IT1253265B - Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo. - Google Patents

Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo.

Info

Publication number
IT1253265B
IT1253265B ITTO910907A ITTO910907A IT1253265B IT 1253265 B IT1253265 B IT 1253265B IT TO910907 A ITTO910907 A IT TO910907A IT TO910907 A ITTO910907 A IT TO910907A IT 1253265 B IT1253265 B IT 1253265B
Authority
IT
Italy
Prior art keywords
transdermal
acrylic
extradiol
release
based adhesive
Prior art date
Application number
ITTO910907A
Other languages
English (en)
Inventor
Luigi Rovati
Lucio Rovati
Francesco Makovec
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Publication of ITTO910907A0 publication Critical patent/ITTO910907A0/it
Priority to ITTO910907A priority Critical patent/IT1253265B/it
Priority to EP92923782A priority patent/EP0614356B1/en
Priority to AT92923782T priority patent/ATE128029T1/de
Priority to JP5509788A priority patent/JPH07501335A/ja
Priority to DK92923782.4T priority patent/DK0614356T3/da
Priority to DE69205010T priority patent/DE69205010T2/de
Priority to AU29451/92A priority patent/AU666151B2/en
Priority to US08/244,132 priority patent/US6156335A/en
Priority to ES92923782T priority patent/ES2078066T3/es
Priority to CA002124209A priority patent/CA2124209A1/en
Priority to PCT/EP1992/002704 priority patent/WO1993010772A1/en
Publication of ITTO910907A1 publication Critical patent/ITTO910907A1/it
Application granted granted Critical
Publication of IT1253265B publication Critical patent/IT1253265B/it
Priority to GR950403422T priority patent/GR3018303T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Cerotto medicato transdermico per il rilascio controllato alla pelle di 17-beta-estradiolo, consistente di una matrice adesiva copolimerica sensibile alla pressione, in cui si scioglie o disperde il principio attivo, di uno strato protettivo staccabile al momento dell'impiego e di uno strato esterno fisso in cui la matrice adesiva copolimerica è formata da 2-etil-esilacrilato, metacrilato, acido acrilico, vinil acetato, idrossil-etilacrilato e le loro miscele, nonché eventuali altri additivi presenti in quantità inferiori allo 0,5% (p/p) nella matrice adesiva.
ITTO910907A 1991-11-25 1991-11-25 Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo. IT1253265B (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
ITTO910907A IT1253265B (it) 1991-11-25 1991-11-25 Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo.
AU29451/92A AU666151B2 (en) 1991-11-25 1992-11-24 Transdermal estradiol delivery system
ES92923782T ES2078066T3 (es) 1991-11-25 1992-11-24 Sistema de suministro transdermico de estradiol.
JP5509788A JPH07501335A (ja) 1991-11-25 1992-11-24 エストラジオール経皮投与用のアクリル系接着性共重合マトリックスを備えた新規な調合物
DK92923782.4T DK0614356T3 (da) 1991-11-25 1992-11-24 Transdermalt estradiolafgivelsessystem
DE69205010T DE69205010T2 (de) 1991-11-25 1992-11-24 Transdermales estradiol als therapeutisches system.
EP92923782A EP0614356B1 (en) 1991-11-25 1992-11-24 Transdermal estradiol delivery system
US08/244,132 US6156335A (en) 1991-11-25 1992-11-24 Preparation with an acrylic-based, adhesive copolymeric matrix for the transdermal delivery of estradiol
AT92923782T ATE128029T1 (de) 1991-11-25 1992-11-24 Transdermales estradiol als therapeutisches system.
CA002124209A CA2124209A1 (en) 1991-11-25 1992-11-24 A new preparation with an acrylic-based adhesive copolymeric matrix for the transdermal delivery of estradiol
PCT/EP1992/002704 WO1993010772A1 (en) 1991-11-25 1992-11-24 Transdermal estradiol delivery system
GR950403422T GR3018303T3 (en) 1991-11-25 1995-12-05 Transdermal estradiol delivery system.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITTO910907A IT1253265B (it) 1991-11-25 1991-11-25 Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo.

Publications (3)

Publication Number Publication Date
ITTO910907A0 ITTO910907A0 (it) 1991-11-25
ITTO910907A1 ITTO910907A1 (it) 1993-05-25
IT1253265B true IT1253265B (it) 1995-07-14

Family

ID=11409742

Family Applications (1)

Application Number Title Priority Date Filing Date
ITTO910907A IT1253265B (it) 1991-11-25 1991-11-25 Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo.

Country Status (12)

Country Link
US (1) US6156335A (it)
EP (1) EP0614356B1 (it)
JP (1) JPH07501335A (it)
AT (1) ATE128029T1 (it)
AU (1) AU666151B2 (it)
CA (1) CA2124209A1 (it)
DE (1) DE69205010T2 (it)
DK (1) DK0614356T3 (it)
ES (1) ES2078066T3 (it)
GR (1) GR3018303T3 (it)
IT (1) IT1253265B (it)
WO (1) WO1993010772A1 (it)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554381A (en) * 1993-08-09 1996-09-10 Cygnus, Inc. Low flux matrix system for delivering potent drugs transdermally
DE4333595A1 (de) * 1993-10-01 1995-04-06 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Arzneimitteln auf die Haut
GR1002079B (en) * 1994-07-26 1995-12-05 Lavipharm A E System of a special structure and composition for the rapid transdermal administration of oestrogens.
DE19526864A1 (de) * 1995-07-22 1997-01-23 Labtec Gmbh Hormonpflaster
US6623763B2 (en) 1996-01-08 2003-09-23 Lts Lohmann Therape-System Ag Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-β-estradiol to the human organism
DE19600347A1 (de) * 1996-01-08 1997-07-10 Lohmann Therapie Syst Lts Hauthaftende pharmazeutische Zubereitung, insbesondere TTS zur Abgabe von 17-beta-Estradiol an den menschlichen Organismus
DE19830649C2 (de) * 1998-07-09 2003-04-10 Lohmann Therapie Syst Lts Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe
GB0019745D0 (en) * 2000-08-10 2000-09-27 Univ Surrey Gene expression element
WO2002045701A2 (en) * 2000-12-05 2002-06-13 Noven Pharmaceuticals, Inc. Crystallization inhibition of drugs in transdermal drug delivery systems
DE10141652B4 (de) 2001-08-24 2011-04-07 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung
US6927267B1 (en) 2002-03-07 2005-08-09 Basf Ag High solids dispersion for wide temperature, pressure sensitive adhesive applications
DE10229733A1 (de) * 2002-07-02 2004-01-22 Basf Ag Haftklebstoffe für Träger aus Weich-PVC
CA2494915C (en) 2002-08-09 2012-07-10 Teikoku Seiyaku Co., Ltd. Female hormone-containing patch
MX2007004135A (es) * 2004-10-04 2007-06-15 Oreal Composicion cosmetica y/o dermatologica para pieles sensibles.
FR2889057B1 (fr) * 2005-08-01 2008-07-18 Oreal Composition cosmetique et/ou dermatologique pour la prevention et/ou le traitement des peaux sensibles ou seches
US7754256B2 (en) * 2007-03-07 2010-07-13 Stan Dennison Nutritional composition
US20080226698A1 (en) 2007-03-16 2008-09-18 Mylan Technologies, Inc. Amorphous drug transdermal systems, manufacturing methods, and stabilization
FR2919501B1 (fr) * 2007-08-02 2010-12-31 Oreal Utilisation d'hesperidine ou de l'un de ses derives pour la prevention et/ou le traitement des peaux relachees
FR2920304B1 (fr) 2007-09-04 2010-06-25 Oreal Utilisation cosmetique de lysat bifidobacterium species pour le traitement de la secheresse.
CA2697735C (en) * 2007-09-04 2014-02-18 L'oreal Use of a combination of hesperidin and of a microorganism for influencing the barrier function of the skin
DE102008013701A1 (de) 2008-03-11 2009-09-17 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System mit stabilisierter Membran
BRPI0913214B1 (pt) * 2008-05-30 2022-05-17 Mylan Laboratories Inc Dispositivo de fornecimento de drogas transdérmico e método de fabricação do mesmo
US8231906B2 (en) * 2008-07-10 2012-07-31 Noven Pharmaceuticals, Inc. Transdermal estrogen device and delivery
CA2739380C (en) * 2008-10-06 2014-12-09 Mylan Technologies, Inc. Amorphous rotigotine transdermal system
DE102008059054A1 (de) 2008-11-26 2010-05-27 Otto Bock Pur Life Science Gmbh Polyurethanpflaster für die transdermale Applikation von Wirkstoffen und Verfahren zu dessen Herstellung
WO2011009800A1 (en) * 2009-07-21 2011-01-27 Basf Se Film-to-film laminate, made by using an aqueous polymer dispersion as adhesive agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
DE68917292T2 (de) * 1988-02-26 1995-02-02 Riker Laboratories Inc Transdermales estradiol als therapeutisches sytem.
US4994267A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
AU637496B2 (en) * 1990-04-24 1993-05-27 Teijin Limited Plaster

Also Published As

Publication number Publication date
ITTO910907A0 (it) 1991-11-25
AU2945192A (en) 1993-06-28
JPH07501335A (ja) 1995-02-09
ES2078066T3 (es) 1995-12-01
EP0614356B1 (en) 1995-09-20
AU666151B2 (en) 1996-02-01
DE69205010T2 (de) 1996-02-22
WO1993010772A1 (en) 1993-06-10
DK0614356T3 (da) 1995-11-13
US6156335A (en) 2000-12-05
GR3018303T3 (en) 1996-03-31
CA2124209A1 (en) 1993-06-10
ITTO910907A1 (it) 1993-05-25
EP0614356A1 (en) 1994-09-14
ATE128029T1 (de) 1995-10-15
DE69205010D1 (en) 1995-10-26

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Legal Events

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971129