticals, Inc. Stable and palatable oral liquid sumatriptan compositions
US8716231B2 (en) 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US8492431B2 (en) 2005-12-19 2013-07-23 Janssen Pharmaceutica, N.V. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US20070191461A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
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US8653066B2 (en) 2006-10-09 2014-02-18 Charleston Laboratories, Inc. Pharmaceutical compositions
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EP2451274B1 (en) 2009-07-08 2017-10-04 Charleston Laboratories, Inc. Pharmaceutical compositions
NZ599344A (en) 2009-09-25 2015-02-27 Reddy’S Lab Ltd Dr Formulations comprising triptan compounds
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
BR112017018944A2 (en) 2015-03-02 2018-05-15 Afgin Pharma, Llc method of treating a disease state or condition in humans with a carbinoid drug, and method of treating a disease state or condition in a mammal other than a human with carbinoid drug (s)
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
JP6897971B2 (ja) 2015-05-15 2021-07-07 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 関節炎を処置するための、方法および組成物
US10179109B2 (en) 2016-03-04 2019-01-15 Charleston Laboratories, Inc. Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
WO2019094469A1 (en) 2017-11-07 2019-05-16 The Regents Of The University Of Michigan Small molecule inhibitors of shared epitope-calreticulin interactions and methods of use
US20220096438A1 (en) 2018-09-07 2022-03-31 Upsher-Smith Laboratories, Llc Methods of treating migraine
US11364225B2 (en) * 2019-08-21 2022-06-21 Bn Intellectual Properties, Inc. Pharmaceutical formulation for treating symptoms of migraine and cluster headaches, and method of using the same
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GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative
GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
GB8928208D0 (en) * 1989-12-13 1990-02-14 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
EP0490689B1 (en) 1995-03-15
EP0490689A1 (en) 1992-06-17
YU48926B (sh) 2002-12-10
GR3015430T3 (en) 1995-06-30
ITRM910922A0 (it) 1991-12-11
IS3790A7 (is) 1992-06-13
MY109265A (en) 1996-12-31
CN1128259A (zh) 1996-08-07
NZ240942A (en) 1994-03-25
EG20219A (en) 1997-11-30
DE69108200T2 (de) 1995-07-20
ZA919750B (en) 1992-10-28
GB9026998D0 (en) 1991-01-30
HU211937A9 (en) 1996-01-29
IL100330A (en) 1996-06-18
HK82697A (en) 1997-06-27
US5705520A (en) 1998-01-06
DE69108200D1 (de) 1995-04-20
CN1030890C (zh) 1996-02-07
NL9102071A (nl) 1992-07-01
AP9100339A0 (en) 1992-01-31
GB9126297D0 (en) 1992-02-12
DK0490689T3 (da) 1995-05-22
US5554639A (en) 1996-09-10
MX9102501A (es) 1992-09-01
TW300886B (es) 1997-03-21
CH684192A5 (fr) 1994-07-29
ATE119881T1 (de) 1995-04-15
IE914317A1 (en) 1992-06-17
CA2098302C (en) 2001-10-16
FR2670487A1 (fr) 1992-06-19
IT1252868B (it) 1995-06-28
CZ281931B6 (cs) 1997-04-16
GB2251614A (en) 1992-07-15
CN1050831C (zh) 2000-03-29
GB2251614B (en) 1994-12-14
CN1063099A (zh) 1992-07-29
CZ114093A3 (en) 1994-02-16
CY2005A (en) 1997-12-05
IS1706B (is) 1998-12-10
FR2670487B1 (fr) 1993-08-20
JPH06503560A (ja) 1994-04-21
CA2098302A1 (en) 1992-06-13
PT99757B (pt) 1999-05-31
IE62894B1 (en) 1995-03-08
YU191491A (sh) 1994-04-05
IL100330A0 (en) 1992-09-06
ITRM910922A1 (it) 1993-06-11
BE1005085A3 (fr) 1993-04-13
KR100211479B1 (ko) 1999-08-02
PT99757A (pt) 1992-12-31
AP230A (en) 1993-01-27
WO1992010477A1 (en) 1992-06-25
TW205035B (es) 1993-05-01
RU2108328C1 (ru) 1998-04-10
JP2994037B2 (ja) 1999-12-27
AU9072091A (en) 1992-07-08
AU650706B2 (en) 1994-06-30

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