ES2072397T3 - Metodo y dispositivo para la administracion transdermica de dexmedetomidina. - Google Patents

Metodo y dispositivo para la administracion transdermica de dexmedetomidina.

Info

Publication number
ES2072397T3
ES2072397T3 ES90308637T ES90308637T ES2072397T3 ES 2072397 T3 ES2072397 T3 ES 2072397T3 ES 90308637 T ES90308637 T ES 90308637T ES 90308637 T ES90308637 T ES 90308637T ES 2072397 T3 ES2072397 T3 ES 2072397T3
Authority
ES
Spain
Prior art keywords
dexmedetomidine
skin
adhesive layer
therapeutic system
transdermic administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90308637T
Other languages
English (en)
Inventor
Kenneth J Colley
Donald R Wilson
Gary W Cleary
Risto Lammintausta
Harry Jalonen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Cygnus Therapeutic Systems
Original Assignee
Orion Yhtyma Oy
Cygnus Therapeutic Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtyma Oy, Cygnus Therapeutic Systems filed Critical Orion Yhtyma Oy
Application granted granted Critical
Publication of ES2072397T3 publication Critical patent/ES2072397T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE LA ADMINISTRACION TRANSDERMAL DE DEXMEDETOMIDINA, EL ISOMERO DEXTROGIRATORIO DE MEDETOMIDINA. EL METODO IMPLICA SEDAR A UN PACIENTE ADMINISTRANDOLE DEXMEDETOMIDINA EN UNA ZONA PREDETERMINADA DE LA PIEL EN UNA TASA DE ADMINISTRACION Y DURANTE UN PERIODO DE TIEMPO EFECTIVO PARA ALCANZAR EL NIVEL DE SEDACION DESEADO. TAMBIEN SE PROPORCIONA UN SISTEMA TERAPEUTICO PARA ADMINISTRAR TRANSDERMALMENTE LA DROGA. EL SISTEMA TERAPEUTICO TIENE LA FORMA DE UNA PIEZA INSERTADA EN LA PIEL QUE ES UN COMPUESTO LAMINADO DE UNA CAPA DE REFUERZO, UNA CAPA ADHESIVA DE ANCLA OPCIONAL, UNA CAPA ADHESIVA DE CONTACTO, Y UNA O MAS CAPAS ADICIONALES.
ES90308637T 1989-08-18 1990-08-06 Metodo y dispositivo para la administracion transdermica de dexmedetomidina. Expired - Lifetime ES2072397T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/395,717 US5124157A (en) 1989-08-18 1989-08-18 Method and device for administering dexmedetomidine transdermally

Publications (1)

Publication Number Publication Date
ES2072397T3 true ES2072397T3 (es) 1995-07-16

Family

ID=23564195

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90308637T Expired - Lifetime ES2072397T3 (es) 1989-08-18 1990-08-06 Metodo y dispositivo para la administracion transdermica de dexmedetomidina.

Country Status (25)

Country Link
US (1) US5124157A (es)
EP (1) EP0413487B1 (es)
JP (1) JP3043064B2 (es)
CN (1) CN1035922C (es)
AT (1) ATE122899T1 (es)
AU (1) AU639015B2 (es)
BG (1) BG95935A (es)
CA (1) CA2064687C (es)
DD (1) DD297066A5 (es)
DE (1) DE69019628T2 (es)
DK (1) DK0413487T3 (es)
ES (1) ES2072397T3 (es)
FI (1) FI100857B (es)
HU (1) HUT64223A (es)
IE (1) IE67127B1 (es)
LT (1) LT3753B (es)
LV (1) LV10685B (es)
NO (1) NO300408B1 (es)
NZ (1) NZ234749A (es)
PL (1) PL165023B1 (es)
PT (1) PT95002B (es)
RU (1) RU2098083C1 (es)
UA (1) UA26988C2 (es)
WO (1) WO1991002505A1 (es)
ZA (1) ZA906539B (es)

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US5217718A (en) * 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
GB9111732D0 (en) * 1991-05-31 1991-07-24 Orion Yhtymae Oy The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs
GB2256135B (en) * 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
AU2782592A (en) * 1991-10-15 1993-05-21 Cygnus Therapeutic Systems Thermal enhancement of transdermal drug administration
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GB9614098D0 (en) 1996-07-05 1996-09-04 Orion Yhtymae Oy Transdermal delivery of levosimendan
DE19814084B4 (de) * 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
US6716867B1 (en) 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
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ATE312606T1 (de) 1999-10-29 2005-12-15 Orion Corp Verwendung eines imidazolderivats zur behandlung oder verhütung von hypotension und schock
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US8246980B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
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IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
DE60204229T2 (de) * 2002-12-02 2006-02-02 Schwarz Pharma Ag Verabreichung von Rotigotine zur Behandlung der Parkinson'schen Krankheit durch Iontophorese
DE10261696A1 (de) * 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE102006054733A1 (de) * 2006-11-21 2008-05-29 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit
US20090291127A1 (en) * 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
US7795263B2 (en) * 2008-07-08 2010-09-14 Wildlife Laboratories, Inc. Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals
EP3305281A1 (en) * 2009-05-15 2018-04-11 Recro Pharma, Inc. Sublingual dexmedetomidine compositions and methods of use thereof
EP2521544A4 (en) * 2010-01-08 2013-08-21 Recro Pharma Inc TOPICAL TRANSDERMAL DEXMEDETOMIDINE COMPOSITIONS AND METHOD FOR THEIR USE
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
CA2858721C (en) 2011-12-11 2021-03-16 Recro Pharma, Inc. Intranasal dexmedetomidine compositions and methods of use thereof
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
WO2013173317A1 (en) * 2012-05-14 2013-11-21 Prospire, Llc TREATMENT OF OBSTRUCTIVE SLEEP APNEA WITH α2-ADRENERGIC RECEPTOR AGONISTS
RU2648449C2 (ru) * 2013-10-07 2018-03-26 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Способы и композиции для трансдермальной доставки неседативного количества дексмедетомидина
CN110604728A (zh) * 2013-10-07 2019-12-24 帝国制药美国公司 用于管理疼痛的包含右旋美托咪啶经皮组合物的方法及组合物
TWI709417B (zh) * 2013-10-07 2020-11-11 美商帝國製藥美國股份有限公司 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物
EP3054934B1 (en) * 2013-10-07 2024-05-22 Teikoku Pharma USA, Inc. Methods and compositions for treating withdrawal syndromes using non-sedative dexmedetomidine transdermal compositions
RU2018105761A (ru) * 2013-10-07 2019-02-26 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Устройства для трансдермальной доставки дексмедетомидина и способы их применения
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CA3038702A1 (en) * 2016-10-18 2018-04-26 Lts Lohmann Therapie-Systeme Ag Two-layer topical therapeutic system
KR20210113439A (ko) * 2016-10-31 2021-09-15 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법
ES2895764T3 (es) * 2016-12-26 2022-02-22 Hisamitsu Pharmaceutical Co Dispositivo de microagujas
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CN111346072B (zh) * 2018-12-21 2022-05-27 宜昌人福药业有限责任公司 一种透皮给药的药物组合物及其制备方法
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Also Published As

Publication number Publication date
NO920521L (no) 1992-02-10
LV10685A (lv) 1995-06-20
HU9200517D0 (en) 1992-05-28
CA2064687C (en) 1998-04-21
JPH05503916A (ja) 1993-06-24
DE69019628D1 (de) 1995-06-29
WO1991002505A1 (en) 1991-03-07
ATE122899T1 (de) 1995-06-15
DK0413487T3 (da) 1995-07-17
JP3043064B2 (ja) 2000-05-22
CN1035922C (zh) 1997-09-24
AU6183490A (en) 1991-04-03
DE69019628T2 (de) 1995-09-28
PL165023B1 (pl) 1994-11-30
NO920521D0 (no) 1992-02-10
CA2064687A1 (en) 1991-02-19
AU639015B2 (en) 1993-07-15
PT95002A (pt) 1992-02-28
DD297066A5 (de) 1992-01-02
CN1049450A (zh) 1991-02-27
US5124157A (en) 1992-06-23
NZ234749A (en) 1992-03-26
LT3753B (en) 1996-03-25
EP0413487A1 (en) 1991-02-20
HUT64223A (en) 1993-12-28
FI100857B (fi) 1998-03-13
LV10685B (en) 1995-12-20
FI920576A0 (fi) 1992-02-11
ZA906539B (en) 1991-06-26
PL286525A1 (en) 1991-05-20
IE67127B1 (en) 1996-03-06
BG95935A (bg) 1993-12-24
PT95002B (pt) 1997-10-31
EP0413487B1 (en) 1995-05-24
LTIP1773A (en) 1995-07-25
UA26988C2 (uk) 2000-02-28
NO300408B1 (no) 1997-05-26
IE902993A1 (en) 1991-02-27
RU2098083C1 (ru) 1997-12-10

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