ES2072928T3 - Antigenos de celulas de islotes pancreaticos obtenidos por clonaje molecular. - Google Patents

Antigenos de celulas de islotes pancreaticos obtenidos por clonaje molecular.

Info

Publication number
ES2072928T3
ES2072928T3 ES90102179T ES90102179T ES2072928T3 ES 2072928 T3 ES2072928 T3 ES 2072928T3 ES 90102179 T ES90102179 T ES 90102179T ES 90102179 T ES90102179 T ES 90102179T ES 2072928 T3 ES2072928 T3 ES 2072928T3
Authority
ES
Spain
Prior art keywords
cells
antigens
proteins
molecular cloning
iddm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90102179T
Other languages
English (en)
Inventor
Daniel Rabin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of ES2072928T3 publication Critical patent/ES2072928T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

ANTIGENOS DE CELULAS DE ISLOTES DE LANG. PANCREATICOS (ICA) QUE SE ASOCIAN CON ANTICUERPOS ENCONTRADOS EN EL SUERO DE PACIENTES AFECTADOS DE DIABETES (IDDM) DEPENDIENTE DE INSULINA (TIPO I). LAS PROTEINAS ICA SE EXPRESAN MEDIANTE VEHICULOS DE CLONES RECOMBINADOS COMPRENDIENDO INSERCIONES AISLADAS DE DNA DE CELULAS DE ISLOTES DE L. SECUENCIAS COMPLETAS DE PROTEINAS ICA NATIVAS, O PROTEINAS, O FRAGMENTOS DE PEPTIDAS DE ELLAS, SE PUEDEN USAR EN EL DIAGNOSTICO DE LA IDDM, Y EN DETECCION O BLOQUEO DE INMUNOGLOBULINA HUMANA, CELULAS T, O CELULAS B INCLUIDAS EN IDDM.
ES90102179T 1989-02-17 1990-02-03 Antigenos de celulas de islotes pancreaticos obtenidos por clonaje molecular. Expired - Lifetime ES2072928T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31254389A 1989-02-17 1989-02-17
US44170389A 1989-12-04 1989-12-04

Publications (1)

Publication Number Publication Date
ES2072928T3 true ES2072928T3 (es) 1995-08-01

Family

ID=26978437

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90102179T Expired - Lifetime ES2072928T3 (es) 1989-02-17 1990-02-03 Antigenos de celulas de islotes pancreaticos obtenidos por clonaje molecular.

Country Status (14)

Country Link
EP (1) EP0383129B1 (es)
JP (1) JP2858467B2 (es)
AT (1) ATE122394T1 (es)
AU (1) AU626636B2 (es)
CA (1) CA2010275C (es)
DE (1) DE69019190T2 (es)
DK (1) DK0383129T3 (es)
ES (1) ES2072928T3 (es)
FI (1) FI103730B (es)
GR (1) GR3017019T3 (es)
IE (1) IE66997B1 (es)
IL (1) IL93397A (es)
NO (1) NO306996B1 (es)
PT (1) PT93166B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5645998A (en) 1988-12-13 1997-07-08 University Of Florida Research Foundation Methods and compositions for the early detection and treatment of insulin dependent diabetes mellitus
US6001360A (en) * 1988-12-13 1999-12-14 University Of Florida Method and compositions for early detection and treatment of insulin dependent diabetes mellitus
JPH02200700A (ja) * 1989-01-30 1990-08-08 Shionogi & Co Ltd 新規ｒｅｇ蛋白質
US5175085A (en) * 1990-02-20 1992-12-29 Board Of Regents, The University Of Texas System Methods and compositions for diagnosing autoimmune insulin dependent diabetes mellitus
US5744327A (en) * 1990-02-20 1998-04-28 Board Of Regents, The University Of Texas System Methods for producing insulin in response to non-glucose secretagogues
US5427940A (en) * 1991-06-03 1995-06-27 Board Of Regents, The University Of Texas System Engineered cells producing insulin in response to glucose
JP2727377B2 (ja) 1990-09-07 1998-03-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 糖尿病自己抗体の検出方法
US6682906B1 (en) 1990-09-21 2004-01-27 The Regents Of The University Of California Cloned glutamic acid decarboxylase
US5674978A (en) * 1990-09-21 1997-10-07 The Regents Of The University Of California Peptides derived from glutamic acid decarboxylase
US5998366A (en) * 1990-09-21 1999-12-07 The Regents Of The University Of California Method for ameliorating glutamic acid decarboxylase associated autoimmune disorders
WO1992006105A1 (en) * 1990-10-02 1992-04-16 Trigen Incorporated Antibodies and methods for diagnosis and treatment of diabetes
JPH06508030A (ja) * 1991-05-15 1994-09-14 ザイモジェネティクス，インコーポレイティド ヒトすい島グルタミン酸デカルボキシラーゼ自己抗原のクローニング及び発現
US5792656A (en) * 1991-06-03 1998-08-11 Board Of Regents, The University Of Texas System Methods of preparing genetically engineered cells that produce insulin in response to glucose
JPH07508503A (ja) * 1992-02-27 1995-09-21 ザ・ボード・オブ・トラステイーズ・オブ・ザ・リランド・スタンフオード・ジユニア・ユニバーシテイ 自己免疫性糖尿病のための初期抗原（ｅａｒｌｙ　ａｎｔｉｇｅｎ）
US5200318A (en) * 1992-05-13 1993-04-06 Miles Inc. Diagnosis of IDDM with a panel of immunoreagents
WO1996038479A1 (fr) * 1995-05-30 1996-12-05 Fujisawa Pharmaceutical Co., Ltd. Procede de diagnostic du diabete sucre insulino-dependant et kit de diagnostic
EP0929683A1 (en) 1996-03-06 1999-07-21 ZymoGenetics, Inc. DIABETES MELLITUS 37 kD AUTOANTIGEN PROTEIN-TYROSINE PHOSPHATASE
JP2001527403A (ja) * 1997-04-25 2001-12-25 ジェネティックス・インスチチュート・インコーポレーテッド 分泌蛋白およびそれらをコードするポリヌクレオチド
CN110244051A (zh) * 2019-07-05 2019-09-17 许昌学院 一种用于糖尿病的多组分标记免疫检测系统

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE53862T1 (de) * 1982-01-22 1990-06-15 Cetus Corp Verfahren zur charakterisierung von hla und die darin benutzten cdns-testmittel.
IL69686A (en) * 1983-09-11 1988-03-31 Yeda Res & Dev Compositions containing cell membrane proteins and process for their preparation
WO1986007464A1 (en) * 1985-06-14 1986-12-18 Genetic Systems Corporation Methods for identifying alleles associated with increased risk of diabetes
CA1327162C (en) * 1987-04-09 1994-02-22 Board Of Trustees Of The Leland Stanford Junior University (The) Method for prophylactically treating an individual for an autoimmune disease
EP0359783B2 (en) * 1987-06-24 2002-04-17 Autoimmune, Inc. Treatment of autoimmune diseases by oral administration of autoantigens

Also Published As

Publication number Publication date
PT93166A (pt) 1990-08-31
IE66997B1 (en) 1996-02-21
CA2010275C (en) 2000-08-29
IE900589L (en) 1990-08-17
CA2010275A1 (en) 1990-08-17
NO306996B1 (no) 2000-01-24
AU626636B2 (en) 1992-08-06
DE69019190T2 (de) 1995-09-14
JPH0347133A (ja) 1991-02-28
EP0383129B1 (en) 1995-05-10
EP0383129A3 (en) 1991-07-31
DE69019190D1 (de) 1995-06-14
FI103730B1 (fi) 1999-08-31
FI900759A0 (fi) 1990-02-15
IL93397A (en) 1997-06-10
GR3017019T3 (en) 1995-11-30
NO900474D0 (no) 1990-02-01
JP2858467B2 (ja) 1999-02-17
NO900474L (no) 1990-08-20
EP0383129A2 (en) 1990-08-22
IL93397A0 (en) 1990-11-29
DK0383129T3 (da) 1995-10-09
ATE122394T1 (de) 1995-05-15
FI103730B (fi) 1999-08-31
AU4988390A (en) 1990-08-23
PT93166B (pt) 1997-11-28

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