ES2071683T3 - Sistema de suministro de un farmaco transdermico a base de multipolimero acrilico. - Google Patents

Sistema de suministro de un farmaco transdermico a base de multipolimero acrilico.

Info

Publication number
ES2071683T3
ES2071683T3 ES90100430T ES90100430T ES2071683T3 ES 2071683 T3 ES2071683 T3 ES 2071683T3 ES 90100430 T ES90100430 T ES 90100430T ES 90100430 T ES90100430 T ES 90100430T ES 2071683 T3 ES2071683 T3 ES 2071683T3
Authority
ES
Spain
Prior art keywords
multipolymer
drug
transdermic
supply system
dermal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90100430T
Other languages
English (en)
Inventor
Steven Sablotsky
Joseph A Gentile
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noven Pharmaceuticals Inc
Original Assignee
Noven Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noven Pharmaceuticals Inc filed Critical Noven Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2071683T3 publication Critical patent/ES2071683T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
    • B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • A61L15/585—Mixtures of macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
    • B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
    • B26F1/38—Cutting-out; Stamping-out
    • B26F1/44—Cutters therefor; Dies therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B26—HAND CUTTING TOOLS; CUTTING; SEVERING
    • B26F—PERFORATING; PUNCHING; CUTTING-OUT; STAMPING-OUT; SEVERING BY MEANS OTHER THAN CUTTING
    • B26F1/00—Perforating; Punching; Cutting-out; Stamping-out; Apparatus therefor
    • B26F1/38—Cutting-out; Stamping-out
    • B26F1/384—Cutting-out; Stamping-out using rotating drums

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Forests & Forestry (AREA)
  • Manufacturing & Machinery (AREA)
  • Botany (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Combined Means For Separation Of Solids (AREA)
  • Discharge Of Articles From Conveyors (AREA)
  • Sorting Of Articles (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Una composición dérmica adhesiva sensible a la presión que comprende (a) un fármaco, (b) una mezcla polímera que contiene un copolímero de acetato de vinilo/etileno, que contiene de 0 a 5% de ácido acrílico y un polímero acrílico que contiene al menos el 50% en peso de un monómero de acrilato o de alquil-acrilato, (c) un caucho natural o sintético, y (d) un agente de pegajosidad, en la que la relación en peso de la mezcla polímera a caucho es de 1:10 a 30:1, y la relación en peso de copolímero de acetato de vinilo/etileno a polímero acrílico es de 20:1 a 1:20.
ES90100430T 1989-01-11 1990-01-10 Sistema de suministro de un farmaco transdermico a base de multipolimero acrilico. Expired - Lifetime ES2071683T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/295,847 US4994267A (en) 1988-03-04 1989-01-11 Transdermal acrylic multipolymer drug delivery system

Publications (1)

Publication Number Publication Date
ES2071683T3 true ES2071683T3 (es) 1995-07-01

Family

ID=23139462

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90100430T Expired - Lifetime ES2071683T3 (es) 1989-01-11 1990-01-10 Sistema de suministro de un farmaco transdermico a base de multipolimero acrilico.

Country Status (14)

Country Link
US (1) US4994267A (es)
EP (3) EP0634179A1 (es)
JP (1) JPH0793939B2 (es)
KR (1) KR920703220A (es)
AT (1) ATE122240T1 (es)
CA (1) CA2044132C (es)
DE (1) DE69019175T2 (es)
DK (1) DK0379045T3 (es)
ES (1) ES2071683T3 (es)
HK (1) HK1006155A1 (es)
IE (1) IE69048B1 (es)
NL (1) NL9020159A (es)
PT (1) PT92830B (es)
WO (1) WO1990007940A1 (es)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5560922A (en) * 1986-05-30 1996-10-01 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process
US5719197A (en) * 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5300291A (en) * 1988-03-04 1994-04-05 Noven Pharmaceuticals, Inc. Method and device for the release of drugs to the skin
US5656286A (en) 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5252334A (en) * 1989-09-08 1993-10-12 Cygnus Therapeutic Systems Solid matrix system for transdermal drug delivery
AR246186A1 (es) † 1989-11-17 1994-07-29 Beta Pharm Co Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica.
JP3273430B2 (ja) * 1989-12-28 2002-04-08 日東電工株式会社 エストロゲン含有ゲル製剤
ES2097145T3 (es) 1990-03-28 1997-04-01 Noven Pharma Metodo y dispositivo para la liberacion de farmacos en la piel.
US5248676A (en) * 1990-05-17 1993-09-28 Hisamitsu Pharmaceutical Co., Inc. Estradiol percutaneous administration preparations
DE4020144A1 (de) * 1990-06-25 1992-01-09 Lohmann Therapie Syst Lts Pflaster mit hohem gehalt an weichmachenden inhaltsstoffen
DE4110027C2 (de) * 1991-03-27 1996-08-29 Lohmann Therapie Syst Lts Verfahren zur Konfektionierung transdermaler therapeutischer Pflaster
US5498418A (en) * 1991-06-10 1996-03-12 Schwarz Pharma Ag Nitroglycerine plaster and process for its production
US5705185A (en) * 1991-09-25 1998-01-06 Beta Pharmaceuticals Co. Transdermal delivery of estradiol and process for manufacturing said device
US5518734A (en) * 1991-09-25 1996-05-21 Beta Pharmaceuticals Co. Transdermal delivery system for estradiol and process for manufacturing said device
US5352456A (en) * 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
IT1253265B (it) * 1991-11-25 1995-07-14 Rotta Research Lab Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo.
JP2960832B2 (ja) * 1992-05-08 1999-10-12 ペルマテック テクノロジー アクチェンゲゼルシャフト エストラジオールの投与システム
DE69310887T2 (de) * 1992-07-29 1998-01-22 Baxter Int Pharmazeutische behälter und medizinische geräte mit hydrophilen, proteinverträglichen oberflächen
DE4230588C1 (de) * 1992-09-12 1993-10-07 Lohmann Therapie Syst Lts Dexpanthenol-haltiges Pflaster zur transdermalen Applikation von Steroidhormonen und Verfahren zu seiner Herstellung
DE4237453C1 (es) * 1992-11-06 1993-08-19 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
FR2699406B1 (fr) * 1992-12-21 1995-03-10 Commissariat Energie Atomique Films à base de copolymères, leurs applications dans des systèmes transdermiques et leurs procédés de préparation.
US5762952A (en) * 1993-04-27 1998-06-09 Hercon Laboratories Corporation Transdermal delivery of active drugs
JP2539330B2 (ja) * 1993-05-11 1996-10-02 日東電工株式会社 医療用粘着剤及びこれを用いて形成された医療用外用材
WO1995001767A1 (en) * 1993-07-08 1995-01-19 Cygnus Therapeutic Systems Monolithic matrix transdermal delivery system
US5460820B1 (en) * 1993-08-03 1999-08-03 Theratech Inc Method for providing testosterone and optionally estrogen replacement therapy to women
US5554381A (en) * 1993-08-09 1996-09-10 Cygnus, Inc. Low flux matrix system for delivering potent drugs transdermally
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6080428A (en) 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US5494680A (en) * 1993-12-08 1996-02-27 Minnesota Mining And Manufacturing Company Transdermal delivery device
FR2717689B1 (fr) * 1994-03-28 1996-07-05 Lhd Lab Hygiene Dietetique Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base de copolymère styrène-isoprène-styrène.
FR2717688B1 (fr) * 1994-03-28 1996-07-05 Lhd Lab Hygiene Dietetique Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base d'EVA.
CA2198390C (en) * 1994-09-14 2009-08-11 James E. Garbe Matrix for transdermal drug delivery
CN1170424A (zh) * 1994-12-20 1998-01-14 美国3M公司 逆向反射片制品
US6024974A (en) * 1995-01-06 2000-02-15 Noven Pharmaceuticals, Inc. Composition and methods for transdermal delivery of acid labile drugs
IL116539A (en) * 1995-01-06 2002-02-10 Noven Pharma Preparations given through the skin of unstable anti-acid drugs
WO1996022083A1 (en) * 1995-01-19 1996-07-25 Cygnus, Inc. POLYISOBUTYLENE ADHESIVES CONTAINING HIGH Tg TACKIFIER FOR TRANSDERMAL DEVICES
US6632522B1 (en) 1995-02-16 2003-10-14 3M Innovative Properties Company Blended pressure-sensitive adhesives
US6630238B2 (en) 1995-02-16 2003-10-07 3M Innovative Properties Company Blended pressure-sensitive adhesives
US6063838A (en) * 1995-02-16 2000-05-16 3M Innovative Properties Company Blended pressure-sensitive adhesives
US5573778A (en) * 1995-03-17 1996-11-12 Adhesives Research, Inc. Drug flux enhancer-tolerant pressure sensitive adhesive composition
CA2223588C (en) * 1995-06-07 2004-01-06 Noven Pharmaceuticals, Inc. Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
CN1188189C (zh) * 1995-06-07 2005-02-09 奥瑟－麦内尔制药公司 基质层含有17－脱乙酰基诺孕酯的经皮贴片及基质的用途
US6316022B1 (en) * 1995-06-07 2001-11-13 Noven Pharmaceuticals, Inc. Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures
US5795834A (en) * 1995-12-22 1998-08-18 Minnesota Mining & Manufacturing Company Adhesive tape and method of making
DE19628999C1 (de) * 1996-07-18 1998-03-12 Lohmann Gmbh & Co Kg Medizinische Haftklebstoffe mit hoher Wasserdampfdurchlässigkeit und Klebkraft und damit versehene Pflaster und ihre Verwendung
US5783208A (en) * 1996-07-19 1998-07-21 Theratech, Inc. Transdermal drug delivery matrix for coadministering estradiol and another steroid
JP3865787B2 (ja) * 1997-01-07 2007-01-10 帝三製薬株式会社 硝酸イソソルビド含有貼付剤
DE19700913C2 (de) * 1997-01-14 2001-01-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur Abgabe von Hormonen
IT1290255B1 (it) * 1997-02-05 1998-10-22 Wallcovering Pubblicita S R L Supporto sagomato aderente all'epidermide per la cessione di sostanze cosmetiche o farmacologiche e metodo per la sua fabbricazione
DE19706824C1 (de) * 1997-02-21 1998-03-26 Lohmann Therapie Syst Lts Transdermales oder topisches Plastersystem mit Polyacrylatmatrix mit verbesserten physikalischen Eigenschaften
JP4136029B2 (ja) * 1997-05-12 2008-08-20 帝國製薬株式会社 硝酸イソソルビド含有貼付剤
US7150881B2 (en) * 1997-06-26 2006-12-19 Mylan Technologies, Inc. Adhesive mixture for transdermal delivery of highly plasticizing drugs
US5948433A (en) * 1997-08-21 1999-09-07 Bertek, Inc. Transdermal patch
GB9720470D0 (en) 1997-09-25 1997-11-26 Ethical Pharmaceuticals South Inhibition of crystallization in transdermal devices
US20020188037A1 (en) * 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
US20050260246A1 (en) * 1998-04-27 2005-11-24 Chudzik Stephen J Bioactive agent release coating
DE19830648A1 (de) * 1998-07-09 2000-01-13 Lohmann Therapie Syst Lts Glyceroltrinitrathaltige Zusammensetzung, Verfahren zu ihrer Herstellung und ihre Verwendung
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
US6159497A (en) * 1998-10-30 2000-12-12 Noven Pharmaceuticals, Inc. Patch applicator
US6129929A (en) * 1998-10-30 2000-10-10 Noven Pharmaceuticals, Inc. Patch applicator
ATE404172T1 (de) 1998-12-30 2008-08-15 Dexcel Ltd Dispergierbares konzentrat zur verabreichung von cyclosporin
AU3470600A (en) * 1999-01-14 2000-08-01 David Houze Compositions and methods for drug delivery
US20030170195A1 (en) * 2000-01-10 2003-09-11 Noven Pharmaceuticals, Inc. Compositions and methods for drug delivery
US6337086B1 (en) 1999-02-06 2002-01-08 Dow Corning Corporation Pressure sensitive adhesive compositions for transdermal drug delivery devices
JP4180244B2 (ja) 1999-04-16 2008-11-12 ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド 内部センサを有する電気的な移動による送出装置系
US7063859B1 (en) * 1999-04-28 2006-06-20 Noven Pharmaceuticals, Inc. Barrier film lined backing layer composition and method for topical administration of active agents
WO2000074661A2 (en) 1999-06-05 2000-12-14 Noven Pharmaceuticals, Inc. Solubility enhancement of drugs in transdermal drug delivery systems and methods of use
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
GB9918291D0 (en) * 1999-08-03 1999-10-06 Croda Int Plc Cold sealable adhesive
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
AU3104301A (en) 2000-01-20 2001-07-31 Noven Pharmaceuticals, Inc. Compositions and methods to effect the release profile in the transdermal administration of active agents
US6905016B2 (en) 2000-03-14 2005-06-14 Noven Pharmaceuticals, Inc. Packaging system for transdermal drug delivery systems
US6706836B1 (en) * 2000-03-31 2004-03-16 Avery Dennison Corporation Hydrophilic polymers, pressure sensitive adhesives and coatings
US6743880B2 (en) * 2000-03-31 2004-06-01 Avery Denison Corporation Hydrophilic polymers and methods of preparation
US6653427B2 (en) 2000-03-31 2003-11-25 Avery Dennison Corporation Hydrophilic polymers, pressure sensitive adhesives and coatings
DE10032537A1 (de) * 2000-07-05 2002-01-31 Labtec Gmbh Dermales System, enthaltend 2-(3-Benzophenyl)Propionsäure
US9056060B2 (en) * 2000-09-19 2015-06-16 Henkel Ag & Co. Kgaa Non-reactive adhesive useful in transdermal drug delivery system
US20020119187A1 (en) * 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
DE10060550C1 (de) * 2000-12-06 2002-04-18 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten
ES2559666T3 (es) * 2001-03-07 2016-02-15 Hisamitsu Pharmaceutical Co., Inc. Parche adhesivo
ES2270746T3 (es) * 2001-03-16 2007-12-01 Alza Corporation Parche transdermico para administrar fentanilo.
DE10118282A1 (de) * 2001-04-12 2002-12-05 Lohmann Therapie Syst Lts Haftkleber auf Basis von Ethylen-Vinylacetat-Copolymeren und Klebharzen, für medizinische Verwendungszwecke
ES2331302T3 (es) 2001-05-01 2009-12-29 A.V. Topchiev Institute Of Petrochemical Synthesis Composiciones de hidrogel.
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
BRPI0210074B1 (pt) * 2001-05-31 2017-05-30 Hisamitsu Pharmaceutical Co emplastro de anti-inflamatórios não esteroidais percutaneamente absorvível, contendo sais de amônio, promotores de permeação e/ou agentes de solubilização em uma camada de substrato adesivo
EP1421955A1 (en) * 2001-08-10 2004-05-26 Hisamitsu Pharmaceutical Co., Inc. Percutaneous absorption preparations
US20030175333A1 (en) * 2002-03-06 2003-09-18 Adi Shefer Invisible patch for the controlled delivery of cosmetic, dermatological, and pharmaceutical active ingredients onto the skin
US20030175328A1 (en) * 2002-03-06 2003-09-18 Adi Shefer Patch for the controlled delivery of cosmetic, dermatological, and pharmaceutical active ingredients into the skin
JP4354678B2 (ja) * 2002-08-28 2009-10-28 久光製薬株式会社 貼付剤
US20140107555A1 (en) * 2002-10-23 2014-04-17 Covidien Lp Antimicrobial multilayer wound dressing
DE10304988A1 (de) * 2003-02-07 2004-09-09 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System mit verbessertem Hautklebeverhalten
US8790689B2 (en) 2003-04-30 2014-07-29 Purdue Pharma L.P. Tamper resistant transdermal dosage form
RS20050812A (sr) * 2003-04-30 2007-12-31 Purdue Pharma L.P., Transdermalni dozni oblik otporan na promene
EP1682102A2 (en) * 2003-09-10 2006-07-26 Noven Pharmaceuticals, Inc. Multi-layer transdermal drug delivery device
CA2542778C (en) * 2003-10-28 2012-05-29 Noven Pharmaceuticals, Inc. Transdermal drug delivery composition
RU2380092C2 (ru) 2004-01-30 2010-01-27 Кориум Интернэшнл, Инк. Быстро растворяющаяся пленка для доставки активного агента
EP1791575B1 (en) 2004-08-05 2014-10-08 Corium International, Inc. Adhesive composition
US8246976B2 (en) * 2004-10-08 2012-08-21 Noven Pharmaceuticals, Inc. Transdermal delivery of drugs based on crystal size
WO2006041911A2 (en) 2004-10-08 2006-04-20 Noven Pharmaceuticals, Inc. Device transdermal administration of drugs including acrylic polymers
EP1807033B1 (en) 2004-10-08 2016-07-20 Noven Pharmaceuticals, Inc. Transdermal drug delivery device including an occlusive backing
US8343538B2 (en) * 2004-10-08 2013-01-01 Noven Pharmaceuticals, Inc. Compositions and methods for controlling the flux of a drug from a transdermal drug delivery systems
US20060127463A1 (en) * 2004-12-15 2006-06-15 Nugara Peter N Composite structure including a low vinyl acetate layer
KR100810947B1 (ko) 2005-01-28 2008-03-10 롬 앤드 하아스 컴패니 에멀젼 폴리머로부터 제조된 의료용 필름 및 제품
AU2006269944A1 (en) * 2005-07-19 2007-01-25 Inverseon, Inc. Improved pharmacokinetic profile of beta-adrenergic inverse agonists for the treatment of pulmonary airway diseases
US20100233247A1 (en) * 2005-09-13 2010-09-16 Sabine Hohmann Dressing Material Comprising Active Substances
DE102005056393A1 (de) * 2005-11-24 2007-05-31 Grünenthal GmbH Multicyclische Verbindungen in druckempfindlichen Klebstoffen
CA2643037C (en) * 2006-02-27 2014-08-05 Noven Pharmaceuticals, Inc. Compositions and methods for delivery of amino-functional drugs
US20070259029A1 (en) * 2006-05-08 2007-11-08 Mcentire Edward Enns Water-dispersible patch containing an active agent for dermal delivery
US20070258935A1 (en) * 2006-05-08 2007-11-08 Mcentire Edward Enns Water dispersible films for delivery of active agents to the epidermis
US20070287727A1 (en) * 2006-06-08 2007-12-13 Jacob Hiller Anti-Nicotine Treatment
US20080057090A1 (en) * 2006-09-01 2008-03-06 Mcentire Edward Enns Wrinkle masking film composition for skin
US7879942B2 (en) * 2006-10-05 2011-02-01 Eastman Chemical Company Switchable adhesive article for attachment to skin and method of using the same
EP2089007A2 (en) * 2006-10-27 2009-08-19 Noven Pharmaceuticals, INC. Transdermal delivery of ketoprofen polar derivatives
JP5358574B2 (ja) * 2007-08-17 2013-12-04 アルション セラピューティクス， インコーポレイテッド 高濃度の局所麻酔薬調合物
MY154027A (en) * 2007-10-15 2015-04-30 Alza Corp Once-a-day replacement transdermal administration of fentanyl
US8231906B2 (en) 2008-07-10 2012-07-31 Noven Pharmaceuticals, Inc. Transdermal estrogen device and delivery
DE102008037845A1 (de) * 2008-08-15 2010-02-18 Tesa Se Haftklebemasse
US8119694B2 (en) 2008-08-15 2012-02-21 Arcion Therapeutics, Inc. High concentration local anesthetic formulations
WO2010083035A2 (en) 2009-01-14 2010-07-22 Corium International, Inc. Transdermal administration of tamsulosin
EP2506838A1 (en) 2009-12-01 2012-10-10 Noven Pharmaceuticals, INC. Transdermal testosterone device and delivery
DE102011100619A1 (de) 2010-05-05 2012-01-05 Amw Gmbh Transdermales therapeutisches System (TTS) mit einem Gehalt an einem Opiod-Analgetikum
WO2012092165A1 (en) 2010-12-29 2012-07-05 Noven Pharmaceuticals, Inc. Transdermal drug delivery system comprising levonorgestrel acetate
DE102011114411A1 (de) * 2011-09-26 2013-03-28 Lts Lohmann Therapie-Systeme Ag Pflaster mit einstellbarer Okklusion
TW201431570A (zh) 2012-11-22 2014-08-16 Ucb Pharma Gmbh 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片
WO2014105783A1 (en) 2012-12-28 2014-07-03 Noven Pharmaceuticals, Inc. Compositions and methods for transdermal delivery of amphetamine and clonidine
US20140220336A1 (en) * 2013-02-05 2014-08-07 Honeywell International Inc. Pressure-sensitive adhesives that minimize plasticizer migration, pressure-sensitive adhesive articles with such pressure-sensitive adhesives, and methods for fabricating such pressure-sensitive adhesives
AR095259A1 (es) 2013-03-15 2015-09-30 Noven Pharma Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria
JP6726096B2 (ja) 2013-07-03 2020-07-22 エルテーエス ローマン テラピー−システメ アーゲー 電子部品を有する経皮治療システム
CA2924236C (en) * 2013-10-07 2020-01-07 Teikoku Pharma Usa, Inc. Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine
CA2924233C (en) 2013-10-07 2018-10-23 Teikoku Pharma Usa, Inc. Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions
KR101948779B1 (ko) 2013-10-07 2019-05-21 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
US10307380B1 (en) 2014-03-04 2019-06-04 Prosolus, Inc. Composition and method for transdermal lidocaine delivery
CN106456566B (zh) 2014-05-20 2020-06-16 Lts勒曼治疗系统股份公司 含罗替戈汀的经皮递送系统
US11752110B2 (en) 2014-05-20 2023-09-12 Lts Lohmann Therapie-Systeme Ag Transdermal delivery system including an interface mediator
CA2948219C (en) 2014-05-20 2023-04-04 Lts Lohmann Therapie-Systeme Ag Method for adjusting the release of active agent in a transdermal delivery system
FR3021973B1 (fr) * 2014-06-05 2016-07-01 Bostik Sa Composition de colle pelable
KR102454410B1 (ko) * 2014-08-06 2022-10-12 듀폰 테이진 필름즈 유.에스. 리미티드 파트너쉽 필름 코팅 조성물 및 방법
US10406116B2 (en) 2015-02-06 2019-09-10 Noven Pharmaceuticals, Inc. Pressure-sensitive adhesives for transdermal drug delivery
EP3253840B1 (en) 2015-02-06 2019-07-31 Noven Pharmaceuticals, INC. Pressure-sensitive adhesives for transdermal drug delivery
WO2016140874A1 (en) 2015-03-04 2016-09-09 Noven Pharmaceuticals, Inc. Oligomeric/polymeric silicone fluids for use in transdermal drug delivery systems
US20170000745A1 (en) 2015-07-02 2017-01-05 Noven Pharmaceuticals, Inc. Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol
US20170136124A1 (en) 2015-11-16 2017-05-18 Noven Pharmaceuticals, Inc. Stretchable backing layers for transdermal drug delivery systems
BR112019006955A2 (pt) 2016-10-31 2019-07-02 Teikoku Pharma Usa Inc métodos de controle da dor usando dispositivos de distribuição transdérmica de dexmedetomidina
AR110566A1 (es) * 2016-12-21 2019-04-10 Braskem Sa Composiciones de etilvinilacetato modificado, películas y mezclas de polímeros producidas a partir de ellas
US12491166B2 (en) 2020-08-31 2025-12-09 Wacker Chemie Ag Method of delivering an active compound and delivery device for use in the same

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57116011A (en) * 1981-01-08 1982-07-19 Nitto Electric Ind Co Ltd Pharmaceutical preparation
JPS57181020A (en) * 1981-04-30 1982-11-08 Kao Corp Poultice base composition
AU553343B2 (en) * 1981-08-10 1986-07-10 Advance Electrode Kabushikikaisya Absorbent adhesive bandage with medicament release
GB2105990B (en) * 1981-08-27 1985-06-19 Nitto Electric Ind Co Adhesive skin patches
US4552872A (en) * 1983-06-21 1985-11-12 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing corticosteroids
US4573996A (en) * 1984-01-03 1986-03-04 Jonergin, Inc. Device for the administration of an active agent to the skin or mucosa
ZA853488B (en) * 1984-05-10 1986-12-30 American Home Prod Transdermal dosage form
US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
DE3682165D1 (de) * 1985-11-08 1991-11-28 Nitto Denko Corp Verwendung von heftpflastern fuer die haut und perkutanen praeparaten.
US4764381A (en) * 1985-12-06 1988-08-16 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
EP0375689B1 (en) * 1987-06-01 1992-08-12 Warner-Lambert Company A pharmaceutical composition adapted for transdermal delivery of an opoid drug.
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US4814168A (en) * 1988-03-04 1989-03-21 Noven Pharmaceuticals, Inc. Transdermal multipolymer drug delivery system
CA2004203A1 (en) * 1988-12-01 1990-06-01 Sharad K. Govil Compositions for transdermal delivery of estradiol

Also Published As

Publication number Publication date
JPH0793939B2 (ja) 1995-10-11
EP0634179A1 (en) 1995-01-18
DK0379045T3 (da) 1995-10-09
CA2044132A1 (en) 1990-07-12
ATE122240T1 (de) 1995-05-15
CA2044132C (en) 1997-05-06
IE69048B1 (en) 1996-08-07
WO1990007940A1 (en) 1990-07-26
AU632534B2 (en) 1993-01-07
EP0379045A1 (en) 1990-07-25
AU5034990A (en) 1990-08-13
HK1006155A1 (en) 1999-02-12
IE900090L (en) 1990-07-11
PT92830A (pt) 1990-07-31
DE69019175T2 (de) 1996-01-18
EP0453505A1 (en) 1991-10-30
JPH04502719A (ja) 1992-05-21
US4994267A (en) 1991-02-19
PT92830B (pt) 1995-12-29
KR920703220A (ko) 1992-12-17
NL9020159A (nl) 1991-01-02
DE69019175D1 (de) 1995-06-14
EP0379045B1 (en) 1995-05-10

Similar Documents

Publication Publication Date Title
ES2071683T3 (es) Sistema de suministro de un farmaco transdermico a base de multipolimero acrilico.
ATE99176T1 (de) Transdermales arzneimittelabgabesytem auf der grundlage eines multipolymers.
FI920960A0 (fi) Fast matrissystem foer transdermal dosering av laekemedelsaemnen.
JP2588180B2 (ja) 皮膚浸透ニトログリセリン投薬系
CA1319104C (en) Skin permeation enhancer compositions using sucrose esters
US4940586A (en) Skin permeation enhancer compositions using sucrose esters
US4900555A (en) Skin permeation enhancer compositions using sucrose esters
EP0279986A1 (en) Skin permeation enhancer compositions using glycerol monolaurate
DE69401945D1 (de) Einarbeitung eines poly-n-vinylamids in ein transdermales system
KR900701242A (ko) 에스트라디올의 경피전달용 조성물
DK0429039T3 (da) Anvendelse af en opiat-antagonist til fremstilling af en farmaceutisk sammensætning, der skal indgives transdermalt, samt organ til transdermal afgivelse
DE69108683D1 (de) Zubereitung zur transdermalen Verabreichung von Arzneimitteln.
ATE112139T1 (de) Verkapselung von mischgetrockneter sucralose mit polyvinylacetat zur verwendung in kaugummi.
DK0768867T3 (da) Doseringsform til indgivelse af lægemiddel i væskeformig formulering
KR900009084A (ko) 1-이소부틸-1H-이미다조[4,5-c] 퀴놀린-4-아민을 함유하는 국소제제 및 경피 투여시스템
DE3789288D1 (de) Basische, wirkstoffdurchlässige haftklebende Polymermasse, Verfahren zu ihrer Herstellung und ihre Verwendung.
KR910018019A (ko) 니트로글리세린의 경피 투여형 약제
ATE69724T1 (de) Selbstklebende vorrichtung zur transdermalen verabreichung eines wirkstoffs.
PL319259A1 (en) Scopolamine containing plaster
KR910009259A (ko) 천식 또는 특정 피부 질환의 치료를 위한 피리미돈 유도체 및 동족체
ATE98486T1 (de) Selbstklebende vorrichtung zur transdermalen verabreichung eines wirkstoffs.
SE7614371L (sv) Sjelvheftande massor
JP3218473B2 (ja) 角質軟化硬膏剤
JPS57183714A (en) Medicinal pharmaceutical
JPS5942314A (ja) 外用部材

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 379045

Country of ref document: ES