PT99757A - Processo para a preparacao de um sal sulfato de 3-{2-(dimetilamino)-etil}-n-metil-1h-indole-5-metanossulfonamida e de composicoes farmaceuticas que o contem - Google Patents

Processo para a preparacao de um sal sulfato de 3-{2-(dimetilamino)-etil}-n-metil-1h-indole-5-metanossulfonamida e de composicoes farmaceuticas que o contem

Info

Publication number
PT99757A
PT99757A PT99757A PT9975791A PT99757A PT 99757 A PT99757 A PT 99757A PT 99757 A PT99757 A PT 99757A PT 9975791 A PT9975791 A PT 9975791A PT 99757 A PT99757 A PT 99757A
Authority
PT
Portugal
Prior art keywords
methanosulfonamide
indole
dimethylamino
sulfate
ethyl
Prior art date
Application number
PT99757A
Other languages
English (en)
Other versions
PT99757B (pt
Inventor
Joanne Craig
Derek Leslie Crookes
Stephen John Skittrall
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PT99757A publication Critical patent/PT99757A/pt
Publication of PT99757B publication Critical patent/PT99757B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
PT99757A 1990-12-12 1991-12-11 Processo para a preparacao de um sal sulfato de 3-{2-(dimetilamino)-etil}-n-metil-1h-indole-5-metanossulfonamida e de composicoes farmaceuticas que o contem PT99757B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026998A GB9026998D0 (en) 1990-12-12 1990-12-12 Medicaments

Publications (2)

Publication Number Publication Date
PT99757A true PT99757A (pt) 1992-12-31
PT99757B PT99757B (pt) 1999-05-31

Family

ID=10686904

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99757A PT99757B (pt) 1990-12-12 1991-12-11 Processo para a preparacao de um sal sulfato de 3-{2-(dimetilamino)-etil}-n-metil-1h-indole-5-metanossulfonamida e de composicoes farmaceuticas que o contem

Country Status (36)

Country Link
US (2) US5554639A (pt)
EP (1) EP0490689B1 (pt)
JP (1) JP2994037B2 (pt)
KR (1) KR100211479B1 (pt)
CN (2) CN1030890C (pt)
AP (1) AP230A (pt)
AT (1) ATE119881T1 (pt)
AU (1) AU650706B2 (pt)
BE (1) BE1005085A3 (pt)
CA (1) CA2098302C (pt)
CH (1) CH684192A5 (pt)
CY (1) CY2005A (pt)
CZ (1) CZ281931B6 (pt)
DE (1) DE69108200T2 (pt)
DK (1) DK0490689T3 (pt)
EG (1) EG20219A (pt)
ES (1) ES2069836T3 (pt)
FR (1) FR2670487B1 (pt)
GB (2) GB9026998D0 (pt)
GR (1) GR3015430T3 (pt)
HK (1) HK82697A (pt)
HU (1) HU211937A9 (pt)
IE (1) IE62894B1 (pt)
IL (1) IL100330A (pt)
IS (1) IS1706B (pt)
IT (1) IT1252868B (pt)
MX (1) MX9102501A (pt)
MY (1) MY109265A (pt)
NL (1) NL9102071A (pt)
NZ (1) NZ240942A (pt)
PT (1) PT99757B (pt)
RU (1) RU2108328C1 (pt)
TW (2) TW300886B (pt)
WO (1) WO1992010477A1 (pt)
YU (1) YU48926B (pt)
ZA (1) ZA919750B (pt)

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US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6187790B1 (en) 1999-03-04 2001-02-13 Neal R. Cutler Use of cilostazol for treatment of sexual dysfunction
US6132757A (en) 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6426084B1 (en) 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
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US6610271B2 (en) * 2000-05-10 2003-08-26 University Of Kentucky Research Foundation System and method for intranasal administration of lorazepam
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US6562838B2 (en) * 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
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US20030096748A1 (en) * 2001-06-04 2003-05-22 The Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
US20030013753A1 (en) * 2001-06-05 2003-01-16 Ronald Aung-Din Transdermal migraine therapy
US8329734B2 (en) * 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US7208628B2 (en) * 2002-05-13 2007-04-24 Kansas State University Research Foundation Compositions and methods for the treatment of hepatitis C virus infection
US7074893B2 (en) * 2002-06-03 2006-07-11 Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
ES2380827T3 (es) * 2002-12-26 2012-05-18 Pozen, Inc. Formas de dosificación con múltiples capas que contienen naproxeno y triptanes
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
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EP1644004A4 (en) 2003-06-20 2010-10-06 Ronald Aung-Din LOCAL THERAPY FOR THE TREATMENT OF MIGRAINS, MUSCLE CLARIFICATIONS, MUSCLE SPASMS, SPASTICITY AND RELATED CONDITIONS
US20050089558A1 (en) * 2003-10-28 2005-04-28 Alamo Pharmaceuticals, Llc Compositions and methods for the co-formulation and administration of tramadol and propoxyphene
US20050269402A1 (en) * 2004-06-03 2005-12-08 Tyfone, Inc. System and method for securing financial transactions
US20060002989A1 (en) * 2004-06-10 2006-01-05 Ahmed Salah U Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
CA2609185A1 (en) 2005-05-20 2006-11-30 Ahmed F. Abdel-Magid Process for preparation of sulfamide derivatives
WO2007070504A2 (en) * 2005-12-13 2007-06-21 Morton Grove Pharmaceuticals, Inc. Stable and palatable oral liquid sumatriptan compositions
US8716231B2 (en) 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US8492431B2 (en) 2005-12-19 2013-07-23 Janssen Pharmaceutica, N.V. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US20070191461A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
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US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
JP6897971B2 (ja) 2015-05-15 2021-07-07 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 関節炎を処置するための、方法および組成物
US10179109B2 (en) 2016-03-04 2019-01-15 Charleston Laboratories, Inc. Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
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US20220096438A1 (en) 2018-09-07 2022-03-31 Upsher-Smith Laboratories, Llc Methods of treating migraine
US11364225B2 (en) * 2019-08-21 2022-06-21 Bn Intellectual Properties, Inc. Pharmaceutical formulation for treating symptoms of migraine and cluster headaches, and method of using the same
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GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
GB8928208D0 (en) * 1989-12-13 1990-02-14 Glaxo Group Ltd Medicaments

Also Published As

Publication number Publication date
EP0490689B1 (en) 1995-03-15
EP0490689A1 (en) 1992-06-17
YU48926B (sh) 2002-12-10
GR3015430T3 (en) 1995-06-30
ITRM910922A0 (it) 1991-12-11
IS3790A7 (is) 1992-06-13
MY109265A (en) 1996-12-31
ES2069836T3 (es) 1995-05-16
CN1128259A (zh) 1996-08-07
NZ240942A (en) 1994-03-25
EG20219A (en) 1997-11-30
DE69108200T2 (de) 1995-07-20
ZA919750B (en) 1992-10-28
GB9026998D0 (en) 1991-01-30
HU211937A9 (en) 1996-01-29
IL100330A (en) 1996-06-18
HK82697A (en) 1997-06-27
US5705520A (en) 1998-01-06
DE69108200D1 (de) 1995-04-20
CN1030890C (zh) 1996-02-07
NL9102071A (nl) 1992-07-01
AP9100339A0 (en) 1992-01-31
GB9126297D0 (en) 1992-02-12
DK0490689T3 (da) 1995-05-22
US5554639A (en) 1996-09-10
MX9102501A (es) 1992-09-01
TW300886B (pt) 1997-03-21
CH684192A5 (fr) 1994-07-29
ATE119881T1 (de) 1995-04-15
IE914317A1 (en) 1992-06-17
CA2098302C (en) 2001-10-16
FR2670487A1 (fr) 1992-06-19
IT1252868B (it) 1995-06-28
CZ281931B6 (cs) 1997-04-16
GB2251614A (en) 1992-07-15
CN1050831C (zh) 2000-03-29
GB2251614B (en) 1994-12-14
CN1063099A (zh) 1992-07-29
CZ114093A3 (en) 1994-02-16
CY2005A (en) 1997-12-05
IS1706B (is) 1998-12-10
FR2670487B1 (fr) 1993-08-20
JPH06503560A (ja) 1994-04-21
CA2098302A1 (en) 1992-06-13
PT99757B (pt) 1999-05-31
IE62894B1 (en) 1995-03-08
YU191491A (sh) 1994-04-05
IL100330A0 (en) 1992-09-06
ITRM910922A1 (it) 1993-06-11
BE1005085A3 (fr) 1993-04-13
KR100211479B1 (ko) 1999-08-02
AP230A (en) 1993-01-27
WO1992010477A1 (en) 1992-06-25
TW205035B (pt) 1993-05-01
RU2108328C1 (ru) 1998-04-10
JP2994037B2 (ja) 1999-12-27
AU9072091A (en) 1992-07-08
AU650706B2 (en) 1994-06-30

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