ATE119879T1 - N-(merkaptoalkyl)amide. - Google Patents

N-(merkaptoalkyl)amide.

Info

Publication number: ATE119879T1
Authority: AT; Austria
Prior art keywords: lower alkyl; aryl; alkyl; hydrogen; mercaptoalkyl
Prior art date: 1990-12-21

Application number

AT92901485T

Other languages

English (en)

Inventor

Bernard R Neustadt

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-21

Filing date

1991-12-19

Publication date

1995-04-15

1991-12-19 Application filed by Schering Corp filed Critical Schering Corp

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE119879T1 publication Critical patent/ATE119879T1/de

Links

150000001408 amides Chemical class 0.000 title abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 9
125000003118 aryl group Chemical group 0.000 abstract 3
125000001072 heteroaryl group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
208000024172 Cardiovascular disease Diseases 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
239000005541 ACE inhibitor Substances 0.000 abstract 1
206010029155 Nephropathy toxic Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
230000001746 atrial effect Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
239000002833 natriuretic agent Substances 0.000 abstract 1
230000007694 nephrotoxicity Effects 0.000 abstract 1
231100000417 nephrotoxicity Toxicity 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/42—Y being a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Peptides Or Proteins (AREA)

AT92901485T 1990-12-21 1991-12-19 N-(merkaptoalkyl)amide. ATE119879T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/633,696 US5232920A (en)	1990-12-21	1990-12-21	N-(mercaptoalkyl)amides

Publications (1)

Publication Number	Publication Date
ATE119879T1 true ATE119879T1 (de)	1995-04-15

Family

ID=24540737

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92901485T ATE119879T1 (de)	1990-12-21	1991-12-19	N-(merkaptoalkyl)amide.

Country Status (15)

Country	Link
US (1)	US5232920A (de)
EP (1)	EP0563153B1 (de)
JP (1)	JP2511625B2 (de)
AT (1)	ATE119879T1 (de)
AU (1)	AU9104691A (de)
DE (1)	DE69108262T2 (de)
DK (1)	DK0563153T3 (de)
ES (1)	ES2072138T3 (de)
IE (1)	IE73256B1 (de)
IL (1)	IL100427A0 (de)
NZ (1)	NZ241063A (de)
PT (1)	PT99861A (de)
TW (1)	TW199139B (de)
WO (1)	WO1992011235A1 (de)
ZA (1)	ZA9110014B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5177064A (en) *	1990-07-13	1993-01-05	University Of Florida	Targeted drug delivery via phosphonate derivatives
US5552397A (en) *	1992-05-18	1996-09-03	E. R. Squibb & Sons, Inc.	Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5654294A (en) *	1993-05-13	1997-08-05	Bristol-Myers Squibb	Spiro lactam dual action inhibitors
US5508272A (en) *	1993-06-15	1996-04-16	Bristol-Myers Squibb Company	Compounds containing a fused bicycle ring and processes therefor
US5362727A (en) *	1993-07-26	1994-11-08	Bristol-Myers Squibb	Substituted azepino[2,1-a]isoquinoline compounds
US5462964A (en) *	1993-10-20	1995-10-31	The Du Pont Merck Pharmaceutical Company	Dipeptide boronic acid inhibitors of trypsin-like enzymes
US5616775A (en) *	1994-05-05	1997-04-01	Bristol-Myers Squibb Co.	Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5587375A (en) *	1995-02-17	1996-12-24	Bristol-Myers Squibb Company	Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en)	1995-05-17	1999-03-02	Bristol-Myers Squibb	Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) *	1995-06-07	1997-06-03	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
US5650408A (en) *	1995-06-07	1997-07-22	Karanewsky; Donald S.	Thiazolo benzazepine containing dual action inhibitors
WO2016168090A1 (en) *	2015-04-14	2016-10-20	Nueon, Inc.	Method and apparatus for determining markers of health by analysis of blood

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4256761A (en) *	1979-07-13	1981-03-17	Usv Pharmaceutical Corporation	Antihypertensive amides
US4820729A (en) *	1981-03-30	1989-04-11	Rorer Pharmaceutical Corporation	N-substituted-amido-amino acids
US4470973A (en) *	1982-07-19	1984-09-11	E. R. Squibb & Sons, Inc.	Substituted peptide compounds
ZA852359B (en) *	1984-04-02	1985-11-27	Squibb & Sons Inc	Enkephalinase inhibitors
FR2589468B1 (fr) *	1985-07-30	1987-12-31	Roussel Uclaf	Nouveaux derives du 2-acylamino ethanethiol 2-substitue, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US4740499A (en) *	1986-07-28	1988-04-26	Monsanto Company	Method of enhancing the bioactivity of atrial peptides

1990
- 1990-12-21 US US07/633,696 patent/US5232920A/en not_active Expired - Fee Related
1991
- 1991-12-19 PT PT99861A patent/PT99861A/pt not_active Application Discontinuation
- 1991-12-19 JP JP4501584A patent/JP2511625B2/ja not_active Expired - Fee Related
- 1991-12-19 EP EP92901485A patent/EP0563153B1/de not_active Expired - Lifetime
- 1991-12-19 IL IL100427A patent/IL100427A0/xx unknown
- 1991-12-19 DK DK92901485.0T patent/DK0563153T3/da active
- 1991-12-19 AT AT92901485T patent/ATE119879T1/de not_active IP Right Cessation
- 1991-12-19 ZA ZA9110014A patent/ZA9110014B/xx unknown
- 1991-12-19 TW TW080109946A patent/TW199139B/zh active
- 1991-12-19 DE DE69108262T patent/DE69108262T2/de not_active Expired - Fee Related
- 1991-12-19 AU AU91046/91A patent/AU9104691A/en not_active Abandoned
- 1991-12-19 ES ES92901485T patent/ES2072138T3/es not_active Expired - Lifetime
- 1991-12-19 NZ NZ241063A patent/NZ241063A/en unknown
- 1991-12-19 WO PCT/US1991/009189 patent/WO1992011235A1/en not_active Ceased
- 1991-12-20 IE IE448791A patent/IE73256B1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0563153A1 (de)	1993-10-06
EP0563153B1 (de)	1995-03-15
WO1992011235A1 (en)	1992-07-09
PT99861A (pt)	1992-12-31
DE69108262T2 (de)	1995-07-06
AU9104691A (en)	1992-07-22
NZ241063A (en)	1995-04-27
IE914487A1 (en)	1992-07-01
DK0563153T3 (da)	1995-05-29
JPH05509331A (ja)	1993-12-22
ES2072138T3 (es)	1995-07-01
DE69108262D1 (de)	1995-04-20
JP2511625B2 (ja)	1996-07-03
IL100427A0 (en)	1992-09-06
TW199139B (de)	1993-02-01
US5232920A (en)	1993-08-03
ZA9110014B (en)	1992-08-26
IE73256B1 (en)	1997-05-21

Legal Events

Date	Code	Title	Description
1995-08-15	UEP	Publication of translation of european patent specification
1999-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69108262D1 (de)	1995-04-20	N-(merkaptoalkyl)amide.
AP1687A (en)	2006-12-04	Therapeutic biaryl derivatives.
AU7578894A (en)	1995-05-04	Methods for inhibiting smooth muscle cell proliferation and restinosis
IS1959B (is)	2004-11-15	Bensimídazól efnasambönd, lyfjablöndur sem innihalda efnasamböndin og notkun þeirra
NZ331613A (en)	2000-03-27	Piperazinyl or piperidinyl substituted 1,2,3,4-tetrahydronaphthalene derivatives
NO305174B1 (no)	1999-04-12	Heterocykliske forbindelser
RU2006106922A (ru)	2006-08-27	Амидное производное
DE69808326D1 (de)	2002-10-31	Azetidinonderivate zur behandlung von hcmv entzündungen
AU8445591A (en)	1992-03-17	N-(mercaptoalkyl)ureas and carbamates
NO971261D0 (no)	1997-03-19	Kinoksalin-derivater nyttige innen terapi
MXPA03011032A (es)	2004-03-19	Activadores de derivados de oxazol/tiazol del receptor hppar-alfa.
AP2002002595A0 (en)	2002-09-30	Heterocyclic amide derivatives.
ATE295172T1 (de)	2005-05-15	Propylaxe und behandlung der arzneimittel induzierten nierenstörungen
DK1049672T3 (da)	2004-01-19	Azetidincarboxamid-derivater til behandling af CNS-lidelser
DK0393441T3 (da)	1993-09-27	Mercapto-acylaminosyrer
AP2001002356A0 (en)	2001-12-31	Tricyclic analgesics.
EP0372410A3 (de)	1991-05-22	Verwendung heterozyklischer Amide zur Verhinderung der Tumormetastasierung
DE69916577D1 (de)	2004-05-27	Azetidincarboxamid-derivate zur behandlung von zns störungen
DE69107207D1 (de)	1995-03-16	Disulfidderivate von mercapto-acyl-aminsäuren.
DK1049670T3 (da)	2002-11-11	Azetidincarboxamidderivater til behandling af CNS-lidelser
ATE239707T1 (de)	2003-05-15	2-phenylpyridine-derivate und verfahren zu deren herstellung
TH19278A (th)	1996-06-21	อนุพันธ์ของ 5-อิมิโน-2-อิมิแดโซลีน ซึ่งมีฤทธิ์ฆ่าเชื้อรา