ES2071332T3 - Particulas coloidales de lipidos mixtos-bicarbonato para administrar farmacos o calorias. - Google Patents

Particulas coloidales de lipidos mixtos-bicarbonato para administrar farmacos o calorias.

Info

Publication number
ES2071332T3
ES2071332T3 ES91917082T ES91917082T ES2071332T3 ES 2071332 T3 ES2071332 T3 ES 2071332T3 ES 91917082 T ES91917082 T ES 91917082T ES 91917082 T ES91917082 T ES 91917082T ES 2071332 T3 ES2071332 T3 ES 2071332T3
Authority
ES
Spain
Prior art keywords
calories
bicarbonate
carbon atoms
particles
colloid particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91917082T
Other languages
English (en)
Inventor
David W Yesair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2071332T3 publication Critical patent/ES2071332T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE MUESTRA UNA COMPOSICION QUE CONTIENE ACIDOS GRASOS NO ESTERIFICADOS QUE TIENEN DE 14 A 18 ATOMOS DE CARBONO, MONOGLICERIDOS QUE SON MONOESTERES DE GLICEROL Y ACIDOS GRASOS QUE TIENEN DE 14 A 18 ATOMOS DE CARBONO, LISOFOSFOTIDILCOLINA EN LA CUAL LA MITAD DEL ACIDO GRASO TIENE DE 14 A 18 ATOMOS DE CARBONO Y BICARBONATO. LAS COMPOSICIONES PUEDEN TENER OPCIONALMENTE SALES. ESTAS COMPOSICIONES FORMAN PARTICULAS COLOIDALES DE TALLA SUBMICRON Y PUEDEN ACTUAR COMO VEHICULOS PARA TRANSPORTAR FARMACOS ADMINISTRADOS ORALMENTE, FUENTES DE CALORIAS EN FORMA DE GRASAS FACILMENTE ABSORBIBLES Y COMO PARTICULAS PARA LA APLICACION TOPICA EN LA PIEL. TAMBIEN SE DESCRIBE UN METODO PARA FABRICAR ESTAS PARTICULAS.
ES91917082T 1990-08-13 1991-08-12 Particulas coloidales de lipidos mixtos-bicarbonato para administrar farmacos o calorias. Expired - Lifetime ES2071332T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56724390A 1990-08-13 1990-08-13

Publications (1)

Publication Number Publication Date
ES2071332T3 true ES2071332T3 (es) 1995-06-16

Family

ID=24266341

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91917082T Expired - Lifetime ES2071332T3 (es) 1990-08-13 1991-08-12 Particulas coloidales de lipidos mixtos-bicarbonato para administrar farmacos o calorias.

Country Status (9)

Country Link
US (3) US5314921A (es)
EP (1) EP0543943B1 (es)
JP (1) JP3273785B2 (es)
AT (1) ATE121618T1 (es)
AU (1) AU666293B2 (es)
CA (1) CA2089003C (es)
DE (1) DE69109297T2 (es)
ES (1) ES2071332T3 (es)
WO (1) WO1992003121A1 (es)

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US5891466A (en) * 1990-08-13 1999-04-06 Yesair; David W. Mixed Liped-Bicarbonate colloidal particles for delivering drugs or calories
CA2089003C (en) * 1990-08-13 2001-03-20 David W. Yesair Mixed lipid-bicarbonate colloidal particles for delivering drugs or calories
GB9212511D0 (en) * 1992-06-12 1992-07-22 Cortecs Ltd Pharmaceutical compositions
US5514670A (en) * 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
US5744155A (en) * 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
ATE161527T1 (de) * 1994-03-14 1998-01-15 Morten Sloth Weidner Methode zur solubilisierung organischer verbindungen in lipophilen systemen ,neue chemische komplexe solcher verbindungen und verschiedene anwendungen dieser komplexe
DE69614855T2 (de) * 1995-06-06 2002-03-28 Biomolecular Products, Inc. Gemischte lipid-bicarbonat kolloidale partikel zur abgabe von arzneistoffen oder kalorien
ATE277596T1 (de) * 1997-02-24 2004-10-15 Sla Pharma Ag Topische pharmazeutische zusammensetzung, enthaltend einen cholinergischen wirkstoff oder einen kalziumkanalblocker
US6086915A (en) * 1998-04-01 2000-07-11 Bioresponse L.L.C. Compositions and methods of adjusting steroid hormone metabolism through phytochemicals
US6524620B2 (en) 1998-07-20 2003-02-25 Andrx Pharmaceuticals, Inc. Diltiazem controlled release formulation and method of manufacture
IL141801A0 (en) 1998-09-08 2002-03-10 Biomolecular Products Inc Methods and compositions for increasing intestinal absorption of fats
US6172122B1 (en) 1998-12-17 2001-01-09 The Lubrizol Corporation Stable emulsions from gelled overbased substrates with surfactants and aqueous liquids
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6383471B1 (en) 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US6861060B1 (en) 2000-04-21 2005-03-01 Elena Luriya Personal care formulations
JP4384409B2 (ja) * 2000-12-05 2009-12-16 チルドレンズ・ホスピタル・ロス・アンジエルス バイオアベイラビリティが増加したフェンレチニドの医薬組成物、およびその使用方法
EP1434593B1 (en) 2001-10-11 2017-03-29 Biomolecular Products, Inc. MODIFICATIONS OF SOLID 3-sn-PHOSPHOGLYCERIDES
US20050008686A1 (en) * 2003-01-15 2005-01-13 Mannino Raphael J. Cochleate preparations of fragile nutrients
CA2513260C (en) * 2003-01-31 2013-01-08 Childrens Hospital Los Angeles Oral compositions of fenretinide having increased bioavailability and methods of using the same
DE60317063T2 (de) * 2003-09-18 2008-08-07 Técnimede-Sociedade Técnico-Medicinal, S.A. Stabile Diltiazemhydrochlorid enthaltende pharmazeutische Zusammensetzung zur Anwendung auf der Haut und Verfahren zu ihrer Herstellung
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
AU2007233155B2 (en) 2006-03-29 2012-04-26 Scitech Development Llc Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery
EP2200613B1 (en) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazine derivatives and uses thereof
CA2718416C (en) * 2008-03-13 2018-01-02 Mallinckrodt Inc. Multi-function, foot-activated controller for imaging system
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US20160361322A1 (en) 2015-06-15 2016-12-15 Lipocine Inc. Composition and method for oral delivery of androgen prodrugs
US11559530B2 (en) 2016-11-28 2023-01-24 Lipocine Inc. Oral testosterone undecanoate therapy
WO2020018974A1 (en) 2018-07-20 2020-01-23 Lipocine Inc. Liver disease

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JPS5321393B2 (es) * 1974-10-19 1978-07-03
JPS53107408A (en) * 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
FR2427100A1 (fr) * 1978-06-02 1979-12-28 Kali Chemie Pharma Gmbh Composition pharmaceutique a propriete de resorption amelioree et procede pour sa fabrication
JPS6030652B2 (ja) * 1979-05-07 1985-07-17 株式会社ミドリ十字 静脈注射用脂肪乳剤
JPS5618914A (en) * 1979-07-25 1981-02-23 Eisai Co Ltd Ubidecarenone composition having good absorbability
FR2497668B1 (fr) * 1981-01-15 1986-03-21 Gattefosse Ets Sa Emulsions lipoproteiques injectables, leur procede de preparation et leurs applications en therapeutique
JPS57167926A (en) * 1981-04-08 1982-10-16 Mitsubishi Chem Ind Ltd External base for skin
EP0084052A1 (en) * 1981-07-23 1983-07-27 Arthur D. Little, Inc. Micellular drug delivery system
US4454113A (en) * 1982-09-21 1984-06-12 Scm Corporation Stabilization of oil and water emulsions using polyglycerol esters of fatty acids
US4874795A (en) * 1985-04-02 1989-10-17 Yesair David W Composition for delivery of orally administered drugs and other substances
IE59067B1 (en) * 1985-04-02 1993-12-15 Yesair David W Composition for delivery of orally administered drugs and other substances
US4849132A (en) * 1986-05-16 1989-07-18 Asahi Denka Kogyo Kabushiki Kaisha Surfactant composition having improved functions
CA2089003C (en) * 1990-08-13 2001-03-20 David W. Yesair Mixed lipid-bicarbonate colloidal particles for delivering drugs or calories

Also Published As

Publication number Publication date
US5314921A (en) 1994-05-24
WO1992003121A1 (en) 1992-03-05
US5707873A (en) 1998-01-13
JP3273785B2 (ja) 2002-04-15
EP0543943B1 (en) 1995-04-26
ATE121618T1 (de) 1995-05-15
DE69109297D1 (de) 1995-06-01
US5741822A (en) 1998-04-21
CA2089003A1 (en) 1992-02-14
EP0543943A1 (en) 1993-06-02
CA2089003C (en) 2001-03-20
AU8646291A (en) 1992-03-17
AU666293B2 (en) 1996-02-08
DE69109297T2 (de) 1995-11-09
JPH06503815A (ja) 1994-04-28

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