ES2074721T3 - Derivados de ciclopentano, procedimientos para su preparacion y su utilizacion farmaceutica. - Google Patents

Derivados de ciclopentano, procedimientos para su preparacion y su utilizacion farmaceutica.

Info

Publication number
ES2074721T3
ES2074721T3 ES91912997T ES91912997T ES2074721T3 ES 2074721 T3 ES2074721 T3 ES 2074721T3 ES 91912997 T ES91912997 T ES 91912997T ES 91912997 T ES91912997 T ES 91912997T ES 2074721 T3 ES2074721 T3 ES 2074721T3
Authority
ES
Spain
Prior art keywords
pharmaceutical use
derivatives
cyclopentan
procedures
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91912997T
Other languages
English (en)
Inventor
Ulrich Dr Klar
Hartmut Dr Rehwinkel
Helmut Prof Vorbruggen
Karl-Heinz Dr Thierauch
Peter Dr Verhallen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2074721T3 publication Critical patent/ES2074721T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION SE REFIERE A DERIVADOS DEL CICLOPENTANO DE LA FORMULA (I) EN LA QUE HAY UN DOBLE ENLACE ENTRE LOS ATOMOS DE CARBONO DE CENTROS A-B O C-D, Y A SUS SALES CON BASES TOLERABLES FISIOLOGICAMENTE, ASI COMO LOS CICLODEXTRINA CLATRATOS (ALFA), (BETA) O Y, ASI COMO LOS COMPUESTOS ENCAPSULADOS CON LIPOSOMAS DE LA FORMULA (I), PROCESO PARA SU FABRICACION Y SU EMPLEO FARMACEUTICO.
ES91912997T 1990-07-27 1991-07-22 Derivados de ciclopentano, procedimientos para su preparacion y su utilizacion farmaceutica. Expired - Lifetime ES2074721T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4024347A DE4024347A1 (de) 1990-07-27 1990-07-27 Cyclopentanderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung

Publications (1)

Publication Number Publication Date
ES2074721T3 true ES2074721T3 (es) 1995-09-16

Family

ID=6411402

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91912997T Expired - Lifetime ES2074721T3 (es) 1990-07-27 1991-07-22 Derivados de ciclopentano, procedimientos para su preparacion y su utilizacion farmaceutica.

Country Status (13)

Country Link
EP (1) EP0541594B1 (es)
JP (1) JPH06502390A (es)
AT (1) ATE122036T1 (es)
AU (1) AU8221291A (es)
CA (1) CA2088161A1 (es)
DE (3) DE4024347A1 (es)
DK (1) DK0541594T3 (es)
ES (1) ES2074721T3 (es)
IE (1) IE67507B1 (es)
IL (1) IL98970A0 (es)
PT (1) PT98464B (es)
WO (1) WO1992002495A1 (es)
ZA (1) ZA915905B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4036140A1 (de) * 1990-11-09 1992-05-14 Schering Ag 9-halogen-11ss-hydroxy-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
AU687906B2 (en) * 1993-12-15 1998-03-05 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
WO1999012896A1 (en) * 1997-09-09 1999-03-18 The Procter & Gamble Company Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
ATE270660T1 (de) * 1997-09-09 2004-07-15 Univ Duke Aromatische c16-c20-substituierte tetrahydro- prostaglandine verwendbar wie fp agoniste
DK1012137T3 (da) * 1997-09-09 2003-03-10 Procter & Gamble Aromatiske C-16-C-20-substituerede tetrahydro-prostaglandiner og deres anvendelse som prostaglandin FP-agonister
EP1071648A2 (en) * 1998-03-13 2001-01-31 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
US6242493B1 (en) 1998-03-13 2001-06-05 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
ES2232434T3 (es) 1999-03-05 2005-06-01 Duke University Analogos de prostaglandinas c-16 fp selectivas insaturadas.
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US7323591B2 (en) * 2006-01-10 2008-01-29 Allergan, Inc. Substituted cyclopentanes or cyclopentanones as therapeutic agents
AU2009246573B2 (en) * 2008-05-15 2014-04-24 Allergan, Inc. Therapeutic substituted cyclopentanes
CN106928227B (zh) * 2010-07-15 2020-06-30 浙江奥翔药业股份有限公司 恩替卡韦的合成方法及其中间体化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1431561A (en) * 1973-01-31 1976-04-07 Ici Ltd Cyclopentane derivatives
IT1053781B (it) * 1974-09-25 1981-10-10 Erba C S P A Ora Farmitalia Omega nor cicloalcil 13.14 deidro prostaglandine
FR2349328A1 (fr) * 1976-04-30 1977-11-25 Roussel Uclaf Nouveaux derives de la 11-desoxy prostaglandine f2, leur procede de preparation et leur application comme medicaments
DE3126924A1 (de) * 1981-07-03 1983-01-20 Schering Ag, 1000 Berlin Und 4619 Bergkamen 9-fluor-prostaglandinderivate, verfahren zur herstellung und verwendung als arzneimittel
DE3325175A1 (de) * 1983-07-08 1985-01-17 Schering AG, 1000 Berlin und 4709 Bergkamen 11-halogen-prostanderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3510978A1 (de) * 1985-03-22 1986-09-25 Schering AG, Berlin und Bergkamen, 1000 Berlin Neue 9-halogenprostaglandine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
HU206084B (en) * 1987-07-17 1992-08-28 Schering Ag Process for producing 9-halogen-/z/-prostaglandin derivatives and pharmaceutical compositions comprising such active ingredient
DE3923797A1 (de) * 1989-07-14 1991-01-24 Schering Ag 9-fluor-prostaglandin-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung

Also Published As

Publication number Publication date
PT98464A (pt) 1992-05-29
IE912654A1 (en) 1992-01-29
EP0541594A1 (de) 1993-05-19
WO1992002495A1 (de) 1992-02-20
IE67507B1 (en) 1996-04-03
CA2088161A1 (en) 1992-01-28
PT98464B (pt) 1997-10-31
AU8221291A (en) 1992-03-02
IL98970A0 (en) 1992-07-15
JPH06502390A (ja) 1994-03-17
DK0541594T3 (da) 1995-10-02
EP0541594B1 (de) 1995-05-03
DE4191848D2 (de) 1993-10-07
ZA915905B (en) 1992-04-29
DE4024347A1 (de) 1992-01-30
DE59105400D1 (de) 1995-06-08
ATE122036T1 (de) 1995-05-15

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