ES2072467T3 - Derivados de indol. - Google Patents
Derivados de indol.Info
- Publication number
- ES2072467T3 ES2072467T3 ES91103628T ES91103628T ES2072467T3 ES 2072467 T3 ES2072467 T3 ES 2072467T3 ES 91103628 T ES91103628 T ES 91103628T ES 91103628 T ES91103628 T ES 91103628T ES 2072467 T3 ES2072467 T3 ES 2072467T3
- Authority
- ES
- Spain
- Prior art keywords
- quinuclidinyl
- ind
- indol
- derivatives
- indolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- -1 3-indolyl group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- CJTOFAIRBFMRTI-UHFFFAOYSA-N 3-(1-azabicyclo[2.2.2]octan-3-yl)-1h-indole Chemical class C1=CC=C2C(C3C4CCN(C3)CC4)=CNC2=C1 CJTOFAIRBFMRTI-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LAS 3-(3-INDOLIL)-QUINUCLIDINAS CON FORMULA (I) IND-R (I) EN LA QUE IND ES UN GRUPO 3-INDOLIL SUSTITUIDO UNA A CUATRO VECES POR 1-4-C-ALQUILO, TRIFLUORMETILO, 1-4-C-ALCOXI, 1-4-C-ALQUILTIO, FLUOR, CLORO, HIDROXI, HIDROXIMETILO, 6-10-C-ARILOXI, 7-11-C-ARALQUILOXI, 1-5-C-ACILOXI, 6-10-C-AROILOXI, 1-4-C-ALQUILSULFONILOXI, 6-10-C-ARILSULFONILOXI, CARBOXI, 1-4-C-ALCOXICARBONILO Y/O METILENDIOXI Y R 3-QUINUCLIDINIL O 2, 3-DEHIDRO-3-QUINUCLIDINIL ASI COMO SUS SALES FISIOLOGICAMENTE INNOCUAS SE PUEDEN UTILIZAR COMO PSICOFARMACOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4009565A DE4009565A1 (de) | 1990-03-24 | 1990-03-24 | Indolderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2072467T3 true ES2072467T3 (es) | 1995-07-16 |
Family
ID=6403022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91103628T Expired - Lifetime ES2072467T3 (es) | 1990-03-24 | 1991-03-09 | Derivados de indol. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5227386A (es) |
| EP (1) | EP0450345B1 (es) |
| JP (1) | JPH04235184A (es) |
| KR (1) | KR910016747A (es) |
| AT (1) | ATE123031T1 (es) |
| AU (1) | AU631303B2 (es) |
| CA (1) | CA2038908A1 (es) |
| DE (2) | DE4009565A1 (es) |
| DK (1) | DK0450345T3 (es) |
| ES (1) | ES2072467T3 (es) |
| HU (1) | HU207069B (es) |
| IE (1) | IE70661B1 (es) |
| PT (1) | PT97100A (es) |
| TW (1) | TW217411B (es) |
| ZA (1) | ZA912198B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9201038D0 (en) * | 1992-01-16 | 1992-03-11 | Glaxo Group Ltd | Chemical compounds |
| SE9201478D0 (sv) * | 1992-05-11 | 1992-05-11 | Kabi Pharmacia Ab | Heteroaromatic quinuclidinenes, their use and preparation |
| GB9314174D0 (en) * | 1993-07-08 | 1993-08-18 | American Home Prod | 5-ht3-antagonists |
| EP1315493A4 (en) * | 2000-08-21 | 2007-12-05 | Univ Georgetown | 2-3-DISUBSTITUTED QUINUCLIDINS AS MONOAMINE CARRIER MODULATORS AND THERAPEUTIC AND DIAGNOSTIC METHODS BASED THEREON |
| DE10045112A1 (de) * | 2000-09-11 | 2002-03-21 | Merck Patent Gmbh | Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems |
| ATE385497T1 (de) * | 2000-12-01 | 2008-02-15 | Neurosearch As | 3-substituierte quinuclidin-derivate und deren verwendung als nikotinischen agonisten |
| DE10121215A1 (de) | 2001-04-30 | 2002-10-31 | Merck Patent Gmbh | Dihydro-imidazo[4,5-e]indol- und 7H-Pyrrolo[3,2-f]chinoxalin Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden |
| CN1656093A (zh) * | 2002-05-30 | 2005-08-17 | 神经研究公司 | 3－取代的奎宁环及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4605652A (en) * | 1985-02-04 | 1986-08-12 | A. H. Robins Company, Inc. | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
| AU611976B2 (en) * | 1987-12-24 | 1991-06-27 | John Wyeth & Brother Limited | Aroyl urea and carbamic acid derivatives of azabicyclo compounds |
| DE3810552A1 (de) * | 1988-03-29 | 1989-10-19 | Sandoz Ag | Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben |
| WO1990014347A1 (fr) * | 1989-05-24 | 1990-11-29 | Nippon Shinyaku Co., Ltd. | Derives d'indole et medicament |
-
1990
- 1990-03-24 DE DE4009565A patent/DE4009565A1/de not_active Withdrawn
-
1991
- 1991-03-09 ES ES91103628T patent/ES2072467T3/es not_active Expired - Lifetime
- 1991-03-09 DK DK91103628.3T patent/DK0450345T3/da active
- 1991-03-09 AT AT91103628T patent/ATE123031T1/de not_active IP Right Cessation
- 1991-03-09 EP EP91103628A patent/EP0450345B1/de not_active Expired - Lifetime
- 1991-03-09 DE DE59105550T patent/DE59105550D1/de not_active Expired - Fee Related
- 1991-03-19 AU AU73609/91A patent/AU631303B2/en not_active Ceased
- 1991-03-21 TW TW080102231A patent/TW217411B/zh active
- 1991-03-21 PT PT97100A patent/PT97100A/pt not_active Application Discontinuation
- 1991-03-22 HU HU91972A patent/HU207069B/hu not_active IP Right Cessation
- 1991-03-22 JP JP3130776A patent/JPH04235184A/ja active Pending
- 1991-03-22 ZA ZA912198A patent/ZA912198B/xx unknown
- 1991-03-22 KR KR1019910004550A patent/KR910016747A/ko not_active Ceased
- 1991-03-22 US US07/673,544 patent/US5227386A/en not_active Expired - Fee Related
- 1991-03-22 IE IE96391A patent/IE70661B1/en not_active IP Right Cessation
- 1991-03-22 CA CA002038908A patent/CA2038908A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK0450345T3 (da) | 1995-08-07 |
| IE70661B1 (en) | 1996-12-11 |
| CA2038908A1 (en) | 1991-09-25 |
| AU631303B2 (en) | 1992-11-19 |
| IE910963A1 (en) | 1991-09-25 |
| TW217411B (es) | 1993-12-11 |
| EP0450345B1 (de) | 1995-05-24 |
| HU207069B (en) | 1993-03-01 |
| US5227386A (en) | 1993-07-13 |
| DE59105550D1 (de) | 1995-06-29 |
| KR910016747A (ko) | 1991-11-05 |
| DE4009565A1 (de) | 1991-09-26 |
| AU7360991A (en) | 1991-10-03 |
| ATE123031T1 (de) | 1995-06-15 |
| HU910972D0 (en) | 1991-10-28 |
| JPH04235184A (ja) | 1992-08-24 |
| EP0450345A1 (de) | 1991-10-09 |
| ZA912198B (en) | 1992-01-29 |
| HUT57761A (en) | 1991-12-30 |
| PT97100A (pt) | 1991-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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