ES2071058T3 - Procedimiento de solubilizacion de peptidos y procedimiento de sintesis de peptidos. - Google Patents

Procedimiento de solubilizacion de peptidos y procedimiento de sintesis de peptidos.

Info

Publication number
ES2071058T3
ES2071058T3 ES90402677T ES90402677T ES2071058T3 ES 2071058 T3 ES2071058 T3 ES 2071058T3 ES 90402677 T ES90402677 T ES 90402677T ES 90402677 T ES90402677 T ES 90402677T ES 2071058 T3 ES2071058 T3 ES 2071058T3
Authority
ES
Spain
Prior art keywords
peptide
group
synthesis
lipophilic
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90402677T
Other languages
English (en)
Inventor
Christian Gervais
Jean-Marie Bernard
Kamel Bouzid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhodia Chimie SAS
Original Assignee
Rhone Poulenc Chimie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Chimie SA filed Critical Rhone Poulenc Chimie SA
Application granted granted Critical
Publication of ES2071058T3 publication Critical patent/ES2071058T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)

Abstract

PROCESO DE SOLUBILIZACION DE PEPTIDO EN UN DISOLVENTE ORGANICO NO MISCIBLE EN EL AGUA, CONSISTENTE EN LIGAR AL GRUPO CARBOXILICO TERMINAL DE DICHO PEPTIDO, UN LIPOFILO POR UN ENLACE AMIDO O ESTER; ESTE GRUPO LIPOFILO ESTA CARACTERIZADO POR EL HECHO DE QUE CUANDO ESTA LIGADO A LA L-SERINA, SE OBTIENE UNA MOLECULA CUYA SOLUBILIDAD EN EL AGUA A 25 C ES INFERIOR A 30 G/LITRO. ESTE GRUPO LIPOFILO ESTA QUIMICAMENTE DEFINIDO Y NO POLIMERICO. EL PRESENTE INVENTO CONCIERNE TAMBIEN UN PROCESO DE SINTESIS DE PEPTIDOS EVENTUALMENTE PROTEGIDOS, EN MEDIO LIQUIDO, CARACTERIZADO EN QUE SE PARTE DE UN AMINOACIDO O DE UN PEPTIDO SOLUBILIZADO EN MEDIO ORGANICO POR UN GRUPO A-L LIPOFILO LIGADO A LA FUNCION CARBOXILICA DEL AMINOACIDO O DEL PEPTIDO DE PARTIDA Y QUE SE LE AÑADE LOS AMINOACIDOS O LOS PEPTIDOS A CONDENSAR ACTIVADOS SOBRE SU FUNCION ACIDA Y PROTEGIDOS SOBRE SU FUNCION AMINA Y EVENTUALMENTE SOBRE SU CADENA LATERAL. LOS PEPTIDOS SALIDOS DE LA SINTESIS SON UTILIZADOS EVENTUALMENTE PARA LA SINTESIS DE MEDICAMENTOS, VACUNAS, PRODUCTOS AGROALIMENTICIOS O FITOSANITARIOS.
ES90402677T 1989-10-02 1990-09-28 Procedimiento de solubilizacion de peptidos y procedimiento de sintesis de peptidos. Expired - Lifetime ES2071058T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8913054A FR2652581B1 (fr) 1989-10-02 1989-10-02 Procede de solubilisation de peptides et procede de synthese de peptides.

Publications (1)

Publication Number Publication Date
ES2071058T3 true ES2071058T3 (es) 1995-06-16

Family

ID=9386132

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90402677T Expired - Lifetime ES2071058T3 (es) 1989-10-02 1990-09-28 Procedimiento de solubilizacion de peptidos y procedimiento de sintesis de peptidos.

Country Status (13)

Country Link
US (1) US5712367A (es)
EP (1) EP0421848B1 (es)
JP (2) JP2579699B2 (es)
AT (1) ATE118219T1 (es)
CA (1) CA2026655C (es)
DD (1) DD299189A5 (es)
DE (1) DE69016732T2 (es)
DK (1) DK0421848T3 (es)
ES (1) ES2071058T3 (es)
FR (1) FR2652581B1 (es)
GR (1) GR3015802T3 (es)
IE (1) IE67453B1 (es)
PT (1) PT95478B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004018501A1 (en) * 2002-08-26 2004-03-04 A & Pep Inc. Method for synthesizing peptides
ATE410437T1 (de) * 2003-12-31 2008-10-15 Hoffmann La Roche Verfahren und systeme zur rückgewinnung von peptiden
ES2615083T3 (es) * 2005-09-20 2017-06-05 Jitsubo Co., Ltd. Vehículo de separación, método de separación de un compuesto, y método de síntesis del péptido utilizando el vehículo
US8569453B2 (en) 2009-03-12 2013-10-29 Ajinomoto Co., Inc. Fluorene compound
WO2010113939A1 (ja) 2009-03-30 2010-10-07 味の素株式会社 ジフェニルメタン化合物
EP2518041A4 (en) 2009-12-25 2013-12-11 Ajinomoto Kk benzyl
CN106220482B (zh) 2010-08-30 2020-01-07 味之素株式会社 含有支链的芳香族化合物
WO2021060048A1 (ja) 2019-09-25 2021-04-01 日産化学株式会社 ペプチド化合物の製造方法
CA3107841C (en) * 2019-10-18 2023-05-09 Deciem Beauty Group Inc. Skin care formulation with lipophilic peptides

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1172768A (en) * 1966-04-26 1969-12-03 Ici Australia Ltd New Graft Copolymers
US4156683A (en) * 1973-03-26 1979-05-29 Schering Corporation Complexes of macrocyclic compounds
LU75628A1 (es) * 1976-08-19 1978-04-13
FR2451915A1 (fr) * 1979-03-23 1980-10-17 Clin Midy Nouveau procede de preparation de la somatostatine
JPS5753445A (en) * 1980-09-16 1982-03-30 Torii Yakuhin Kk Peptide compound
JPS5753446A (en) * 1980-09-16 1982-03-30 Torii Yakuhin Kk Peptide derivative
US4436874A (en) * 1981-11-19 1984-03-13 Societe D'expansion Scientifique "Expansia" Acrylic copolymers and their use in solid phase peptide synthesis
GB8317697D0 (en) * 1983-06-29 1983-08-03 Shell Int Research Dissolution of peptides in non-aqueous and mixed non-aqueous/aqueous solvents
DE3608083A1 (de) * 1986-03-07 1987-09-10 Gruszecki Wojciech Verfahren zur herstellung von peptiden
US4857656A (en) * 1986-05-08 1989-08-15 Sanshin Kagaku Kogyo Co., Ltd. Active esters used for production of esters or amides and process for producing esters or amides

Also Published As

Publication number Publication date
IE903511A1 (en) 1991-04-10
GR3015802T3 (en) 1995-07-31
IE67453B1 (en) 1996-04-03
DD299189A5 (de) 1992-04-02
EP0421848B1 (fr) 1995-02-08
JP2579699B2 (ja) 1997-02-05
FR2652581A1 (fr) 1991-04-05
JPH08311095A (ja) 1996-11-26
JPH03204894A (ja) 1991-09-06
FR2652581B1 (fr) 1991-12-13
US5712367A (en) 1998-01-27
ATE118219T1 (de) 1995-02-15
PT95478A (pt) 1991-06-25
CA2026655C (fr) 2000-12-05
CA2026655A1 (fr) 1991-04-03
EP0421848A1 (fr) 1991-04-10
DE69016732D1 (de) 1995-03-23
DE69016732T2 (de) 1995-06-01
PT95478B (pt) 1997-07-31
DK0421848T3 (da) 1995-04-03

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