ES2072397T3 - Metodo y dispositivo para la administracion transdermica de dexmedetomidina. - Google Patents

Metodo y dispositivo para la administracion transdermica de dexmedetomidina.

Info

Publication number
ES2072397T3
ES2072397T3 ES90308637T ES90308637T ES2072397T3 ES 2072397 T3 ES2072397 T3 ES 2072397T3 ES 90308637 T ES90308637 T ES 90308637T ES 90308637 T ES90308637 T ES 90308637T ES 2072397 T3 ES2072397 T3 ES 2072397T3
Authority
ES
Spain
Prior art keywords
dexmedetomidine
skin
adhesive layer
therapeutic system
transdermic administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90308637T
Other languages
English (en)
Inventor
Kenneth J Colley
Donald R Wilson
Gary W Cleary
Risto Lammintausta
Harry Jalonen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Cygnus Therapeutic Systems
Original Assignee
Orion Yhtyma Oy
Cygnus Therapeutic Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtyma Oy, Cygnus Therapeutic Systems filed Critical Orion Yhtyma Oy
Application granted granted Critical
Publication of ES2072397T3 publication Critical patent/ES2072397T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBE LA ADMINISTRACION TRANSDERMAL DE DEXMEDETOMIDINA, EL ISOMERO DEXTROGIRATORIO DE MEDETOMIDINA. EL METODO IMPLICA SEDAR A UN PACIENTE ADMINISTRANDOLE DEXMEDETOMIDINA EN UNA ZONA PREDETERMINADA DE LA PIEL EN UNA TASA DE ADMINISTRACION Y DURANTE UN PERIODO DE TIEMPO EFECTIVO PARA ALCANZAR EL NIVEL DE SEDACION DESEADO. TAMBIEN SE PROPORCIONA UN SISTEMA TERAPEUTICO PARA ADMINISTRAR TRANSDERMALMENTE LA DROGA. EL SISTEMA TERAPEUTICO TIENE LA FORMA DE UNA PIEZA INSERTADA EN LA PIEL QUE ES UN COMPUESTO LAMINADO DE UNA CAPA DE REFUERZO, UNA CAPA ADHESIVA DE ANCLA OPCIONAL, UNA CAPA ADHESIVA DE CONTACTO, Y UNA O MAS CAPAS ADICIONALES.
ES90308637T 1989-08-18 1990-08-06 Metodo y dispositivo para la administracion transdermica de dexmedetomidina. Expired - Lifetime ES2072397T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/395,717 US5124157A (en) 1989-08-18 1989-08-18 Method and device for administering dexmedetomidine transdermally

Publications (1)

Publication Number Publication Date
ES2072397T3 true ES2072397T3 (es) 1995-07-16

Family

ID=23564195

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90308637T Expired - Lifetime ES2072397T3 (es) 1989-08-18 1990-08-06 Metodo y dispositivo para la administracion transdermica de dexmedetomidina.

Country Status (25)

Country Link
US (1) US5124157A (es)
EP (1) EP0413487B1 (es)
JP (1) JP3043064B2 (es)
CN (1) CN1035922C (es)
AT (1) ATE122899T1 (es)
AU (1) AU639015B2 (es)
BG (1) BG95935A (es)
CA (1) CA2064687C (es)
DD (1) DD297066A5 (es)
DE (1) DE69019628T2 (es)
DK (1) DK0413487T3 (es)
ES (1) ES2072397T3 (es)
FI (1) FI100857B (es)
HU (1) HUT64223A (es)
IE (1) IE67127B1 (es)
LT (1) LT3753B (es)
LV (1) LV10685B (es)
NO (1) NO300408B1 (es)
NZ (1) NZ234749A (es)
PL (1) PL165023B1 (es)
PT (1) PT95002B (es)
RU (1) RU2098083C1 (es)
UA (1) UA26988C2 (es)
WO (1) WO1991002505A1 (es)
ZA (1) ZA906539B (es)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217718A (en) * 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
GB2256135B (en) * 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
GB9111732D0 (en) * 1991-05-31 1991-07-24 Orion Yhtymae Oy The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs
AU2782592A (en) * 1991-10-15 1993-05-21 Cygnus Therapeutic Systems Thermal enhancement of transdermal drug administration
US5883115A (en) * 1992-11-09 1999-03-16 Pharmetrix Division Technical Chemicals & Products, Inc. Transdermal delivery of the eutomer of a chiral drug
US5591767A (en) * 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
AU6491494A (en) * 1993-04-07 1994-10-24 Rexham Industries Corp. Method of coating microporous membranes and resulting products
US5536263A (en) * 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
US5635203A (en) * 1994-09-29 1997-06-03 Alza Corporation Transdermal device having decreased delamination
US5807570A (en) * 1995-09-29 1998-09-15 Cygnus, Inc. Transdermal administration of ropinirole and analogs thereof
GB9521680D0 (en) * 1995-10-23 1996-01-03 Orion Yhtymo Oy New use of imidazole derivatives
US5730721A (en) * 1996-01-25 1998-03-24 Vesture Corporation Medical applicator and method
GB9614098D0 (en) 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
DE19814084B4 (de) * 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
US6716867B1 (en) 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
DE19925338A1 (de) * 1999-06-02 2000-12-07 Lohmann Therapie Syst Lts Substratabschnitte mit erhöhter Lagerstabilität während ihrer Lagerung in Beutelverpackung, sowie Verfahren zu ihrer Herstellung
EP1223931B1 (en) 1999-10-29 2005-12-14 Orion Corporation Use of a imidazole derivative for the treatment or prevention of hypotension and shock
AU4842100A (en) 1999-12-10 2001-06-18 Teri Buseman Anti pruritic patch
ATE521270T1 (de) 2000-07-10 2011-09-15 Uni Charm Corp Gegenstand zum reinigen
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
JP4358978B2 (ja) * 2000-09-05 2009-11-04 日東電工株式会社 経皮吸収製剤
US20020198215A1 (en) * 2000-10-23 2002-12-26 Lino Tavares Terazosin transdermal device and methods
US20030195272A1 (en) * 2001-02-01 2003-10-16 Michael Harwell Scented hot melt adhesives
US20030026830A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
US20030027793A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal treatment of parkinson's disease
DE10234673B4 (de) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8211462B2 (en) * 2002-07-30 2012-07-03 Ucb Pharma Gmbh Hot-melt TTS for administering rotigotine
US8246979B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
US8246980B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
US8133505B2 (en) 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US7662404B2 (en) 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
US7383084B2 (en) 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
ES2239196T3 (es) * 2002-12-02 2005-09-16 Schwarz Pharma Ag Suministro iontoforetico de rotigotina para el tratamiento de la enfermedad de parkinson.
DE10261696A1 (de) * 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE102006054733A1 (de) * 2006-11-21 2008-05-29 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit
US20090291127A1 (en) * 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
US7795263B2 (en) * 2008-07-08 2010-09-14 Wildlife Laboratories, Inc. Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals
SG175979A1 (en) * 2009-05-15 2011-12-29 Recro Pharma Inc Sublingual dexmedetomidine compositions and methods of use thereof
US20130072532A1 (en) * 2010-01-08 2013-03-21 Recro Pharma, Inc. Topical transdermal dexmedetomidine compositions and methods of use thereof
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
WO2013090278A2 (en) 2011-12-11 2013-06-20 Recro Pharma, Inc. Intranasal dexmedetomidine compositions and methods of use thereof
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
WO2013173317A1 (en) * 2012-05-14 2013-11-21 Prospire, Llc TREATMENT OF OBSTRUCTIVE SLEEP APNEA WITH α2-ADRENERGIC RECEPTOR AGONISTS
KR101948779B1 (ko) * 2013-10-07 2019-05-21 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
US20150098982A1 (en) * 2013-10-07 2015-04-09 Teikoku Pharma Usa, Inc. Methods and Compositions for Managing Pain Comprising Dexmedetomidine Transdermal Compositions
KR101881791B1 (ko) * 2013-10-07 2018-07-25 테이코쿠 팔마 유에스에이, 인코포레이티드 비진정성 덱스메데토미딘 경피 조성물을 사용하여 금단 증후군을 치료하기 위한 방법 및 조성물
CA2924233C (en) * 2013-10-07 2018-10-23 Teikoku Pharma Usa, Inc. Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions
CA2924236C (en) * 2013-10-07 2020-01-07 Teikoku Pharma Usa, Inc. Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine
US9974754B2 (en) 2013-12-18 2018-05-22 Maruishi Pharmaceutical Co., Ltd. Hydrous adhesive patch
US9717796B1 (en) 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
BR112019007325A2 (pt) * 2016-10-18 2019-07-02 Lts Lohmann Therapie Systeme Ag sistema terapêutico tópico de duas camadas
BR112019006955A2 (pt) 2016-10-31 2019-07-02 Teikoku Pharma Usa Inc métodos de controle da dor usando dispositivos de distribuição transdérmica de dexmedetomidina
US20190350840A1 (en) * 2016-12-26 2019-11-21 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
KR102437993B1 (ko) 2018-06-26 2022-08-29 히사미쓰 세이야꾸 가부시키가이샤 마이크로 니들 디바이스 및 그것을 제조하는 방법
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags
CN111346072B (zh) * 2018-12-21 2022-05-27 宜昌人福药业有限责任公司 一种透皮给药的药物组合物及其制备方法
EP3960238A4 (en) * 2019-04-24 2023-01-25 MEDRx Co., Ltd. Lidocaine-containing patch
TWI772807B (zh) 2019-05-27 2022-08-01 日商救急藥品工業股份有限公司 外用製劑

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3598122A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3854480A (en) * 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3731683A (en) * 1971-06-04 1973-05-08 Alza Corp Bandage for the controlled metering of topical drugs to the skin
US3731583A (en) 1971-07-30 1973-05-08 Automated Building Components Connector plate
US3923939A (en) * 1974-06-07 1975-12-02 Alza Corp Process for improving release kinetics of a monolithic drug delivery device
US3926188A (en) * 1974-11-14 1975-12-16 Alza Corp Laminated drug dispenser
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
FI844786A0 (fi) * 1984-12-04 1984-12-04 Farmos Oy Terapeutiskt utnyttjbar foerening.
US4717568A (en) * 1985-08-09 1988-01-05 Alza Corporation Laminar arrangement for increasing delivery of beneficial agent from dispenser
US4826686A (en) * 1985-12-14 1989-05-02 Boehringer Ingelheim Kg Therapeutic system
FI864570A0 (fi) * 1986-11-11 1986-11-11 Farmos Oy Terapeutiskt anvaendbar foerening.
AU607172B2 (en) * 1986-12-22 1991-02-28 Cygnus, Inc. Diffusion matrix for transdermal drug administration
US4906463A (en) * 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
AU601528B2 (en) * 1986-12-22 1990-09-13 Ortho-Mcneil Pharmaceutical, Inc. Resilient transdermal drug-delivery device and compositions and devices employing fatty acid esters/ethers of alkanediols and percutaneous absorption enhancers
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
US4915950A (en) * 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device

Also Published As

Publication number Publication date
EP0413487B1 (en) 1995-05-24
FI100857B (fi) 1998-03-13
PL286525A1 (en) 1991-05-20
UA26988C2 (uk) 2000-02-28
NO300408B1 (no) 1997-05-26
US5124157A (en) 1992-06-23
LV10685A (lv) 1995-06-20
LTIP1773A (en) 1995-07-25
PT95002B (pt) 1997-10-31
DE69019628D1 (de) 1995-06-29
ATE122899T1 (de) 1995-06-15
NO920521L (no) 1992-02-10
CN1035922C (zh) 1997-09-24
CN1049450A (zh) 1991-02-27
LT3753B (en) 1996-03-25
HUT64223A (en) 1993-12-28
WO1991002505A1 (en) 1991-03-07
IE902993A1 (en) 1991-02-27
EP0413487A1 (en) 1991-02-20
PT95002A (pt) 1992-02-28
JP3043064B2 (ja) 2000-05-22
CA2064687A1 (en) 1991-02-19
NO920521D0 (no) 1992-02-10
DE69019628T2 (de) 1995-09-28
ZA906539B (en) 1991-06-26
FI920576A0 (fi) 1992-02-11
JPH05503916A (ja) 1993-06-24
DK0413487T3 (da) 1995-07-17
HU9200517D0 (en) 1992-05-28
AU639015B2 (en) 1993-07-15
AU6183490A (en) 1991-04-03
NZ234749A (en) 1992-03-26
LV10685B (en) 1995-12-20
RU2098083C1 (ru) 1997-12-10
CA2064687C (en) 1998-04-21
PL165023B1 (pl) 1994-11-30
IE67127B1 (en) 1996-03-06
DD297066A5 (de) 1992-01-02
BG95935A (bg) 1993-12-24

Similar Documents

Publication Publication Date Title
ES2072397T3 (es) Metodo y dispositivo para la administracion transdermica de dexmedetomidina.
PL330212A1 (en) Preparation administered by transcutaneous absorption
ES2035928T3 (es) Dispositivo para administrar un agente activo a la piel o a la mucosa.
WO2002036072A3 (en) Method for short-term and long-term drug dosimetry
ES2103271T3 (es) Dispositivo para administrar un agente activo a la piel o a mucosas.
ATE288743T1 (de) Pharmazeutische trägervorrichtung welche zur verabreichung von wirkstoffen an schleimhautoberflächen geeignet ist
ATE290856T1 (de) Hydroxide freisetzende verbindungen zum verbessern der hautdurchlässigkeit
MX9709644A (es) Dispositivo para el suministro transdermico por electrotransporte de fentanilo y sufentanilo.
UY24117A1 (es) Tratamiento antifungal de las uñas.
DE69916492D1 (de) Pflaster zur transdermalen applikation von flüchtigen, flüssigen wirkstoffen
ES2188907T3 (es) Dispositivo de soporte farmaceutico adecuado ppara la administracion de compuestos farmaceuticos a las superficies de las mucosas.
AR042815A1 (es) Dispositivo de suministro de agente activo que tiene miembros compuestos
MXPA04001491A (es) Dispositivo de liberacion de farmaco erosionable mucoadhesivo para la administracion controlada de compuestos activos farmaceuticos y otros compuestos activos.
CZ113790A3 (cs) Náplast jako transdermální terapeutický systém, způsob její výroby a její použití
LV10047A (lv) Medetomidina saju un to optiski aktivo enantiomeru izmantosana medicinisko preperatu transdermalas iedarbibas pakapes regulesanai
ATE396714T1 (de) Transdermales therapeutisches system mit verbessertem langzeittragekomfort
BR0109893A (pt) Preparação farmacêutica de lerisetron na forma de um sistema terapêutico transdêrmico, uso da preparação, uso da substância ativa lerisetron e método para administrar a substância ativa lerisetron a um paciente
AR003979A1 (es) Administracion transdermica de vorozol.
US6868286B1 (en) Device for a transdermal and phonophoretic combination therapy and the use thereof in a method for medical application
ATE280575T1 (de) Transdermales therapeutisches system zur anwendung von candesartan
LV10749A (lv) Transdermala terapeitiska sistema fizostigmina uzliksanai uz adas un tas izgatavosanas panemiens
DE69423616D1 (de) Molekulares transdermales transportsystem
DE59506962D1 (de) Estradiol-tts mit wasserbindenden zusätzen
AR013498A1 (es) Uso de ifn-alfa y amantadine para el tratamiento de hepatitis c cronica uso de ifn-alfa
WO2008116636A8 (de) Therapeutisches pflaster für trigger- und akupunkturpunkte sowie zur meridiantherapie

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 413487

Country of ref document: ES