ES2073414T3 - Inhibicion de la migracion de celulas con unos peptidos sinteticos. - Google Patents

Inhibicion de la migracion de celulas con unos peptidos sinteticos.

Info

Publication number
ES2073414T3
ES2073414T3 ES89103359T ES89103359T ES2073414T3 ES 2073414 T3 ES2073414 T3 ES 2073414T3 ES 89103359 T ES89103359 T ES 89103359T ES 89103359 T ES89103359 T ES 89103359T ES 2073414 T3 ES2073414 T3 ES 2073414T3
Authority
ES
Spain
Prior art keywords
cells
gly
asp
membrane
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89103359T
Other languages
English (en)
Inventor
Erkki I Ruoslahti
Michael D Pierschbacher
Kurt R Gehlsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanford Burnham Prebys Medical Discovery Institute
Original Assignee
Sanford Burnham Prebys Medical Discovery Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanford Burnham Prebys Medical Discovery Institute filed Critical Sanford Burnham Prebys Medical Discovery Institute
Application granted granted Critical
Publication of ES2073414T3 publication Critical patent/ES2073414T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE PRESENTA UN METODO PARA INHIBIR LAS CELULAS DE INVASION, PARTICULARMENTE CELULAS MALIGNAS, A TRAVES DE UNA MEMBRANA EXTRACELULAR POR MEDIO DE LA PUESTA EN CONTACTO DE LA INTERCONEXION DE LA MEMBRANA CELULAR CON PEPTIDOS SINTETICOS CONTENIENDO ARG - GLY - ASP. EL UNA FORMA EL INVENTO SUMINISTRA PEPTIDOS CONTENIENDO LA SECUENCIA ARG - GLY - ASP - THR DE ACIDO AMINO, MAS ESPECIFICAMENTE GLY - ARG - GLY - ASP - THR - PRO, QUE INHIBE LA UNION DE CELULAS AL COLAGENO DE TIPO I AÑADIDO A FIBROLECTINA Y VITRONECTINA Y UN METODO DE INHIBIR LA UNION DE CELULAS AL COLAGENO DE TIPO I. EL INVENTO ADEMAS SUMINISTRA UN ENSAYO PARA CUANTIFICAR LA CALIDAD INVASIVA DE LAS CELULAS DETERMINANDO LA CANTIDAD DE DICHOS PEPTIDOS PARA EVITAR QUE LAS CELULAS PENETRAN UNA MEMBRANA EXTRACELULAR, TAL COMO UNA MEMBRANA AMNIOTICA IN VITRO.
ES89103359T 1988-03-10 1989-02-25 Inhibicion de la migracion de celulas con unos peptidos sinteticos. Expired - Lifetime ES2073414T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16653088A 1988-03-10 1988-03-10

Publications (1)

Publication Number Publication Date
ES2073414T3 true ES2073414T3 (es) 1995-08-16

Family

ID=22603704

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89103359T Expired - Lifetime ES2073414T3 (es) 1988-03-10 1989-02-25 Inhibicion de la migracion de celulas con unos peptidos sinteticos.

Country Status (6)

Country Link
EP (1) EP0332912B1 (es)
JP (2) JPH024716A (es)
AT (1) ATE121421T1 (es)
CA (1) CA1324954C (es)
DE (1) DE68922234T2 (es)
ES (1) ES2073414T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2662830B2 (ja) * 1990-10-26 1997-10-15 富士写真フイルム株式会社 Ｃｍ−キチン誘導体およびその用途
CA2074945A1 (en) * 1990-11-30 1992-05-31 Atsushi Isoai Tumor cell invasion-inhibiting peptides, peptide complexes and cancer metastasis inhibitors
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
WO2003038431A1 (en) * 2001-10-26 2003-05-08 The Regents Of The University Of California Method for screening combinatorial bead library, capturing cells from body fluids, and ligands for cancer cells
WO2004085473A2 (en) * 2003-03-28 2004-10-07 Fuji Photo Film B.V. Rgd-enriched gelatine-like proteins with enhanced cell binding
AU2008306264A1 (en) * 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of a platelet fibrinogen receptor hexapeptide antagonist and alpha-endorphin as therapeutic agents
JP2010538991A (ja) * 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト 治療剤としてのｓｆｌｌｒ−ｏｈおよびムラミルジペプチドの使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1311583C (en) * 1986-12-15 1992-12-15 Gerard Armand Marguerie De Rotrou Peptide derivatives and their application, in particular in therapy
IT1222437B (it) * 1987-08-04 1990-09-05 Ellem Ind Farmaceutica Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione

Also Published As

Publication number Publication date
DE68922234D1 (de) 1995-05-24
ATE121421T1 (de) 1995-05-15
DE68922234T2 (de) 1995-08-31
CA1324954C (en) 1993-12-07
JP2744902B2 (ja) 1998-04-28
EP0332912A3 (en) 1989-11-08
EP0332912B1 (en) 1995-04-19
JPH08332097A (ja) 1996-12-17
JPH024716A (ja) 1990-01-09
EP0332912A2 (en) 1989-09-20

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