ATE123062T1 - Bordetella pertussis-toxin mit veränderter toxizität. - Google Patents

Bordetella pertussis-toxin mit veränderter toxizität.

Info

Publication number
ATE123062T1
ATE123062T1 AT88117742T AT88117742T ATE123062T1 AT E123062 T1 ATE123062 T1 AT E123062T1 AT 88117742 T AT88117742 T AT 88117742T AT 88117742 T AT88117742 T AT 88117742T AT E123062 T1 ATE123062 T1 AT E123062T1
Authority
AT
Austria
Prior art keywords
toxin
altered
bordetella pertussis
polypeptides
preparation
Prior art date
Application number
AT88117742T
Other languages
English (en)
Inventor
Mariagrazia Pizza
Rino Rappuoli
Antonella Bartoloni
Original Assignee
Sclavo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11196853&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE123062(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sclavo Spa filed Critical Sclavo Spa
Application granted granted Critical
Publication of ATE123062T1 publication Critical patent/ATE123062T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT88117742T 1987-11-02 1988-10-25 Bordetella pertussis-toxin mit veränderter toxizität. ATE123062T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22481/87A IT1223334B (it) 1987-11-02 1987-11-02 Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse

Publications (1)

Publication Number Publication Date
ATE123062T1 true ATE123062T1 (de) 1995-06-15

Family

ID=11196853

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88117742T ATE123062T1 (de) 1987-11-02 1988-10-25 Bordetella pertussis-toxin mit veränderter toxizität.

Country Status (9)

Country Link
US (1) US7410646B1 (de)
EP (1) EP0322533B1 (de)
JP (2) JP2728275B2 (de)
AT (1) ATE123062T1 (de)
CA (1) CA1341582C (de)
DE (1) DE3853876T2 (de)
ES (1) ES2072857T3 (de)
HK (1) HK192995A (de)
IT (1) IT1223334B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
US5244657A (en) * 1987-11-24 1993-09-14 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
US5332583A (en) * 1987-11-24 1994-07-26 Connaught Laboratories Limited Vaccine containing genetically-detoxified pertussis holotoxin
US5358868A (en) * 1987-11-24 1994-10-25 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin
IT1223529B (it) * 1987-12-18 1990-09-19 Sclavo Spa Epitopo immunodominante protettivo contenuto nella subunita' s1 della tossina della pertosse
AP8900132A0 (en) * 1988-07-22 1991-01-14 Smithkline Biolog Bordetella pertussis vaccine
ATE127347T1 (de) * 1989-04-28 1995-09-15 Sclavo Spa Pertussistoxin-mutanten, dieselbe produzierende bordetella-stämme und ihre verwendung als vakzin gegen pertussis.
US5786189A (en) * 1989-11-29 1998-07-28 Smithkline Beecham Biologicals (S.A.) Vaccine
IT1248735B (it) * 1990-06-21 1995-01-26 Sclavo Spa Vaccini acellulari contro la pertosse
US5856122A (en) * 1993-08-24 1999-01-05 University Of Alberta Modification of pertussis toxin
GB9908263D0 (en) * 1999-04-13 1999-06-02 Binding Site The Limited Eliciting improved immune responses
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
GB0313242D0 (en) * 2003-06-09 2003-07-16 Imp College Innovations Ltd Pulmonary immunopathology
GB0313916D0 (en) 2003-06-16 2003-07-23 Glaxosmithkline Biolog Sa Vaccine composition
JP5814507B2 (ja) 2006-09-07 2015-11-17 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン
JP2010525035A (ja) 2007-05-02 2010-07-22 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン
TW201103980A (en) 2009-07-08 2011-02-01 Abbott Biologicals Bv Viral vaccine and use thereof
GB201105981D0 (en) 2011-04-08 2011-05-18 Glaxosmithkline Biolog Sa Novel process
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
AU2013301312A1 (en) 2012-08-06 2015-03-19 Glaxosmithkline Biologicals S.A. Method for eliciting in infants an immune response against RSV and B. pertussis
EP2906239A1 (de) * 2012-10-12 2015-08-19 GlaxoSmithKline Biologicals SA Unvernetzte azelluläre pertussis-antigene zur verwendung in kombinationsimpfstoffen
WO2014135651A1 (en) 2013-03-08 2014-09-12 Crucell Holland B.V. Acellular pertussis vaccine
MX2016001695A (es) 2013-08-05 2016-05-02 Glaxosmithkline Biolog Sa Composiciones inmunogenas de combinacion.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340373C (en) * 1986-01-28 1999-02-02 Rino Rappuoli Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin
ES2044959T3 (es) * 1986-12-23 1994-01-16 Univ Leland Stanford Junior Exotoxina de tos ferina modificada.
KR0168039B1 (ko) * 1987-09-04 1999-01-15 로버트 디. 웨스트 재조합 dna에서 유도한 보르데텔라 외독소 소단위체의 유사체 및 그를 포함하는 백신
GB8727489D0 (en) * 1987-11-24 1987-12-23 Connaught Lab Detoxification of pertussis toxin

Also Published As

Publication number Publication date
IT8722481A0 (it) 1987-11-02
CA1341582C (en) 2008-10-07
JPH09157293A (ja) 1997-06-17
JPH01165370A (ja) 1989-06-29
HK192995A (en) 1995-12-29
EP0322533B1 (de) 1995-05-24
ES2072857T3 (es) 1995-08-01
JP2857105B2 (ja) 1999-02-10
JP2728275B2 (ja) 1998-03-18
DE3853876D1 (de) 1995-06-29
EP0322533A1 (de) 1989-07-05
IT1223334B (it) 1990-09-19
US7410646B1 (en) 2008-08-12
DE3853876T2 (de) 1995-10-05

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time
RZN Patent revoked