ES2072288T3 - Preparacion de enantiomeros de dropropizina. - Google Patents

Preparacion de enantiomeros de dropropizina.

Info

Publication number
ES2072288T3
ES2072288T3 ES89201651T ES89201651T ES2072288T3 ES 2072288 T3 ES2072288 T3 ES 2072288T3 ES 89201651 T ES89201651 T ES 89201651T ES 89201651 T ES89201651 T ES 89201651T ES 2072288 T3 ES2072288 T3 ES 2072288T3
Authority
ES
Spain
Prior art keywords
dropropizine
enantiomers
preparation
phenylpiperazine
recrystallization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89201651T
Other languages
English (en)
Inventor
Iersel Jacobus Theodorus M Van
Vincentius Henricus M Elferink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19852523&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2072288(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of ES2072288T3 publication Critical patent/ES2072288T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE ENANTIOMEROS DE DROPROPIZINA POR ACOPLAMIENTO DE 1-FENILPIPERAZINA CON UN GLICIDOL QUE CONTIENE UN EXCESO DE UNO DE LOS ENANTIOMEROS Y PURIFICAR LA DROPROPIZINA POR RECRISTALIZACION.
ES89201651T 1988-06-25 1989-06-22 Preparacion de enantiomeros de dropropizina. Expired - Lifetime ES2072288T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8801622A NL8801622A (nl) 1988-06-25 1988-06-25 Bereiding van enantiomeren van dropropizine.

Publications (1)

Publication Number Publication Date
ES2072288T3 true ES2072288T3 (es) 1995-07-16

Family

ID=19852523

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89201651T Expired - Lifetime ES2072288T3 (es) 1988-06-25 1989-06-22 Preparacion de enantiomeros de dropropizina.

Country Status (5)

Country Link
EP (1) EP0349066B1 (es)
AT (1) ATE121737T1 (es)
DE (1) DE68922344T2 (es)
ES (1) ES2072288T3 (es)
NL (1) NL8801622A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1226570B (it) * 1988-08-01 1991-01-24 Bidachem Spa Procedimento di preparazione della levo- e destro-dropropizina
IT1231158B (it) * 1989-07-20 1991-11-19 Dompe Farmaceutici Spa Procedimento per la risoluzione ottica della dropropizina.
IT1254452B (it) * 1992-02-14 1995-09-25 Dompe Farmaceutici Spa N-ossidi ed n,n'-diossidi di 3-(piperazin-1-il)-propan-1,2-dioli
IT1254993B (it) * 1992-06-24 1995-10-11 Procedimento per la preparazione degli enantiomeri della dropropizina
IT1318650B1 (it) * 2000-07-28 2003-08-27 Dompe Spa 1,3-diossolani ad attivita' antitosse.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE601394A (es) *
IT1203721B (it) * 1983-12-29 1989-02-23 Dompe Farmaceutici Spa Composti otticamente attivi ad attivita' antitosse e sedativa centrale,procedimento per la preparazione e composizioni che li contengono

Also Published As

Publication number Publication date
EP0349066A1 (en) 1990-01-03
DE68922344D1 (de) 1995-06-01
EP0349066B1 (en) 1995-04-26
ATE121737T1 (de) 1995-05-15
DE68922344T2 (de) 1995-12-14
NL8801622A (nl) 1990-01-16

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