ES2072857T3 - Toxina de bordetella pertussis con toxicidad alterada. - Google Patents

Toxina de bordetella pertussis con toxicidad alterada.

Info

Publication number
ES2072857T3
ES2072857T3 ES88117742T ES88117742T ES2072857T3 ES 2072857 T3 ES2072857 T3 ES 2072857T3 ES 88117742 T ES88117742 T ES 88117742T ES 88117742 T ES88117742 T ES 88117742T ES 2072857 T3 ES2072857 T3 ES 2072857T3
Authority
ES
Spain
Prior art keywords
bordetella pertussis
pertussis toxin
polypeptides
toxicity
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88117742T
Other languages
English (en)
Inventor
Mariagrazia Pizza
Rino Rappuoli
Antonella Bartoloni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sclavo SpA
Original Assignee
Sclavo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11196853&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2072857(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sclavo SpA filed Critical Sclavo SpA
Application granted granted Critical
Publication of ES2072857T3 publication Critical patent/ES2072857T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

POLIPEPTINAS INMUNOLOGICAMENTE ACTIVAS SIN O CON TOXICIDAD REDUCIDA SE USAN PARA LA PREPARACION DE UNA VACUNA CONTRA LA TOS. METODO PARA LA PREPARACION DE DICHAS POLIPEPTIDAS EL CUAL COMPRENDE: CULTIVAR UN MICRO ORGANISMO TRANSFORMADO CON UN PLASMODIO HIBRIDO INCLUYENDO EL/LOS GEN(ES) LOS CUALES SE INCLUYEN PARA AL MENOS UNA DE DICHAS POLIPEPTIDAS EN UN MEDIO CONVENIENTE Y RECUPERAR LA POLIPEPTIDA DESEADA DE LAS CELULAS O DEL MEDIO DE CULTIVO.
ES88117742T 1987-11-02 1988-10-25 Toxina de bordetella pertussis con toxicidad alterada. Expired - Lifetime ES2072857T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22481/87A IT1223334B (it) 1987-11-02 1987-11-02 Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse

Publications (1)

Publication Number Publication Date
ES2072857T3 true ES2072857T3 (es) 1995-08-01

Family

ID=11196853

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88117742T Expired - Lifetime ES2072857T3 (es) 1987-11-02 1988-10-25 Toxina de bordetella pertussis con toxicidad alterada.

Country Status (9)

Country Link
US (1) US7410646B1 (es)
EP (1) EP0322533B1 (es)
JP (2) JP2728275B2 (es)
AT (1) ATE123062T1 (es)
CA (1) CA1341582C (es)
DE (1) DE3853876T2 (es)
ES (1) ES2072857T3 (es)
HK (1) HK192995A (es)
IT (1) IT1223334B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
US5332583A (en) * 1987-11-24 1994-07-26 Connaught Laboratories Limited Vaccine containing genetically-detoxified pertussis holotoxin
US5244657A (en) * 1987-11-24 1993-09-14 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
US5358868A (en) * 1987-11-24 1994-10-25 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
IT1223529B (it) * 1987-12-18 1990-09-19 Sclavo Spa Epitopo immunodominante protettivo contenuto nella subunita' s1 della tossina della pertosse
AP8900132A0 (en) * 1988-07-22 1991-01-14 Smithkline Biolog Bordetella pertussis vaccine
ES2078258T3 (es) * 1989-04-28 1995-12-16 Sclavo Spa Mutantes de toxina pertussica, cepas de bordetella capaces de producir tales mutantes y su uso en el desarrollo de vacunas antipertussicas.
US5786189A (en) * 1989-11-29 1998-07-28 Smithkline Beecham Biologicals (S.A.) Vaccine
IT1248735B (it) * 1990-06-21 1995-01-26 Sclavo Spa Vaccini acellulari contro la pertosse
US5856122A (en) * 1993-08-24 1999-01-05 University Of Alberta Modification of pertussis toxin
GB9908263D0 (en) * 1999-04-13 1999-06-02 Binding Site The Limited Eliciting improved immune responses
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
GB0313242D0 (en) * 2003-06-09 2003-07-16 Imp College Innovations Ltd Pulmonary immunopathology
GB0313916D0 (en) 2003-06-16 2003-07-23 Glaxosmithkline Biolog Sa Vaccine composition
US8945582B2 (en) 2006-09-07 2015-02-03 Glaxosmithkline Biologicals S.A. Vaccine
BRPI0810778A2 (pt) 2007-05-02 2011-09-13 Glaxosmithkline Biolog Sa kit, vacina combinada, e, métodos de diminuição da interferência de vizinhança de crm sobre um antìgeno sensìvel em um esquema de imunização primária de uma vacina, e de diminuição da interferência de vizinhança sobre um antìgeno sensìvel, e, uso de conjugados de sacarìdeo
AR077636A1 (es) 2009-07-08 2011-09-14 Abbott Biologicals Bv Vacuna viral y uso de la misma
GB201105981D0 (en) 2011-04-08 2011-05-18 Glaxosmithkline Biolog Sa Novel process
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
WO2014024026A1 (en) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Method for eliciting in infants an immune response against rsv and b. pertussis
US20150273036A1 (en) * 2012-10-12 2015-10-01 Glaxosmithkline Biologicals Sa Non-cross-linked acellular pertussis antigens for use in combination vaccines
AP2015008702A0 (en) 2013-03-08 2015-09-30 Crucell Holland Bv Acellular pertussis vaccine
AU2014304545A1 (en) 2013-08-05 2016-02-25 Glaxosmithkline Biologicals S.A. Combination immunogenic compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340373C (en) * 1986-01-28 1999-02-02 Rino Rappuoli Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin
ES2044959T3 (es) * 1986-12-23 1994-01-16 Univ Leland Stanford Junior Exotoxina de tos ferina modificada.
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin

Also Published As

Publication number Publication date
JP2857105B2 (ja) 1999-02-10
JPH01165370A (ja) 1989-06-29
IT8722481A0 (it) 1987-11-02
DE3853876D1 (de) 1995-06-29
IT1223334B (it) 1990-09-19
US7410646B1 (en) 2008-08-12
JP2728275B2 (ja) 1998-03-18
CA1341582C (en) 2008-10-07
DE3853876T2 (de) 1995-10-05
EP0322533A1 (en) 1989-07-05
ATE123062T1 (de) 1995-06-15
HK192995A (en) 1995-12-29
JPH09157293A (ja) 1997-06-17
EP0322533B1 (en) 1995-05-24

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