ES2070303T3 - Acidos aminoalquilfosfinicos sustituidos. - Google Patents

Acidos aminoalquilfosfinicos sustituidos.

Info

Publication number
ES2070303T3
ES2070303T3 ES90810346T ES90810346T ES2070303T3 ES 2070303 T3 ES2070303 T3 ES 2070303T3 ES 90810346 T ES90810346 T ES 90810346T ES 90810346 T ES90810346 T ES 90810346T ES 2070303 T3 ES2070303 T3 ES 2070303T3
Authority
ES
Spain
Prior art keywords
denotes
hydrogen
halogen
hydroxy
methyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90810346T
Other languages
English (en)
Inventor
Roger Graham Dr Hall
Ludwig Dr Maier
Wolfgang Dr Frostl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2070303T3 publication Critical patent/ES2070303T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/36—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Luminescent Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)

Abstract

SE PRESENTAN ACIDOS AMINOALQUILFOSFINICOS SUBSTITUIDOS EN P DE LA FORMULA I, EN DONDE R REPRESENTA UN GRUPO METIL OPCIONALMENTE FLUORINATADO, R1 REPRESENTA HIDROGENO, ALQUIL INFERIOR, ALCOXIDO INFERIOR, HIDROXIDO, HALOGENO O UN GRUPO METIL FLUORINATADO Y R2 Y R3 REPRESENTAN HIDROGENO O BIEN R2 REPRESENTA HIDROXIDO, ALCOXIDO INFERIOR O HALOGENO Y R3 ES HIDROGENO O BIEN R2 Y R3 TOMADAS JUNTAS REPRESENTAN UN GRUPO OXO, O SUS SALES FARMACEUTICAMENTE ACEPTABLES. ESTOS ACIDOS SON ACTIVOS COMO ANTAGONISTAS DE GABAB Y PUEDEN USARSE EN EL TRATAMIENTO DE LA ESPASTICIDAD ESPINAL, ESCLEROSIS MULTIPLE Y PARALISIS CEREBRAL, NEURALGIA DE TRIGEMINO, SINDROME DE ABSTINENCIA Y / O CONDICIONES DE DOLOR. PUEDEN MANUFACTURARSE MEDIANTE METODOS CONOCIDOS "PER SE" DESCRIBIENDOSE LOS METODOS MAS ADECUADOS.
ES90810346T 1989-05-13 1990-05-08 Acidos aminoalquilfosfinicos sustituidos. Expired - Lifetime ES2070303T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898911017A GB8911017D0 (en) 1989-05-13 1989-05-13 Substituted aminoalkylphosphinic acids

Publications (1)

Publication Number Publication Date
ES2070303T3 true ES2070303T3 (es) 1995-06-01

Family

ID=10656689

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90810346T Expired - Lifetime ES2070303T3 (es) 1989-05-13 1990-05-08 Acidos aminoalquilfosfinicos sustituidos.

Country Status (24)

Country Link
EP (1) EP0399949B1 (es)
JP (1) JP2930366B2 (es)
KR (1) KR0159501B1 (es)
AT (1) ATE121095T1 (es)
AU (1) AU629335B2 (es)
CA (1) CA2016631C (es)
DD (1) DD294265A5 (es)
DE (1) DE69018514T2 (es)
DK (1) DK0399949T3 (es)
ES (1) ES2070303T3 (es)
FI (1) FI94416C (es)
GB (1) GB8911017D0 (es)
GR (1) GR3015770T3 (es)
HR (1) HRP940178A2 (es)
HU (1) HU206885B (es)
IE (1) IE66165B1 (es)
IL (1) IL94317A (es)
MX (1) MX20639A (es)
NO (1) NO176761C (es)
NZ (1) NZ233647A (es)
PT (1) PT94014B (es)
SI (1) SI9010917B (es)
YU (1) YU91790A (es)
ZA (1) ZA903611B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0543780A3 (en) * 1991-11-21 1993-09-01 Ciba-Geigy Ag Novel aminoalkanephosphinic acids and their salts
US6001876A (en) 1996-07-24 1999-12-14 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
CN1309659A (zh) 1998-07-15 2001-08-22 哈桑·朱马 有机磷化合物及其用途
GB9906882D0 (en) * 1999-03-25 1999-05-19 Novartis Ag Organic compounds
SE9904508D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
US7319095B2 (en) 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904507D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
AR033779A1 (es) 2001-06-08 2004-01-07 Astrazeneca Ab Compuestos utiles en la enfermedad de reflujo
SE0102055D0 (sv) * 2001-06-08 2001-06-08 Astrazeneca Ab New Compounds
WO2005060968A1 (en) 2003-12-11 2005-07-07 Sepracor Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
BRPI0620372A2 (pt) 2005-12-23 2011-11-08 Astrazeneca Ab composto, composição farmaceutica, e, uso de um composto
BRPI0620464A2 (pt) 2005-12-23 2011-11-16 Astrazeneca Ab composto, composição farmacêutica, uso de um composto, e, método para o tratamento de uma doença
DE102008056228A1 (de) * 2008-11-06 2010-05-12 Clariant International Limited Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, deren Salze und Ester und ihre Verwendung
DE102008056339A1 (de) * 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von mono-aminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
WO2011113904A1 (en) 2010-03-17 2011-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration
EP3753410A3 (en) 2010-09-28 2021-04-28 The Regents Of The University Of California Combinations comprising gaba agonists in treatment of hyperglycemia

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3311475C1 (de) * 1983-03-29 1984-08-16 Siemens AG, 1000 Berlin und 8000 München Mikroprogramm-Steuereinrichtung
DE3312165A1 (de) * 1983-04-02 1984-10-04 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von phosphinothricin
GB8728483D0 (en) * 1987-12-04 1988-01-13 Ciba Geigy Ag Chemical compounds
GB8820266D0 (en) * 1988-08-26 1988-09-28 Smith Kline French Lab Compounds

Also Published As

Publication number Publication date
FI94416B (fi) 1995-05-31
GB8911017D0 (en) 1989-06-28
KR900018124A (ko) 1990-12-20
HU206885B (en) 1993-01-28
NO176761C (no) 1995-05-24
NO902109D0 (no) 1990-05-11
NO902109L (no) 1990-11-14
FI94416C (fi) 1995-09-11
DK0399949T3 (da) 1995-07-03
KR0159501B1 (ko) 1999-01-15
PT94014B (pt) 1996-12-31
NZ233647A (en) 1992-08-26
IE901716L (en) 1990-11-13
EP0399949A1 (en) 1990-11-28
DE69018514T2 (de) 1995-09-21
HRP940178A2 (en) 1996-08-31
ZA903611B (en) 1991-02-27
HUT53656A (en) 1990-11-28
JP2930366B2 (ja) 1999-08-03
IL94317A0 (en) 1991-03-10
IE66165B1 (en) 1995-12-13
SI9010917A (en) 1997-06-30
FI902368A0 (fi) 1990-05-11
CA2016631C (en) 2000-08-29
ATE121095T1 (de) 1995-04-15
NO176761B (no) 1995-02-13
DD294265A5 (de) 1991-09-26
DE69018514D1 (de) 1995-05-18
IL94317A (en) 1997-07-13
HU903012D0 (en) 1990-09-28
AU629335B2 (en) 1992-10-01
EP0399949B1 (en) 1995-04-12
GR3015770T3 (en) 1995-07-31
PT94014A (pt) 1991-01-08
SI9010917B (sl) 1999-10-31
YU91790A (sh) 1992-07-20
AU5480990A (en) 1990-11-15
MX20639A (es) 1993-12-01
CA2016631A1 (en) 1990-11-13
JPH0395195A (ja) 1991-04-19

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